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公开(公告)号：US20140105961A1
公开(公告)日：2014-04-17
申请号：US14053091
申请日：2013-10-14
Applicant: Texas Tech University System
Inventor： Harvinder S. Gill , Shashwati Atwe , Yunzhe Ma
CPC classification number: A61K9/167 , A61K39/00 , A61K39/07 , A61K39/12 , A61K39/39 , A61K2039/542 , A61K2039/55588 , C12N2740/16034
Abstract: The present invention includes compositions, methods of making and using the compositions for modulating the immune response in a subject by providing a vaccine composition having a pollen/spore disposed in a pharmaceutical carrier for delivery to a subject, wherein the pollen/spore comprises multiple pores that connect an outer surface of the pollen/spore to an inner cavity and one or more antigens disposed on the outer surface, in the inner cavity, in the multiple pores, or a combination thereof, wherein the one or more antigens modulate an immune responses in the subject.
Abstract translation: 本发明包括组合物，制备和使用该组合物以调节受试者的免疫应答的方法，其方法是提供一种疫苗组合物，该疫苗组合物具有置于药物载体中的用于递送至受试者的花粉/孢子，其中所述花粉/孢子包含多个孔 其将花粉/孢子的外表面连接到内腔和设置在外表面，内腔中，多孔中或其组合中的一种或多种抗原，其中所述一种或多种抗原调节免疫应答 在主题。
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82.发明申请Methods and Devices for Hydraulic Fracturing Design and Optimization: A Modification to Zipper Frac 有权液压压裂设计与优化方法与装置：拉链压缩机的改进公开(公告)号：US20140048270A1
公开(公告)日：2014-02-20
申请号：US13970880
申请日：2013-08-20
Applicant: Texas Tech University System
Inventor： Mohamed Soliman , Mehdi Rafiee , Elias Pirayesh
IPC: E21B43/26
CPC classification number: E21B43/26
Abstract: The present invention provides a method of optimizing the placement of fractures along deviated wellbores by identifying at least two parallel lateral wellbores in a subterranean formation comprising at least a first wellbore and a second wellbore; introducing a first fracture and a second fracture in the first wellbore; introducing a third fracture in the second wellbore between the first fracture and the second fracture, wherein the third fracture extends to an intermediate area between the first two fractures and alters the stress field in that region; and forming one or more complex fractures extending from the first fracture, the second fracture, the third fracture or a combination thereof to form a complex fracture network.
Abstract translation: 本发明提供了一种通过在包括至少第一井孔和第二井眼的地下地层中识别至少两个平行的侧向井筒来优化沿着偏斜井眼的断裂位置的方法; 在第一井筒中引入第一断裂和第二断裂; 在所述第一裂缝和所述第二断裂之间在所述第二井眼中引入第三裂缝，其中所述第三裂缝延伸到所述前两个裂缝之间的中间区域并改变所述区域中的应力场; 并形成从第一断裂，第二断裂，第三断裂或其组合延伸的一个或多个复合断裂，以形成复合断裂网络。
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公开(公告)号：US12286452B2
公开(公告)日：2025-04-29
申请号：US17119301
申请日：2020-12-11
Applicant: Texas Tech University System , Utah University
Inventor： Guillermo A. Altenberg , Cheng-Wei Tom Chang
IPC: C07H15/234
Abstract: The present invention includes novel molecules and methods of using an amphiphilic kanamycin molecule having substitutions at the O-4″, O-6″, or O-4″ and O-6″ positions having reduced antimicrobial activity for targeting Connexin Hemichannels.
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公开(公告)号：US20250093491A1
公开(公告)日：2025-03-20
申请号：US18728142
申请日：2023-01-13
Applicant: Texas Tech University System
Inventor： Changzhi Li , Davi Valerio de Queiroz Rodrigues , Dongyang Tang
IPC: G01S13/62 , A61B5/0507
Abstract: A microwave passive sensor includes a microwave receiver, a low noise amplifier coupled to the microwave receiver, a mixer coupled to the low noise amplifier, and a baseband amplifier coupled to the mixer.
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公开(公告)号：US20250034018A1
公开(公告)日：2025-01-30
申请号：US18909776
申请日：2024-10-08
Applicant: Texas Tech University System
Inventor： Gerardine G. BOTTE , Eshan ABBASI , Christian E. ALVAREZ-PUGLIESE
IPC: C02F11/00 , C02F103/20 , C02F103/32 , C05F3/00 , C05F7/00 , C05F9/00
Abstract: Methods and systems for pre-treatment of sludge and biosolids in preparation for electrochemical valorization is disclosed herein. Such methods can include selecting a sludge source; preparing a slurry, where the slurry comprises the sludge source and an electrolyte; adjusting a pH of the slurry, where the adjusting the pH of the slurry results in the slurry having an adjusted pH in a range between approximately 8 and 13; flowing the slurry through a first electrochemical cell, where the first electrochemical cell enables partial oxidation of the sludge via hydroxyl radicals; and flowing the partially oxidized slurry from the first electrochemical cell to a second electrochemical cell for selective conversion, where the second electrochemical cell includes an anode, a cathode, and a catalyst.
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Patent Agency Ranking
公开(公告)号：US20250011390A1
公开(公告)日：2025-01-09
申请号：US18712507
申请日：2022-12-02
Applicant: Texas Tech University System
Inventor： Roger B. Sutton , Matthew Hirsch
Abstract: Provided herein is a fusion protein, expression vector, nucleic acid, or method of making and using a first HLA-G monomer and a second HLA-G monomer connected by a linker peptide expressed as a single chain, and optionally, comprising a providence virus globulin domain to prevent or reduce neovascularization.
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公开(公告)号：US20240407712A1
公开(公告)日：2024-12-12
申请号：US18741371
申请日：2024-06-12
Applicant: Texas Tech University System
Inventor： James Yang , Ritwik Rakshit
Abstract: Embodiments pertain to a computer-implemented method of predicting muscle fatigue in a subject by: (1) receiving data related to muscle fatigue in a muscle of the subject; (2) feeding the data into an algorithm to predict the muscle fatigue; and (3) outputting the predicted muscle fatigue. The algorithm my include: (a) an active compartment (M_A) model representing individual motor units (MUs) generating force at full capacity, (b) a resting compartment (M_R) model representing inactive MUs capable of rapid activation into force production, (c) a centrally fatigued compartment (M_FC) model representing fatigued MUs due to a central mechanism dominant at zero or near-zero joint velocities, with rapid recovery, and (d) a peripherally fatigued compartment (M_FP) model representing fatigued MUs due to a peripheral mechanism dominant at higher velocities, with slow recovery. Further embodiments pertain to a computing device for predicting muscle fatigue in a subject in accordance with such methods.
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公开(公告)号：US12134962B2
公开(公告)日：2024-11-05
申请号：US18317621
申请日：2023-05-15
Applicant: Texas Tech University System
Inventor： James J. Sheng
Abstract: Methods for optimization of liquid oil production by huff-n-puff in shale reservoirs to achieve an improved (and optimal) oil recovery factor. The process determines and utilizes the optimum huff and puff times, number of cycles and soaking time under practical operation and reservoir conditions. The huff time in the process is a period so long that the pressure near the wellbore reaches the set maximum injection pressure during the huff period. The puff time in the process is the time required for the pressure near the wellbore to reach the set minimum production pressure during the puff period. Soaking is typically not necessary during the huff-n-puff gas injection in shale oil reservoirs. The number of huff-n-puff cycles is determinable by the time in which the economic rate cut-off is reached.
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公开(公告)号：US20240337657A1
公开(公告)日：2024-10-10
申请号：US18744403
申请日：2024-06-14
Applicant: Texas Tech University System
Inventor： Dimitri Pappas
IPC: G01N33/569 , B01L3/00 , C12Q1/00 , G01N33/00 , G01N33/543
CPC classification number: G01N33/56972 , B01L3/50273 , G01N33/54366 , G01N33/569 , C12Q1/00 , G01N33/00
Abstract: Disclosed is a system and method for a microdevice to separate blood cells based on differences in antigen expression. Specifically, cells of the same phenotype are separated based on whether or not they are activated during infection or resting. The device of the present disclosure takes a small sample of blood and provides differential cell counts that can be used to test for infection and inflammatory response. The device can be used to identify sepsis and other infections rapidly. By measuring differences in activated white cell counts such as neutrophils, the device of the present disclosure measures physiological response to infection in hospitalized patients recovering from burns, surgeries, etc.
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公开(公告)号：US20240310465A1
公开(公告)日：2024-09-19
申请号：US18608144
申请日：2024-03-18
Applicant: Texas Tech University System
Inventor： David P. Cistola
IPC: G01N33/72
CPC classification number: G01R33/50 , G01N33/4925 , G01N33/726 , G01R33/465
Abstract: Embodiments of the present disclosure pertain to methods of detecting hypoxemia in a subject by: (1) receiving a blood sample from the subject; (2) measuring the T2 relaxation time constant of the blood cell (e.g., blood cell pellet) of the blood sample (T2P value); and (3) correlating the measured T2P value to hypoxemia. In some embodiments, the methods of the present disclosure also include a step of correlating the measured T2P value to the subject's susceptibility to one or more hypoxemia-related conditions. Further embodiments of the present disclosure pertain to systems for detecting hypoxemia in a subject in accordance with the methods of the present disclosure.
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