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    SYNTHESIS OF AVRAINVILLAMIDE, STEPHACIDIN B, AND ANALOGUES THEREOF
    82.
    发明申请
    SYNTHESIS OF AVRAINVILLAMIDE, STEPHACIDIN B, AND ANALOGUES THEREOF 审中-公开
    阿维菌素，去甲胆碱B及其类似物的合成

    公开(公告)号：US20110166170A1

    公开(公告)日：2011-07-07

    申请号：US12913091

    申请日：2010-10-27

    Applicant: Andrew G. Myers ,  Seth B. Herzon ,  Jeremy Earle Wulff ,  Romain Siegrist ,  Jakub Svenda ,  Matthew Allen Zajac

    Inventor： Andrew G. Myers ,  Seth B. Herzon ,  Jeremy Earle Wulff ,  Romain Siegrist ,  Jakub Svenda ,  Matthew Allen Zajac

    IPC: A61K31/437 ,  C07D487/04 ,  C07D471/22 ,  C07D209/56 ,  C07D209/82 ,  A61K31/407 ,  A61K31/403 ,  A61P35/00

    CPC classification number: C07D209/88 ,  C07D471/22 ,  C07D491/052 ,  C07D491/22 ,  C07D495/22

    Abstract: The syntheses of the natural products, avrainvillamide and stephacidin B, are provided. The α,β-unsaturated nitrone functionality of avrainvillamide and its 3-alkylidene-3H-indole 1-oxide core is shown to covalently and reversibly bond to heteroatom-based nucleophiles. This capability may allow these molecules to bind active site nucleophiles and may provide the basis for designing potent and selective enzyme inhibitors. Both avrainvillamide and its dimer stephacidin B have been reported to exhibit antiproliferative activity, and avrainvillamide has been reported to exhibit antimicrobial activity against multi-drug resistant bacteria. Avrainvillamide has been found to target cytoskeleton-linking membrane protein (CLIMP-63) thereby preventing cells from undergoing mitosis. The invention provides syntheses of these natural products as well as analogs of these natural products and their functional cores. The compounds of the invention may be used in the treatment of diseases such as cancer, autoimmune diseases, and bacterial infection.

    Abstract translation: 提供了天然产物，维生素A和抗抑郁素B的合成。 显示出avrainvillamide及其3-亚烷基-3H-吲哚-1-氧化物核心的α，bgr-不饱和硝酮官能团共价和可逆地键合到基于杂原子的亲核试剂。 这种能力可以允许这些分子结合活性位点亲核试剂，并且可以为设计有效和选择性酶抑制剂提供依据。 已经报道了丙氨酰维他命和其二聚杀生物素蛋白B都具有抗增殖活性，据报道，抗谷氨酰胺具有抗多药耐药细菌的抗微生物活性。 已经发现Avrainvillamide靶向细胞骨架连接膜蛋白（CLIMP-63），从而防止细胞发生有丝分裂。 本发明提供这些天然产物以及这些天然产物及其功能核心的类似物的合成。 本发明的化合物可用于治疗诸如癌症，自身免疫性疾病和细菌感染等疾病。

    System and software for providing recommendations to optimize a portfolio of items
    84.
    发明授权
    System and software for providing recommendations to optimize a portfolio of items 有权
    系统和软件提供优化项目组合的建议

    公开(公告)号：US07822669B2

    公开(公告)日：2010-10-26

    申请号：US11691618

    申请日：2007-03-27

    Applicant: Rajesh Tyagi ,  Kete Chalermkraivuth ,  Marc Anthony Garbiras ,  John Andrew Ellis ,  Matthew Allen ,  James G. Russo

    Inventor： Rajesh Tyagi ,  Kete Chalermkraivuth ,  Marc Anthony Garbiras ,  John Andrew Ellis ,  Matthew Allen ,  James G. Russo

    IPC: G06Q40/00

    CPC classification number: G06Q40/06 ,  G06Q50/16

    Abstract: A method of operating a computer system includes storing, in the computer system, a database containing performance measure data regarding performance measures of a plurality of items. The method further includes inputting into the computer system a plurality of performance measure constraints. The method also includes modeling the performance measure constraints with a set of equations. The equations include a plurality of variables. Each of the variables corresponds to a respective one of the items. Each variable is, for example, to be assigned either the value “1” or the value “0”. The value “1” may represent a recommendation to take an action relative to the corresponding item in the portfolio and the value “0” may represent a recommendation to take another action. The computer system is used to solve the set of equations to generate one or more solutions that satisfy the performance measure constraints.

    Abstract translation: 一种操作计算机系统的方法包括在计算机系统中存储包含关于多个项目的性能测量的性能测量数据的数据库。 该方法还包括向计算机系统输入多个性能测量约束。 该方法还包括使用一组方程建模性能测量约束。 方程式包括多个变量。 每个变量对应于相应的一个项目。 例如，每个变量被赋予值“1”或值“0”。 值“1”可以表示相对于投资组合中的相应项目采取行动的建议，值“0”可以表示采取另一动作的建议。 计算机系统用于解决方程组，以生成满足性能测量约束的一个或多个解决方案。

    Revoking Malware in a Computing Device
    86.
    发明申请
    Revoking Malware in a Computing Device 审中-公开
    在计算设备中撤销恶意软件

    公开(公告)号：US20100115269A1

    公开(公告)日：2010-05-06

    申请号：US12306343

    申请日：2007-06-26

    Applicant: Matthew Allen ,  Craig Heath ,  Andrew Harker

    Inventor： Matthew Allen ,  Craig Heath ,  Andrew Harker

    IPC: H04L29/06 ,  G06F21/00

    CPC classification number: G06F21/33 ,  G06F21/51 ,  G06F21/57

    Abstract: A computing device is operated in a manner which provides improved checking to determine whether or not an authentication certificate for a software application being loaded onto the device has been revoked. In the case of trusted certificate chains that contain no revocation information, the device checks using an AuthorityInfoAccess extension (AIA) as selected by the device. In the case of untrusted certificate chains, notably including self-signed certificates, the device is controlled so that it ignores any authentication revocation information provided with the software application and always uses information stored on the device.

    Abstract translation: 计算设备以提供改进的检查以确定正在加载到设备上的软件应用的认证证书是否已被撤销的方式操作。 在不包含撤销信息的可信证书链的情况下，设备将使用设备选择的AuthorityInfoAccess扩展（AIA）进行检查。 在不可信证书链的情况下，特别是包括自签名证书，该设备被控制，使其忽略软件应用提供的任何认证撤销信息，并且始终使用设备上存储的信息。

    Combination stuffed toy with characteristics of multiple kinds of entities
    89.
    发明申请
    Combination stuffed toy with characteristics of multiple kinds of entities 审中-公开
    组合玩具具有多种实体的特点

    公开(公告)号：US20090176437A1

    公开(公告)日：2009-07-09

    申请号：US12006971

    申请日：2008-01-07

    Applicant: Steve Jaqua ,  Matthew Allen Perry

    Inventor： Steve Jaqua ,  Matthew Allen Perry

    IPC: A63H33/00 ,  A63H3/02

    CPC classification number: A63H3/16 ,  A63H3/02

    Abstract: A combination stuffed toy contains features of both a plant and an animal or another combination of entities. Preferably, the toy is a stuffed plant-animal combination comprising a cover with a plant component and an animal component which stores a stuffing material. Plant-animal combination toys are not only aesthetically pleasing but are also intellectually stimulating. Plant-animal combination toys require users to think to determine what the plant-animal combination is, as well as encourage users to utilize their imaginations. Plant-animal combination toys are also able to be used as a support, either emotionally or physically.

    Abstract translation: 组合填充玩具包含植物和动物的特征或其他实体的组合。 优选地，玩具是填充植物 - 动物组合，其包括具有植物成分的盖和存储填充材料的动物部件。 植物 - 动物组合玩具不仅在美学上令人愉快，而且在智力上也是刺激性的。 植物 - 动物组合玩具需要用户考虑确定植物 - 动物组合是什么，并鼓励用户利用他们的想象力。 植物 - 动物组合玩具也可以在情绪上或身体上用作支持。

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