Abstract:
Compositions of matter are disclosed comprising nitrogen containing hydrocarbons which are modified with at least one of the elements selected from the group consisting of sulfur, phosphorus an arsenic, with the modified hydrocarbons being covalently bonded to trialkoxysilane. These modified hydrocarbons are further covalently bonded to a solid inorganic support such as silica to form a solid complexing agent. The complexing agents are particularly useful in a process of removing and/or concentrating certain ions, such as noble metal ions and other transition metal ions, from solutions thereof admixed with other ions by forming a complex of the desired ion(s) with the complexing agent. The solution preferably flow through a column packed with the complexing agent to form the complex of the desired ion(s). The desired ion(s) are recovered from the column by subsequently flowing a receiving liquid through the column, wherein the receiving liquid is adapted to break the complex and receive ion(s) in solution in the receiving liquid. The receiving ion(s) can then be separated from the receiving liquid if so desired.
Abstract:
Metal ions contained in hydrogen peroxide can be removed efficiently, safely and inexpensively by contacting hydrogen peroxide to be purified with an anion exchange resin with a chelating agent adsorbed therein.
Abstract:
An ion-exchange media comprising a modified polysaccharide material and a modified silica material, said modified materials comprising a polysaccharide and silica materials covalently bonded to a synthetic polymer, said synthetic polymer comprising a copolymer made from a polymerization of:(a) a polymerizable compound having a chemical group capable of covalently coupling, directly or indirectly, to said materials; and(b) a polymerizable compound containing (i) an ionizable chemical group or (ii) a chemical group capable of transformation to an ionizable chemical group.The media is used to selectively remove heavy metal contaminants from aqueous solutions containing said contaminants.
Abstract:
Metal chelate resins whose complexed nitrilotriacetic acid residues are bound to a carrier matrix via a spacer and which are suitable for metal chelate chromatography of proteins, especially those which contain neighboring histidines.
Abstract:
New derivatives of polyamidoamines which contain at least one phosphonic, alkylphosphonic, hydroxyalkyl, carboxyalkly, alkylsulfonic or salts of the acid groups as substituents on a nitrogen are useful as chelating and/or threshold agents for preventing precipitation of metal ions. The preferred agents contain phosphonic acid groups or their salts.
Abstract:
A composite porous material comprising a particulate inorganic porous material and, contained in the pores of the material, an organic resin having a micro-void. The composite porous material has a surface area larger than that of the inorganic porous material. The composite porous material has a high dimensional stability comparable to that of an inorganic porous material while exhibiting a high separating and adsorbing capacity comparable to that of the conventional ion exchange resin or chelate resin. Therefore, it can advantageously be used as an adsorbent for various compounds or ions as well as a packing material for gas or liquid chromatography.
Abstract:
There are provided magnetic and non-magnetic agarose and agar polyaldehyde beads with diameters ranging from 40 microns up to 1 cm, and processes for the synthesis of such beads. The polyaldehyde compounds e.g. polyacrolein, polymethacrolein or polyglutaraldehyde, were used as microspheres or as powders. The agarose-polyaldehyde beads are capable of covalently binding in a single step, through their aldehyde groups, compounds containing primary amino groups of thiol groups, such as proteins, antibodies, enzymes and drugs. The beads are useful for various biological applications e.g. affinity chromatography, hemoperfusion, ion exchange resins, cell labeling, diagnostic purposes and cell separation.
Abstract:
A detectable molecule of the formulaA.sup.3 --(--X--R.sup.1 --E--Det.sup.b).sub.mwhere A.sup.3 is A.sup.2 or a polymer, where A.sup.3 has at least one modifiable reactive group selected from the group consisting of amino, hydroxy, cis OH, halides, aryl, imidazoyl, carbonyl, carboxy, thiol or a residue comprising an activated carbon; --X-- is selected from the group consisting of ##STR1## --R.sup.1 -- is ##STR2## or a C.sub.1 -C.sub.10 branched or unbranched alkyl or aralkyl, which may be substituted by --OH; --Y-- is a direct bond to --E--, or --Y-- is --E--R.sup.2 -- where R.sup.2 is a C.sub.1 -C.sub.10 branched or unbranched alkyl; Z.sub.a is chlorine, bromine or iodine; E is O, NH or an acyclic divalent sulfur atom; Det.sup.b is a chemical moiety capable of being detected, preferably comprising biotin or a metal chelator of the formula: ##STR3## or the 4-hydroxy or acyloxy derivative thereof, where R.sup.3 is C.sub.1 -C.sub.4 alkyl or CH.sub.2 COOM, M is the same or different and selected from the group consisting of hydrogen, a metal or non-metal cation or is C.sub.1 -C.sub.10 alkyl, aryl or aralkyl; and m is an integer from 1 to the total number of modified reactive groups on A.sup.3. The detectable molecules are useful in in virto or in vivo assays or therapy.
Abstract:
The compounds of the invention comprise the condensation product, as well as derivatives thereof, of two equivalents of a trimethyl cyclohexane-anhydride acid chloride derivative with one equivalent of an aromatic diamine. The scope of the invention includes the method of using the compounds of the invention as chelating agents for metals, metal ions or ions of metal complexes. In a preferred embodiment of the invention the binding moieties of the cyclohexane derivatives are rigidly held opposite each other, by restricting their rotation about the N-C aryl bonds, in order to more effectively bind the metals or the ions.
Abstract:
A technique for contacting a fluid with an ion exchange resin which comprises flowing the contacting fluid through a moving bed of ion exchange resin in a direction essentially perpendicular to the direction of flow of said ion exchange resin bed.