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71.发明授权公开(公告)号：US11548894B2
公开(公告)日：2023-01-10
申请号：US16139865
申请日：2018-09-24
Inventor： Jef DeBrabander , Luis Parada
IPC: C07D487/04 , C07C205/58 , C07D207/09 , C07D209/48 , C07D211/14 , C07D213/16 , C07D213/70 , C07C205/61 , C07C235/50 , C07C255/57 , C07C271/20 , C07C323/22 , C07D401/12 , C07D307/14 , C07D295/13 , C07C323/62
Abstract: The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not affect normally dividing cells.
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72.发明授权公开(公告)号：US11531617B2
公开(公告)日：2022-12-20
申请号：US17156347
申请日：2021-01-22
Applicant: Oracle International Corporation , The Board of Regents of the University of Texas System
Inventor： Lizy John , Jee Ho Ryoo , Hung-Ming Hsu , Karthik Ganesan
IPC: G06F12/02 , G06F12/06 , G06F12/0864 , G06F12/08 , G06F3/06 , G06F12/1027
Abstract: A heterogeneous memory system is implemented using a low-latency near memory (NM) and a high-latency far memory (FM). Pages in the memory system include NM blocks stored in the NM and FM blocks stored in the FM. A page is assigned to a region in the memory system based on the proportion of NM blocks in the page. When accessing a block, the block address is used to determine a region of the memory system, and a block offset is used to determine whether the block is stored in NM or FM. The memory system may observe memory accesses to determine the access statistics of the page and the block. Based on a page's hotness and access density, the page may be migrated to a different region. Based on a block's hotness, the block may be migrated between NM and FM allocated to the page.
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公开(公告)号：US20220387520A1
公开(公告)日：2022-12-08
申请号：US17755008
申请日：2020-10-19
Applicant: Texas Biomedical Research Institute , The Board Of Regents of The University of Texas System
Inventor： Russell AULT , Niannian JI , Juan I. MOLIVA , Robert SVATEK , Jordi B. TORRELLES
Abstract: Provided are methods for treatment of bladder cancer using compositions of modified Mycobacterium bovis Bacillus Calmette et Guerin (BCG). Also, provided are methods of treatment of non-muscle invasive bladder cancer by intra-bladder injection of these modified BCG compositions. Also, provided are methods of treatment of muscle-invasive bladder cancer by intra-tumor injection of these modified BCG compositions.
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公开(公告)号：US20220370248A1
公开(公告)日：2022-11-24
申请号：US17763983
申请日：2020-09-25
Inventor： Melissa KIRKWOOD , Jeffrey GUILD , Gary ARBIQUE
IPC: A61F9/02
Abstract: The present disclosure provides a removable eyewear shielding device, an eyewear comprising a removable eyewear shielding device, and methods of uses thereof for reducing eye radiation exposure, reducing ipsilateral brain radiation exposure, reducing FGI-induced lens opacification, reducing cataract development, or protecting an eye or ipsilateral brain from radiation exposure.
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公开(公告)号：US20220347194A1
公开(公告)日：2022-11-03
申请号：US17761014
申请日：2020-09-18
Inventor： MAHMOUD SALMA AHMED , ENAS KANDIL , HESHAM SADEK , PING WANG , ROBERT BACHOO , MARK HENKEMEYER
IPC: A61K31/65 , A61K31/167 , A61K31/165 , A61K31/045 , A61K31/195 , A61P29/00 , A61P35/00 , A61K45/06
Abstract: Inhibition of EphB receptors (e.g., EphB1) can be used in therapeutic methods for treating EphB receptor-associated conditions (e.g., pain, cancer). Demeclocycline, chlortetracycline, and minocycline are identified as EphB receptor inhibitors. Accordingly, aspects of the disclosure relate to methods for treating pain comprising providing demeclocycline, chlortetracycline, minocycline, or derivatives thereof, alone or in combination, to an individual in need thereof. Further aspects relate to pharmaceutical compositions comprising two or more of minocycline, demeclocycline, chlortetracycline, and/or derivatives thereof.
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Patent Agency Ranking
公开(公告)号：US11471449B2
公开(公告)日：2022-10-18
申请号：US16591875
申请日：2019-10-03
Inventor： Michal Geva , Ilya Bezprozvanny , Merav Bassan , Michael Hayden
IPC: A61P25/08 , A61K31/451 , A61P25/28 , A61K45/06
Abstract: This invention provides a method of improving cognitive function in a subject comprising periodically administering to the subject an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to improve a cognitive function in the subject.
The invention also provides a method of treating a subject afflicted with Alzheimer's disease, comprising periodically administering to the subject a pharmaceutical composition comprising an amount of pridopidine or a pharmaceutically acceptable salt thereof effective to treat the subject.-
公开(公告)号：US20220313962A1
公开(公告)日：2022-10-06
申请号：US17709155
申请日：2022-03-30
Inventor： Daniel H. KIM , Dong Suk SHIN
IPC: A61M25/09
Abstract: Provided herein as a guidewire controller cassette for positioning a guidewire within a patient body, including a housing having an interior space; a translational module received within the interior space and having an entry side, an opposed exit side and a lateral wall being disposed therebetween, the translational module comprising a first guidewire path extending between the entry side and the exit side and configured to move the guidewire translationally along the first guidewire path; and a rotational module received within the interior space and mounted at the lateral wall, the rotational module comprising an opening for receiving the proximal end of the guidewire, a rotating axis allowing the proximal end of the guidewire being rotated thereabout, and a second guidewire path which is a loop path extending out from the opening to the entry side.
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公开(公告)号：US20220306584A1
公开(公告)日：2022-09-29
申请号：US17596816
申请日：2020-06-20
Inventor： Jer-Tsong HSIEH , Jung-Mo AHN , Zhi-Ping LIU
IPC: C07D215/26 , C07D401/12 , C07D401/14 , C07D405/14 , A61P35/00
Abstract: The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyquinoline-based potent KDM4 inhibitors, or a pharmaceutically acceptable salt thereof, and method of use thereof, for treating cancer and neoplastic diseases and the like.
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公开(公告)号：US11450087B2
公开(公告)日：2022-09-20
申请号：US17048817
申请日：2019-04-18
Inventor： Karen Panetta , Shreyas Kamath Kalasa Mohandas , Sos Agaian
Abstract: The present disclosure includes systems and methods for multimedia image analytic including automated binarization, segmentation, and enhancement using bio-inspired based visual morphology schemes. The present disclosure further includes systems and methods for biometric multimedia content authentication using extracted geometric features and one or more of the binarization, segmentation, and enhancement methods.
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公开(公告)号：US20220277427A1
公开(公告)日：2022-09-01
申请号：US17633133
申请日：2020-08-10
Inventor： Raquel Bromberg , Zbyszek Otwinowski , Dominika Borek
Abstract: Methods for correcting one or more image aberrations in an electron microscopy image, including cryo-EM images, are provided. The method includes obtaining a plurality of electron microscope (EM) images of an internal reference grid sample having one or more known properties, the plurality of electron microscope images obtained for a plurality of optical conditions and for a plurality of coordinated beam-image shifts. The method may also include, among other features, determining an aberration correction function that predicts aberrations for every point in the imaged area using kernel canonical correlation analysis (KCCA).
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