公开(公告)号：US20190239515A1

公开(公告)日：2019-08-08

申请号：US16389147

申请日：2019-04-19

Applicant: Academia Sinica

Inventor： Yet-Ran Chen ,  Ying-Lan Chen ,  Mei-Chun Tseng

IPC: A01N65/38 ,  C12N15/82 ,  C07K14/415

CPC classification number: A01N65/38 ,  A61K38/00 ,  C07K14/415 ,  C12N15/8271 ,  C12N15/8279

Abstract: The present invention related to a novel plant defense signaling peptide and applications thereof.

公开(公告)号：US10342818B2

公开(公告)日：2019-07-09

申请号：US14849782

申请日：2015-09-10

Applicant: Academia Sinica

Inventor： Yun-Lian Lin ,  Yijuang Chern ,  Jim-Min Fang ,  Jung-Hsing Lin ,  Nai-Kuei Huang

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7076 ,  C07H19/167 ,  A61K31/706 ,  A61K31/7064

Abstract: The present invention provides therapeutic agents for preventing and treating neurodegenerative diseases. These agents synergistically target both the adenosine A2A receptor (A2AR) and the equilibrative nucleoside transporter 1 (ENT1).

公开(公告)号：US20190192487A1

公开(公告)日：2019-06-27

申请号：US16233280

申请日：2018-12-27

Applicant: Academia Sinica

Inventor： Chinpan CHEN ,  Tien-Sheng TSENG ,  Keng-Chang TSAI

IPC: A61K31/422 ,  A61K45/06 ,  A61K31/385

CPC classification number: A61K31/422 ,  A61K31/385 ,  A61K45/06

Abstract: Disclosed herein are novel uses of a compound of formula (I) as an inhibitor of bacterial two component signal transduction system (TCS), A-L-B-L-A   (I) wherein, A is a moiety having a negative charge; L is —(C2H5—O)n—CH2— or a moiety consists of a carbocyclyl and a heterocyclyl respectively having 5 to 10 ring atoms and coupling together, in which n is 0 or 1; and B is a 5 to 10-membered carbocyclyl or heterocyclyl. The compound of formula (I) may suppress or inhibit the growth of bacteria, including the notorious multi-drug resistant bacteria.

公开(公告)号：US10329570B2

公开(公告)日：2019-06-25

申请号：US15500354

申请日：2015-07-31

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Pan-Chyr Yang ,  Yi-Chung Chang ,  Wei-Yun Lai

IPC: C12N15/11 ,  C12N15/115 ,  A61K31/7088 ,  C12N15/113 ,  A61K31/713 ,  C12N15/117 ,  A61K47/60

Abstract: Aptamers that bind to and antagonize programmed cell death protein 1 (PD-1). Also provided herein are pharmaceutical compositions comprising such anti-PD-1 aptamers and methods for using the same for promoting T cell proliferation, treating cancer or infectious diseases, such as human immunodeficiency virus (HIV) infection.

公开(公告)号：US10317393B2

公开(公告)日：2019-06-11

申请号：US15729317

申请日：2017-10-10

Applicant: Academia Sinica

Inventor： Chi-Huey Wong ,  Tsui-Ling Hsu ,  Sarah R. Hanson ,  Masaaki Sawa

IPC: G01N33/50 ,  G01N33/533

Abstract: Methods for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates are disclosed. Alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars are incorporated into cellular glycoconjugates. Chemical probes comprising an azide group and a visual or fluorogenic probe and used to label alkyne-derivatized sugar-tagged glycoconjugates are disclosed. Chemical probes bind covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and are visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA, confocal microscopy, and mass spectrometry.

公开(公告)号：US10283714B2

公开(公告)日：2019-05-07

申请号：US15421221

申请日：2017-01-31

Applicant: ACADEMIA SINICA ,  National Taiwan University

Inventor： Kuang-Lieh Lu ,  Muhammad Usman ,  Yang-Fang Chen ,  Golam Haider ,  Shruti Mendiratta ,  Tzuoo-Tsair Luo

IPC: H01L51/54 ,  C09K11/06 ,  H01L51/00 ,  C08G79/00 ,  H01L51/52 ,  H01L51/50

Abstract: An organic electroluminescent material is shown in the following general formula (1), {[M(L)(H2O)x].(H2O)y}n  General Formula (1) wherein x is between 1 and 4, y is between 1 and 8, and n is a positive integer. M is any one selected from the group consisting of beryllium (Be), strontium (Sr), and radium (Ra). L is an organic ligand containing a naphthalene group and an anhydride group. M and L form metal-organic frameworks. An organic electroluminescent device containing the organic electroluminescent material is also disclosed.

公开(公告)号：US10238631B2

公开(公告)日：2019-03-26

申请号：US15316700

申请日：2015-06-05

Applicant: Academia Sinica

Inventor： Lie-Fen Shyur ,  Kuo-Hsiung Lee ,  Kyoko Nakagawa-Goto ,  Jia-Hua Feng ,  Jo-Yu Chen ,  Wai-Leng Lee ,  Yu-Ting Cheng ,  Jing-Ying Huang

IPC: A61K31/365 ,  A61K45/06 ,  A61K31/337 ,  A61K31/437 ,  C07D493/18 ,  A61K31/198 ,  A61K31/655

Abstract: A new class of sesquiterpene derivative useful for treating cancerous and inflammatory diseases are disclosed. These deoxyelephantopin derivatives are effective in suppressing proliferation, migration, mobility, invasion, growth, and/or metastasis of cancer cells in a patient, or useful for enhancing an anti-proliferative effect of another anti-cancer drug on cancer cells when treating a patient, or for sensitizing and/or enhancing an anti-cancer effect of a gluthathione synthesis blocker on inhibition of triple negative breast cancer cell activity, or for treatment and/or prophylaxis of lipopolysaccharide-stimulated inflammatory response in a patient, or for all of the above. Also disclosed are methods of preparing the deoxyelephantopin derivatives.

公开(公告)号：US10214765B2

公开(公告)日：2019-02-26

申请号：US15881581

申请日：2018-01-26

Applicant: Academina Sinica

Inventor： Chi-Huey Wong ,  Jim-Min Fang ,  Yih-Shyun E. Cheng ,  Chamg-Sheng Tsai

IPC: C07H5/00 ,  C07H13/04 ,  C07H13/12 ,  C12N9/24 ,  C12Q1/04 ,  C12Q1/34 ,  C12Q1/40 ,  C12Q1/70

Abstract: Provided herein are compounds for use as sialidase inhibitors, including alkynyl-3-fluorosialyl fluoride. The compounds, which include the compound DFSA, function by trapping a 3-fluorosialylenzyme intermediate (reporter-inhibitor-enzyme conjugate). These compounds can be conjugated with a detectable tagging moiety for isolation and identification of sialidases.

公开(公告)号：US10213967B2

公开(公告)日：2019-02-26

申请号：US14302243

申请日：2014-06-11

Applicant: ACADEMIA SINICA

Inventor： Keng-Hui Lin ,  Yi-Hsuan Lee

IPC: B29C67/20 ,  B29K77/00 ,  B29K105/00 ,  B29K105/04 ,  B29K105/24

Abstract: A fabricating device of a three-dimensional (3-D) scaffold comprises a bubble generator, a bubble mixing channel, a coagulating solution channel and a bubble collector. The bubble generator includes a gas channel and a gel solution channel crossing the gas channel. The bubble mixing channel is connected with a first outlet of the bubble generator. The coagulating solution channel is connected with the bubble mixing channel. The bubble collector is connected with a second outlet of the bubble mixing channel.

公开(公告)号：US10117890B2

公开(公告)日：2018-11-06

申请号：US15376281

申请日：2016-12-12

Applicant: Academia Sinica

Inventor： Chih-Cheng Chen ,  Yun-Lian Lin ,  Jim-Min Fang ,  Yijuang Chern ,  Chia-Ching John Lin ,  Wei-Nan Chen ,  Chun-Jung Lin

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7076 ,  A61K36/8988 ,  A61K45/06

Abstract: Methods for treating pain such as fibromyalgia, comprising administering to a subject in need thereof an effective amount of an adenosine analog, wherein the adenosine analog may be a compound of Formula (I): (I), or a pharmaceutically acceptable salt thereof. Pharmaceutical compositions comprising the adenosine analog for use in treating pain (e.g., fibromyalgia), optionally further comprising Substance P (SP), are also provided.