公开(公告)号：US20130184257A1

公开(公告)日：2013-07-18

申请号：US13823041

申请日：2011-09-15

Applicant: Thomas Daniel Aicher ,  Josef R. Bencsik ,  Steven Armen Boyd ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John P. Fischer ,  Ronald Jay Hinklin ,  Scott Alan Pratt

Inventor： Thomas Daniel Aicher ,  Josef R. Bencsik ,  Steven Armen Boyd ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John P. Fischer ,  Ronald Jay Hinklin ,  Scott Alan Pratt

IPC: C07D413/14 ,  C07D401/04 ,  C07D401/14 ,  C07D211/76

CPC classification number: C07D413/14 ,  A61K31/4468 ,  A61K31/454 ,  C07D211/76 ,  C07D401/04 ,  C07D401/14

Abstract: Compounds of Formula (I) and pharmaceutically acceptable salts thereof in which X1, X2, L, R3, R4, R5, R7 and n have the meanings given in the specification, are modulators of GPR119 and are useful in the treatment or prevention of diseases such as such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.

Abstract translation: 其中X1，X2，L，R3，R4，R5，R7和n具有本说明书中给出的含义的式（I）化合物及其药学上可接受的盐是GPR119的调节剂，可用于治疗或预防疾病 例如但不限于2型糖尿病，糖尿病并发症，糖尿病症状，代谢综合征，肥胖症，血脂异常和相关病症。

公开(公告)号：US08481159B2

公开(公告)日：2013-07-09

申请号：US12868453

申请日：2010-08-25

Applicant: Rainer Dobrawa ,  Thomas Daniel ,  Uwe Stueven ,  Marco Krüger ,  Francisco Javier Lopez Villanueva ,  Norbert Herfert ,  Karin Flore ,  Stefan Blei ,  Michael A. Mitchell

Inventor： Rainer Dobrawa ,  Thomas Daniel ,  Uwe Stueven ,  Marco Krüger ,  Francisco Javier Lopez Villanueva ,  Norbert Herfert ,  Karin Flore ,  Stefan Blei ,  Michael A. Mitchell

IPC: B32B5/18 ,  B29C67/20 ,  B29C67/24

CPC classification number: B01J20/26 ,  A61L15/60 ,  B01J20/264 ,  B01J20/3085 ,  C08F2/10 ,  C08F220/06 ,  C08F222/1006 ,  Y10T428/249958 ,  Y10T428/249981 ,  Y10T428/254 ,  Y10T428/2982 ,  Y10T428/31935

Abstract: The present invention relates to a process for producing water-absorbent polymer particles by polymerizing droplets of a monomer solution in a surrounding heated gas phase and flowing the gas cocurrent through the polymerization chamber, wherein the temperature of the gas leaving the polymerization chamber is 130° C. or less, the gas velocity inside the polymerization chamber is at least 0.5 m/s, and the droplets are generated by using a droplet plate having a multitude of bores.

Abstract translation: 本发明涉及一种通过在周围加热气相中聚合单体溶液的液滴并使气体并流通过聚合室流过气体聚合物颗粒的方法，其中离开聚合室的气体的温度为130℃ 聚合室内的气体速度为至少0.5m / s，通过使用具有多个孔的液滴板产生液滴。

公开(公告)号：US08450428B2

公开(公告)日：2013-05-28

申请号：US13070173

申请日：2011-03-23

Applicant: Thomas Daniel ,  Marco Krüger ,  Karin Flore ,  Stefan Blei ,  Uwe Stueven ,  Norbert Herfert ,  Michael A. Mitchell

Inventor： Thomas Daniel ,  Marco Krüger ,  Karin Flore ,  Stefan Blei ,  Uwe Stueven ,  Norbert Herfert ,  Michael A. Mitchell

IPC: C08F8/00 ,  C08F2/10 ,  C08F20/06

CPC classification number: C08F2/10 ,  A61L15/60 ,  B01J8/0045 ,  B01J8/006 ,  B01J8/1827 ,  B01J2208/00274 ,  B01J2219/00006 ,  C08F2/34 ,  C08F220/06 ,  C08F222/1006

Abstract: The present invention relates to a process for producing water-absorbent polymer particles by polymerizing droplets of a monomer solution in a surrounding heated gas phase and flowing the gas cocurrent through the polymerization chamber, which comprises thermal postcrosslinking in the presence of steam.

Abstract translation: 本发明涉及通过在周围加热的气相中聚合单体溶液的液滴并使气体并流通过聚合室（其包括在蒸汽存在下进行热后交联）而生产吸水性聚合物颗粒的方法。

公开(公告)号：US20120308507A1

公开(公告)日：2012-12-06

申请号：US13482450

申请日：2012-05-29

Applicant: Asif Karim ,  Thomas Daniel

Inventor： Asif Karim ,  Thomas Daniel

IPC: A61L11/00

CPC classification number: A61L9/014

Abstract: Odor-inhibiting mixtures comprising water-absorbing polymer particles and spherical activated carbon for use in incontinence articles.

Abstract translation: 包含吸水聚合物颗粒和用于失禁制品的球形活性炭的气味抑制混合物。

公开(公告)号：US08299056B2

公开(公告)日：2012-10-30

申请号：US12555018

申请日：2009-09-08

Applicant: Sogole Bahmanyar ,  R.J. Bates ,  Kate Blease ,  Andrew Calabrese ,  Thomas Daniel ,  Mercedes Delgado ,  Jan Elsner ,  Paul Erdman ,  Bruce Fahr ,  Gregory Ferguson ,  Branden Lee ,  Lisa Nadolny ,  Garrick Packard ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  Jennifer Riggs ,  Patricia Rohane ,  Sabita Sankar ,  John Sapienza ,  Yoshitaka Satoh ,  Victor Sloan ,  Randall Stevens ,  Lida Tehrani ,  Jayashree Tikhe ,  Eduardo Torres ,  Andrew Wallace ,  Brandon Wade Whitefield ,  Jingjing Zhao

Inventor： Sogole Bahmanyar ,  R.J. Bates ,  Kate Blease ,  Andrew Calabrese ,  Thomas Daniel ,  Mercedes Delgado ,  Jan Elsner ,  Paul Erdman ,  Bruce Fahr ,  Gregory Ferguson ,  Branden Lee ,  Lisa Nadolny ,  Garrick Packard ,  Patrick Papa ,  Veronique Plantevin-Krenitsky ,  Jennifer Riggs ,  Patricia Rohane ,  Sabita Sankar ,  John Sapienza ,  Yoshitaka Satoh ,  Victor Sloan ,  Randall Stevens ,  Lida Tehrani ,  Jayashree Tikhe ,  Eduardo Torres ,  Andrew Wallace ,  Brandon Wade Whitefield ,  Jingjing Zhao

IPC: A61K31/437 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/55 ,  C07D471/02

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: Provided herein are Heteroaryl Compounds of formula (I): wherein R1 and R2 are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing inflammatory conditions or cancer, and conditions treatable or preventable by inhibition of a kinase or a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a subject in need thereof.

Abstract translation: 本文提供了式（I）的杂芳基化合物：其中R 1和R 2如本文所定义，包含有效量的杂芳基化合物的组合物和用于治疗或预防炎性病症或癌症的方法，以及可通过抑制激酶治疗或预防的病症 或激酶途径，其包括向有需要的受试者施用有效量的杂芳基化合物。

公开(公告)号：US08263620B2

公开(公告)日：2012-09-11

申请号：US12747188

申请日：2008-12-19

Applicant: Jag Paul Heer ,  Thomas Daniel Heightman

Inventor： Jag Paul Heer ,  Thomas Daniel Heightman

IPC: C07D413/04 ,  A61K31/4725

CPC classification number: C07D217/22 ,  C07D217/06 ,  C07D217/16 ,  C07D413/04 ,  C07D413/14

Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

Abstract translation: 本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。

公开(公告)号：US20120209848A1

公开(公告)日：2012-08-16

申请号：US13452783

申请日：2012-04-20

Applicant: Kelly M. Christensen ,  John Phillip Hansen ,  Thomas Daniel Mock

Inventor： Kelly M. Christensen ,  John Phillip Hansen ,  Thomas Daniel Mock

IPC: G06F17/30

CPC classification number: G06Q30/0261 ,  G06Q30/02 ,  G06Q30/0251 ,  G06Q30/0267 ,  G06Q30/0272 ,  G06Q30/0276 ,  G11C7/1066 ,  G11C7/1078 ,  G11C7/1096 ,  G11C7/22 ,  G11C7/222 ,  G11C11/4076 ,  G11C11/4096 ,  G11C2207/2254 ,  H04L67/00

Abstract: The disclosure herein provides systems and methods for a media enhancement system configured to associate a secondary media signal (for example, the secondary media signal can comprise an advertisement) to a primary media signal (for example, a radio broadcast). The disclosure herein additionally provides systems and methods for a media enhancement system that enables the generating, transmitting, displaying, and/or responding to a plurality of associated and/or unassociated secondary media signals, based on a primary media content from a primary media signal, user characteristics (for example, demographic and/or geographic information), and/or third-party preferences (for example, the goals of advertisers). The secondary media signals can be used to enhance the primary media content already being provided to the user on a user device. The secondary media signals can also be used to create psychological associations or relationships with the primary media content already being provided to the user.

Abstract translation: 本文的公开内容提供用于媒体增强系统的系统和方法，该系统和方法被配置为将辅媒体信号（例如，辅媒体信号可以包括广告）与主媒体信号（例如，无线电广播）相关联。 本文的公开内容还提供了用于媒体增强系统的系统和方法，其能够基于来自主要媒体信号的主要媒体内容来生成，发送，显示和/或响应多个相关联和/或未关联的次要媒体信号 ，用户特征（例如，人口统计学和/或地理信息）和/或第三方偏好（例如，广告主的目标）。 辅助媒体信号可用于增强已经在用户设备上向用户提供的主要媒体内容。 辅助媒体信号也可用于与已经提供给用户的主要媒体内容产生心理关联或关系。

公开(公告)号：US08212045B2

公开(公告)日：2012-07-03

申请号：US12678995

申请日：2008-09-15

Applicant: Thomas Daniel Aicher ,  Steven Armen Boyd ,  Mark Joseph Chicarelli ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John P. Fischer ,  Indrani W. Gunawardana ,  Ronald Jay Hinklin ,  Ajay Singh ,  Timothy M. Turner ,  Eli M. Wallace

Inventor： Thomas Daniel Aicher ,  Steven Armen Boyd ,  Mark Joseph Chicarelli ,  Kevin Ronald Condroski ,  Jay Bradford Fell ,  John P. Fischer ,  Indrani W. Gunawardana ,  Ronald Jay Hinklin ,  Ajay Singh ,  Timothy M. Turner ,  Eli M. Wallace

IPC: A61K31/44 ,  C07D417/00

CPC classification number: C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14

Abstract: Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.

Abstract translation: 提供式（I）的化合物：其中R2，R3，R13，L和D2如说明书中所定义，其可用于治疗和/或预防由缺乏葡萄糖激酶水平的活性介导的疾病或病症，或可以 通过激活葡糖激酶，包括但不限于糖尿病，葡萄糖耐量降低，IFG（空腹血糖受损）和IFG（空腹血糖受损））以及其它疾病和病症如本文讨论的疾病和病症。

公开(公告)号：US20120101459A1

公开(公告)日：2012-04-26

申请号：US13277314

申请日：2011-10-20

Applicant: Axel Meyer ,  Michaela Monika Czupik ,  Robin Lynn McKiernan ,  Thomas Daniel ,  Yvonne Hagen ,  Ulrich Riegel ,  Dieter Hermeling ,  Stefan Bruhns

Inventor： Axel Meyer ,  Michaela Monika Czupik ,  Robin Lynn McKiernan ,  Thomas Daniel ,  Yvonne Hagen ,  Ulrich Riegel ,  Dieter Hermeling ,  Stefan Bruhns

IPC: A61L15/22 ,  C08L33/02 ,  C08F220/06

CPC classification number: C08J3/12 ,  A61L15/22 ,  A61L15/60 ,  A61L2400/18 ,  C08J3/122 ,  C08J3/243 ,  C08J2333/02 ,  Y10T428/2991 ,  Y10T428/2998

Abstract: Absorbent structures comprising vacuum-treated (optionally coated) post-crosslinked water-absorbing polymeric particles, obtainable by vacuum-treating and optionally plasma-treating post-crosslinked water-absorbent polymeric particles (that may optionally be coated), the resulting vacuum-treated post-crosslinked water-absorbing polymeric particles having an improved absorption, whilst having good gel bed permeability.

Abstract translation: 吸收结构包括经真空处理（任选涂覆）后交联的吸水聚合物颗粒，可通过真空处理和任选地等离子处理后交联吸水性聚合物颗粒（可任选地被涂布）获得，所得真空处理 后交联的吸水聚合物颗粒具有改善的吸收，同时具有良好的凝胶层渗透性。

公开(公告)号：US20120091392A1

公开(公告)日：2012-04-19

申请号：US13378442

申请日：2010-06-24

Applicant: Thomas Daniel ,  Christophe Bauduin ,  Norbert Herfert

Inventor： Thomas Daniel ,  Christophe Bauduin ,  Norbert Herfert

IPC: B01J20/26 ,  B05D5/04

CPC classification number: B01J20/321 ,  C08F220/06 ,  C08F222/1006 ,  C08J3/24

Abstract: A process for producing water-absorbing polymer particles with low caking tendency and high absorption under pressure, comprising polymerization of a monomer solution or suspension, drying of the resulting polymer gel, grinding, classifying, thermal surface postcrosslinking and coating with silicon dioxide, wherein the water-absorbing polymer particles have been coated, before, during or after the surface postcrosslinking with aluminum cations.

Abstract translation: 一种生产具有低结块倾向和高压吸收的吸水聚合物颗粒的方法，包括单体溶液或悬浮液的聚合，所得聚合物凝胶的干燥，研磨，分级，热表面后交联和用二氧化硅涂覆，其中 吸水聚合物颗粒在与铝阳离子的后交联之前，期间或之后已被涂覆。