公开(公告)号：US20050132425A1

公开(公告)日：2005-06-16

申请号：US10970189

申请日：2004-10-21

Applicant: David Lowe ,  Gerhard Koenig ,  Christopher Cummings

Inventor： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

IPC: A01K67/033

CPC classification number: A01K67/0333 ,  A01K67/0339 ,  A01K2267/0312

Abstract: The present invention discloses a transgenic fly that expresses the Italian mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Italian peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

公开(公告)号：US20050132423A1

公开(公告)日：2005-06-16

申请号：US10969895

申请日：2004-10-21

Applicant: David Lowe ,  Gerhard Koenig ,  Christopher Cummings

Inventor： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

IPC: A01K67/033 ,  C12N15/85

CPC classification number: A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/0312 ,  C12N15/8509

Abstract: The present invention discloses a transgenic fly that expresses the Flemish mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Flemish peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

Abstract translation: 本发明公开了一种表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的佛兰芒突变体型的转基因飞行物，以及表达Tau蛋白和人类Abeta42前体蛋白（APP）的双转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

公开(公告)号：US20050132421A1

公开(公告)日：2005-06-16

申请号：US10969893

申请日：2004-10-21

Applicant: David Lowe ,  Gerhard Koenig ,  Christopher Cummings

Inventor： David Lowe ,  Gerhard Koenig ,  Christopher Cummings

IPC: A01K67/00 ,  A01K67/033 ,  C12N15/85 ,  G01N33/00

CPC classification number: A01K67/0339 ,  A01K2217/05 ,  A01K2227/706 ,  A01K2267/0312 ,  C12N15/8509

Abstract: The present invention discloses a transgenic fly that expresses the Arctic mutant version of the human Aβ42 peptide of human amyloid-β precursor protein (APP), and a double transgenic fly that expresses both the Tau protein and the human Aβ42Arctic peptide of human amyloid-β precursor protein (APP). The transgenic flies of the present invention provide for models of neurodegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening methods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.

Abstract translation: 本发明公开了表达人淀粉样蛋白-β前体蛋白（APP）的人Abeta42肽的北极突变体版本的转基因飞行物，以及表达Tau蛋白质和人Abeta42二极体的双重转基因飞行物， 人淀粉样蛋白-β前体蛋白质（APP）的肽。 本发明的转基因苍蝇提供了神经变性疾病如阿尔茨海默氏病的模型。 本发明进一步公开了用于鉴定遗传修饰剂的方法，以及用于鉴定使用转基因苍蝇治疗神经变性疾病的治疗化合物的筛选方法。

公开(公告)号：US20050107865A1

公开(公告)日：2005-05-19

申请号：US10992976

申请日：2004-11-19

Applicant: Anton Clifford ,  Kevin Kang ,  David Lowe ,  Jeff Pappas ,  Erik Eli ,  Howard Huang ,  Lisa Weldon ,  Ketan Muni ,  Eugene Young

Inventor： Anton Clifford ,  Kevin Kang ,  David Lowe ,  Jeff Pappas ,  Erik Eli ,  Howard Huang ,  Lisa Weldon ,  Ketan Muni ,  Eugene Young

IPC: A61F2/00 ,  A61F2/06 ,  A61F2/90

CPC classification number: A61F2/915 ,  A61F2/91 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2220/0008 ,  A61F2230/0054 ,  A61F2250/0098 ,  Y10T29/49826 ,  Y10T29/49908

Abstract: Endoprosthesis, such as a stent, includes at least one annular element defined by a first set of strut members interconnected to define apices proximate opposite sides of the annular element. The annular element further includes a foot extension extending between at least one pair of circumferentially-adjacent strut members. The foot extension has first and second foot portions extending circumferentially from corresponding ends of the circumferentially-adjacent strut members, and are contoured to provide at least two areas of flexure. The first and second foot portions are joined at a toe portion of the foot extension, and define a circumferentially-directed apex between the pair of circumferentially-adjacent strut members. Preferably, at least one or more additional annular elements, each defined by interconnected strut members, are provided. The annular elements are generally expandable between a delivery configuration and a deployed configuration. The annular elements are longitudinally aligned and connected at connection locations. Preferably, each connection location includes a foot extension, such as by an overlapping pattern between the longitudinally-adjacent annular elements or by a connector extending therebetween.

Abstract translation: 内置假体，例如支架，包括至少一个环形元件，所述至少一个环形元件由第一组支柱构件限定，所述第一组撑杆构件互相连接以限定靠近所述环形元件相对侧的顶点。 环形元件还包括在至少一对周向相邻的支柱构件之间延伸的脚延伸部。 脚部延伸部具有从周向相邻的支柱构件的对应端部周向延伸的第一和第二脚部，并且具有轮廓以提供至少两个弯曲区域。 第一和第二脚部在脚延伸部的脚趾部分处连接，并且在一对周向相邻的支柱构件之间限定圆周方向的顶点。 优选地，提供至少一个或多个另外的环形元件，每个环形元件由互连的支柱构件限定。 环形元件通常在输送配置和展开配置之间可扩展。 环形元件在连接位置处纵向对齐并连接。 优选地，每个连接位置包括脚部延伸部，例如通过在纵向相邻的环形元件之间的重叠图案，或者通过在它们之间延伸的连接器。

公开(公告)号：US20140335961A1

公开(公告)日：2014-11-13

申请号：US14338298

申请日：2014-07-22

Applicant: David B. Lockton ,  Mark K. Berner ,  Mark J. Micheli ,  David Lowe

Inventor： David B. Lockton ,  Mark K. Berner ,  Mark J. Micheli ,  David Lowe

IPC: A63F13/30

CPC classification number: A63F13/358 ,  A63F13/12 ,  A63F13/216 ,  A63F13/22 ,  A63F13/285 ,  A63F13/32 ,  A63F13/332 ,  A63F13/335 ,  A63F13/338 ,  A63F13/50 ,  A63F13/795 ,  A63F13/92 ,  A63F2300/406 ,  A63F2300/407 ,  A63F2300/409 ,  A63F2300/534 ,  H04N5/04 ,  H04N21/2385 ,  H04N21/25866 ,  H04N21/27 ,  H04N21/4302 ,  H04N21/435 ,  H04N21/43615 ,  H04N21/44209 ,  H04N21/4508 ,  H04N21/47217 ,  H04N21/4781 ,  H04N21/6131

Abstract: A method of and system for handling latency issues encountered in producing real-time entertainment such as games of skill synchronized with live or taped televised events is described herein. There are multiple situations that are dealt with regarding latencies in receiving a television signal with respect to real-time entertainment based on the unfolding games played along with the telecasts. Systemic delays, arbitrarily imposed delays of a broadcast signal and variances in the precise broadcast times of taped television programs have to be equalized so as to provide fair entertainment.

公开(公告)号：US20130124407A1

公开(公告)日：2013-05-16

申请号：US13620922

申请日：2012-09-15

Applicant: Benjamin Quigley ,  Robert Sandler ,  Fletcher Jones ,  Rajesh Mahajan ,  Prakash Muppirala ,  David Lowe ,  Laura Price ,  Seth Goldstein ,  Venkatesh Subramanya ,  Jai Rawat

Inventor： Benjamin Quigley ,  Robert Sandler ,  Fletcher Jones ,  Rajesh Mahajan ,  Prakash Muppirala ,  David Lowe ,  Laura Price ,  Seth Goldstein ,  Venkatesh Subramanya ,  Jai Rawat

IPC: G06Q20/36

CPC classification number: G06Q20/36 ,  G06Q20/105 ,  G06Q20/206 ,  G06Q20/363 ,  G06Q20/40 ,  G07F7/0866 ,  G07F7/1008 ,  G07F7/1025

Abstract: A system and method for electronic wallet conversion allows conversion of a basic electronic wallet to a more flexible wallet account, providing additional services and requiring additional authentication. The basic accountholder eventually requires the additional services provided by the more flexible wallet, typically editing rights and making purchases at sites requiring authentication beyond the basic level. To convert the account, the account holder is presented with a one-time challenge and response mechanism that requires the accountholder to summon information that only the account holder would know. If a successful match is made, the account is converted to the more flexible account for all time. The accountholder replaces the one-time challenge and response with a second-level password that grants the accountholder ongoing access to more sensitive wallet features, such as the ability to purchase at sites requiring a second-level password, and editing rights to the information stored in the wallet.

公开(公告)号：US20130047025A1

公开(公告)日：2013-02-21

申请号：US13212392

申请日：2011-08-18

Applicant: Kenneth Sabir ,  David Lowe

Inventor： Kenneth Sabir ,  David Lowe

IPC: G06F11/20

CPC classification number: G06F11/2035

Abstract: A method, computer program product, and system for de-centralized stream processing is provided. The method may include providing a plurality of processing nodes in a hierarchical genome having a plurality of levels, wherein each of said processing nodes is configured to transmit and receive a stream of data. The method may further include restricting a subset of the plurality of processing nodes from differentiating into a role within each level of the hierarchical genome. The method may also include identifying a failure at one of the processing nodes and replacing the failed node with one of the processing nodes from the restricted subset.

Abstract translation: 提供了一种用于去集中式流处理的方法，计算机程序产品和系统。 该方法可以包括在具有多个级别的分层基因组中提供多个处理节点，其中每个所述处理节点被配置为发送和接收数据流。 该方法还可以包括将多个处理节点的子集限制为在分级基因组的每个级别内的角色。 该方法还可以包括在处理节点之一处识别出故障，并且从受限子集中用处理节点之一替换故障节点。

公开(公告)号：US20130046858A1

公开(公告)日：2013-02-21

申请号：US13212449

申请日：2011-08-18

Applicant: Kenneth Sabir ,  David Lowe

Inventor： Kenneth Sabir ,  David Lowe

IPC: G06F15/16

CPC classification number: G06F9/5072 ,  G06F19/28

Abstract: A method, computer program product, and system for de-centralized stream processing is provided. The method may include providing a plurality of processing nodes each of said processing nodes configured to transmit and receive a stream of data. The method may also include providing a genome including a hierarchical set of tasks that represent a hierarchical functional decomposition of one or more problem scenarios. The method may further include identifying, at each of the processing nodes, one or more tasks for a first genome level. The method may additionally include differentiating, at one or more of the plurality of processing nodes, into one or more tasks, based upon, at least in part, the first genome level. The method may further include grouping a plurality of the processing nodes together to achieve a power level. The method may also include activating a second genome level once the power level has been reached. The method may further include repeating until one or more of the nodes differentiates into a further genome level.

Abstract translation: 提供了一种用于去集中式流处理的方法，计算机程序产品和系统。 该方法可以包括提供多个处理节点，每个处理节点被配置成发送和接收数据流。 该方法还可以包括提供基因组，其包括表示一个或多个问题场景的分层功能分解的任务的分层组。 该方法还可以包括在每个处理节点处识别用于第一基因组水平的一个或多个任务。 该方法可以另外包括在至少部分地基于第一基因组水平的基础上将多个处理节点中的一个或多个处理区分成一个或多个任务。 该方法还可以包括将多个处理节点分组在一起以实现功率水平。 一旦达到功率水平，该方法还可以包括激活第二基因组水平。 该方法可以进一步包括重复，直到一个或多个节点区分为进一步的基因组水平。

公开(公告)号：USD671737S1

公开(公告)日：2012-12-04

申请号：US29378857

申请日：2010-11-10

Applicant: Anders Fahrendorff ,  Andrew David Lowe

Designer： Anders Fahrendorff ,  Andrew David Lowe

公开(公告)号：US20120157178A1

公开(公告)日：2012-06-21

申请号：US13403845

申请日：2012-02-23

Applicant: David B. Lockton ,  Mark K. Berner ,  Mark J. Micheli ,  David Lowe

Inventor： David B. Lockton ,  Mark K. Berner ,  Mark J. Micheli ,  David Lowe

IPC: A63F9/24

CPC classification number: A63F13/358 ,  A63F13/12 ,  A63F13/216 ,  A63F13/22 ,  A63F13/285 ,  A63F13/32 ,  A63F13/332 ,  A63F13/335 ,  A63F13/338 ,  A63F13/50 ,  A63F13/795 ,  A63F13/92 ,  A63F2300/406 ,  A63F2300/407 ,  A63F2300/409 ,  A63F2300/534 ,  H04N5/04 ,  H04N21/2385 ,  H04N21/25866 ,  H04N21/27 ,  H04N21/4302 ,  H04N21/435 ,  H04N21/43615 ,  H04N21/44209 ,  H04N21/4508 ,  H04N21/47217 ,  H04N21/4781 ,  H04N21/6131

Abstract: A method of and system for handling latency issues encountered in producing real-time entertainment such as games of skill synchronized with live or taped televised events is described herein. There are multiple situations that are dealt with regarding latencies in receiving a television signal with respect to real-time entertainment based on the unfolding games played along with the telecasts. Systemic delays, arbitrarily imposed delays of a broadcast signal and variances in the precise broadcast times of taped television programs have to be equalized so as to provide fair entertainment.

Abstract translation: 这里描述了一种用于处理在生产实时娱乐中遇到的延迟问题的方法和系统，例如与实况或录音电视事件同步的技能游戏。 基于与电视广播一起播放的展开游戏，关于实时娱乐接收电视信号的延迟有多种情况。 系统延误，任意施加的广播信号的延迟和录像电视节目的精确广播时间的差异必须相等，以提供公平的娱乐。