公开(公告)号：US5488870A

公开(公告)日：1996-02-06

申请号：US307260

申请日：1994-09-16

Applicant: Hiroyuki Yoshimura ,  Osamu Kashimura

Inventor： Hiroyuki Yoshimura ,  Osamu Kashimura

IPC: G01F1/84 ,  G01F1/78

CPC classification number: G01F1/8409 ,  G01F1/8413 ,  G01F1/8422 ,  G01F1/8427 ,  G01F1/8431 ,  G01F1/8436 ,  G01F1/8472 ,  G01F1/849

Abstract: Measurement of a mass flow rate is accomplished by equalizing the output amplitude values of upstream and downstream sensors without causing a lowering of the mechanical Q of a vibration system. One of the upstream and downstream sensors includes a permanent magnet disposed on a side of a tube and an induction coil disposed on a side of a base, the output voltage amplitude of which is fixed. Another sensor includes a ferromagnetic member disposed on the side of the tube and an excitation coil and an induction coil disposed on the side of the base. The output voltage amplitude of the induction coil is controlled to be coincident with the output voltage amplitude of the induction coil by adjusting a DC current flowing through the excitation coil.

Abstract translation: 通过均衡上下游传感器的输出振幅值而不会导致振动系统的机械Q的降低来实现质量流量的测量。 上游和下游传感器中的一个包括设置在管侧的永磁体和设置在基座侧的感应线圈，其输出电压振幅是固定的。 另一传感器包括设置在管侧的铁磁部件和设置在基座一侧的励磁线圈和感应线圈。 感应线圈的输出电压振幅通过调节流过励磁线圈的直流电流而被控制为与感应线圈的输出电压振幅一致。

公开(公告)号：US5382579A

公开(公告)日：1995-01-17

申请号：US751632

申请日：1991-08-26

Applicant: Kazuo Okano ,  Shuhei Miyazawa ,  Richard S. J. Clark ,  Shinya Abe ,  Tetsuya Kawahara ,  Naoyuki Shimomura ,  Osamu Asano ,  Hiroyuki Yoshimura ,  Mitsuaki Miyamoto ,  Yoshimori Sakuma ,  Kenzo Muramoto ,  Hiroshi Obaishi ,  Koukichi Harada ,  Hajime Tsunoda ,  Satoshi Katayama ,  Kouji Yamada ,  Shigeru Souda ,  Yoshimasa Machida ,  Kouichi Katayama ,  Isao Yamatsu

Inventor： Kazuo Okano ,  Shuhei Miyazawa ,  Richard S. J. Clark ,  Shinya Abe ,  Tetsuya Kawahara ,  Naoyuki Shimomura ,  Osamu Asano ,  Hiroyuki Yoshimura ,  Mitsuaki Miyamoto ,  Yoshimori Sakuma ,  Kenzo Muramoto ,  Hiroshi Obaishi ,  Koukichi Harada ,  Hajime Tsunoda ,  Satoshi Katayama ,  Kouji Yamada ,  Shigeru Souda ,  Yoshimasa Machida ,  Kouichi Katayama ,  Isao Yamatsu

IPC: C07D495/14 ,  C07D495/22 ,  C07F9/6561 ,  A61K31/55

CPC classification number: C07D495/14 ,  C07F9/6561

Abstract: A triazolo-1,4-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

Abstract translation: 公开了以下给定式的三唑并-1,1-吖庚因化合物及其药理学上可接受的盐，并且在制药领域尤其是过敏性疾病中有用。 和其中R 1和R 2为氢或烷基，R 3为氢或卤素，R 4为氢或烷基，X为-OCO - ， - NHCO - ， - CO-或其它物质的

公开(公告)号：US5306738A

公开(公告)日：1994-04-26

申请号：US17437

申请日：1993-02-12

Applicant: Hiroyuki Yoshimura ,  Yutaka Tamano ,  Shoji Arai

Inventor： Hiroyuki Yoshimura ,  Yutaka Tamano ,  Shoji Arai

IPC: C08G18/18 ,  C08G18/20 ,  C08G101/00 ,  C08J9/02

CPC classification number: C08G18/2027 ,  C08G2101/0008 ,  C08G2101/0083

Abstract: Process for producing a flexible polyurethane foam through reaction of a polyol with a polyisocyanate in the presence of an amine catalyst, a blowing agent, and a foam stabilizer, the amine catalyst comprising at least one of the imidazoles represented by the general formula below: ##STR1## wherein R.sup.1 is alkyl of 1 to 4 carbons, dimethylaminopropyl, benzyl, vinyl, or hydroxyalkyl of 1 to 3 carbons; R.sup.2 is hydrogen, alkyl of 1 to 4 carbons, allyl, benzyl, or phenyl; and R.sup.3 and R.sup.4 are respectively hydrogen, alkyl of 1 to 4 carbons, or hydroxymethyl.

Abstract translation: 在胺催化剂，发泡剂和泡沫稳定剂的存在下通过多元醇与多异氰酸酯的反应制备软质聚氨酯泡沫的方法，所述胺催化剂包含由以下通式表示的至少一种咪唑：（ *化学结构*）其中R 1为1至4个碳的烷基，二甲基氨基丙基，苄基，乙烯基或1至3个碳的羟烷基; R2是氢，1至4个碳的烷基，烯丙基，苄基或苯基; R3和R4分别为氢，1〜4个碳的烷基或羟甲基。

公开(公告)号：US5221671A

公开(公告)日：1993-06-22

申请号：US778563

申请日：1991-10-17

Applicant: Kazuo Okano ,  Shuhei Miyazawa ,  Richard S. J. Clark ,  Shinya Abe ,  Tetsuya Kawahara ,  Naoyuki Shimomura ,  Osamu Asano ,  Hiroyuki Yoshimura ,  Mitsuaki Miyamoto ,  Yoshimori Sakuma ,  Kenzo Muramoto ,  Hiroshi Obaishi ,  Koukichi Harada ,  Hajime Tsunoda ,  Satoshi Katayama ,  Kouji Yamada ,  Shigeru Souda ,  Yoshimasa Machida ,  Kouichi Katayama ,  Isao Yamatsu

Inventor： Kazuo Okano ,  Shuhei Miyazawa ,  Richard S. J. Clark ,  Shinya Abe ,  Tetsuya Kawahara ,  Naoyuki Shimomura ,  Osamu Asano ,  Hiroyuki Yoshimura ,  Mitsuaki Miyamoto ,  Yoshimori Sakuma ,  Kenzo Muramoto ,  Hiroshi Obaishi ,  Koukichi Harada ,  Hajime Tsunoda ,  Satoshi Katayama ,  Kouji Yamada ,  Shigeru Souda ,  Yoshimasa Machida ,  Kouichi Katayama ,  Isao Yamatsu

IPC: C07D495/14 ,  C07D495/22

CPC classification number: C07D495/14

Abstract: A triazolo-1,4-di-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

Abstract translation: 公开了以下给定式的三唑并-1,4-二氮杂化合物及其药理学上可接受的盐，特别适用于过敏性疾病。 和其中R 1和R 2为氢或烷基，R 3为氢或卤素，R 4为氢或烷基，X为-OCO - ， - NHCO - ， - CO-或其它物质的

公开(公告)号：US5206403A

公开(公告)日：1993-04-27

申请号：US609374

申请日：1990-11-05

Applicant: Youji Yamagishi ,  Kozo Akasaka ,  Takeshi Suzuki ,  Mitsuaki Miyamoto ,  Kouji Nakamoto ,  Kazuo Okano ,  Shinya Abe ,  Hironori Ikuta ,  Kenji Hayashi ,  Hiroyuki Yoshimura ,  Tohru Fujimori ,  Koukichi Harada ,  Isao Yamatsu

Inventor： Youji Yamagishi ,  Kozo Akasaka ,  Takeshi Suzuki ,  Mitsuaki Miyamoto ,  Kouji Nakamoto ,  Kazuo Okano ,  Shinya Abe ,  Hironori Ikuta ,  Kenji Hayashi ,  Hiroyuki Yoshimura ,  Tohru Fujimori ,  Koukichi Harada ,  Isao Yamatsu

IPC: A61K31/275 ,  C07C59/64 ,  C07C235/14 ,  C07C235/34 ,  C07C251/16 ,  C07C251/40 ,  C07C251/60 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/16 ,  C07C311/17 ,  C07C327/58 ,  C07D207/46 ,  C07D213/40 ,  C07D213/75 ,  C07D257/04 ,  C07D339/08 ,  C07D521/00

CPC classification number: C07D213/40 ,  C07C235/14 ,  C07C235/34 ,  C07C251/40 ,  C07C251/60 ,  C07C255/00 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/17 ,  C07C327/58 ,  C07C59/64 ,  C07D207/46 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D257/04 ,  C07D339/08

Abstract: A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime either derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COR6, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

Abstract translation: 新的二苯基甲烷衍生物可用于抑制血液凝聚，并由式定义，包括二苯基乙烯衍生物和二苯甲酮肟衍生物。 其中R 1和R 2各自为氢，羟基或低级烷氧基，U为= XY =或NOW，X为氢，氰基或-COR 6，R6为羟基或氨基，Y为-R10- COR6，R3为氢或低级烷氧基，R10为碳原子数为1〜3的亚烷基，为直链或支链，-CO-NR4R5，R4和R5各自为氢，低级烷基或低级芳基烷基，-CH2-NHSO2- C6H5或-C（R8）= NR7，R7为低级烷氧基或芳基，R8为-VR9，V为氧，硫或氮，R9为烷基或芳基，W为-CH2-CO-CH2-COOR13 ，R13为氢或低级烷基，-CH2-C（= NOR14）-CH2-COOR15，R15为氢或低级烷基，R14为低级烷基，-CH（CN） - （CH2）q-COOR16，R16 是氢或低级烷基，q是1至3的整数，或 - （CH 2）pZ，Z是-SH，-SCN或衍生自五元或六元环的一价基团，其可以被 环在环中具有一个或多个硫原子，p为1或2。

公开(公告)号：US5182301A

公开(公告)日：1993-01-26

申请号：US659518

申请日：1991-02-21

Applicant: Youji Yamagishi ,  Kozo Akasaka ,  Takeshi Suzuki ,  Mitsuaki Miyamoto ,  Kouji Nakamoto ,  Kazuo Okano ,  Shinya Abe ,  Hironori Ikuta ,  Kenji Hayashi ,  Hiroyuki Yoshimura ,  Tohru Fujimori ,  Koukichi Harada ,  Isao Yamatsu

Inventor： Youji Yamagishi ,  Kozo Akasaka ,  Takeshi Suzuki ,  Mitsuaki Miyamoto ,  Kouji Nakamoto ,  Kazuo Okano ,  Shinya Abe ,  Hironori Ikuta ,  Kenji Hayashi ,  Hiroyuki Yoshimura ,  Tohru Fujimori ,  Koukichi Harada ,  Isao Yamatsu

IPC: A61K31/275 ,  C07C59/64 ,  C07C69/616 ,  C07C235/14 ,  C07C235/34 ,  C07C251/40 ,  C07C251/60 ,  C07C255/32 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/17 ,  C07C327/58 ,  C07D207/46 ,  C07D213/40 ,  C07D213/75 ,  C07D257/04 ,  C07D339/08 ,  C07D521/00

CPC classification number: C07D213/40 ,  C07C235/14 ,  C07C235/34 ,  C07C251/40 ,  C07C251/60 ,  C07C255/00 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/17 ,  C07C327/58 ,  C07C59/64 ,  C07D207/46 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D257/04 ,  C07D339/08

Abstract: A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCH or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

Abstract translation: 新的二苯基甲烷衍生物可用于抑制血液凝聚，并由式定义，包括二苯基乙烯衍生物和二苯甲酮肟醚衍生物。 其中R 1和R 2各自为氢，羟基或低级烷氧基，U为= XY =或NOW，X为氢，氰基或-COR 6，R6为羟基或氨基，Y为-R10- COOR 3，R 3为氢或低级烷氧基，R 10为具有1至3个碳原子的直链或支链的亚烷基，-CO-NR4R5，R4和R5各自为氢，低级烷基或低级芳基烷基，-CH2-NHSO2- C6H5或-C（R8）= NR7，R7为低级烷氧基或芳基，R8为-VR9，V为氧，硫或氮，R9为烷基或芳基，W为-CH2-CO-CH2-COOR13 ，R13为氢或低级烷基，-CH2-C（= NOR14）-CH2-COOR15，R15为氢或低级烷基，R14为低级烷基，-CH（CN） - （CH2）q-COOR16，R16 是氢或低级烷基，q为1〜3的整数，或 - （CH 2）p Z，Z为-SH，-SCH或衍生自五元或六元环的一价基团，其可以被 环在环中具有一个或多个硫原子，p为1或2。

公开(公告)号：US5034418A

公开(公告)日：1991-07-23

申请号：US364711

申请日：1989-06-09

Applicant: Youji Yamagishi ,  Kozo Akasaka ,  Takeshi Suzuki ,  Mitsuaki Miyamoto ,  Kouji Nakamoto ,  Kazuo Okano ,  Shinya Abe ,  Hironori Ikuta ,  Kenji Hayashi ,  Hiroyuki Yoshimura ,  Tohru Fujimori ,  Koukichi Harada ,  Isao Yamatsu

Inventor： Youji Yamagishi ,  Kozo Akasaka ,  Takeshi Suzuki ,  Mitsuaki Miyamoto ,  Kouji Nakamoto ,  Kazuo Okano ,  Shinya Abe ,  Hironori Ikuta ,  Kenji Hayashi ,  Hiroyuki Yoshimura ,  Tohru Fujimori ,  Koukichi Harada ,  Isao Yamatsu

IPC: C07C57/42 ,  A61K31/15 ,  A61K31/165 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/275 ,  A61K31/277 ,  A61K31/33 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  C07C51/00 ,  C07C59/64 ,  C07C67/00 ,  C07C69/618 ,  C07C231/00 ,  C07C231/02 ,  C07C233/01 ,  C07C233/02 ,  C07C233/11 ,  C07C235/14 ,  C07C235/34 ,  C07C237/20 ,  C07C239/00 ,  C07C241/00 ,  C07C251/40 ,  C07C251/60 ,  C07C253/00 ,  C07C253/30 ,  C07C255/04 ,  C07C255/32 ,  C07C255/34 ,  C07C255/37 ,  C07C255/41 ,  C07C255/61 ,  C07C255/62 ,  C07C257/04 ,  C07C257/06 ,  C07C257/10 ,  C07C257/18 ,  C07C301/00 ,  C07C303/38 ,  C07C311/00 ,  C07C311/13 ,  C07C311/15 ,  C07C311/17 ,  C07C325/00 ,  C07C327/00 ,  C07C327/58 ,  C07D207/46 ,  C07D213/40 ,  C07D213/72 ,  C07D213/75 ,  C07D249/12 ,  C07D257/04 ,  C07D339/08 ,  C07D521/00

CPC classification number: C07D257/04 ,  C07C235/14 ,  C07C235/34 ,  C07C251/40 ,  C07C251/60 ,  C07C255/00 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/17 ,  C07C327/58 ,  C07C59/64 ,  C07D207/46 ,  C07D213/40 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D339/08

Abstract: A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--N4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

Abstract translation: 二苯基甲烷衍生物。 式（I）为新的（其中R 1和R 2各自为H，OH或低级烷氧基; U = -C XY或= NOW; X = H，CN或-COR 6; R 6 = OH或NH 2; Y = COOR 3，-CONR 4 R 5，-CH 2 NHSO 2 -C 6 H 5或-C（R 8）= NR 7; R 3 = H或低级烷氧基; R 10 =支链1-3C亚烷基; R 4和R 5各自为H，低级烷基或低级芳基烷基; 低级烷氧基或芳基; R8 = -VR9; V = O，S或N; R9 =烷基或芳基; W = -CH2-CO-CH2-COOR13，-CH2-C（= NOR14）-CH2-COOR15，-CH （CN） - （CH 2）q -COOR 16或 - （CH 2）pZ; R 13 = H或低级烷基; R 14 =低级烷基; R 15 = H或低级烷基; R 16 = H或低级烷基; q = = -SH，-SCN或衍生自5-或6-元环选择的单价gp，通过环中具有1个或更多个S的环; p = 1或2。

公开(公告)号：US4886834A

公开(公告)日：1989-12-12

申请号：US24737

申请日：1987-03-11

Applicant: Youji Yamagishi ,  Kozo Akasaka ,  Takeshi Suzuki ,  Mitsuaki Miyamoto ,  Kouji Nakamoto ,  Kazuo Okano ,  Shinya Abe ,  Hironori Ikuta ,  Kenji Hayashi ,  Hiroyuki Yoshimura ,  Tohru Fujimori ,  Koukichi Harada ,  Isao Yamatsu

Inventor： Youji Yamagishi ,  Kozo Akasaka ,  Takeshi Suzuki ,  Mitsuaki Miyamoto ,  Kouji Nakamoto ,  Kazuo Okano ,  Shinya Abe ,  Hironori Ikuta ,  Kenji Hayashi ,  Hiroyuki Yoshimura ,  Tohru Fujimori ,  Koukichi Harada ,  Isao Yamatsu

IPC: C07C57/42 ,  A61K31/15 ,  A61K31/165 ,  A61K31/18 ,  A61K31/19 ,  A61K31/215 ,  A61K31/22 ,  A61K31/275 ,  A61K31/277 ,  A61K31/33 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  C07C51/00 ,  C07C59/64 ,  C07C67/00 ,  C07C69/618 ,  C07C231/00 ,  C07C231/02 ,  C07C233/01 ,  C07C233/02 ,  C07C233/11 ,  C07C235/14 ,  C07C235/34 ,  C07C237/20 ,  C07C239/00 ,  C07C241/00 ,  C07C251/40 ,  C07C251/60 ,  C07C253/00 ,  C07C253/30 ,  C07C255/04 ,  C07C255/32 ,  C07C255/34 ,  C07C255/37 ,  C07C255/41 ,  C07C255/61 ,  C07C255/62 ,  C07C257/04 ,  C07C257/06 ,  C07C257/10 ,  C07C257/18 ,  C07C301/00 ,  C07C303/38 ,  C07C311/00 ,  C07C311/13 ,  C07C311/15 ,  C07C311/17 ,  C07C325/00 ,  C07C327/00 ,  C07C327/58 ,  C07D207/46 ,  C07D213/40 ,  C07D213/72 ,  C07D213/75 ,  C07D249/12 ,  C07D257/04 ,  C07D339/08 ,  C07D521/00 ,  C07C121/40

CPC classification number: C07D257/04 ,  C07C235/14 ,  C07C235/34 ,  C07C251/40 ,  C07C251/60 ,  C07C255/00 ,  C07C255/41 ,  C07C255/62 ,  C07C257/06 ,  C07C257/18 ,  C07C311/13 ,  C07C311/17 ,  C07C327/58 ,  C07C59/64 ,  C07D207/46 ,  C07D213/40 ,  C07D213/75 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D339/08

Abstract: A new diphenyl-methane derivative is useful to inhibit agglomeration of blood and is defined by the formula, including a diphenylethylene derivative and a benzophenone oxime ether derivative. ##STR1## in which R1 and R2 each are hydrogen, hydroxyl or a lower alkoxy, U is .dbd.CXY or .dbd.N--O--W,X is hydrogen, cyano or --COR6, R6 being hydroxyl or an amino, Y is --R10--COOR3, R3 being hydrogen or a lower alkoxy, R10 being an alkylene having 1 to 3 carbon atoms, straight or branched, --CO--NR4R5, R4 and R5 each being hydrogen, a lower alkyl or a lower arylalkyl, --CH2--NHSO2--C6H5 or --C(R8).dbd.NR7, R7 being a lower alkoxy or an aryl, R8 is --VR9, V being oxygen, sulfur or nitrogen, R9 being an alkyl or an aryl,W is --CH2--CO--CH2--COOR13, R13 being hydrogen or a lower alkyl, --CH2--C(C.dbd.NOR14)--CH2--COOR15, R15 being hydrogen or a lower alkyl, R14 being a lower alkyl, --CH(CN)--(CH2)q--COOR16, R16 being hydrogen or a lower alkyl, q being an integer of 1 to 3, or --(CH2)p--Z, Z being --SH, --SCN or a monovalent group derived from a five- or six-membered ring which may be substituted by a ring having one or more sulfur atoms in the ring, p being 1 or 2.

Abstract translation: 二苯基甲烷衍生物。 式（I）为新的（其中R 1和R 2各自为H，OH或低级烷氧基; U = -C XY或= NOW; X = H，CN或-COR 6; R 6 = OH或NH 2; Y = COOR 3，-CONR 4 R 5，-CH 2 NHSO 2 -C 6 H 5或-C（R 8）= NR 7; R 3 = H或低级烷氧基; R 10 =支链1-3C亚烷基; R 4和R 5各自为H，低级烷基或低级芳基烷基; 低级烷氧基或芳基; R8 = -VR9; V = O，S或N; R9 =烷基或芳基; W = -CH2-CO-CH2-COOR13，-CH2-C（= NOR14）-CH2-COOR15，-CH （CN） - （CH 2）q -COOR 16或 - （CH 2）pZ; R 13 = H或低级烷基; R 14 =低级烷基; R 15 = H或低级烷基; R 16 = H或低级烷基; q = = -SH，-SCN或衍生自5-或6-元环选择的单价gp，通过环中具有1个或更多个S的环; p = 1或2。