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    Method of improving fracture toughness of implantable medical devices through annealing
    81.
    发明授权
    Method of improving fracture toughness of implantable medical devices through annealing 有权
    通过退火提高可植入医疗器械的断裂韧性的方法

    公开(公告)号：US08961862B2

    公开(公告)日：2015-02-24

    申请号：US13794537

    申请日：2013-03-11

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Yunbing Wang ,  James Oberhauser

    IPC: B29C49/00 ,  B29C49/64 ,  B29C51/00 ,  A61L31/06 ,  A61L31/14

    CPC classification number: B29C51/002 ,  A61L31/06 ,  A61L31/14 ,  Y10T29/49 ,  C08L67/04

    Abstract: Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing are disclosed herein. A polymeric construct is annealed with no or substantially no crystal growth to increase nucleation density. After the annealing, crystallites are grown around the formed nuclei. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the crystallite growth.

    Abstract translation: 本文公开了通过退火制造具有改善的断裂韧性的聚合物可植入装置的方法。 将聚合物构件退火，没有或基本上没有晶体生长以增加成核密度。 退火后，在形成的核周围生长微晶。 在微晶生长之后，可由聚合物构造体制造诸如支架的可植入医疗装置。

    SYSTEM FOR MANUFACTURING A POLYMER ENDOPROSTHESIS BY INJECTION MOLDING AND BLOW MOLDING
    84.
    发明申请
    SYSTEM FOR MANUFACTURING A POLYMER ENDOPROSTHESIS BY INJECTION MOLDING AND BLOW MOLDING 审中-公开
    通过注塑成型和吹塑制造聚合物内部结构的系统

    公开(公告)号：US20140239558A1

    公开(公告)日：2014-08-28

    申请号：US14268396

    申请日：2014-05-02

    Applicant: ABBOTT CARDIOVASCULAR SYSTEMS INC.

    Inventor： Yunbing Wang ,  James Oberhauser

    IPC: B29C49/06

    CPC classification number: B29C49/06 ,  A61F2/91 ,  B29K2067/043 ,  B29K2067/046 ,  B29L2031/7532

    Abstract: A polymer endoprosthesis is fabricated by a combination of injection molding and blow molding which form a tubular substrate of polymer material, followed by laser cutting, crimping and sterilization. After the injection and blow molding processes, a subtractive process is performed on the tubular substrate to transform it into a stent having a network of stent struts. The tubular substrate can be made in an injection mold and blow mold which are attached to each other. The transition from injection molding and blow molding can be performed while the injection molded substrate remains at a temperature at or above Tg of the polymer material.

    Abstract translation: 通过注射成型和吹塑成型的组合制造聚合物内用假体，其形成聚合物材料的管状基材，随后进行激光切割，卷曲和灭菌。 在注射和吹塑成型工艺之后，对管状基材进行减色处理以将其转变成具有支架支架网络的支架。 管状基板可以制造成彼此附接的注射模具和吹塑模具。 注射成型和吹塑成型的过渡可以在注塑基材保持在聚合物材料的Tg以上的温度下进行。

    Method to minimize chain scission and monomer generation in processing of poly(L-lactide) stent
    86.
    发明授权
    Method to minimize chain scission and monomer generation in processing of poly(L-lactide) stent 有权
    在聚（L-丙交酯）支架加工过程中减少链断裂和单体产生的方法

    公开(公告)号：US08703038B2

    公开(公告)日：2014-04-22

    申请号：US13946964

    申请日：2013-07-19

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Yunbing Wang ,  James Oberhauser

    IPC: A61F2/82

    CPC classification number: A61F2/82 ,  A61F2/958 ,  A61F2002/9583 ,  A61L31/06 ,  A61L31/148 ,  H01J2237/31 ,  C08L67/04

    Abstract: Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD.

    Abstract translation: 公开了制造可植入医疗装置的方法，例如由可生物降解的聚合物制成的支架，其可减少或最小化加工步骤期间的链断裂和单体产生。 该方法包括在熔融状态的挤出机中加工数均分子量为150〜200kD的聚（L-丙交酯）树脂。 由处理后的树脂形成聚（L-丙交酯）管，并由管制造支架。 灭菌后支架的聚（L-丙交酯）数均分子量为70〜100kD。

    BIOABSORBABLE SCAFFOLDS MADE FROM COMPOSITES
    88.
    发明申请
    BIOABSORBABLE SCAFFOLDS MADE FROM COMPOSITES 审中-公开
    从复合材料制成的生物可溶性淀粉

    公开(公告)号：US20140039603A1

    公开(公告)日：2014-02-06

    申请号：US14042543

    申请日：2013-09-30

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Yunbing Wang

    IPC: A61F2/82

    CPC classification number: A61F2/82 ,  A61F2/915 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0076 ,  A61F2230/0054 ,  A61L31/127 ,  A61L31/128 ,  A61L31/148 ,  C08K3/013 ,  C08L67/04

    Abstract: Bioabsorbable scaffolds made at least in part of a poly(L-lactide)-based composite are disclosed. The composite includes poly(4-hydroxybutyrate) or poly(L-lactide)-b-polycaprolactone block copolymer, which increases the fracture toughness or fracture resistance of the scaffold. The composite can further include bioceramic particles, L-lactide monomer, or both dispersed throughout the composite. The bioceramic particles improve the radial strength and stiffness of the scaffold. The L-lactide monomer is used to control the absorption rate of the scaffold.

    Abstract translation: 公开了至少部分由（L-丙交酯）基复合材料制成的生物可吸收支架。 复合材料包括聚（4-羟基丁酸酯）或聚（L-丙交酯）-b-聚己内酯嵌段共聚物，其增加了支架的断裂韧性或抗断裂性。 复合材料还可以包括分散在整个复合材料中的生物陶瓷颗粒，L-丙交酯单体或两者。 生物陶瓷颗粒改善了支架的径向强度和刚度。 L-丙交酯单体用于控制支架的吸收速率。

    FABRICATING AN IMPLANTABLE MEDICAL DEVICE FROM AN AMORPHOUS OR VERY LOW CRYSTALLINITY POLYMER CONSTRUCT
    90.
    发明申请
    FABRICATING AN IMPLANTABLE MEDICAL DEVICE FROM AN AMORPHOUS OR VERY LOW CRYSTALLINITY POLYMER CONSTRUCT 有权
    从非晶体或非常低的结晶聚合物构造制造可植入医疗器械

    公开(公告)号：US20130134623A1

    公开(公告)日：2013-05-30

    申请号：US13745668

    申请日：2013-01-18

    Applicant: Abbott Cardiovascular Systems Inc.

    Inventor： Yunbing Wang ,  Lothar W. Kleiner

    IPC: B29C71/00

    CPC classification number: B29D23/00 ,  A61L31/06 ,  A61L31/14 ,  B29C71/0063 ,  C08L67/04

    Abstract: Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing, nucleating agents, or both are disclosed herein. A polymeric construct that is completely amorphous or that has a very low crystallinity is annealed with no or substantially no crystal growth to increase nucleation density. Alternatively, the polymer construct includes nucleating agent. The crystallinity of the polymer construct is increased with a high nucleation density through an increase in temperature, deformation, or both. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the increase in crystallinity.

    Abstract translation: 本文公开了通过退火，成核剂或两者制造具有改善的断裂韧性的聚合物可植入装置的方法。 完全无定形或具有非常低的结晶度的聚合物构件被退火，没有或基本上没有晶体生长以增加成核密度。 或者，聚合物构造物包括成核剂。 通过增加温度，变形或两者，聚合物构造物的结晶度随着成核密度的增加而增加。 在结晶度增加之后，可以由聚合物构造体制造可植入的医疗装置，例如支架。

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