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公开(公告)号：US09320850B2
公开(公告)日：2016-04-26
申请号：US14320093
申请日：2014-06-30
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
CPC classification number: A61M25/10 , A61B18/00 , A61B18/04 , A61B2018/00011 , A61B2018/00279 , A61B2018/00404 , A61B2018/00517 , A61B2018/00577 , A61B2018/046 , A61B2090/3966 , A61B2218/002 , A61M5/158 , A61M25/0084 , A61M25/0662 , A61M2005/1585 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, or such as nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also controls the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
Abstract translation: 用于周围血管或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线膨胀以接合肾动脉壁或其他容器的内表面，允许注射 用于烧蚀组织的消融液，或诸如外层中的神经纤维或深层至血管的外层，或前列腺组织中。 该系统还可以控制烧蚀流体渗透到血管壁的组织内和外部的渗透深度。 导管还可以包括向引导管提供径向和/或侧向支撑的结构，使得引导管均匀地膨胀并且当尖锐的注射针被推入以穿透血管壁时将其位置保持抵靠血管壁的内表面 。
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72.发明授权Peri-vascular tissue ablation catheter with deflection surface support structures 有权周围血管组织消融导管与偏转面支撑结构公开(公告)号：US09254360B2
公开(公告)日：2016-02-09
申请号：US14320085
申请日：2014-06-30
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
CPC classification number: A61M25/10 , A61B18/00 , A61B18/04 , A61B2018/00011 , A61B2018/00279 , A61B2018/00404 , A61B2018/00517 , A61B2018/00577 , A61B2018/046 , A61B2090/3966 , A61B2218/002 , A61M5/158 , A61M25/0084 , A61M25/0662 , A61M2005/1585 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
Abstract translation: 用于周围血管和/或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线膨胀以接合肾动脉或其他人体容器的壁的内表面，允许 注射用于烧蚀组织的消融液，和/或外层中的神经纤维或深层到容器的外层，或在前列腺组织中。 系统还可以限制和/或调节烧蚀流体渗透到血管壁的组织中和超出血管壁的组织的深度。 导管还可以包括向引导管提供径向和/或侧向支撑的结构，使得引导管均匀地膨胀并且当尖锐的注射针被推入以穿透血管壁时将其位置保持抵靠血管壁的内表面 。
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公开(公告)号：US09179962B2
公开(公告)日：2015-11-10
申请号：US14096254
申请日：2013-12-04
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
CPC classification number: A61B18/04 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/37 , A61B90/39 , A61B2018/00166 , A61B2018/00285 , A61B2018/00351 , A61B2018/00404 , A61B2018/00434 , A61B2018/00547 , A61B2018/00577 , A61B2018/046 , A61B2090/3735 , A61B2090/376 , A61B2090/3762 , A61B2090/378 , A61B2090/3782 , A61B2090/3966 , A61M25/0084 , A61M25/0108 , A61M25/1002 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, such as nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also controls the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
Abstract translation: 用于周围血管或尿道周围组织消融的血管内导管包括穿过支撑导管的多个针，其以围绕中心轴线的开放端部扩张，以接合肾动脉壁或其他人体容器的内表面，允许 注射用于烧蚀组织的消融液，例如在外层中的神经纤维或深层到血管的外层，或在前列腺组织中。 该系统还控制烧蚀流体渗透到血管壁的组织内和外部的渗透深度。 导管的优选实施例包括向引导管提供径向和侧向支撑的结构，使得引导管均匀地打开并且当尖锐的注射针推进以穿透血管壁时将其位置保持抵靠血管壁的内表面 。
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公开(公告)号：US20140121644A1
公开(公告)日：2014-05-01
申请号：US14096254
申请日：2013-12-04
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden
IPC: A61B18/00
CPC classification number: A61B18/04 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/37 , A61B90/39 , A61B2018/00166 , A61B2018/00285 , A61B2018/00351 , A61B2018/00404 , A61B2018/00434 , A61B2018/00547 , A61B2018/00577 , A61B2018/046 , A61B2090/3735 , A61B2090/376 , A61B2090/3762 , A61B2090/378 , A61B2090/3782 , A61B2090/3966 , A61M25/0084 , A61M25/0108 , A61M25/1002 , A61M2025/0087
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.
Abstract translation: 用于周围血管和/或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线以开口端膨胀，以接合肾动脉壁或人的其他血管的内表面 允许注射用于烧蚀组织的消融液体，和/或外层中的神经纤维或深层到血管的外层，或在前列腺组织中。 该系统还包括限制和/或调节烧蚀液体渗透到血管壁组织内和/或超过血管壁组织的深度的手段。 导管的优选实施例包括向引导管提供径向和侧向支撑的结构，使得引导管均匀地打开并且当尖锐的注射针推进以穿透血管壁时将其位置保持抵靠血管壁的内表面 。
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公开(公告)号：US20140046298A1
公开(公告)日：2014-02-13
申请号：US14057972
申请日：2013-10-18
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell
CPC classification number: A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00375 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/143 , A61M5/00
Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.
Abstract translation: 目前，医生经常使用射频（RF）导管系统治疗房颤患者，以消融肺静脉周围心脏左心房壁的导电组织。 这些系统是昂贵的并且花费耗时的使用。 本发明的圆形消融系统CAS包括多个可扩展的针，其可以围绕中心轴线扩张并且被定位成像乙醇一样注入流体，以便快速地在肺静脉的口周围环绕环中的导电组织，而不需要昂贵的 资本设备。 针的膨胀通过自膨胀或球囊可膨胀结构来实现。 本发明包括定心装置，使得针头将位于围绕静脉口的外侧的图案中。 还包括限制针头进入左心房壁的距离的成员。 本发明还可用于消除肾动脉口周围的组织用于治疗高血压。
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Patent Agency Ranking
76.发明申请INTRAVASCULAR ABLATION CATHETER WITH PRECISION DEPTH OF PENETRATION CALIBRATION 审中-公开具有精密深度穿透校准的血管内导管公开(公告)号：US20130274674A1
公开(公告)日：2013-10-17
申请号：US13835556
申请日：2013-03-15
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell
IPC: A61M5/162
CPC classification number: A61M5/162 , A61B5/6848 , A61B2018/00404 , A61B2018/00434 , A61B2018/044 , A61B2090/378 , A61B2090/3966 , A61M25/0084 , A61M25/0097 , A61M2025/0086
Abstract: A catheter-based/intravascular ablation system includes needles which expand around a central axis to engage a blood vessel or left atrium wall, allowing the injection of an ablative solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein or around the renal artery. The system includes means to adjust the depth of penetration into the tissue of the targeted blood vessel wall. The catheter can include expandable guide tubes that engage the blood vessel wall. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the blood vessel wall to a prescribed depth. The ability to provide PeriVascular injection only affecting the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in or outside the adventitia of the renal artery.
Abstract translation: 基于导管的/血管内消融系统包括围绕中心轴线扩张以接合血管或左心房壁的针，允许注射消融溶液以消融导管或围绕肺静脉口或周围的神经纤维 肾动脉。 该系统包括调节穿透到目标血管壁的组织中的深度的装置。 导管可以包括与血管壁接合的可扩张的导管。 然后在其尖锐的远端处或其附近注射出口的注射针穿过引导管穿过血管壁达规定的深度。 提供血管周围注射仅影响血管外层而不影响培养基的能力特别适用于位于肾动脉外膜或其外侧的交感神经的血管外肾去神经（PVRD）。
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77.发明申请公开(公告)号：US20130274673A1
公开(公告)日：2013-10-17
申请号：US13835221
申请日：2013-03-15
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell
IPC: A61M5/162
CPC classification number: A61M5/162 , A61B5/6848 , A61M25/0084 , A61M25/0097 , A61M25/0662 , A61M25/104 , A61M2025/0086 , A61M2025/0681 , A61M2025/1052
Abstract: A catheter-based/intravascular ablation system includes needles which expand around a central axis to engage a blood vessel or left atrium wall, allowing the injection of an ablative solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein or around the renal artery. The system includes means to adjust the depth of penetration into the tissue of the targeted blood vessel wall. The catheter can include expandable guide tubes that engage the blood vessel wall. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the blood vessel wall to a prescribed depth. The ability to provide PeriVascular injection only affecting the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in or outside the adventitia of the renal artery.
Abstract translation: 基于导管的/血管内消融系统包括围绕中心轴线扩张以接合血管或左心房壁的针，允许注射消融溶液以消融导管或围绕肺静脉口或周围的神经纤维 肾动脉。 该系统包括调节穿透到目标血管壁的组织中的深度的装置。 导管可以包括与血管壁接合的可扩张的导管。 然后在其尖锐的远端处或其附近注射出口的注射针穿过引导管穿过血管壁达规定的深度。 提供血管周围注射仅影响血管外层而不影响培养基的能力特别适用于位于肾动脉外膜或其外侧的交感神经的血管外肾去神经（PVRD）。
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78.发明授权公开(公告)号：US12245790B2
公开(公告)日：2025-03-11
申请号：US16984690
申请日：2020-08-04
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell , Robert Ryan Ragland , Darrin James Kent , Andy Edward Denison , Eric Thomas Johnson , Jeff Alan Burke , Christopher Scott Hayden , Robert E. Fischell
Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. A method can involve injection/infusion of the ablative fluid over an extended time period of at least 10 seconds or with two injections at two different penetration depths to reduce or eliminate patient pain during ablation.
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公开(公告)号：US12108982B2
公开(公告)日：2024-10-08
申请号：US17101729
申请日：2020-11-23
Applicant: Ablative Solutions, Inc.
Inventor： Andy Edward Denison , David R. Fischell , Tim A. Fischell , Darrin James Kent , Nicole Haratani
CPC classification number: A61B18/1492 , A61B18/06 , A61B18/1477 , A61B90/39 , A61B2018/00011 , A61B2018/00214 , A61B2018/00351 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00517 , A61B2018/00577 , A61B2018/046 , A61B2018/143 , A61B2018/1475 , A61B2090/376 , A61M25/0068 , A61M25/0074 , A61M25/0084 , A61M25/0662
Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple penetrators advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, nerve sensing, nerve stimulation, or ablation by application of energy. The catheter can include a proximal handle for the advancement of guide tubes and penetrators.
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80.发明公开公开(公告)号：US20240307657A1
公开(公告)日：2024-09-19
申请号：US18615759
申请日：2024-03-25
Applicant: Ablative Solutions, Inc.
Inventor： David R. Fischell , Tim A. Fischell
CPC classification number: A61M25/0084 , A61B5/283 , A61B18/1492 , A61B90/39 , A61B2017/22038 , A61B2017/22068 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00375 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00839 , A61B18/06 , A61B2018/143 , A61B2018/1475 , A61B18/1477 , A61B2090/3966 , A61M2025/0087
Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.
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