公开(公告)号：US07335368B2

公开(公告)日：2008-02-26

申请号：US10398570

申请日：2001-10-15

Applicant: Denis Martin ,  Stephane Rioux ,  Martine Boyer ,  Josée Hamel ,  Bernard R Brodeur

Inventor： Denis Martin ,  Stephane Rioux ,  Martine Boyer ,  Josée Hamel ,  Bernard R Brodeur

IPC: A61K39/09

CPC classification number: C07K14/315 ,  A61K39/00 ,  C07K2319/00 ,  Y10S435/975

Abstract: Group B streptococcus polypeptides and polynucleotides encoding them are disclosed. Said polypeptides may be useful for the prophylaxis, diagnostic and/or therapy of streptococcal infection in mammals. Also disclosed are recombinant methods of producing the polypeptide antigens as well as diagnostic assays for detecting streptococcal infections, particularly GBS.

Abstract translation: B组链球菌多肽和编码它们的多核苷酸被公开。 所述多肽可用于哺乳动物中链球菌感染的预防，诊断和/或治疗。 还公开了产生多肽抗原的重组方法以及用于检测链球菌感染，特别是GBS的诊断测定法。

公开(公告)号：US20080038268A1

公开(公告)日：2008-02-14

申请号：US11775131

申请日：2007-07-09

Applicant: Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Stephane Rioux ,  Martine Boyer

Inventor： Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Stephane Rioux ,  Martine Boyer

IPC: A61K39/00 ,  A61K31/70 ,  A61K39/395 ,  A61P43/00 ,  C07K14/00 ,  C07K16/18 ,  C12N15/00 ,  C12N15/11 ,  C12N5/06 ,  C12P21/04 ,  C12Q1/68 ,  G01N33/569

CPC classification number: C07K14/315 ,  A61K39/00

Abstract: The present invention relates to antigens, more particularly an antigen of Streptococcus pyogenes (also called group A Streptococcus (GAS)) bacterial pathogen which is useful as vaccine component for therapy and/or prophylaxis.

Abstract translation: 本发明涉及用作治疗和/或预防的疫苗组分的抗原，更特别是化脓性链球菌（也称为A链球菌（GAS））细菌病原体的抗原。

公开(公告)号：US07262024B2

公开(公告)日：2007-08-28

申请号：US10324143

申请日：2002-12-20

Applicant: Josée Hamel ,  Nathalie Charland ,  Bernard R. Brodeur ,  Denis Martin ,  Normand Blais ,  Catherine Ouellet ,  Steve Labbe

Inventor： Josée Hamel ,  Nathalie Charland ,  Bernard R. Brodeur ,  Denis Martin ,  Normand Blais ,  Catherine Ouellet ,  Steve Labbe

IPC: C12P21/06

CPC classification number: C07K14/3156 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00

Abstract: The present invention relates to polypeptides of Streptococcus pneumoniae which may be used for prophylaxis, diagnostic and/or therapy purposes.

Abstract translation: 本发明涉及可用于预防，诊断和/或治疗目的的肺炎链球菌多肽。

公开(公告)号：US20070110763A1

公开(公告)日：2007-05-17

申请号：US10568737

申请日：2004-08-16

Applicant: Stephane Rioux ,  Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Patrick Rheault ,  Nathalie Drouin

Inventor： Stephane Rioux ,  Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Patrick Rheault ,  Nathalie Drouin

IPC: A61K39/02 ,  C07H21/04 ,  C12N1/21 ,  C07K14/315

CPC classification number: A61K39/092 ,  A61K38/00 ,  A61K2039/53 ,  A61K2039/55577 ,  C07K14/315 ,  C07K2319/00

Abstract: The present invention relates to polypeptides of S. pyogenes which may be useful to prevent, diagnose and/or treat S. pyogenes infections.

Abstract translation: 本发明涉及化脓性链球菌的多肽，其可用于预防，诊断和/或治疗化脓性链球菌感染。

公开(公告)号：US20070014842A1

公开(公告)日：2007-01-18

申请号：US11369183

申请日：2006-03-07

Applicant: Denis Martin ,  Stephane Rioux

Inventor： Denis Martin ,  Stephane Rioux

IPC: A61K39/095 ,  A61K9/127 ,  C12Q1/68 ,  G01N33/574

CPC classification number: A61K9/127 ,  A61K38/00 ,  A61K39/095 ,  A61K39/39 ,  C07K14/22 ,  C07K16/1217 ,  C07K2317/34 ,  C12Q1/689 ,  G01N33/56911 ,  G01N2333/22

Abstract: Pharmaceutical compositions comprising a liposome associated to N. meningitidis polypeptides fragments or analogs thereof or corresponding DNA fragments, can be used to prevent, diagnose and/or treat neisserial infections.

Abstract translation: 包含与脑膜炎奈瑟氏球菌多肽片段或其类似物相关的脂质体或相应的DNA片段的药物组合物可用于预防，诊断和/或治疗子宫颈感染。

公开(公告)号：US20060177465A1

公开(公告)日：2006-08-10

申请号：US11338847

申请日：2006-01-25

Applicant: Josee Hamel ,  Catherine Ouellet ,  Nathalie Charland ,  Denis Martin ,  Bernard Brodeur

Inventor： Josee Hamel ,  Catherine Ouellet ,  Nathalie Charland ,  Denis Martin ,  Bernard Brodeur

IPC: A61K39/02 ,  C07H21/04 ,  C12N1/20 ,  C07K14/315 ,  C12N15/74

CPC classification number: C07K14/315 ,  A61K39/00

Abstract: Streptococcus polypeptides and polynucleotides encoding them are disclosed. Said polypeptides may be useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.

公开(公告)号：US20050070691A1

公开(公告)日：2005-03-31

申请号：US10495643

申请日：2002-11-15

Applicant: Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Stephane Rioux ,  Julie Couture

Inventor： Denis Martin ,  Josee Hamel ,  Bernard Brodeur ,  Stephane Rioux ,  Julie Couture

IPC: G01N33/53 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61P11/02 ,  A61P11/04 ,  A61P11/14 ,  A61P27/16 ,  C07H21/04 ,  C07K14/195 ,  C07K14/21 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12N15/74 ,  C12P21/02 ,  G01N33/569

CPC classification number: C07K14/212 ,  A61K38/00 ,  A61K39/1045 ,  C07K9/00 ,  C07K16/1214 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/21 ,  C12N5/10 ,  G01N33/53 ,  G01N33/569 ,  G01N33/56911

Abstract: The present invention relates to polypeptides, more particularly polypeptides of Moraxella (Branhamella) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella (Branhamella) catarrhalis infection.

Abstract translation: 本发明涉及可用于预防，诊断和/或治疗莫拉氏菌（布拉汉氏菌）卡他莫氏菌感染的莫拉氏菌（布拉汉氏菌）卡他氏菌多肽。

公开(公告)号：US06615380B1

公开(公告)日：2003-09-02

申请号：US09469729

申请日：1999-12-21

Applicant: Rohit Kapur ,  Denis Martin ,  Thomas W. Williams

Inventor： Rohit Kapur ,  Denis Martin ,  Thomas W. Williams

IPC: G06F1100

CPC classification number: G06F11/263 ,  G01R31/318544 ,  G01R31/318547 ,  G06F11/267

Abstract: According to the present invention, during scan conversion, non-scan memory cells of a circuit design are replaced with scan cells to form a scan chain. The scan chain is transformed by the test synthesis tool of the present invention into dynamic scan chains with the addition of reconfiguration circuitry. The reconfiguration circuitry partitions the scan chain into multiple segments and enables each segment to be selectively “bypassed” (or deactivated) during test application. Shorter test patterns that are only pertinent to one or more segments are necessary, resulting in a reduction in overall test data volume and test application time. The present invention also provides a modified ATPG technique for generating test patterns for the dynamic scan chains.

Abstract translation: 根据本发明，在扫描转换期间，将电路设计的非扫描存储单元替换为扫描单元以形成扫描链。 扫描链由本发明的测试合成工具转化成动态扫描链，并添加了重构电路。 重新配置电路将扫描链分成多个段，并使测试应用中的每个段选择性地“旁路”（或停用）。 与一个或多个部分相关的更短的测试模式是必要的，导致整体测试数据量和测试应用时间的减少。 本发明还提供了一种用于生成动态扫描链的测试模式的改进的ATPG技术。

公开(公告)号：US06248786B1

公开(公告)日：2001-06-19

申请号：US09508222

申请日：2000-03-22

Applicant: Itzchak Angel ,  Denis Martin ,  Sonia Arbilla

Inventor： Itzchak Angel ,  Denis Martin ,  Sonia Arbilla

IPC: A61K3118

CPC classification number: A61K31/18

Abstract: Descriptive summary: use of a compound with the formula (I) where R1 is a hydrogen atom, a C1-2 alkyl group, a C1-2 fluoroalkyl group or a C1-2 perfluoroalkyl group and R2, R3 and R4, which may be the same or different, all represent a hydrogen atom, a straight- or branched-chain C1-4 alkyl group or a C3-4 cycloalkyl group, and R5 is a hydrogen atom, a halogen such as fluorine or chlorine, a C1-4 alkyl group or a straight- or branched-chain C1-4 alkoxy group to manufacture a medicinal agent which can be used to treat ejaculation problems such as retrograde ejaculation or aspermia.

Abstract translation: 描述性概述：使用式（I）的化合物，其中R 1是氢原子，C 1-2烷基，C 1-2烷基或C 1-2全氟烷基，R 2，R 3和R 4可以是 相同或不同，均表示氢原子，直链或支链C 1-4烷基或C 3-4环烷基，R 5为氢原子，卤素如氟或氯，C 1-4烷基 或直链或支链C 1-4烷氧基，以制备可用于治疗射精问题如逆行性射精或精子症的药剂。