公开(公告)号：US20050196349A1

公开(公告)日：2005-09-08

申请号：US10849067

申请日：2004-05-19

Applicant: Dianqing Wu ,  Yazhou Zhang ,  Peng Liu ,  Xiaofeng Li ,  Jie Zhang ,  Jufang Shan ,  Dean Engelhardt

Inventor： Dianqing Wu ,  Yazhou Zhang ,  Peng Liu ,  Xiaofeng Li ,  Jie Zhang ,  Jufang Shan ,  Dean Engelhardt

IPC: A61K9/68 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/68 ,  G06F19/00 ,  A61K7/28

CPC classification number: G01N33/6893 ,  A61K38/00 ,  G01N33/6887 ,  G01N2500/00 ,  G01N2800/10 ,  G01N2800/108

Abstract: The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors' transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm. Together with the observation that osteoblast cells produce autocrine canonical Wnt, Wnt7b, and that osteocytes produce paracrine Dkk1, we believe that the G171V mutation may cause an increase in Wnt activity in osteoblasts by reducing the number of targets for paracrine Dkk1 to antagonize without affecting the activity of autocrine Wnt.

Abstract translation: 研究了Wnt共同受体LRP5的高骨量（HBM）突变（G171V）调节规范Wnt信号传导的机制。 以前显示突变可以降低Dkk蛋白-1介导的拮抗作用，这表明G171位于第一个YWTD重复结构域可能是Dkk蛋白介导的拮抗作用的原因。 然而，我们发现第三个YWTD重复，但不是第一个重复结构域，是DKK1介导的拮抗作用所必需的。 相反，我们发现G171V突变破坏了LRP5与Mesd的相互作用，Mesd是共受体转运到细胞表面所需的LRP5 / 6的伴侣蛋白，导致细胞表面上较少的LRP5分子。 尽管细胞表面LRP5分子水平的降低导致旁分泌范例中Wnt信号传导的降低，但突变似乎不影响共表达Wnt在自分泌范式中的活性。 连同观察到成骨细胞产生自分泌的正常Wnt，Wnt7b，并且该骨细胞产生旁分泌的Dkk1，我们认为G171V突变可能通过减少旁分泌Dkk1靶向拮抗的数目而引起成骨细胞中Wnt活性的增加，而不影响 自分泌Wnt的活性。

公开(公告)号：US20050191566A1

公开(公告)日：2005-09-01

申请号：US10789703

申请日：2004-02-27

Applicant: Peng Liu ,  Vivek Singh

Inventor： Peng Liu ,  Vivek Singh

IPC: G03C5/00 ,  G03F9/00 ,  G06F17/50 ,  H01L21/76

CPC classification number: G06F17/5081 ,  G03F1/36 ,  G06F2217/12 ,  Y02P90/265

Abstract: Systems and techniques to quickly and accurately model a transmitted electromagnetic field through a mask, to design a mask, and to create a library of corrections including edge corrections, edge-to-edge corrections, and corner corrections.

Abstract translation: 通过掩模快速准确地对传输的电磁场建模的系统和技术，设计一个掩模，并创建一个校正库，包括边缘校正，边缘到边缘校正和角修正。

公开(公告)号：US20050166448A1

公开(公告)日：2005-08-04

申请号：US10770497

申请日：2004-02-04

Applicant: Yu-Peng Liu

Inventor： Yu-Peng Liu

IPC: A01G13/02 ,  A47G33/04 ,  F21V33/00 ,  A47G33/12

CPC classification number: A01G13/0281 ,  A47G33/045 ,  F21S4/10 ,  F21V33/0004

Abstract: The invention relates to a skirt of a Christmas tree having decorative light string, which mainly provides an improvement of the tree skirt used on the Christmas tree. The improved tree skirt can be connected with a light string by any desired method to provide a lighting effect for increasing decorative purpose of the whole assembly.

Abstract translation: 本发明涉及一种具有装饰灯串的圣诞树的裙部，其主要提供了在圣诞树上使用的树裙的改进。 改进的树裙可以通过任何所需的方法与灯串连接，以提供用于增加整个组件的装饰目的的照明效果。

公开(公告)号：US20050150435A1

公开(公告)日：2005-07-14

申请号：US10946720

申请日：2004-09-21

Applicant: Hsuan-Tsung Chen ,  Ying Tin ,  Pin-Shian Wu ,  Peng Liu

Inventor： Hsuan-Tsung Chen ,  Ying Tin ,  Pin-Shian Wu ,  Peng Liu

IPC: A47B57/00 ,  A47B91/00 ,  G06F1/16 ,  G06F1/18 ,  H05K5/00

CPC classification number: A47B91/005 ,  G06F1/181

Abstract: A pedestal assembly (20) includes a chassis (200), a gear wheel (300) pivotably mounted to the chassis, two supporting members (400) coupled to the chassis, and a coil spring (500) received between the chassis and the gear wheel. The chassis includes a stop portion (222) depending downwardly from a side of a top wall (210) thereof. The gear wheel includes first teeth (330) extending from a periphery thereof. Each supporting member includes a rack (440) comprises second teeth (444) engaging with the first teeth, and a first clasping portion (448) formed on an outer side thereof. When one of the first clasping portions is locked by the stop portion, the coil spring is compressed, while when the first clasping portion is unlocked from the stop portion, the coil spring is decompressed and drives the gear wheel to rotate to cause the supporting members to move relative to the gear wheel.

Abstract translation: 基座组件（20）包括底盘（200），可枢转地安装到底盘的齿轮（300），联接到底盘的两个支撑构件（400）和容纳在底盘和齿轮之间的螺旋弹簧（500） 轮。 底盘包括从其顶壁（210）的侧面向下悬垂的止挡部分（222）。 齿轮包括从其周边延伸的第一齿（330）。 每个支撑构件包括齿条（440），齿条（440）包括与第一齿啮合的第二齿（444）和形成在其外侧上的第一夹紧部分（448）。 当第一夹紧部中的一个被止动部锁定时，螺旋弹簧被压缩，而当第一夹紧部从止动部解锁时，螺旋弹簧被减压并驱动齿轮旋转，从而使支撑构件 相对于齿轮移动。

公开(公告)号：US06575604B2

公开(公告)日：2003-06-10

申请号：US10042223

申请日：2002-01-11

Applicant: Yu-Peng Liu

Inventor： Yu-Peng Liu

IPC: F21S1310

CPC classification number: F21V19/04 ,  F21W2121/00

Abstract: A bulb holder for decorative lamp includes a main body that is connected to a frame of the lamp for holding a plurality of bulbs and has retaining spaces equally spaced at a lower side thereof, and a tubular connector that includes a lower tube portion that may be differently sized, and a horizontal flange portion. The flange portion is provided along an outer edge with equally spaced teeth corresponding to the retaining spaces on the main body. By aligning the tube portion with a central mounting hole of the main body and turning the tubular connector to move the teeth into the retaining spaces, the tubular connector is detachably connected to the lower side of the main body. By connecting the main body to a tubular connector having a differently sized tube portion, the decorative lamp may be conveniently mounted onto a differently sized post via the tube portion.

公开(公告)号：US5353964A

公开(公告)日：1994-10-11

申请号：US197764

申请日：1994-02-16

Applicant: Yin-Peng Liu ,  Miin-Tsang Sheu

Inventor： Yin-Peng Liu ,  Miin-Tsang Sheu

IPC: A61J7/00 ,  A61J9/00 ,  A61J11/00 ,  B65D81/32 ,  B67D5/60

CPC classification number: A61J11/001 ,  A61J11/0005 ,  A61J7/0046 ,  A61J9/00 ,  B65D81/3227

Abstract: A twin-bottle nursing bottle includes an outer bottle having a mouth at the top; an outer cap fastened to the mouth of the outer bottle through a screw joint to hold a nipple; an inner bottle disposed inside the outer bottle; a cup-like inner cap supported above the mouth of the outer bottle to hold the inner bottle inside the outer bottle; and a diversion control switch received within the outer cap between the nipple and the cup-like inner cap and turned to let a first fluid in the outer bottle or a second fluid in the inner bottle flow into the nipple for suction by the baby or to let both the first and second fluids flow into the nipple simultaneously.

Abstract translation: 双瓶护理瓶包括在顶部有口的外瓶; 外盖通过螺纹接头固定在外瓶口上以保持乳头; 设置在外瓶内部的内瓶; 一个杯状的内盖支撑在外部瓶子的口部上方以将内部瓶子保持在外部瓶子的内部; 以及分配控制开关，其接收在所述外部盖之间的所述接头和所述杯状内盖之间，并且转向以使得所述外部瓶中的第一流体或所述内部瓶中的第二流体流入所述乳头以供所述婴儿吸引， 使第一和第二流体同时流入乳头。

公开(公告)号：US20240420819A1

公开(公告)日：2024-12-19

申请号：US18519196

申请日：2023-11-27

Applicant: Gyanna Gao ,  Yang Gao ,  Feihong Wang ,  Hao-Yu Liao ,  Peng Liu

Inventor： Gyanna Gao ,  Yang Gao ,  Feihong Wang ,  Hao-Yu Liao ,  Peng Liu

IPC: G16H20/30 ,  G06N20/10

Abstract: A machine-learning (ML) based motion analysis and training method and systems are provided. The method includes acquiring data of measurements of kinematics of a user performing a task with his/her hands or arms; analyzing the data of measurements based on a machine-learning (ML) model to evaluate patterns of hand/arm movements of the user; and providing feedback and/or advice based on results of the analysis for improvement of skills of the hand/arm motions of the user. The analyzing the data of measurements includes data preprocessing for preparing raw data for analysis, feature engineering for creating relevant features from the raw data for training the ML model, model training for training the ML model based on the preprocessed data, model evaluating for assessing performance of the trained model based on predetermined evaluation metrics, hyperparameter tuning for fine-tuning the hyperparameters of the ML model to improve its performance, model validating, and model testing.

公开(公告)号：US10223650B2

公开(公告)日：2019-03-05

申请号：US12277934

申请日：2008-11-25

Applicant: Xin Peng Liu ,  Xi Ning Wang ,  Liang Xue ,  Ke Xin Zhou ,  Yu Chen Zhou

Inventor： Xin Peng Liu ,  Xi Ning Wang ,  Liang Xue ,  Ke Xin Zhou ,  Yu Chen Zhou

IPC: G06F17/30 ,  G06Q10/06 ,  G06F9/448

Abstract: A method for enforcing a number of context model based policies with forward chaining comprising applying a policy set including a plurality of policies to an instantiated context model which includes a set of referenced instance documents in XML format, determining whether the instantiated context model should be updated, if the instantiated context model should be updated, executing an updating operation, re-generating a new instantiated context model according to the updated instance documents and the instantiated context model, and applying the policy set to the new instantiated context model, and wherein the policies include a condition part and an action part.

公开(公告)号：US09940427B2

公开(公告)日：2018-04-10

申请号：US13753401

申请日：2013-01-29

Applicant: Michael Matthew M. Crouse ,  Youri Johannes Laurentius Maria Van Dommelen ,  Peng Liu ,  Hua-Yu Liu ,  Aiqin Jiang ,  Wenjin Huang

Inventor： Michael Matthew M. Crouse ,  Youri Johannes Laurentius Maria Van Dommelen ,  Peng Liu ,  Hua-Yu Liu ,  Aiqin Jiang ,  Wenjin Huang

IPC: G06F17/50 ,  G03F7/20

CPC classification number: G06F17/5081 ,  G03F7/70125 ,  G03F7/70433 ,  G03F7/705 ,  G03F7/70891

Abstract: A computer-implemented method for improving a lithographic process for imaging a portion of a design layout onto a substrate using a lithographic projection apparatus comprising an illumination source and projection optics, the method including computing a multi-variable cost function of a plurality of design variables that are characteristics of the lithographic process, at least some of the design variables being characteristics of the illumination source and the design layout, the computing of the multi-variable cost function accounting for lens heating effects; and reconfiguring the characteristics of the lithographic process by adjusting the design variables until a predefined termination condition is satisfied.

公开(公告)号：US09381055B2

公开(公告)日：2016-07-05

申请号：US13942387

申请日：2013-07-15

Applicant: Thach Duong ,  Min Frank Zeng ,  Peng Liu ,  Chaohua Xin

Inventor： Thach Duong ,  Min Frank Zeng ,  Peng Liu ,  Chaohua Xin

IPC: A61B18/02 ,  A61B18/00

CPC classification number: A61B18/02 ,  A61B2017/00323 ,  A61B2018/00101 ,  A61B2018/0022 ,  A61B2018/00285 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0287

Abstract: A cryoablation system has a gas source which provides a working nitrogen gas at room temperature and at a constant set pressure, a liquid generator which is coupled to the gas source to receive the working gas, and which then generates a working cryogen fluid, and a catheter coupled to the liquid generator for receiving the working cryogen, the catheter having a distal section having a freezing element which delivers the working cryogen to a treatment location, the catheter also having a balloon positioned adjacent the distal section.