公开(公告)号：US20110306850A1

公开(公告)日：2011-12-15

申请号：US13215592

申请日：2011-08-23

Applicant: John D. Hatlestad ,  Quan Ni ,  Jeffrey E. Stahmann ,  Jesse Hartley ,  Qingsheng Zhu ,  Bruce H. KenKnight ,  Douglas R. Daum ,  Kent Lee

Inventor： John D. Hatlestad ,  Quan Ni ,  Jeffrey E. Stahmann ,  Jesse Hartley ,  Qingsheng Zhu ,  Bruce H. KenKnight ,  Douglas R. Daum ,  Kent Lee

IPC: A61B5/00

CPC classification number: A61B5/4815 ,  A61B5/0031 ,  A61B5/0205 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/0809 ,  A61B5/11 ,  A61B5/4528 ,  A61B5/4818 ,  A61N1/3621 ,  G06F19/00

Abstract: A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an implantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.

Abstract translation: 睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。 使用可植入装置执行检测患者状况和收集数据中的至少一个。 可以使用可植入或患者外部的睡眠质量处理器收集的数据来评估睡眠质量。 睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。

公开(公告)号：US20110301530A1

公开(公告)日：2011-12-08

申请号：US13209938

申请日：2011-08-15

Applicant: Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

Inventor： Yi Zhang ,  John D. Hatlestad ,  Gerrard M. Carlson ,  Yousufali Dalal ,  Marina V. Brockway ,  Kent Lee ,  Richard O. Kuenzler ,  Carlos Haro ,  Krzysztof Z. Siejko ,  Abhilash Patangay

IPC: A61N1/08 ,  A61N1/365 ,  A61M5/142

CPC classification number: A61M5/1723 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/024 ,  A61B5/02405 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7275 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/3621 ,  A61N1/365 ,  A61N1/36585 ,  G06F19/00

Abstract: The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.

Abstract translation: 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。

公开(公告)号：US20100324438A1

公开(公告)日：2010-12-23

申请号：US12847711

申请日：2010-07-30

Applicant: Quan Ni ,  John D. Hatlestad ,  Jesse W. Hartley ,  Jeff E. Stahmann ,  Jaeho Kim ,  Kent Lee

Inventor： Quan Ni ,  John D. Hatlestad ,  Jesse W. Hartley ,  Jeff E. Stahmann ,  Jaeho Kim ,  Kent Lee

IPC: A61B5/08

CPC classification number: A61B5/4818 ,  A61B5/0205 ,  A61B5/4806 ,  A61B5/4809 ,  A61B5/7264

Abstract: Devices and methods for detecting disordered breathing involve determining that the patient is asleep and sensing one or more signals associated with disordered breathing indicative of sleep-disordered breathing while the patient is asleep. Sleep-disordered breathing is detected using the sensed signals associated with disordered breathing. The sensed signals associated with disordered breathing may also be used to acquire a respiration pattern of one or more respiration cycles. Characteristics of the respiration pattern are determined. The respiration pattern is classified as a disordered breathing episode based on the characteristics of the respiration pattern. One or more processes involved in the detection of disordered breathing are performed using an implantable device.

Abstract translation: 用于检测无序呼吸的装置和方法涉及确定患者睡着并且感测与患者睡着时指示睡眠呼吸紊乱的无序呼吸相关联的一个或多个信号。 使用与无序呼吸相关的感测信号来检测睡眠呼吸障碍。 与无序呼吸相关联的感测信号也可用于获取一个或多个呼吸循环的呼吸模式。 确定呼吸模式的特征。 根据呼吸模式的特点，呼吸模式被分类为无序呼吸发作。 使用可植入装置进行涉及无序呼吸检测的一个或多个过程。

公开(公告)号：US07775983B2

公开(公告)日：2010-08-17

申请号：US11229316

申请日：2005-09-16

Applicant: Yi Zhang ,  John D. Hatlestad ,  Yousufali H. Dalal ,  Marina Brockway

Inventor： Yi Zhang ,  John D. Hatlestad ,  Yousufali H. Dalal ,  Marina Brockway

IPC: A61B5/02 ,  A61B5/08

CPC classification number: A61B5/091 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/411 ,  A61B2562/0219 ,  A61N1/3627 ,  A61N1/36521

Abstract: Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.

Abstract translation: 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。

公开(公告)号：US20100174207A1

公开(公告)日：2010-07-08

申请号：US12723998

申请日：2010-03-15

Applicant: Kent Lee ,  Quan Ni ,  Jesse W. Hartley ,  John D. Hatlestad ,  Jeffrey E. Stahmann

Inventor： Kent Lee ,  Quan Ni ,  Jesse W. Hartley ,  John D. Hatlestad ,  Jeffrey E. Stahmann

IPC: A61B5/08

CPC classification number: A61B5/4806 ,  A61B5/0205 ,  A61B5/08 ,  A61B5/082 ,  A61N1/08

Abstract: Patient respiration may be characterized using a marked respiration waveform involving a respiration waveform annotated with symbols, markers or other indicators representing one or more respiration characteristics. A respiration waveform may be acquired by sensing a physiological parameter modulated by respiration. A marked respiration waveform may be generated based on the acquired respiration waveform and one or more detected respiration waveform characteristics and/or respiration-related conditions. One or more components used to generate the marked respiratory waveform may be fully or partially implantable.

Abstract translation: 患者呼吸可以使用标示的呼吸波形来表征，该呼吸波形涉及用符号，标记或代表一个或多个呼吸特征的其它指示符注释的呼吸波形。 可以通过感测由呼吸调制的生理参数来获取呼吸波形。 可以基于所获取的呼吸波形和一个或多个检测到的呼吸波形特征和/或呼吸相关条件来生成标记的呼吸波形。 用于产生标记的呼吸波形的一个或多个组件可以是完全或部分可植入的。

公开(公告)号：US07704215B2

公开(公告)日：2010-04-27

申请号：US12384271

申请日：2009-04-02

Applicant: Aaron Lewicke ,  Yi Zhang ,  John D. Hatlestad

Inventor： Aaron Lewicke ,  Yi Zhang ,  John D. Hatlestad

IPC: A61B5/00

CPC classification number: A61B5/0816 ,  A61B5/0205 ,  A61B5/1116 ,  A61B5/7264 ,  G06F19/00

Abstract: A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.

Abstract translation: 一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。 该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。 关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。 呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。 这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。

公开(公告)号：US20100094102A1

公开(公告)日：2010-04-15

申请号：US12576453

申请日：2009-10-09

Applicant: Yi Zhang ,  Jeffrey E. Stahmann ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Julie A. Thompson ,  John D. Hatlestad ,  Kenneth C. Beck

Inventor： Yi Zhang ,  Jeffrey E. Stahmann ,  Krzysztof Z. Siejko ,  Ramesh Wariar ,  Julie A. Thompson ,  John D. Hatlestad ,  Kenneth C. Beck

IPC: A61B5/02

CPC classification number: A61B5/02055 ,  A61B5/0008 ,  A61B5/0031 ,  A61B5/01 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/0215 ,  A61B5/026 ,  A61B5/029 ,  A61B5/042 ,  A61B5/0452 ,  A61B5/0531 ,  A61B5/0538 ,  A61B5/0816 ,  A61B5/085 ,  A61B5/1118 ,  A61B5/121 ,  A61B5/14542 ,  A61B5/686 ,  A61B5/6869 ,  A61B5/7275 ,  A61B7/04 ,  A61N1/36585 ,  G06F19/00

Abstract: An apparatus comprises plurality of sensors and a processor. Each sensor provides a sensor signal that includes physiological information and at least one sensor is implantable. The processor includes a physiological change event detection module that detects a physiological change event from a sensor signal and produces an indication of occurrence of one or more detected physiological change events, and a heart failure (HF) detection module. The HF detection module determines, using a first rule, whether the detected physiological change event is indicative of a change in HF status of a subject, determines whether to override the first rule HF determination using a second rules, and declares whether the change in HF status occurred according to the first and second rules.

Abstract translation: 一种装置包括多个传感器和一个处理器。 每个传感器提供包括生理信息的传感器信号，并且至少一个传感器是可植入的。 处理器包括生理变化事件检测模块，其从传感器信号检测生理变化事件，并产生一个或多个检测到的生理变化事件的发生的指示，以及心力衰竭（HF）检测模块。 HF检测模块使用第一规则确定检测到的生理变化事件是否指示受试者的HF状态的变化，使用第二规则确定是否覆盖第一规则HF确定，并且声明HF的变化 状态根据第一和第二规则发生。

公开(公告)号：US20100022911A1

公开(公告)日：2010-01-28

申请号：US12505926

申请日：2009-07-20

Applicant: Ramesh Wariar ,  John D. Hatlestad ,  Kenneth C. Beck ,  Aaron Lewicke

Inventor： Ramesh Wariar ,  John D. Hatlestad ,  Kenneth C. Beck ,  Aaron Lewicke

IPC: A61B5/00

CPC classification number: A61B5/03 ,  A61B5/021 ,  A61B5/0537 ,  A61B5/4878

Abstract: This document discusses, among other things, systems and methods for measuring the dynamics of pulmonary congestion in heart failure subjects over time to monitor the subjects susceptibility to pulmonary edema, including sensing and receiving information indicative of a bodily pressure and information indicative of pulmonary fluid, and using the transient responses of these measurements to compute parameters related to the dynamics of thoracic fluid accumulation, such as a critical pressure (Pc), a critical time (Tc), or a filtration index (Kfi).

Abstract translation: 本文件尤其讨论了随着时间的推移，测量心力衰竭受试者的肺充血动力学的系统和方法，以监测受试者对肺水肿的易感性，包括感测和接收指示身体压力的信息和指示肺动脉的信息， 并且使用这些测量的瞬态响应来计算与胸腔积液的动力学相关的参数，例如临界压力（Pc），临界时间（Tc）或过滤指数（Kfi）。

公开(公告)号：US07572225B2

公开(公告)日：2009-08-11

申请号：US10920569

申请日：2004-08-17

Applicant: Jeffrey E. Stahmann ,  Jesse W. Hartley ,  Quan Ni ,  Kent Lee ,  John D. Hatlestad

Inventor： Jeffrey E. Stahmann ,  Jesse W. Hartley ,  Quan Ni ,  Kent Lee ,  John D. Hatlestad

IPC: A61B5/08 ,  A61B5/02 ,  A61B5/00 ,  A61B5/103

CPC classification number: A61B5/4818 ,  A61B5/00 ,  A61B5/4528 ,  A61B5/4806 ,  A61B5/4812 ,  A61B5/4815 ,  A61N1/36514 ,  A61N1/36521 ,  A61N1/3925

Abstract: An approach to collecting and organizing information associated with events affecting sleep is presented. The sleep logbook system may acquire information associated with the sleep during periods of sleep and/or during periods of wakefulness. The information is organized as a sleep logbook entry. The user can access the sleep information by operating a user interface. The information may be presented in textual or graphical form.

Abstract translation: 介绍收集和组织与影响睡眠事件相关的信息的方法。 休眠日志系统可以在睡眠期间和/或在觉醒期间获取与睡眠相关的信息。 信息被组织为睡眠日志条目。 用户可以通过操作用户界面访问睡眠信息。 信息可以以文本或图形形式呈现。

公开(公告)号：US07530956B2

公开(公告)日：2009-05-12

申请号：US11820002

申请日：2007-06-15

Applicant: Aaron Lewicke ,  Yi Zhang ,  John D. Hatlestad

Inventor： Aaron Lewicke ,  Yi Zhang ,  John D. Hatlestad

IPC: A61B5/00

CPC classification number: A61B5/0816 ,  A61B5/0205 ,  A61B5/1116 ,  A61B5/7264 ,  G06F19/00

Abstract: A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.

Abstract translation: 一种装置和方法可以根据一天中的时间来监视或趋向于患者的呼吸速率测量。 该装置可以植入或外部收集和分类呼吸速率测量随时间的变化。 关于呼吸率测量的特定类别的趋势化信息然后被传送到远程外部设备，远程外部设备又提供心力衰竭失代偿指示。 呼吸速率测量类别的实例包括每日最大呼吸率值，每日最小呼吸率值，每日最大呼吸率变异值，每日最小呼吸率变异性值和每日中心呼吸率值。 这些呼吸率测量可以进一步分为白天或夜间呼吸率测量。