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    INTRAVASCULAR ABLATION CATHETER WITH PRECISION DEPTH OF PENETRATION CALIBRATION
    81.
    发明申请
    INTRAVASCULAR ABLATION CATHETER WITH PRECISION DEPTH OF PENETRATION CALIBRATION 审中-公开
    具有精密深度穿透校准的血管内导管

    公开(公告)号：US20130274674A1

    公开(公告)日：2013-10-17

    申请号：US13835556

    申请日：2013-03-15

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M5/162

    CPC classification number: A61M5/162 ,  A61B5/6848 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/044 ,  A61B2090/378 ,  A61B2090/3966 ,  A61M25/0084 ,  A61M25/0097 ,  A61M2025/0086

    Abstract: A catheter-based/intravascular ablation system includes needles which expand around a central axis to engage a blood vessel or left atrium wall, allowing the injection of an ablative solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein or around the renal artery. The system includes means to adjust the depth of penetration into the tissue of the targeted blood vessel wall. The catheter can include expandable guide tubes that engage the blood vessel wall. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the blood vessel wall to a prescribed depth. The ability to provide PeriVascular injection only affecting the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in or outside the adventitia of the renal artery.

    Abstract translation: 基于导管的/血管内消融系统包括围绕中心轴线扩张以接合血管或左心房壁的针，允许注射消融溶液以消融导管或围绕肺静脉口或周围的神经纤维 肾动脉。 该系统包括调节穿透到目标血管壁的组织中的深度的装置。 导管可以包括与血管壁接合的可扩张的导管。 然后在其尖锐的远端处或其附近注射出口的注射针穿过引导管穿过血管壁达规定的深度。 提供血管周围注射仅影响血管外层而不影响培养基的能力特别适用于位于肾动脉外膜或其外侧的交感神经的血管外肾去神经（PVRD）。

    INTRAVASCULAR ABLATION CATHETER WITH ENHANCED FLUOROSCOPIC VISIBILITY
    82.
    发明申请
    INTRAVASCULAR ABLATION CATHETER WITH ENHANCED FLUOROSCOPIC VISIBILITY 审中-公开
    具有增强的荧光可见性的血管内引流管

    公开(公告)号：US20130274673A1

    公开(公告)日：2013-10-17

    申请号：US13835221

    申请日：2013-03-15

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M5/162

    CPC classification number: A61M5/162 ,  A61B5/6848 ,  A61M25/0084 ,  A61M25/0097 ,  A61M25/0662 ,  A61M25/104 ,  A61M2025/0086 ,  A61M2025/0681 ,  A61M2025/1052

    Abstract: A catheter-based/intravascular ablation system includes needles which expand around a central axis to engage a blood vessel or left atrium wall, allowing the injection of an ablative solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein or around the renal artery. The system includes means to adjust the depth of penetration into the tissue of the targeted blood vessel wall. The catheter can include expandable guide tubes that engage the blood vessel wall. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the blood vessel wall to a prescribed depth. The ability to provide PeriVascular injection only affecting the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in or outside the adventitia of the renal artery.

    Abstract translation: 基于导管的/血管内消融系统包括围绕中心轴线扩张以接合血管或左心房壁的针，允许注射消融溶液以消融导管或围绕肺静脉口或周围的神经纤维 肾动脉。 该系统包括调节穿透到目标血管壁的组织中的深度的装置。 导管可以包括与血管壁接合的可扩张的导管。 然后在其尖锐的远端处或其附近注射出口的注射针穿过引导管穿过血管壁达规定的深度。 提供血管周围注射仅影响血管外层而不影响培养基的能力特别适用于位于肾动脉外膜或其外侧的交感神经的血管外肾去神经（PVRD）。

    INTRAVASCULAR CATHETER WITH PERI-VASCULAR NERVE ACTIVITY SENSORS
    88.
    发明公开
    INTRAVASCULAR CATHETER WITH PERI-VASCULAR NERVE ACTIVITY SENSORS 审中-公开

    公开(公告)号：US20230404457A1

    公开(公告)日：2023-12-21

    申请号：US18358444

    申请日：2023-07-25

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany

    IPC: A61B5/24 ,  A61B5/00

    CPC classification number: A61B5/24 ,  A61B5/6848 ,  A61B5/6852 ,  A61B5/4035 ,  A61M2025/0095

    Abstract: An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

    RADIAL COMPATIBLE CATHETER FOR PERI-VASCULAR FLUID INJECTION
    89.
    发明公开
    RADIAL COMPATIBLE CATHETER FOR PERI-VASCULAR FLUID INJECTION 审中-公开

    公开(公告)号：US20230355292A1

    公开(公告)日：2023-11-09

    申请号：US17662343

    申请日：2022-05-06

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Darrin James Kent

    IPC: A61B18/06 ,  A61M25/00 ,  A61M25/01

    CPC classification number: A61B18/06 ,  A61M25/0084 ,  A61M25/0108 ,  A61B2018/00434

    Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. Applications include renal denervation for the treatment of hypertension, atrial fibrillation, congestive heart failure, tissue ablation for COPD, BPH and prostate cancer and prevention of restenosis after balloon angioplasty or stent implantation and other disorders.

    Catheter systems and packaged kits for dual layer guide tubes
    90.
    发明授权
    Catheter systems and packaged kits for dual layer guide tubes 有权

    公开(公告)号：US11752303B2

    公开(公告)日：2023-09-12

    申请号：US16689604

    申请日：2019-11-20

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M25/00 ,  A61M25/06 ,  A61M25/01 ,  A61B5/00

    CPC classification number: A61M25/0084 ,  A61M25/0074 ,  A61M25/0108 ,  A61M25/0662 ,  A61B5/6848 ,  A61M25/0097 ,  A61M2025/0039 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/0681 ,  A61M2202/0468 ,  A61M2210/12

    Abstract: A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. The preferred embodiment of the catheter delivered through the vascular system of a patient includes a multiplicity of expandable guide tubes that engage the wall of a blood vessel. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the wall of the blood vessel to a prescribed depth. The ability to provide PeriVascular injection so as to only affect the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in the adventitia or outside the adventitia of the renal artery.

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