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    INTRAVASCULAR CATHETER WITH PERI-VASCULAR NERVE ACTIVITY SENSORS
    83.
    发明公开
    INTRAVASCULAR CATHETER WITH PERI-VASCULAR NERVE ACTIVITY SENSORS 审中-公开

    公开(公告)号：US20230404457A1

    公开(公告)日：2023-12-21

    申请号：US18358444

    申请日：2023-07-25

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany

    IPC: A61B5/24 ,  A61B5/00

    CPC classification number: A61B5/24 ,  A61B5/6848 ,  A61B5/6852 ,  A61B5/4035 ,  A61M2025/0095

    Abstract: An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

    Catheter systems and packaged kits for dual layer guide tubes
    84.
    发明授权
    Catheter systems and packaged kits for dual layer guide tubes 有权

    公开(公告)号：US11752303B2

    公开(公告)日：2023-09-12

    申请号：US16689604

    申请日：2019-11-20

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M25/00 ,  A61M25/06 ,  A61M25/01 ,  A61B5/00

    CPC classification number: A61M25/0084 ,  A61M25/0074 ,  A61M25/0108 ,  A61M25/0662 ,  A61B5/6848 ,  A61M25/0097 ,  A61M2025/0039 ,  A61M2025/0086 ,  A61M2025/0087 ,  A61M2025/0681 ,  A61M2202/0468 ,  A61M2210/12

    Abstract: A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. The preferred embodiment of the catheter delivered through the vascular system of a patient includes a multiplicity of expandable guide tubes that engage the wall of a blood vessel. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the wall of the blood vessel to a prescribed depth. The ability to provide PeriVascular injection so as to only affect the outer layer(s) of a blood vessel without affecting the media has particular application for PeriVascular Renal Denervation (PVRD) of the sympathetic nerves which lie in the adventitia or outside the adventitia of the renal artery.

    Methods of ablating tissue using a catheter injection system
    85.
    发明授权
    Methods of ablating tissue using a catheter injection system 有权

    公开(公告)号：US11717345B2

    公开(公告)日：2023-08-08

    申请号：US17232560

    申请日：2021-04-16

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61B18/00 ,  A61B18/14 ,  A61M5/00

    CPC classification number: A61B18/1492 ,  A61M5/00 ,  A61B2018/0022 ,  A61B2018/00214 ,  A61B2018/00375 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/143

    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium. The present invention also has application to ablating tissue around the ostium of a renal artery for the treatment of hypertension.

    EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION
    86.
    发明申请
    EXPANDABLE CATHETER SYSTEM FOR PERI-OSTIAL INJECTION AND MUSCLE AND NERVE FIBER ABLATION 有权

    公开(公告)号：US20210290903A1

    公开(公告)日：2021-09-23

    申请号：US17232662

    申请日：2021-04-16

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M25/00 ,  A61B5/283 ,  A61B18/14 ,  A61B90/00

    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostiurn of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.

    EXPANDABLE CATHETER SYSTEM FOR FLUID INJECTION INTO AND DEEP TO THE WALL OF A BLOOD VESSEL
    87.
    发明申请
    EXPANDABLE CATHETER SYSTEM FOR FLUID INJECTION INTO AND DEEP TO THE WALL OF A BLOOD VESSEL 有权

    公开(公告)号：US20210290860A1

    公开(公告)日：2021-09-23

    申请号：US17232695

    申请日：2021-04-16

    Applicant: ABLATIVE SOLUTIONS, INC.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M5/46 ,  A61M25/00 ,  A61M25/06

    Abstract: A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

    Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation
    88.
    发明授权
    Expandable catheter system for peri-ostial injection and muscle and nerve fiber ablation 有权

    公开(公告)号：US11007346B2

    公开(公告)日：2021-05-18

    申请号：US16238780

    申请日：2019-01-03

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M25/00 ,  A61B5/283 ,  A61B18/14 ,  A61B90/00 ,  A61B18/00 ,  A61B17/22 ,  A61B18/06

    Abstract: At the present time, physicians often treat patients with atrial fibrillation (AF) using radiofrequency (RF) catheter systems to ablate conducting tissue in the wall of the Left Atrium of the heart around the ostium of the pulmonary veins. These systems are expensive and take time consuming to use. The present invention circular ablation system CAS includes a multiplicity of expandable needles that can be expanded around a central axis and positioned to inject a fluid like ethanol to ablate conductive tissue in a ring around the ostium of a pulmonary vein quickly and without the need for expensive capital equipment. The expansion of the needles is accomplished by self-expanding or balloon expandable structures. The invention includes centering means so that the needles will be situated in a pattern surrounding the outside of the ostium of a vein. Also included are members that limit the distance of penetration of the needles into the wall of the left atrium, or the aortic wall. The present invention also has an important application to ablate tissue around the ostium of one or both renal arteries, for the ablation of the sympathetic nerve fibers and/or other afferent or efferent nerves going to or from each kidney in order to treat hypertension.

    INTRAVASCULAR FLUID CATHETER WITH MINIMAL INTERNAL FLUID VOLUME
    89.
    发明申请
    INTRAVASCULAR FLUID CATHETER WITH MINIMAL INTERNAL FLUID VOLUME 审中-公开

    公开(公告)号：US20200269015A1

    公开(公告)日：2020-08-27

    申请号：US16805033

    申请日：2020-02-28

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell

    IPC: A61M25/00 ,  A61M25/06 ,  A61M25/01

    Abstract: A catheter-based/intravascular ablation (denervation) system includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic or/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable needle delivery system is formed with self-expanding materials and include structures, near the end portion of the needles, or using separate guide tubes. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel. The preferred embodiment of the catheter delivered through the vascular system of a patient includes a multiplicity of expandable guide tubes that engage the wall of a blood vessel. Injection needles having injection egress at or near their sharpened distal end are then advanced through the guide tubes to penetrate the wall of the blood vessel to a prescribed depth. The ability to provide Peri.Vascular injection so as to only affect the outer layer(s) of a blood. vessel without affecting the media has particular application for Peri.Vascular Renal Denervation (PVRD) of the sympathetic nerves which lie. in the adventitia or outside the adventitia of the renal artery.

    Intravascular catheter with peri-vascular nerve activity sensors
    90.
    发明授权
    Intravascular catheter with peri-vascular nerve activity sensors 有权

    公开(公告)号：US10736524B2

    公开(公告)日：2020-08-11

    申请号：US15940178

    申请日：2018-03-29

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany

    IPC: A61B5/04 ,  A61M3/02 ,  A61M31/00 ,  A61B5/00 ,  A61B18/14 ,  A61B18/00 ,  A61B17/32 ,  A61B18/18 ,  A61B18/02 ,  A61B18/04 ,  A61M25/00 ,  A61B5/20 ,  A61B90/00

    Abstract: An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

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