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    METHODS OF PRODUCING 1,3,5-TRIAMINO-2,4,6-TRINITROBENZENE
    71.
    发明申请
    METHODS OF PRODUCING 1,3,5-TRIAMINO-2,4,6-TRINITROBENZENE 有权
    生产1,3,5-三甲基-2,4,6-三硝基苯的方法

    公开(公告)号：US20110172463A1

    公开(公告)日：2011-07-14

    申请号：US11744986

    申请日：2007-05-07

    Applicant: Stephen P. Velarde ,  Vincent E. Mancini

    Inventor： Stephen P. Velarde ,  Vincent E. Mancini

    IPC: C07C209/04

    CPC classification number: C07C209/18 ,  C07C201/08 ,  C07C201/12 ,  C07C205/24 ,  C07C211/52

    Abstract: Methods of producing TATB are disclosed. The method comprises providing acid wet TNPG and distilling water from the acid wet TNPG. The TNPG is reacted with an alkoxylating agent to form a solution of 1,3,5-trialkoxy-2,4,6-trinitrobenzene solution, which is reacted with an aminating agent. An alternate method comprises nitrating phloroglucinol in a first vessel to produce TNPG, which is reacted with an alkoxylating agent in a second vessel to form a solution comprising 1,3,5-trialkoxy-2,4,6-trinitrobenzene and at least one of at least one volatile byproduct and at least one nonvolatile byproduct. The at least one of at least one volatile byproduct and at least one nonvolatile byproduct is removed in situ. The 1,3,5-trialkoxy-2,4,6-trinitrobenzene is reacted with an aminating agent.

    Abstract translation: 公开了生产TATB的方法。 该方法包括从酸性湿TNPG提供酸性湿TNPG和蒸馏水。 使TNPG与烷氧基化剂反应，形成与胺化剂反应的1,3,5-三烷氧基-2,4,6-三硝基苯溶液。 替代方法包括在第一容器中硝化间苯三酚以产生TNPG，其在第二容器中与烷氧基化剂反应以形成包含1,3,5-三烷氧基-2,4,6-三硝基苯和至少一种 至少一种挥发性副产物和至少一种非挥发性副产物。 至少一种挥发性副产物和至少一种非挥发性副产物中的至少一种原位被去除。 使1,3,5-三烷氧基-2,4,6-三硝基苯与胺化剂反应。

    Process for the preparation of phenolic hydroxy-substituted compounds
    72.
    发明授权
    Process for the preparation of phenolic hydroxy-substituted compounds 有权
    酚羟基取代化合物的制备方法

    公开(公告)号：US07973185B2

    公开(公告)日：2011-07-05

    申请号：US11577434

    申请日：2005-12-07

    Applicant: András Vass ,  József Dudás ,  László Borbély ,  Ferenc Haász ,  Péter Jekkel

    Inventor： András Vass ,  József Dudás ,  László Borbély ,  Ferenc Haász ,  Péter Jekkel

    IPC: C07J1/00

    CPC classification number: C07C37/055 ,  C07C45/673 ,  C07C49/755 ,  C07C49/84 ,  C07C51/367 ,  C07C201/12 ,  C07C2602/10 ,  C07J1/0059 ,  C07J1/0074 ,  C07C65/03 ,  C07C65/10 ,  C07C39/04 ,  C07C39/14 ,  C07C39/07 ,  C07C39/28 ,  C07C39/27 ,  C07C39/08 ,  C07C39/17 ,  C07C205/22

    Abstract: The invention relates to a process for the preparation of a phenolic hydroxy-substituted compound of the general formula (I) by desalkylation of an alkyl aryl ether of the general formula (II) by treatment with a thiourea/aluminum chloride reagent pair, in said general formulae R1 stands for straight chain or branched C1-6 alkyl group; R2, R3 , R4 , R5, and R6 have the same or different meanings and stand for hydrogen or halogen atom, hydroxy, carboxy, nitro, oxo, C1-6 alkylcarbonyl, straight chain or branched alkyl or -alkoxy, or aryl group, or R2 and R3 together stand for a 5-7 membered ring or fused ring system; said 5-7 membered ring may be a partially saturated ring optionally substituted with an oxo group or can be an unsaturated ring; or said fused ring system may constitute with the first ring a steroid, preferably an estratriene derivative optionally substituted with an oxo or C1-6 alkylcarbonyloxy group in the 17 position.

    Abstract translation: 本发明涉及一种制备通式（I）的酚羟基取代的化合物的方法，该方法通过在所述的硫脲/氯化铝试剂对中用硫脲/氯化铝试剂对进行脱烷基处理来制备通式（Ⅱ）的烷基芳基醚 通式R1代表直链或支链C 1-6烷基; R2，R3，R4，R5和R6具有相同或不同的含义，代表氢或卤素原子，羟基，羧基，硝基，氧代，C1-6烷基羰基，直链或支链烷基或 - 烷氧基或芳基， 或R 2和R 3一起代表5-7元环或稠环体系; 所述5-7元环可以是任选被氧代基取代的部分饱和的环，或者可以是不饱和环; 或所述稠环体系可以与第一环一起构成类固醇，优选在17位任选被氧代或C 1-6烷基羰基氧基取代的雌三烯衍生物。

    Methods of producing 1,3,5-triamino-2,4,6-trinitrobenzene
    73.
    发明授权
    Methods of producing 1,3,5-triamino-2,4,6-trinitrobenzene 有权
    生产1,3,5-三氨基-2,4,6-三硝基苯的方法

    公开(公告)号：US07910776B2

    公开(公告)日：2011-03-22

    申请号：US12484985

    申请日：2009-06-15

    Applicant: Nicholas A. Straessler ,  Stephen P. Velarde

    Inventor： Nicholas A. Straessler ,  Stephen P. Velarde

    IPC: C07C213/02 ,  C07C205/06

    CPC classification number: C07C209/18 ,  C07C201/08 ,  C07C201/12 ,  C07C205/37 ,  C07C211/52

    Abstract: Methods of producing 1,3,5-triamino-2,4,6-trinitrobenzene (TATB), from alkoxy derivatives of phloroglucinol, such as 5-methoxyresorcinol, 3,5-dimethoxyphenol, or 1,3,5-trimethoxybenzene, are disclosed. The alkoxy derivatives may be exposed to and directly nitrated with a reaction mixture comprising a sulfuric acid solution and at least one nitrate salt. The nitrated alkoxy derivative of phloroglucinol may be alkoxylated and, thereafter, aminated to produce the TATB.

    Abstract translation: 从间苯三酚的烷氧基衍生物如5-甲氧基间苯二酚，3,5-二甲氧基苯酚或1,3,5-三甲氧基苯制备1,3,5-三氨基-2,4,6-三硝基苯（TATB）的方法是 披露 烷氧基衍生物可以用包含硫酸溶液和至少一种硝酸盐的反应混合物暴露并直接硝化。 间苯三酚的硝化烷氧基衍生物可以被烷氧基化，然后胺化以产生TATB。

    Process For The Preparation Of Bronopol
    74.
    发明申请
    Process For The Preparation Of Bronopol 有权
    Bronopol的制备方法

    公开(公告)号：US20110065964A1

    公开(公告)日：2011-03-17

    申请号：US12735886

    申请日：2009-02-26

    Applicant: Jacob Oren

    Inventor： Jacob Oren

    IPC: C07C201/12

    CPC classification number: C07C201/10 ,  C07C201/12 ,  C07C205/15

    Abstract: The invention provides a process for preparing bronopol, which process comprises charging a reaction vessel with water, bromopicrin, nitromethane and paraformaldehyde, gradually feeding a base into said reaction vessel under stirring, bringing the reaction to completion and separating bronopol from the aqueous reaction mixture.

    Abstract translation: 本发明提供了一种制备青霉酚的方法，该方法包括向反应容器中加入水，溴氰菊酯，硝基甲烷和多聚甲醛，在搅拌下逐渐向碱性物质中加入碱，使反应完成，并从反应混合物中分离出丙三醇。

    PROCESS FOR PREPARING SUBSTITUTED BIPHENYLS
    76.
    发明申请
    PROCESS FOR PREPARING SUBSTITUTED BIPHENYLS 有权
    制备替代BIPHENYLS的方法

    公开(公告)号：US20100256418A1

    公开(公告)日：2010-10-07

    申请号：US12726196

    申请日：2010-03-17

    Applicant: Sebastian Peer SMIDT ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

    Inventor： Sebastian Peer SMIDT ,  Jochen Dietz ,  Michael Keil ,  Thomas Grote

    IPC: C07C205/04

    CPC classification number: C07C201/12 ,  C07C209/68 ,  C07C211/52 ,  C07C205/12

    Abstract: A process for preparing substituted biphenyls of the formula I in which the substituents are defined as follows: X is fluorine or chlorine; R1 is nitro, amino or NHR3; R2 is cyano, nitro, halogen, C1-C6-alkyl, C1-C-6-alkenyl, C1-C6-alkynyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-alkylcarbonyl or phenyl; R3 is C1-C4-alkyl, C1-C4-alkenyl or C1-C4-alkynyl; n is 1, 2 or 3, where in case that n is 2 or 3, the R.sup.2 radicals may also be different, which comprises reacting the compound of the formula II in which Hal is halogen and X and R1 are as defined above, in the presence of a base and of a palladium catalyst selected from the group of:3 a) palladium-triarylphosphine or -trialkylphosphine complex with palladium in the zero oxidation state, b) salt of palladium in the presence of triarylphospine or trialkylphosphine as a complex ligand or c) metallic palladium, optionally applied to support, in the presence of triarylphosphine or trialkylphosphine, in a solvent, with a diphenylborinic acid (III) in which R2 and n are as defined above, where the triarylphosphines or trialkylphosphines used may be substituted.

    Abstract translation: 制备式I取代的联苯的方法，其中取代基定义如下：X是氟或氯; R1是硝基，氨基或NHR3; R2是氰基，硝基，卤素，C1-C6-烷基，C1-C6-6烯基，C1-C6-炔基，C1-C6-烷氧基，C1-C6-卤代烷基，C1-C6烷基羰基或苯基; R3是C1-C4-烷基，C1-C4-烯基或C1-C4-炔基; n为1,2或3，其中在n为2或3的情况下，R 2基团也可以不同，其包括使其中Hal为卤素且X和R 1的式II化合物与 在碱存在下和选自以下组中的钯催化剂存在下：a）钯 - 三芳基膦或三烷基膦配合物与钯在零氧化状态，b）钯在三芳基膦或三烷基膦存在下的盐 作为络合配体或c）金属钯，任选地在三芳基膦或三烷基膦存在下，在溶剂中与二苯基硼酸（III）反应，其中R 2和n如上所定义，其中使用三芳基膦或三烷基膦 可以被替代。

    Process of preparing bromopicrin
    79.
    发明申请
    Process of preparing bromopicrin 有权
    溴氰菊酯制备方法

    公开(公告)号：US20100152501A1

    公开(公告)日：2010-06-17

    申请号：US11989585

    申请日：2006-08-22

    Applicant: Jakob Oren ,  Leah Golan ,  Ron Frim

    Inventor： Jakob Oren ,  Leah Golan ,  Ron Frim

    IPC: C07C205/02

    CPC classification number: C07C201/12 ,  C07C205/08

    Abstract: Process of preparing high purity bromopicrin, and high purity bromopicrin produced therefrom. Providing a mixture of nitromethane and bromine, and preferably water, and absent of organic solvent. Adding an aqueous solution of an alkaline substance to the mixture, thereby providing a reaction mixture containing bromopicrin, the adding performed such that no excess of the alkaline substance occurs in the reaction mixture during the adding. Collecting the organic phase (containing the bromopicrin) from the reaction mixture. No need for subjecting the organic phase of the reaction mixture to distillation or extraction, for obtaining near quantitative yield of bromopicrin having purity of at least equal to or greater than 96 weight percent. Process parameters controlling selectivity of reaction forming bromopicrin are molar ratio of bromine and nitromethane in the mixture; reaction temperature while bromopicrin is formed; concentration of the alkaline substance in the aqueous solution; and reaction time.

    Abstract translation: 制备高纯度溴氰菊酯和由其制备的高纯度溴氰菊酯的方法。 提供硝基甲烷和溴的混合物，优选水，并且不存在有机溶剂。 向混合物中加入碱性物质的水溶液，由此提供含有溴氰菊酯的反应混合物，进行添加，使得在添加期间反应混合物中不会发生过量的碱性物质。 从反应混合物中收集有机相（含溴氰菊酯）。 不需要使反应混合物的有机相进行蒸馏或萃取，以获得纯度至少等于或大于96重量％的溴定额素的近定量产率。 控制反应形成溴氰菊酯的选择性的工艺参数是混合物中溴和硝基甲烷的摩尔比; 反应温度，同时形成溴化铁; 碱性物质在水溶液中的浓度; 和反应时间。

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