公开(公告)号：US08049017B2

公开(公告)日：2011-11-01

申请号：US13039137

申请日：2011-03-02

Applicant: Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Miβlitz ,  Ernst Baumann

Inventor： Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Miβlitz ,  Ernst Baumann

IPC: C07D261/04

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6烷基，R 2是C 1 -C 6烷基，R 3，R 4，R 5是氢，C 1 -C 6 - 烷基 ，或R4和R5一起形成键，R6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法。

公开(公告)号：US20110152563A1

公开(公告)日：2011-06-23

申请号：US12737739

申请日：2009-08-10

Applicant: Joseph P. Noel ,  Justin A. Ramsey ,  Thomas J. Baiga

Inventor： Joseph P. Noel ,  Justin A. Ramsey ,  Thomas J. Baiga

IPC: C07C69/76 ,  C07C315/00 ,  C07C205/00

CPC classification number: C07C69/013 ,  C07C67/00 ,  C07C69/608 ,  C07C69/78 ,  C07C201/10 ,  C07C205/03 ,  C07C315/04 ,  C07C2602/28 ,  C07C317/14 ,  C07C317/28

Abstract: Disclosed herein is a method for synthesizing terpenoid compounds, as well as compositions comprising terpenoids and methods for their use. In one aspect the process is represented by the scheme wherein G is X is and R1, R2 and R3 independently are selected from H, acyl, lower alkyl and aralkyl; and Y is —O—, —S— or —NH—, and R4 is selected from H, acyl, lower alkyl and aralkyl.

Abstract translation: 本文公开了一种合成萜类化合物的方法，以及包含萜类化合物的组合物及其用途。 在一个方面，该方法由其中G是X是且R 1，R 2和R 3独立地选自H，酰基，低级烷基和芳烷基的方案表示。 并且Y是-O - ， - S-或-NH-，并且R 4选自H，酰基，低级烷基和芳烷基。

公开(公告)号：US20110065964A1

公开(公告)日：2011-03-17

申请号：US12735886

申请日：2009-02-26

Applicant: Jacob Oren

Inventor： Jacob Oren

IPC: C07C201/12

CPC classification number: C07C201/10 ,  C07C201/12 ,  C07C205/15

Abstract: The invention provides a process for preparing bronopol, which process comprises charging a reaction vessel with water, bromopicrin, nitromethane and paraformaldehyde, gradually feeding a base into said reaction vessel under stirring, bringing the reaction to completion and separating bronopol from the aqueous reaction mixture.

Abstract translation: 本发明提供了一种制备青霉酚的方法，该方法包括向反应容器中加入水，溴氰菊酯，硝基甲烷和多聚甲醛，在搅拌下逐渐向碱性物质中加入碱，使反应完成，并从反应混合物中分离出丙三醇。

公开(公告)号：US07663001B2

公开(公告)日：2010-02-16

申请号：US11684630

申请日：2007-03-11

Applicant: Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Miβlitz ,  Ernst Baumann

Inventor： Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Miβlitz ,  Ernst Baumann

IPC: C07C239/08

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6烷基，R 2是C 1 -C 6烷基，R 3，R 4，R 5是氢，C 1 -C 6 - 烷基 ，或R4和R5一起形成键，R6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法。

公开(公告)号：US20040256743A1

公开(公告)日：2004-12-23

申请号：US10864533

申请日：2004-06-10

Applicant: Mitsui Chemicals, Inc.

Inventor： Setsuko Funaki ,  Yoshiteru Taniguchi ,  Tadahito Nobori ,  Yoshihiro Yamamoto ,  Isao Hara ,  Takaomi Hayashi ,  Kazumi Mizutani ,  Shinji Kiyono

IPC: C07F005/00 ,  C07F001/02

CPC classification number: C07D307/33 ,  C07B37/04 ,  C07B41/00 ,  C07B43/00 ,  C07C17/208 ,  C07C29/124 ,  C07C67/10 ,  C07C67/11 ,  C07C67/287 ,  C07C201/10 ,  C07C209/08 ,  C07C253/14 ,  C07C253/30 ,  C07C319/14 ,  C07C331/14 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/18 ,  C07D307/14 ,  C07D307/24 ,  C07C23/08 ,  C07C69/003 ,  C07C323/22 ,  C07C205/02 ,  C07C323/56 ,  C07C255/46 ,  C07C255/41 ,  C07C255/20 ,  C07C255/19 ,  C07C255/16 ,  C07C255/03 ,  C07C211/42 ,  C07C69/145 ,  C07C69/24 ,  C07C69/63 ,  C07C33/24

Abstract: A method for producing an organic compound having Q, the method including a step of reacting a compound represented by general formula (2) with an organic starting material having at least one halogen atom bonded to a carbon atom having four null bonds so as to replace the halogen atom in the organic starting material with Q: MQanullnull(2) wherein M, Q and a are defined in the presence of a compound represented by general formula (1) 1 wherein Znull and Rs are also defined.

Abstract translation: 一种制备具有Q的有机化合物的方法，该方法包括使通式（2）表示的化合物与具有至少一个卤素原子键合的有机原料与具有四个σ键的碳原子反应的步骤，以便代替 在通式（1）表示的化合物的存在下，定义其中M，Q和a的Q：MQa（2）中的卤素原子，其中Z'和R 5也被定义。

公开(公告)号：US20030018200A1

公开(公告)日：2003-01-23

申请号：US10180608

申请日：2002-06-27

Inventor： Joachim Rheinheimer ,  Wolfgang Von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Gotz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

IPC: C07D413/02

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I 1 where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI 2 where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6烷基，R 2是C 1 -C 6烷基，R 3，R 4，R 5是氢，C 1 -C 6 - 烷基 ，或R4和R5一起形成键，R6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法

公开(公告)号：USH1223H

公开(公告)日：1993-08-03

申请号：US702215

申请日：1991-05-17

Applicant: Thomas G. Archibald ,  Nghi Van Nguyen ,  Kurt Baum

Inventor： Thomas G. Archibald ,  Nghi Van Nguyen ,  Kurt Baum

IPC: C07C205/26 ,  C07C31/34 ,  C07C205/00

CPC classification number: C07C201/10 ,  C07C201/12 ,  C07C205/51 ,  C07C205/08 ,  C07C205/26

Abstract: A method of producing FDNE using readily available fluoroolefins as a fluorine source.

公开(公告)号：US5136109A

公开(公告)日：1992-08-04

申请号：US707097

申请日：1991-05-29

Applicant: Osamu Kimura ,  Yasuhiko Horikawa ,  Masaya Yamashita ,  Kazutaka Morino ,  Shinichi Koyama

Inventor： Osamu Kimura ,  Yasuhiko Horikawa ,  Masaya Yamashita ,  Kazutaka Morino ,  Shinichi Koyama

IPC: C07C201/10 ,  C07C205/26

CPC classification number: C07C201/08 ,  C07C201/10 ,  C07C201/16

Abstract: 2-4-Dichloro-3-alkyl-6-nitrophenols which are useful as intermediate of cyan couplers in color photography are prepared by sulfonating 4-chloro-3-alkyl-phenols to obtain 5-chloro-4-alkylhydroxybenzenesulfonic acids, chlorinating the acids in an aqueous phase to obtain 3,5-dichloro-4-alkyl-2-hydroxybenzenesulfonic acids and nitrating the sulfonic acids.

公开(公告)号：US5057630A

公开(公告)日：1991-10-15

申请号：US505861

申请日：1990-04-06

Applicant: John W. Lackey ,  Robert A. Mook, Jr. ,  John J. Partridge

Inventor： John W. Lackey ,  Robert A. Mook, Jr. ,  John J. Partridge

IPC: C07C35/06 ,  C07C69/96 ,  C07C205/18 ,  C07C205/41 ,  C07D473/00

CPC classification number: C07D473/00 ,  C07C201/10 ,  C07C201/12 ,  C07C35/06 ,  C07C69/96 ,  C07C2101/10

Abstract: This invention relates to a new process for preparing certain optically active purine substituted cyclopentene derivatives including the antiviral agent, carbovir, and novel intermediates used in this process. In particular, this invention concerns a synthesis of (1R-cis)-4-hydroxymethyl-2-cyclopenten-1-ol, an intermediate in this process.

Abstract translation: 本发明涉及一种制备某些光学活性嘌呤取代的环戊烯衍生物的新方法，包括抗病毒剂，维生素和该方法中使用的新型中间体。 特别地，本发明涉及在该方法中的中间体的（1R-顺式）-4-羟甲基-2-环戊烯-1-醇的合成。

公开(公告)号：US4605777A

公开(公告)日：1986-08-12

申请号：US744143

申请日：1985-06-12

Applicant: Boris Holm

Inventor： Boris Holm

IPC: C07B61/00 ,  B01J27/00 ,  C07C45/63 ,  C07C67/00 ,  C07C201/00 ,  C07C201/10 ,  C07C205/44 ,  C07C79/36

CPC classification number: C07C201/10 ,  C07C45/63

Abstract: This invention relates to a method of manufacturing ortho- and para-nitrobenzaldehyde from o-chloro or o-bromobenzaldehyde and p-chloro or p-bromobenzaldehyde respectively through a nucleophilic aromatic substitution reaction performed in an organic solvent.

Abstract translation: 本发明涉及分别通过在有机溶剂中进行的亲核芳族取代反应从邻氯或邻溴苯甲醛和对氯或对溴苯甲醛生产邻硝基苯甲醛和对硝基苯甲醛的方法。