公开(公告)号：US5663790A

公开(公告)日：1997-09-02

申请号：US532546

申请日：1995-10-06

Applicant: Bjorn Ekstrom ,  Magnus Oberg

Inventor： Bjorn Ekstrom ,  Magnus Oberg

IPC: G01N21/27 ,  G01N21/41 ,  G01N21/77

CPC classification number: G01N21/7746 ,  G01N21/41 ,  G01N2201/0873

Abstract: In a method of determining the refractive index of a gaseous, liquid or solid sample, preferably a gaseous or liquid sample, there is used a waveguide resonator (1) which includes an open waveguide (4) and a closed waveguide (5) located adjacent the open waveguide. The sample is brought to the vicinity of the closed waveguide (5) so as to influence the proximal surroundings of the waveguide and therewith its effective refractive index. Light derived from a light source (9) is coupled to one end of the open waveguide (4) and transmitted light is measured at the other end of the open waveguide to establish the influence of the sample on the resonance wavelength and therewith determine the refractive index of the sample or a sample-related refractive index difference. A device for carrying out the method includes a waveguide resonator having a sample contact area (12) adjacent the closed waveguide (5) of the waveguide resonator.

Abstract translation: PCT No.PCT / SE94 / 00312 Sec。 371日期1995年10月6日 102（e）日期1995年10月6日PCT 1994年4月8日PCT PCT。 第WO94 / 24542号公报 日期1994年10月27日在确定气体，液体或固体样品（优选气体或液体样品）的折射率的方法中，使用波导谐振器（1），其包括开放波导（4）和闭合波导 （5）位于开放波导附近。 将样品带到封闭波导（5）附近，以便影响波导的近端周边以及其有效折射率。 源自光源（9）的光耦合到开放波导（4）的一端，并且在开放波导的另一端测量透射光，以确定样品对共振波长的影响，从而确定折射率 样品指数或样品相关折射率差异。 用于执行该方法的装置包括具有与波导谐振器的闭合波导（5）相邻的样本接触区域（12）的波导谐振器。

公开(公告)号：US5377008A

公开(公告)日：1994-12-27

申请号：US862494

申请日：1992-04-02

Applicant: Richard W. Ridgway ,  Anthony A. Boiarski ,  Van E. Wood ,  James R. Busch

Inventor： Richard W. Ridgway ,  Anthony A. Boiarski ,  Van E. Wood ,  James R. Busch

IPC: G01N21/27 ,  G01J9/02 ,  G01N21/45 ,  G01N21/77 ,  G01N33/543 ,  G02B6/12 ,  G02B6/122 ,  G01B9/02

CPC classification number: G01N21/7703 ,  G01N21/45 ,  G01N33/54373 ,  G02B6/122 ,  G01J2009/023 ,  G01N2021/1751 ,  G01N21/648 ,  G01N2201/0245 ,  G01N2201/0873 ,  G02B2006/12097 ,  G02B2006/12138 ,  G02B2006/12159

Abstract: An apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a compensation path that includes the sensing region to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. In one embodiment a ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a curved or serpentine path configured so that nonspecific sensing effects are compensated.

Abstract translation: 一种用于对流体进行免疫测定的装置，光被引导到光学传感器，其中光被传送到可在其暴露于流体的感测区域中的折射率的可更换光学装置。 光的一部分经由包括感测区域的补偿路径传送到第一检测器。 光的另一部分经由包括感测区域的感测路径传输到另一个检测器。 在一个实施例中，比例设备接收每个检测器的输出，并且响应于输出的比率提供信号。 可替换的光学器件通常包括一对定向耦合布置中的一个通道波导，或一个干涉仪布置中的一对通道波导，或者具有曲线或蛇形路径的脊波导，其配置为使得非特定的感测效果得到补偿。

公开(公告)号：US5173747A

公开(公告)日：1992-12-22

申请号：US585438

申请日：1990-09-20

Applicant: Anthony A. Boiarski ,  Richard W. Ridgway

Inventor： Anthony A. Boiarski ,  Richard W. Ridgway

IPC: G01N21/27 ,  G01J9/02 ,  G01N21/45 ,  G01N21/77 ,  G01N33/543 ,  G02B6/12 ,  G02B6/122

CPC classification number: G01N21/45 ,  G01N21/7703 ,  G01N33/54373 ,  G02B6/122 ,  G01J2009/023 ,  G01N2021/1751 ,  G01N21/648 ,  G01N2201/0245 ,  G01N2201/0873 ,  G02B2006/12097 ,  G02B2006/12138 ,  G02B2006/12159

Abstract: In apparatus useful in immunoassay of a fluid, light is directed to an optical sensor wherein the light is transmitted to a replaceable optical device that is responsive to index of refraction in a sensing region thereof that is exposed to the fluid. One portion of the light is transmitted via a reference path to a first detector. Another portion of the light is transmitted via a sensing path that includes the sensing region to another detector. A ratioing device receives an output from each detector and provides a signal responsive to the ratio of the outputs. The replaceable optical device typically comprises a pair of channel waveguides in directional coupling arrangement, or a pair of channel waveguides in an interferometer arrangement, or a ridge waveguide having a serpentine path.

Abstract translation: 在用于免疫测定流体的装置中，光被引导到光学传感器，其中光被传送到可替换的光学装置，该装置响应于暴露于流体的感测区域中的折射率。 光的一部分经由参考路径被传送到第一检测器。 光的另一部分经由包括感测区域的感测路径传输到另一个检测器。 比较装置接收每个检测器的输出，并提供响应输出比的信号。 可更换光学器件通常包括一对定向耦合布置中的通道波导，或干涉仪布置中的一对通道波导或具有蛇形路径的脊波导。