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公开(公告)号:US08475713B2
公开(公告)日:2013-07-02
申请号:US13179471
申请日:2011-07-08
Applicant: Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
Inventor: Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
IPC: A61L2/00
CPC classification number: A61L2/08 , A61L2/081 , A61L2/082 , A61L2/085 , A61L2/087 , A61L2/10 , A61L2202/23 , A61L2202/24 , B65B55/00 , B65B55/16
Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.
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公开(公告)号:US08268228B2
公开(公告)日:2012-09-18
申请号:US12001777
申请日:2007-12-11
Applicant: Bin Huang , David C. Gale , Vincent J. Gueriguian
Inventor: Bin Huang , David C. Gale , Vincent J. Gueriguian
IPC: B29C49/00
CPC classification number: A61F2/91 , A61F2/90 , B29C49/0005 , B29C49/6472 , B29C2049/0089 , B29K2105/258 , B29K2995/006 , B29L2031/7542
Abstract: Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stent manufacture and fabrication of a stent therefrom are disclosed.
Abstract translation: 公开了扩展聚合物管的方法,其具有用于支架制造和制造支架的所需或最佳形态和机械性能。
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公开(公告)号:US20120024460A1
公开(公告)日:2012-02-02
申请号:US13267832
申请日:2011-10-06
Applicant: Bin Huang , Daniel Castro , David C. Gale , Yunbing Wang
Inventor: Bin Huang , Daniel Castro , David C. Gale , Yunbing Wang
CPC classification number: A61F2/958 , A61F2002/9522 , A61F2002/9583 , A61F2210/0004 , A61F2240/001 , A61F2250/0067
Abstract: Methods for improved stent retention on an expandable member during delivery are disclosed. Methods include fabricating delivery systems including a degradable or water soluble sheath over the stent, the expandable member, or both for improving retention of the stent on the expandable member during delivery.
Abstract translation: 公开了在递送期间改善可扩张构件上的支架保持性的方法。 方法包括在支架,可膨胀构件或两者之上制造包括可降解或水溶性护套的输送系统,以便在输送期间改善支架在可膨胀构件上的保留。
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74.
公开(公告)号:US20110307053A1
公开(公告)日:2011-12-15
申请号:US13178364
申请日:2011-07-07
Applicant: David C. Gale , Bin Huang , John M. Capek , Houdin Dehnad
Inventor: David C. Gale , Bin Huang , John M. Capek , Houdin Dehnad
IPC: A61F2/82
CPC classification number: A61L31/148 , A61F2/0077 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2002/91533 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0067 , A61L31/022 , A61L31/028 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/604 , A61L2300/606 , A61L2400/12 , Y10T29/49982
Abstract: A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device.
Abstract translation: 这里描述了一种制造植入式医疗装置(例如支架)的装置和方法。 该装置包括由生物侵蚀金属组成的金属区域和由与金属区域接触的可生物降解的聚合物组成的聚合物区域。 当暴露于体液时,当暴露于体液时,金属区域可能以不同于聚合物区域的速度侵蚀。 在某些实施方案中,聚合物区域是外层,金属区域是该装置的内层。
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公开(公告)号:US08052912B2
公开(公告)日:2011-11-08
申请号:US10957022
申请日:2004-10-01
Applicant: David C. Gale , Bin Huang , Anthony Abbate , Stephen D. Pacetti
Inventor: David C. Gale , Bin Huang , Anthony Abbate , Stephen D. Pacetti
IPC: A24B5/00
CPC classification number: A61F2/958 , A61F2002/9522 , A61L31/10 , A61L31/14 , B29B13/024 , B29C65/56 , B29C65/76 , B29C66/9121 , B29C66/91431 , B29C66/91641 , B29C66/919 , B29C66/91921 , B29C66/91941 , B29C66/91945 , B29C2035/0822 , B29C2071/022 , B29K2001/00 , B29K2001/12 , B29K2023/00 , B29K2023/083 , B29K2023/086 , B29K2027/06 , B29K2027/08 , B29K2027/16 , B29K2029/00 , B29K2031/00 , B29K2033/08 , B29K2033/20 , B29K2055/02 , B29K2063/00 , B29K2075/00 , B29K2077/00 , B29K2083/00 , B29L2031/7542 , Y10T29/49865 , Y10T428/24942 , Y10T428/3154 , Y10T428/31544 , Y10T428/31855
Abstract: This disclosure describes a method for crimping a polymeric stent onto a catheter for percutaneous transluminal coronary angioplasty or other intraluminal interventions. The method comprises crimping the stent onto a catheter when the polymer is at a target temperature other than ambient temperature. The polymer can optionally comprise drug(s).
Abstract translation: 本公开描述了一种用于将聚合物支架卷曲到用于经皮冠状动脉腔内冠状动脉成形术或其他管腔内干预的导管上的方法。 该方法包括当聚合物处于不同于环境温度的目标温度时将支架卷曲到导管上。 聚合物可任选地包含药物。
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公开(公告)号:US20110268607A1
公开(公告)日:2011-11-03
申请号:US13179471
申请日:2011-07-08
Applicant: Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
Inventor: Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
CPC classification number: A61L2/08 , A61L2/081 , A61L2/082 , A61L2/085 , A61L2/087 , A61L2/10 , A61L2202/23 , A61L2202/24 , B65B55/00 , B65B55/16
Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.
Abstract translation: 公开了用于降低放射线灭菌的支架的方法和系统。
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公开(公告)号:US07951194B2
公开(公告)日:2011-05-31
申请号:US11805357
申请日:2007-05-22
Applicant: Vincent J. Gueriguian , Bin Huang , David C. Gale
Inventor: Vincent J. Gueriguian , Bin Huang , David C. Gale
IPC: A61F2/06
CPC classification number: A61L31/18 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2420/08 , C08L67/04
Abstract: Various embodiments of stents with a bioabsorbable body having a coating with a radiopaque layer are disclosed.
Abstract translation: 公开了具有具有不透射线层的涂层的具有生物可吸收体的支架的各种实施例。
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公开(公告)号:US20110112627A1
公开(公告)日:2011-05-12
申请号:US12772698
申请日:2010-05-03
Applicant: David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
Inventor: David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
IPC: A61F2/82
CPC classification number: A61F2/915 , A61F2/90 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/9522 , A61F2210/0004 , A61F2220/0016 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4273 , B29C49/4823 , B29C55/22 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , Y10T156/1026 , C08L67/04
Abstract: Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
Abstract translation: 公开了制造具有增强的断裂韧性的支架的支架和方法。
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79.Method of fabricating an implantable medical device with biaxially oriented polymers 有权
Title translation: 用双轴取向聚合物制造可植入医疗器械的方法公开(公告)号:US20110079941A1
公开(公告)日:2011-04-07
申请号:US12806785
申请日:2010-08-19
Applicant: Bin Huang , Stephen Schaible , Richard Kaufman , Jim Kennedy , David C. Gale , Suresh Amin , John Guardiano
Inventor: Bin Huang , Stephen Schaible , Richard Kaufman , Jim Kennedy , David C. Gale , Suresh Amin , John Guardiano
CPC classification number: A61F2/82 , A61F2/91 , A61F2002/825 , A61L31/148 , B23K2103/42 , B23K2103/50 , B29C47/0023 , B29C47/0057 , B29C47/24 , B29C49/786 , B29L2031/7534
Abstract: Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Some embodiments may include inducing molecular orientation by expansion of a molten annular polymer film. Other embodiments may include inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer. In certain embodiments, circumferential orientation may be induced by expansion of a polymer tube. Further embodiments may include manufacturing an implantable medical device from a biaxially oriented planar polymer film.
Abstract translation: 本文描述了用于制造可植入医疗装置(例如支架)的方法和系统,其具有期望的机械性质(例如改善的周向强度和刚度)的管。 可以通过在用于制造可植入医疗装置的材料中诱导分子取向来获得改善的周向强度和刚性。 一些实施方案可以包括通过膨胀熔融的环状聚合物膜诱导分子取向。 其它实施方案可以包括通过诱导熔融聚合物中的周向流动来诱导圆周分子取向。 在某些实施方案中,可以通过聚合物管的膨胀来引起圆周取向。 另外的实施例可以包括从双轴取向的平面聚合物膜制造可植入医疗装置。
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80.
公开(公告)号:US20100289191A1
公开(公告)日:2010-11-18
申请号:US12845536
申请日:2010-07-28
Applicant: DAVID C. GALE , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
Inventor: DAVID C. GALE , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian
IPC: B29C49/08
CPC classification number: A61F2/915 , A61F2/90 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91583 , A61F2002/9522 , A61F2210/0004 , A61F2220/0016 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4273 , B29C49/4823 , B29C55/22 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , Y10T156/1026 , C08L67/04
Abstract: Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
Abstract translation: 公开了制造具有增强的断裂韧性的支架的支架和方法。
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