公开(公告)号：US20070038138A1

公开(公告)日：2007-02-15

申请号：US11202534

申请日：2005-08-11

Applicant: Jong Gill ,  Gene Bornzin

Inventor： Jong Gill ,  Gene Bornzin

IPC: A61B5/04

CPC classification number: A61B5/0452 ,  A61B5/201 ,  A61N1/3702

Abstract: Morphological features within electrical cardiac signals are tracked and changes in features are monitored to detect renal failure. The morphological feature may be an interval between corresponding polarization events such as the interval between QRS-complexes and peaks of corresponding T-waves (QTmax interval); the interval between QRS-complexes and ends of corresponding T-waves (QTend interval); or the interval between P-waves and corresponding QRS-complexes (PR interval). The feature may also be the elevation of a cardiac signal segment between corresponding polarization events, such as QRS-complexes and corresponding T-waves (ST segment); a duration of a polarization event, such as a QRS-complex (QRS width); or an amplitude of a polarization event, such as a T-wave (T-wave amplitude). The change in the feature may comprise a decrease in QTmax intervals, a decrease in QTend intervals, a deviation in ST segment elevation, an increase in QRS width, an increase in PR interval or a deviation in T-wave amplitude.

Abstract translation: 跟踪电心电信号中的形态学特征，监测特征变化以检测肾功能衰竭。 形态特征可以是相应的极化事件之间的间隔，例如QRS-复合物之间的间隔和对应的T波的峰值（QTmax间隔）; QRS复合体与相应T波结束之间的间隔（QTend间隔）; 或P波与相应的QRS复合体之间的间隔（PR间隔）。 该特征还可以是对应的极化事件之间的心脏信号段的升高，例如QRS复合物和相应的T波（ST段）; 极化事件的持续时间，例如QRS复合（QRS宽度）; 或极化事件的振幅，例如T波（T波振幅）。 特征的变化可以包括QTmax间隔的减小，QTend间隔的减小，ST段抬高的偏差，QRS宽度的增加，PR间期的增加或T波幅度的偏差。

公开(公告)号：US07146204B2

公开(公告)日：2006-12-05

申请号：US10974117

申请日：2004-10-26

Applicant: Hadassa Degani ,  Maril Nimrod

Inventor： Hadassa Degani ,  Maril Nimrod

IPC: A61B5/055

CPC classification number: A61B5/201 ,  A61B5/055 ,  A61B5/417 ,  A61K49/0002 ,  A61K49/06 ,  G06T7/0012 ,  G06T2207/30004

Abstract: A method and apparatus for monitoring a kidney that consists of monitoring the corticomedullary sodium concentration gradient in a kidney by an imaging technique selected from the group consisting of MRI, optical imaging, computed tomography (CT), ultrasound or positron emission tomography (PET), to obtain dynamic images; processing the obtained images to quantitatively determine, pixel by pixel of the images, the concentration of sodium along the corticomedullary axis of the kidney; and mapping the sodium distribution at high resolution to indicate the sodium concentration gradient of the corticomedullary axis of the kidney. Preferably the monitoring is carried out using 23Na MRI. Maps of the sodium distribution are displayed.

Abstract translation: 用于监测肾脏的方法和装置包括通过选自MRI，光学成像，计算机断层摄影（CT），超声或正电子发射断层摄影（PET）的成像技术监测肾脏中的肾上腺髓质钠浓度梯度， 获取动态图像; 处理所获得的图像以逐个像素的方式确定肾脏沿肾上皮轴的钠浓度; 并以高分辨率绘制钠分布，以指示肾脏的肾上腺轴的钠浓度梯度。 优选地，使用Na + MRI进行监测。 显示钠分布图。

公开(公告)号：US20060253064A1

公开(公告)日：2006-11-09

申请号：US11409171

申请日：2006-04-21

Applicant: Mark Gelfand ,  Robert Rudko ,  Mark Tauscher ,  Howard Levin

Inventor： Mark Gelfand ,  Robert Rudko ,  Mark Tauscher ,  Howard Levin

IPC: A61M1/00

CPC classification number: A61M5/142 ,  A61B5/201 ,  A61B5/208 ,  A61B5/4839 ,  A61M5/007 ,  A61M5/16895 ,  A61M5/1723 ,  A61M5/365 ,  A61M2205/18 ,  A61M2205/3355 ,  A61M2205/3393 ,  G01G17/04

Abstract: A patient hydration system with a patient urine output measurement device, a hydration fluid administration subsystem, and a controller, responsive to the patient urine output measurement device. The controller is configured to control the hydration fluid administration subsystem to administer hydration fluid to the patient to prevent dehydration of the patient. A hydration sensor is also included to detect at least one patient parameter indicative of the patient's hydration state.

Abstract translation: 具有患者尿液输出测量装置，水合液体给药子系统和控制器的患者水合系统，其响应于患者尿液输出测量装置。 控制器被配置为控制水合流体管理子系统以向患者施用水合流体以防止患者脱水。 还包括水化传感器以检测指示患者的水合状态的至少一个患者参数。

公开(公告)号：US20040068177A1

公开(公告)日：2004-04-08

申请号：US10648167

申请日：2003-08-26

Inventor： Martin R. Prince

IPC: A61B005/05

CPC classification number: A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

Abstract translation: 本发明是用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。

公开(公告)号：US20030060726A1

公开(公告)日：2003-03-27

申请号：US10154365

申请日：2002-05-23

Inventor： Yuh-Jiuan Lin ,  Hong-Ru Guo

IPC: A61B005/08

CPC classification number: A61B5/201 ,  A61B5/097 ,  A61B5/20 ,  G01N33/497 ,  G06F19/00

Abstract: A breath-based diagnostic device. The device includes an array of multiple gas sensors, a database storage device and a microprocessor. The gas sensors contain material capable of reacting with volatile organic chemicals in the exhaled breath of the subject. The database storage device stores established responses to a variety of disease. The microprocessor compares the response detected by the gas sensors and the database so as to perform the diagnosis.

Abstract translation: 一种基于呼吸的诊断装置。 该装置包括多个气体传感器阵列，数据库存储装置和微处理器。 气体传感器包含能够与受试者的呼出气体中的挥发性有机化学物质反应的物质。 数据库存储设备存储针对各种疾病的已建立的响应。 微处理器比较由气体传感器和数据库检测到的响应，以进行诊断。

公开(公告)号：US20020161314A1

公开(公告)日：2002-10-31

申请号：US09959089

申请日：2001-12-05

Inventor： Malla Sarajarvi

IPC: A61B005/00

CPC classification number: A61B5/201 ,  A61B5/14507 ,  A61B5/208

Abstract: The invention relates to an arrangement for a patient monitor arranged to measure one or more parameters from a patient from other than urine or the urinary tract. To improve the ergonomics of patient monitoring work, the arrangement comprises a sensor (8) that is arranged between a patient urinary tract catheter (6) and a urine collection container (7) or the like and that is arranged to measure at least the flow or volume of the patient's urine output, and means (9) for conveying the data measured to the patient monitor (2)

Abstract translation: 本发明涉及一种用于患者监视器的布置，其布置成从除尿液或尿道以外的患者测量一个或多个参数。 为了改善患者监测工作的人体工程学，该装置包括布置在患者尿路导管（6）和尿液收集容器（7）等之间的传感器（8），并被设置成至少测量流量 或体积的患者尿量，以及用于将测量的数据传送到患者监护仪（2）的装置（9）

公开(公告)号：US06463318B2

公开(公告)日：2002-10-08

申请号：US09828429

申请日：2001-04-07

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5055

CPC classification number: A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Abstract translation: 本发明是一种通过将磁共振对比度增强的动脉期期间的磁共振对比度图像的预定部分数据的收集相关联来提供相对于相邻静脉和背景组织的感兴趣的动脉的优先增强的技术和装置 。 对比度增强的动脉期可以描述为相对于相邻静脉的感兴趣动脉中的最大，基本升高或升高的对比浓度的周期。本发明包括用于监测和检测对比度的到达的检测系统 在动脉和组织中的药剂。 当感兴趣区域的动脉中的造影剂的浓度最大时，基本升高或升高（例如，在给予磁性之前一系列磁共振脉冲的感兴趣区域的响应大约20-50％ 共振造影剂），可以获取磁共振图像数据的预定部分（例如，表示k空间的中心的数据）。 因此，本发明有助于将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。 k空间的中心对应于支配图像对比度的最低空间频率数据。

公开(公告)号：US06230041B1

公开(公告)日：2001-05-08

申请号：US09124262

申请日：1998-07-29

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5055

CPC classification number: A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

Abstract translation: 本发明是用于获取用于诊断和表征腹主动脉瘤性疾病等的解剖信息的技术和装置。 该技术以图像的形式使用包括自旋回波和四个对比度增强（例如，钆）磁共振血管造影序列的多个磁共振血管造影术序列的组合来提供解剖信息。 解剖图像可以用于例如主动脉病理学的术前，手术和术后评价，包括动脉瘤，动脉粥样硬化和分支血管如肾动脉的闭塞性疾病。 钆增强磁共振血管造影提供足够的解剖学细节来检测血管造影术中所见的动脉瘤和所有相关主要分支血管异常。 该技术和装置允许以常规造影术的成本的一小部分成像主动脉，并且不存在动脉导管插入或碘化对比的风险。

公开(公告)号：US6001060A

公开(公告)日：1999-12-14

申请号：US865774

申请日：1997-05-30

Applicant: Bernard M. Churchill ,  Edward F. Wahl

Inventor： Bernard M. Churchill ,  Edward F. Wahl

IPC: A61B5/03 ,  A61B5/20 ,  G06F19/00 ,  G06T11/20 ,  A61B5/00

CPC classification number: G06T11/206 ,  A61B5/201 ,  A61B5/202 ,  A61B5/204 ,  A61B5/205 ,  A61B5/42

Abstract: A system for patient diagnostic testing includes the physiological data output is in a two dimensional graphical format. Optionally, the report includes imaging data. Color is a dimension provided to the graphical presentation of normal patient data in horizontal and vertical dimensions. Detrusor pressures are obtained. One detrusor pressure is the difference between average data points of the bladder and rectal pressures. The other is obtained by subtracting curve fitted rectal and bladder pressures. The displayed data is a presentation including bladder capacity information, pressure characteristics, and data as a function of volume such that bladder volume is indicated.

Abstract translation: 用于患者诊断测试的系统包括生理数据输出是二维图形格式。 可选地，报告包括成像数据。 颜色是提供给水平和垂直尺寸的正常患者数据的图形呈现的维度。 达到逼尿肌压力。 一个逼尿肌压力是膀胱平均数据点和直肠压力之间的差异。 另一个是通过减去曲线拟合的直肠和膀胱压力获得的。 显示的数据是包括膀胱容量信息，压力特性和作为体积的函数的数据的呈现，使得指示膀胱体积。

公开(公告)号：US5762065A

公开(公告)日：1998-06-09

申请号：US705818

申请日：1996-08-30

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

Abstract translation: 本发明是一种用于相对于相邻静脉和背景组织提供感兴趣的动脉的优先增强的方法和装置。 所述方法和装置使最大或基本上提高的输注速率的时间适应与对应于k空间中心的图像数据的收集相关。 技术和设备根据感兴趣的动脉的位置，感兴趣的动脉的大小，患者的身体状况，时间上相关联的最大或基本上升高的输注速率的时间和k空间的映射 由于造影剂传送系统的配置引起的时间延迟和/或成像装置采用的脉冲序列的类型。 适应最大或基本上提高的输注速率的时间与对应于k空间中心的图像数据的收集相关联，提供在收集期间相对于相邻静脉的感兴趣动脉中的最大或基本上升高的对比浓度的周期 的图像数据的至少一部分对应于k空间的中心。