公开(公告)号：US07494972B2

公开(公告)日：2009-02-24

申请号：US11319949

申请日：2005-12-27

Applicant: David Stern ,  Ann Marie Schmidt

Inventor： David Stern ,  Ann Marie Schmidt

IPC: A61K38/00 ,  C07K14/00

CPC classification number: A61K38/1774 ,  Y10S514/824 ,  Y10S514/866 ,  Y10S514/909

Abstract: The present invention provides for a method to prevent accelerated atherosclerosis in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent accelerated atherosclerosis in the subject. The present invention also provides for a method to prevent a macrovessel disease in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent macrovessel disease in the subject.

Abstract translation: 本发明提供了预防易感患者的加速动脉粥样硬化的方法，其包括以有效预防受试者加速的动脉粥样硬化的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。 本发明还提供一种预防患者易患有大血管疾病的方法，其包括以有效预防受试者的宏观血管疾病的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。

公开(公告)号：US20090030291A1

公开(公告)日：2009-01-29

申请号：US12175803

申请日：2008-07-18

Applicant: David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

Inventor： David O'Brien ,  Jason White ,  Michael A. Fonseca ,  Jason Kroh ,  Mark Allen ,  David Stern

IPC: A61B5/00

CPC classification number: A61B5/02014 ,  A61B5/0031 ,  A61B5/076 ,  Y10T29/49016 ,  Y10T29/49069 ,  Y10T29/49071 ,  Y10T29/49073

Abstract: A wireless sensor for indicating a physical state within an environment includes a unitary housing defining a cavity. A structure located within the cavity of the housing has elements providing capacitance, the elements being arranged such that the distance and thereby the capacitance of the structure changes when a physical state of the environment changes. The structure has a resonant frequency based at least in part on the capacitance of the structure when in the presence of a fluctuating electromagnetic field. When the sensor is positioned within an environment and is subjected to a fluctuating electromagnetic field, the resonant frequency indicates the physical state of the environment.

Abstract translation: 用于指示环境中的物理状态的无线传感器包括限定空腔的整体壳体。 位于壳体的腔内的结构具有提供电容的元件，该元件被布置成使得当环境的物理状态改变时，结构的距离以及由此的结构的电容改变。 当存在波动的电磁场时，该结构至少部分地基于结构的电容。 当传感器位于环境中并且经受波动的电磁场时，谐振频率表示环境的物理状态。

公开(公告)号：USD583041S1

公开(公告)日：2008-12-16

申请号：US29271099

申请日：2007-01-11

Applicant: David Stern ,  Kenneth H. Stern ,  Fred Bishop ,  Jules Stern ,  John Hofsess

Designer： David Stern ,  Kenneth H. Stern ,  Fred Bishop ,  Jules Stern ,  John Hofsess

公开(公告)号：US20070099829A1

公开(公告)日：2007-05-03

申请号：US11319949

申请日：2005-12-27

Applicant: David Stern ,  Ann Schmidt

Inventor： David Stern ,  Ann Schmidt

IPC: A61K38/17

CPC classification number: A61K38/1774 ,  Y10S514/824 ,  Y10S514/866 ,  Y10S514/909

Abstract: The present invention provides for a method to prevent accelerated atherosclerosis in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent accelerated atherosclerosis in the subject. The present invention also provides for a method to prevent a macrovessel disease in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble receptor for advanced glycation endproduct in an amount effective to prevent macrovessel disease in the subject.

Abstract translation: 本发明提供了预防易感患者的加速动脉粥样硬化的方法，其包括以有效预防受试者加速的动脉粥样硬化的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。 本发明还提供一种预防患者易患有大血管疾病的方法，其包括以有效预防受试者的宏观血管疾病的量向受试者施用衍生自可溶性受体的晚期糖基化终产物的多肽。

公开(公告)号：US20060287602A1

公开(公告)日：2006-12-21

申请号：US11157375

申请日：2005-06-21

Applicant: David O'Brien ,  Jason White ,  Michael Fonseca ,  Florent Cros ,  Jason Kroh ,  David Stern ,  Mark Allen

Inventor： David O'Brien ,  Jason White ,  Michael Fonseca ,  Florent Cros ,  Jason Kroh ,  David Stern ,  Mark Allen

IPC: A61B5/02 ,  A61B5/00

CPC classification number: A61B5/0031 ,  A61B5/0215 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2562/028

Abstract: A sensor suitable for in vivo implantation has a capacitive circuit and a three-dimensional inductor coil connected to the capacitive circuit to form an LC circuit. The LC circuit is hermetically encapsulated within an electrically insulating housing. An electrical characteristic of the LC circuit is responsive to a change in an environmental parameter.

Abstract translation: 适用于体内植入的传感器具有电容电路和连接到电容电路的三维电感线圈，以形成LC电路。 LC电路气密地封装在电绝缘壳体内。 LC电路的电气特性响应于环境参数的变化。

公开(公告)号：US07147604B1

公开(公告)日：2006-12-12

申请号：US10215379

申请日：2002-08-07

Applicant: Mark Allen ,  Michael Fonseca ,  Jason White ,  Jason Kroh ,  David Stern

Inventor： Mark Allen ,  Michael Fonseca ,  Jason White ,  Jason Kroh ,  David Stern

IPC: A61B5/00

CPC classification number: A61B5/0215 ,  A61B5/0031 ,  A61B2562/028

Abstract: A sensor for wirelessly determining a physical property within a defined space comprises an electrical resonance and has a high quality factor Q. The quality factor Q is sufficiently high that a signal generated by the sensor can be received outside the defined space. The sensor may optimally have a dielectric coating.

Abstract translation: 用于在确定的空间内无线地确定物理性质的传感器包括电谐振并且具有高质量因子Q.品质因数Q足够高，使得由传感器产生的信号可被接收在限定的空间之外。 传感器可以最佳地具有电介质涂层。

公开(公告)号：US20060253035A1

公开(公告)日：2006-11-09

申请号：US11379641

申请日：2006-04-21

Applicant: David Stern

Inventor： David Stern

IPC: A61B6/00

CPC classification number: G01N21/6428 ,  G01N21/6452 ,  G01N21/6456

Abstract: An embodiment of a system for acquiring images of a probe array is described that comprises a first light emitting diode that provides light comprising a first range of wavelengths outside of an excitation spectrum; a second light emitting diode that provides light comprising a second range of wavelengths inside of the excitation spectrum; and a detector that detects one or more wavelengths in the first range of wavelengths, wherein the first range of wavelengths comprise light wavelengths emitted from fluorescent molecules associated with one or more probes of the probe array in response to the second range of wavelengths and wavelengths reflected from one or more reflective elements associated with the probe array.

Abstract translation: 描述了一种用于获取探针阵列的图像的系统的实施例，其包括提供包含激发光谱外的第一波长范围的光的第一发光二极管; 第二发光二极管，其提供包含激发光谱内的第二波长范围的光; 以及检测器，其检测所述第一波长范围中的一个或多个波长，其中所述第一波长范围包括响应于所述第二波长和波长范围反射的与所述探针阵列的一个或多个探针相关联的荧光分子发射的光波长 来自与探针阵列相关联的一个或多个反射元件。

公开(公告)号：US07125675B2

公开(公告)日：2006-10-24

申请号：US09851071

申请日：2001-05-08

Applicant: Ann Marie Schmidt ,  David Stern

Inventor： Ann Marie Schmidt ,  David Stern

IPC: G01N33/53 ,  C12Q1/00 ,  C12N5/00

CPC classification number: C07K14/70503 ,  A61K38/00 ,  A61K48/00

Abstract: The present invention provides for a method for inhibiting tumor invasion or metastasis in a subject which comprises administering to the subject a therapeutically effective amount of a form of soluble Receptor for Advanced Glycation Endproducts (RAGE). The present invention also provides a method for evaluating the ability of an agent to inhibit tumor invasion in a local cellular environment which comprises: (a) admixing with cell culture media an effective amount of the agent; (b) contacting a tumor cell in cell culture with the media from step (a); (c) determining the amount of spreading of the tumor cell culture, and (d) comparing the amount of spreading of the tumor cell culture determined in step (c) with the amount determined in the absence of the agent, thus evaluating the ability of the agent to inhibit tumor invasion in the local cellular environment. The present invention also provides a pharmaceutical composition which comprises a therapeutically effective amount of the agent evaluated in the aforementioned method and a pharmaceutically acceptable carrier.

公开(公告)号：US07081241B1

公开(公告)日：2006-07-25

申请号：US09167705

申请日：1998-10-06

Applicant: Ann Marie Schmidt ,  David Stern

Inventor： Ann Marie Schmidt ,  David Stern

IPC: A61K39/395

CPC classification number: A61K38/1703 ,  A01K2217/05 ,  C07K14/70503

Abstract: The present invention provides for an isolated human EN-RAGE peptide. The present invention also provides for a method for determining whether a compound is capable of inhibiting the interaction of an EN-RAGE peptide with a RAGE peptide, which comprises: (a) admixing: (i) a RAGE peptide or an sRAGE peptide or a fragment of either thereof, (ii) an EN-RAGE peptide or a fragment thereof, and (iii) the compound; (b) measuring the level of interaction between the peptide of step (a)(i) and the peptide of step (a)(ii), and (c) comparing the amount of interaction meausred in step (b) with the amount measured between the peptide of step (a) (i) and the peptide of step (a) (ii) in the absence of the compound, thereby determining whether the compound is capable of inhibiting the interaction of the EN-RAGE peptide with the RAGE peptide, wherein a reduction in the amount of interaction in the presence of the compound indicates that the compound is capable of inhibiting the interaction. The present invention also provides for a method for inhibiting inflammation in a subject which comprises administering to the subject a compound capable of interfering with the interaction between EN-RAGE peptide and receptor for advanced glycation endproduct (RAGE) in the subject thereby inhibiting inflammation in the subject.

Abstract translation: 本发明提供了分离的人类EN-RAGE肽。 本发明还提供了一种用于确定化合物是否能够抑制EN-RAGE肽与RAGE肽的相互作用的方法，其包括：（a）混合：（i）RAGE肽或sRAGE肽或 片段，（ii）EN-RAGE肽或其片段，和（iii）化合物; （b）测量步骤（a）（i）的肽与步骤（a）（ii）的肽之间的相互作用水平，和（c）将步骤（b）中所发生的相互作用的量与测量的量进行比较 在步骤（a）（i）的肽和步骤（a）（ii）的肽之间，在不存在化合物的情况下，确定化合物是否能够抑制EN-RAGE肽与RAGE肽的相互作用 其中在化合物存在下相互作用量的减少表明该化合物能够抑制相互作用。 本发明还提供了一种抑制受试者的炎症的方法，其包括向受试者施用能够干扰受试者的EN-RAGE肽和受体之间相互作用的晚期糖基化终产物（RAGE）的相互作用，从而抑制受试者的炎症 学科。

公开(公告)号：US20060134073A1

公开(公告)日：2006-06-22

申请号：US11173537

申请日：2005-07-01

Applicant: Yoshifumi Naka ,  David Pinsky ,  David Stern

Inventor： Yoshifumi Naka ,  David Pinsky ,  David Stern

IPC: C12N5/08 ,  A61K35/14 ,  A61K31/7076 ,  A61K31/52

CPC classification number: A61K35/44 ,  C12N5/0691 ,  Y02A50/395

Abstract: The present invention relates to ex vivo methods for preserving/maintaining blood vessels that are to be used as vascular grafts. The present invention also relates to compositions comprising an analogue of cAMP and/or an analogue of cGMP for use in the methods of the invention, which compositions are free of: (i) an inhibitor of Type I phosphodiesterase, (ii) an inhibitor of Type II phosphodiesterase, (iii) an inhibitor of Type III phosphodiesterase, (iv) an inhibitor of Type IV phosphodiesterase, and (v) an inhibitor of TNF-α.

Abstract translation: 本发明涉及用于保存/维持用作血管移植物的血管的离体方法。 本发明还涉及包含用于本发明方法的cAMP类似物和/或cGMP类似物的组合物，该组合物不含：（i）I型磷酸二酯酶抑制剂，（ii） II型磷酸二酯酶，（iii）III型磷酸二酯酶抑制剂，（iv）IV型磷酸二酯酶抑制剂，和（v）TNF-α抑制剂。