公开(公告)号：US20170342363A1

公开(公告)日：2017-11-30

申请号：US15492690

申请日：2017-04-20

Applicant: Corning Incorporated

Inventor： Ye Fang ,  Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  Gregory Roger Martin ,  Kaitlyn Mary Matias ,  Michael Kurt Schaefer ,  Allison Jean Tanner

IPC: C12M1/32 ,  C12M3/06 ,  C12M1/26

CPC classification number: C12M23/12 ,  C12M1/268 ,  C12M3/065 ,  C12M23/02 ,  C12M23/24

Abstract: The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.

公开(公告)号：US09290730B2

公开(公告)日：2016-03-22

申请号：US14254280

申请日：2014-04-16

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/20 ,  C12M1/12 ,  C12M1/24 ,  C12M1/00 ,  C12M1/04 ,  C12N5/071

CPC classification number: C12M23/08 ,  C12M23/04 ,  C12M23/24 ,  C12M23/34 ,  C12M23/38 ,  C12M23/58 ,  C12M25/02 ,  C12M25/04 ,  C12M25/06 ,  C12M29/04 ,  C12N5/0602

Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.

公开(公告)号：US20150275167A1

公开(公告)日：2015-10-01

申请号：US14663533

申请日：2015-03-20

Applicant: Corning Incorporated

Inventor： Ronald Allen Faris ,  Ann MeeJin Ferrie ,  Vasiliy Nikolaevich Goral ,  Gregory Roger Martin ,  Jin Liu

IPC: C12N5/00 ,  C12N5/071

CPC classification number: A61K9/2866

Abstract: An ex vivo cell culture sustained release composition, including: a mixture comprising: a sustenant; and a non-biodegradable binder; and a non-biodegradable and water insoluble encapsulant coat that encapsulates the mixture, as defined herein. Also disclosed is a method for sustainably providing a sustenant to a cell culture in aqueous media, including contacting a cell culture with the sustained release composition.

Abstract translation: 一种离体细胞培养持续释放组合物，包括：包含：维生素的混合物; 和不可生物降解的粘合剂; 以及包封如本文所定义的混合物的不可生物降解的水不溶性包封剂涂层。 还公开了一种用于将水分介质中的细胞培养物可持续地提供给细胞培养物的方法，包括使细胞培养物与持续释放组合物接触。

公开(公告)号：US20150232796A1

公开(公告)日：2015-08-20

申请号：US14699157

申请日：2015-04-29

Applicant: Corning Incorporated

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/04 ,  C12M1/34 ,  C12M1/00

CPC classification number: C12M23/08 ,  C12M23/04 ,  C12M23/24 ,  C12M23/34 ,  C12M23/38 ,  C12M23/58 ,  C12M25/02 ,  C12M25/04 ,  C12M25/06 ,  C12M29/04 ,  C12M41/00 ,  C12N5/0602

Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.

公开(公告)号：US09045721B2

公开(公告)日：2015-06-02

申请号：US14132749

申请日：2013-12-18

Applicant: CORNING INCORPORATED

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/20 ,  C12M1/12 ,  C12M1/24 ,  C12M1/00 ,  C12M1/04 ,  C12N5/071

CPC classification number: C12M23/08 ,  C12M23/04 ,  C12M23/24 ,  C12M23/34 ,  C12M23/38 ,  C12M23/58 ,  C12M25/02 ,  C12M25/04 ,  C12M25/06 ,  C12M29/04 ,  C12N5/0602

Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.

Abstract translation: 公开了一种培养细胞的多层细胞培养装置。 细胞培养装置被定义为具有与气管空间组合的多个细胞培养室的整体结构。 该装置的主体在其中赋予气体可渗透的膜与气管空间的组合，其将允许细胞培养室与外部环境之间的气体自由流动。 烧瓶主体还包括孔，其将允许通过针或插管进入细胞生长室。 设备的尺寸和可选的颈部和帽部分的位置允许其通过标准自动化测定设备进行操作，进一步使得该设备对于高通量应用是理想的。

公开(公告)号：US20150017711A1

公开(公告)日：2015-01-15

申请号：US14375553

申请日：2013-01-31

Applicant: CORNING INCORPORATED

Inventor： Scott Matthew Bennett ,  David Alan Kenney ,  Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M3/06 ,  C12M1/26 ,  C12M1/34 ,  C12M1/00 ,  C12M1/36

CPC classification number: C12M27/16 ,  C12M23/50 ,  C12M23/52 ,  C12M29/00 ,  C12M29/14 ,  C12M33/08 ,  C12M41/40 ,  C12M41/44 ,  C12M41/48

Abstract: An integrated cell culture system may include one or more cell culture vessels, manipulation apparatus, pumping apparatus, cell release apparatus, monitoring apparatus, and a control apparatus. The control apparatus may be used to monitor and control the system to facilitate effective cell culturing. The cell release apparatus may be used to release a plurality of cells adhered to the cell culture surfaces of the cell culture vessels.

Abstract translation: 综合细胞培养系统可以包括一个或多个细胞培养容器，操作装置，泵送装置，细胞释放装置，监测装置和控制装置。 控制装置可用于监测和控制系统以促进有效的细胞培养。 细胞释放装置可以用于释放粘附于细胞培养容器的细胞培养表面的多个细胞。

公开(公告)号：US08846399B2

公开(公告)日：2014-09-30

申请号：US13904171

申请日：2013-05-29

Applicant: Corning Incorporated

Inventor： Gregory Roger Martin ,  Allison Jean Tanner

IPC: C12M1/20 ,  C12M1/12 ,  C12M1/00 ,  C12M1/04 ,  C12N5/071 ,  C12M1/24

CPC classification number: C12M23/08 ,  C12M23/04 ,  C12M23/24 ,  C12M23/34 ,  C12M23/38 ,  C12M23/58 ,  C12M25/02 ,  C12M25/04 ,  C12M25/06 ,  C12M29/04 ,  C12N5/0602

Abstract: A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between the cell culture chambers and the external environment. The flask body also includes an aperture that will allow access to the cell growth chambers by means of a needle or cannula. The size of the apparatus, and location of an optional neck and cap section, allows for its manipulation by standard automated assay equipment, further making the apparatus ideal for high throughput applications.

Abstract translation: 公开了一种培养细胞的多层细胞培养装置。 细胞培养装置被定义为具有与气管空间组合的多个细胞培养室的整体结构。 该装置的主体在其中赋予气体可渗透的膜与气管空间的组合，其将允许细胞培养室与外部环境之间的气体自由流动。 烧瓶主体还包括孔，其将允许通过针或插管进入细胞生长室。 设备的尺寸和可选的颈部和帽部分的位置允许其通过标准自动化测定设备进行操作，进一步使得该设备对于高通量应用是理想的。