公开(公告)号：US07823468B2

公开(公告)日：2010-11-02

申请号：US11698368

申请日：2007-01-26

Applicant: Dale A. Davison

Inventor： Dale A. Davison

IPC: G01N30/20 ,  F16K11/085

CPC classification number: G01N30/20 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/86541

Abstract: A sample injector includes a rotary valve element with a straight passageway through it, which element may be rotated to connect a port communicating with a source of solvent with a port communicating with an inlet to a column. Another passageway connects two adjacent ports. The valve element may be rotated to one position in which it provides a straight path for sample to be injected, a second position in which it provides a path that connects a source of purge gas to the chromatographic system and a third position in which it provides a path that connects solvent to the column for preconditioning.

Abstract translation: 样品注射器包括具有通过其的直通道的旋转阀元件，该元件可以旋转以连接与溶剂源连通的端口和与入口连通的端口。 另一个通道连接两个相邻的端口。 阀元件可以旋转到一个位置，在该位置，其提供用于样品注射的直线路径，第二位置，其中提供将吹扫气体源连接到色谱系统的路径，以及第三位置，其中提供 将溶剂与柱连接用于预处理的路径。

公开(公告)号：US20100112606A1

公开(公告)日：2010-05-06

申请号：US12581436

申请日：2009-10-19

Applicant: Michael Armstrong ,  Nichole Ann-Marie Reisdorph ,  Nathan Rabinovitch

Inventor： Michael Armstrong ,  Nichole Ann-Marie Reisdorph ,  Nathan Rabinovitch

IPC: G01N33/542 ,  C12Q1/02 ,  C12Q1/26 ,  H01J49/26

CPC classification number: G01N33/6848 ,  G01N30/7233 ,  G01N2030/085 ,  G01N2030/201

Abstract: The present invention provides a new analytical method for measuring leukotrienes in a clinical sample using liquid chromatography and tandem mass spectrometry (LCMSMS). The method provides a simple, rapid and low-cost assay for the measurement of leukotriene levels in a clinical sample with high accuracy and precision over the physiological range. The present invention further provides a method to determine the susceptibility of a subject to treatment with a leukotriene modifier, as wells as methods for diagnosis of a chronic obstructive disease of the airways and for predicting the risk of exacerbation of the same.

Abstract translation: 本发明提供了一种使用液相色谱和串联质谱（LCMSMS）测量临床样品中白三烯的新分析方法。 该方法提供了一种简单，快速和低成本的测定方法，用于在生理范围内以高精度和精确度测量临床样品中的白三烯水平。 本发明还提供一种确定受试者用白三烯改良剂治疗的易感性的方法，作为诊断气道慢性阻塞性疾病的方法以及预测其恶化的风险的方法。

公开(公告)号：US07544293B2

公开(公告)日：2009-06-09

申请号：US11234798

申请日：2005-09-26

Applicant: Anil Rajaram Oroskar ,  Saurabh Paresh Parikh ,  Asha Anil Oroskar ,  Kenneth U. Johnson ,  Anthony Joseph Escarcega

Inventor： Anil Rajaram Oroskar ,  Saurabh Paresh Parikh ,  Asha Anil Oroskar ,  Kenneth U. Johnson ,  Anthony Joseph Escarcega

IPC: B01D15/08

CPC classification number: F16K11/074 ,  B01D15/1821 ,  G01N30/20 ,  G01N30/461 ,  G01N30/6047 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/86815

Abstract: A unique valve assembly for simulated bed moving chromatography employs a combination of pressure compatible sealable materials that permit minimal frictional interaction between moving parts, ensures alignment of parts, and provides a method for conducting SMB countercurrent chromatography on a small scale, in which purity and separation efficiency are enhanced. Machine designs are disclosed which embody the SMB concepts. Finally, a quick disconnect connector and adaptor is provided for mounting chromatographic columns in an SMB device. Demonstration of this system in a fructose-glucose isomer separation with purity-recovery trade-off for this device is also presented.

Abstract translation: 用于模拟床移动色谱的独特阀组件采用压力兼容的可密封材料的组合，其允许运动部件之间的最小摩擦相互作用，确保部件的对准，并提供小规模进行SMB逆流色谱的方法，其中纯度和分离 效率提高。 公开了体现SMB概念的机器设计。 最后，提供快速断开连接器和适配器，用于将色谱柱安装在SMB设备中。 还提出了该系统在用于该装置的纯度恢复权衡的果糖 - 葡萄糖异构体分离中的证明。

公开(公告)号：US20060191581A1

公开(公告)日：2006-08-31

申请号：US10551751

申请日：2004-04-02

Applicant: Hansjorg Cueni ,  Heiner Scherrer ,  Werner Dobelin

Inventor： Hansjorg Cueni ,  Heiner Scherrer ,  Werner Dobelin

IPC: F16K11/074 ,  G01N30/20

CPC classification number: F16K11/0743 ,  G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/86863

Abstract: The rotating valve for high performance liquid chromatography (HPLC) has a stator with connections for the solvent reservoirs, pumps, chromatography columns etc. and a disc-shaped rotor with connecting grooves on the front face for selectively connecting different connections to one another. Said grooves are evenly distributed on two concentrical circles. The connecting grooves on the front face of the rotor are configured in the form of circular segments and are arranged in such a way that fife connections are simultaneously connected to one another in defined positions of the rotor in each circle.

Abstract translation: 用于高效液相色谱（HPLC）的旋转阀具有定子，其具有用于溶剂储存器，泵，色谱柱等的连接，以及具有用于选择性地将不同连接彼此连接的盘形转子，其具有在前表面上的连接凹槽。 所述槽均匀分布在两个同心圆上。 转子前表面上的连接槽被构造成圆形段的形式，并且以这样的方式设置，使得在每个圆圈中的转子的限定位置中，连接件彼此同时连接。

公开(公告)号：US20060011548A1

公开(公告)日：2006-01-19

申请号：US11224904

申请日：2005-09-12

Applicant: Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek

Inventor： Hongfeng Yin ,  Kevin Killeen ,  Daniel Sobek

IPC: B01D15/08

CPC classification number: G01N30/34 ,  G01N30/6095 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/285

Abstract: The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

公开(公告)号：US06874354B2

公开(公告)日：2005-04-05

申请号：US10415872

申请日：2001-11-12

Applicant: Hansjörg Cueni ,  Heinrich Scherrer

Inventor： Hansjörg Cueni ,  Heinrich Scherrer

IPC: G01N35/10 ,  G01N30/20 ,  G01N30/24 ,  G01N31/08

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/86743 ,  G01N2030/402

Abstract: The sample injection valve for high-performance liquid chromatography (HPLC) devices comprises a stator with inlets for the sample and the mobile phase, outlets leading to the chromatography column and to a waste collector, as well as connections for both ends of a sample loop. Its rotor has the customary connection channels. An additional washing liquid inlet (7) opens into the connecting channel (9) that, in one valve position, connects the sample inlet (1) to the outlet (2) leading to the waste collector. This enables the sample inlet and the pipette or syringe located therein to be rinsed.

Abstract translation: 用于高效液相色谱（HPLC）装置的样品注射阀包括具有用于样品和流动相的入口的定子，通向色谱柱和废物收集器的出口，以及样品环两端的连接 。 其转子具有常规的连接通道。 另外的洗涤液入口（7）通向连接通道（9），在一个阀位置，将样品入口（1）连接到通向废物收集器的出口（2）。 这使得样品入口和位于其中的移液管或注射器能够被冲洗。

公开(公告)号：US20040112444A1

公开(公告)日：2004-06-17

申请号：US10650111

申请日：2003-08-26

Applicant: Bruker BioSpin GmbH

Inventor： Martin Hofmann

IPC: F16K011/074

CPC classification number: G01N30/20 ,  G01N2030/201 ,  G01N2030/204 ,  Y10T137/5762 ,  Y10T137/86863

Abstract: A multiport switching valve for a liquid flow system is described, comprising a first member having a plurality of ports for connecting liquid lines thereto, a second member, connected with a first member and movable relative to the first member, the second member comprising a plurality of channels, wherein the channels are arranged such that, according to a selected relative position between the first and second member, one or more of said channel connect predetermined ones of the ports of the first member with one another in a liquid conducting manner. The first member comprises at least one group of ports arranged in one substantially straight line or at least two adjacent substantially parallel and substantially straight lines, and the second member comprises a plurality of segments, wherein the segments have one or more channels arranged therein, the channel or channels of each segment representing a predetermined connection scheme for connecting predetermined ones of the ports with one another.

Abstract translation: 描述了一种用于液体流动系统的多端口切换阀，包括具有用于连接液体管线的多个端口的第一部件，与第一部件连接并可相对于第一部件移动的第二部件，第二部件包括多个 的通道，其中所述通道被布置成使得根据所述第一和第二构件之间的选定的相对位置，所述通道中的一个或多个将所述第一构件的所述端口中的预定端口以液体导通方式彼此连接。 第一构件包括布置在一个基本上直线或至少两个相邻的基本上平行和基本上直线的至少一组端口，并且第二构件包括多个段，其中段具有布置在其中的一个或多个通道， 每个段的通道或通道表示用于将预定端口彼此连接的预定连接方案。

公开(公告)号：US20020131905A1

公开(公告)日：2002-09-19

申请号：US10093599

申请日：2002-03-08

Inventor： Leroy D. Cordill

IPC: B01L011/00

CPC classification number: G01N30/20 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/205 ,  G01N2030/8804 ,  Y10T137/4456 ,  Y10T436/11 ,  Y10T436/118339 ,  Y10T436/2575

Abstract: A multiple port valve integrated with the function of the sample shut off valve is disclosed. The integration of the sample shut off function eliminates extra plumbing and labor costs associated with a separate sample shut off valve. Additionally, the multiple port valve integrated with the function of the sample shut off valve provides a shorter equilibration time and less tubing volume.

Abstract translation: 公开了与样品截止阀的功能集成的多端口阀。 样品关闭功能的集成消除了与单独的样品截止阀相关的额外的管道和人工成本。 另外，集成了样品截止阀功能的多通道阀可以实现更短的平衡时间和更少的管道体积。

公开(公告)号：US6000274A

公开(公告)日：1999-12-14

申请号：US012589

申请日：1998-01-23

Applicant: Ching-Chih Lai ,  Hung-Chiao Cheng ,  Han-Wen Chu ,  Hsiang-Hsien Hsiao

Inventor： Ching-Chih Lai ,  Hung-Chiao Cheng ,  Han-Wen Chu ,  Hsiang-Hsien Hsiao

IPC: G01N30/20 ,  G01N30/24 ,  G01N30/46 ,  G01N30/62 ,  G01N30/88 ,  G01N33/00 ,  G01N30/00 ,  G01N33/18

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/468 ,  G01N33/0047 ,  G01N2030/201 ,  G01N2030/623 ,  G01N2030/8881

Abstract: A method for automatically detecting waste gas. The waste gas is led into a multiple switching valve through which the waste gas is sampled. Then, the waste gas sample is conveyed to an empty column and/or a chromatographic column, via the multiple switching valve. Then, the total hydrocarbon content of the waste gas sample is measured when the waste gas sample is conveyed to the empty column, and the waste gas sample is separated for measuring individual volatile organic compound concentrations of the waste gas sample when the waste as sample is conveyed to the chromatographic column.

Abstract translation: 一种自动检测废气的方法。 废气被引入多个切换阀，通过该多重切换阀对废气进行采样。 然后，废气样品通过多重切换阀输送到空柱和/或色谱柱。 然后，当将废气样品输送到空塔时测量废气样品的总烃含量，并且当废样作为样品时废气样品分离用于测量废气样品的各种挥发性有机化合物浓度 输送到色谱柱。

公开(公告)号：US5906223A

公开(公告)日：1999-05-25

申请号：US715286

申请日：1996-09-16

Applicant: Louis V. Pinkham

Inventor： Louis V. Pinkham

IPC: F16K11/22 ,  F16K27/00 ,  G01N30/20 ,  F16K11/20

CPC classification number: G01N30/20 ,  F16K11/22 ,  F16K27/003 ,  G01N2030/201 ,  G01N2030/205 ,  Y10T137/87249 ,  Y10T137/87338 ,  Y10T137/87885

Abstract: A unitarily formed diverter valve assembly for use in liquid chromatography. The valve assembly comprises a plurality of inlet and outlet ports, diverter valve systems, chambers, and a tortuous network of passageways all of which are arranged to accommodate the flow of fluids in a liquid chromatography system. The valve assembly is configured so as to direct the flow of fluid coming from an inlet port through the valve body where it can then be reversibly directed into or out of a chromatography column. On returning from the column, the fluid reenters the valve assembly where it is directed to an outlet port in order to exit the system. The valve assembly can also be configured so as to bypass the column altogether. Since the entire valve assembly is machined out of a single block of material having smooth liquid passageways, and since all flow compartments are shared and fully flushed when a flow-through valve is opened, dead-legs are virtually eliminated from the system.