公开(公告)号：US20140016093A1

公开(公告)日：2014-01-16

申请号：US13887429

申请日：2013-05-06

Applicant: TearScience, Inc.

Inventor： Donald R. Korb ,  Stephen M. Grenon ,  Caroline Blackie ,  Timothy R. Willis ,  Steve Bacich

IPC: A61B3/10 ,  A61B3/00

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/0058 ,  A61B3/1005 ,  A61B3/14 ,  G06K9/00335 ,  G06K9/00604 ,  G06K9/0061 ,  G06K9/6212 ,  G06K9/78 ,  G06T7/0016 ,  G06T7/11 ,  G06T7/90 ,  G06T7/97 ,  G06T2207/10024 ,  G06T2207/10152 ,  G06T2207/30041

Abstract: Embodiments disclosed herein include devices, systems, and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms. The apparatus and methods for determining tear film break-up time and for detecting eyelid margin contact and blink rates, particularly for diagnosing, measuring, and/or analyzing dry eye conditions and symptoms may employ ocular surface interferometry (OSI) devices or other imaging and display devices capable of imaging and displaying a picture of a patient's eye during tear film break-up time and blink rate related procedures.

Abstract translation: 本文公开的实施方案包括用于确定泪膜破裂时间和用于检测眼睑边缘接触和眨眼速率的装置，系统和方法，特别是用于诊断，测量和/或分析干眼症状和症状。 用于确定泪膜破裂时间和用于检测眼睑边缘接触和眨眼频率，特别是用于诊断，测量和/或分析干眼症状和症状的装置和方法可以采用眼表干涉测量（OSI）装置或其他成像和 显示装置能够在撕裂膜分解时间和眨眼速率相关程序期间成像和显示患者眼睛的图像。

公开(公告)号：US20130229624A1

公开(公告)日：2013-09-05

申请号：US13870214

申请日：2013-04-25

Applicant: TEARSCIENCE, INC.

Inventor： Donald R. Korb ,  William L. Weber ,  Randal B. Chinnock ,  Benjamin T. Gravely ,  Stephen M. Grenon

IPC: A61B3/10

CPC classification number: A61B3/101 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/1005 ,  A61B3/14 ,  G06T7/0012 ,  G06T2207/30041

Abstract: Background reduction apparatuses and methods of Ocular surface interferometry (OSI) employing polarization are disclosed for measuring a tear film layer thickness (TFLT) of the ocular tear film, including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT) and can be used to evaluate and potentially diagnosis dry eye syndrome (DES). In certain disclosed embodiments, a multi-wavelength light source can be controlled to illuminate the ocular tear film. Light emitted from the multi-wavelength light source undergoes optical wave interference interactions in the tear film. An imaging device can be focused on the lipid layer of the tear film to capture optical wave interference interactions of specularly reflected light from the tear film combined with a background signal(s) in at least one image. The at least one image can be processed and analyzed to measure a tear film layer thickness (TFLT), including lipid layer thickness (LLT) and/or aqueous layer thickness (ALT).

Abstract translation: 公开了用于测量眼泪膜的泪膜层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）的眼部表面干涉测量（OSI）的背景减少装置和方法，并且可以 用于评估和潜在诊断干眼综合征（DES）。 在某些公开的实施例中，可以控制多波长光源以照射眼泪膜。 从多波长光源发射的光在泪膜中经历光波干涉相互作用。 成像装置可以集中在泪膜的脂质层上，以捕获与至少一个图像中的背景信号结合的来自泪膜的镜面反射光的光波干涉相互作用。 可以处理和分析至少一个图像以测量泪液层厚度（TFLT），包括脂质层厚度（LLT）和/或水层厚度（ALT）。