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公开(公告)号：US20180299430A1
公开(公告)日：2018-10-18
申请号：US15951114
申请日：2018-04-11
Applicant: Academia Sinica
Inventor： Hung-Chih KUO , Ching-Yu CHUANG , Chan-Hsien YEH
IPC: G01N33/50
Abstract: Disclosed herein are kits comprising transcription factors for inducing a fibroblast cell into an induced embryonic neural progenitor cell. The induced embryonic neural progenitor cell is then capable of differentiating into an astrocyte, an oligodendrocyte or a neuron. Also disclosed are the uses of the kit as a platform for selecting a drug candidate to treat neurological diseases.
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公开(公告)号：US10087450B2
公开(公告)日：2018-10-02
申请号：US15156998
申请日：2016-05-17
Applicant: Academia Sinica
Inventor： Jui-Jen Chang , Wen-Hsiung Li , Chieh-Chen Huang , Hao-Yeh Lin , Ming-Che Shih
Abstract: Described herein is an engineered Kluyveromyces marxianus cell, the cell comprising in its genome: (i) two different nucleic acid molecules that each contain a promoter operably linked to a gene encoding a functional enzyme, and (ii) a selection nucleic acid molecule that contains a promoter operably linked to a gene encoding a selectable marker, wherein all of the nucleic acids molecules of (i) and (ii) are in tandem and the engineered cell expresses all of the proteins encoded by the genes of (i) and (ii).
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公开(公告)号：US20180179172A1
公开(公告)日：2018-06-28
申请号：US15576307
申请日：2016-06-30
Applicant: Academia Sinica
Inventor： Rong-Jie CHIEN , Klim KING , Nai-Pin LIN , Yu-Hong CHENG
IPC: C07D307/22 , A61K31/365 , C07D307/83 , C07D333/36 , A61K45/06
CPC classification number: C07D307/22 , A61K31/155 , A61K31/365 , A61K31/366 , A61K31/4439 , A61K31/48 , A61K31/4985 , A61K31/64 , A61K31/702 , A61K31/7042 , A61K45/06 , C07D307/33 , C07D307/83 , C07D333/32 , C07D333/36 , A61K2300/00
Abstract: Disclosed herein are novel glucagon-like peptide-1 (GLP-1) modulators and their uses in manufacturing medicaments for the treatment and/or prophylaxis of diseases and/or disorders associated with hyperglycemia.
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公开(公告)号：US09958396B2
公开(公告)日：2018-05-01
申请号：US14722510
申请日：2015-05-27
Inventor： Chia-Fu Chou , Thierry Leichle , Yii-Lih Lin , Pattamon Teerapanich
IPC: G01N33/543 , G01N21/76 , B01L3/00 , G01N33/557 , G01N21/64
CPC classification number: G01N21/763 , B01L3/5027 , B01L2300/0636 , B01L2300/0877 , G01N21/6428 , G01N21/6458 , G01N33/54366 , G01N33/54373 , G01N33/557 , G01N2021/6439
Abstract: A sensing device applied to an analyte molecule of a liquid sample and a buffer flow has at least one first inlet, at least one second inlet, a micro-flow channel, and at least one immobilization element. The first inlet is for inputting the liquid sample. The second inlet is for inputting the buffer flow. The micro-flow channel communicates with the first inlet and the second inlet. The immobilization element is for immobilizing sensing molecules for the analyte molecules. The analyte sample flow and the buffer flow, in the reverse direction, in the micro-flow channel enable the association and disassociation kinetics to be obtained. The present invention further provides a sensing system and a sensing method using the sensing device.
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公开(公告)号：US20180099056A1
公开(公告)日：2018-04-12
申请号：US15567931
申请日：2016-04-19
Applicant: Academia Sinica
Inventor： Patrick C.H. Hsieh , Yuan-Yuan Cheng
IPC: A61K48/00 , A61K31/713 , A61K45/06 , A61K38/17 , A61P9/10
CPC classification number: A61K48/005 , A61K31/713 , A61K38/1709 , A61K45/06 , A61P9/10 , C12N2310/531 , C12N2710/10343 , A61K2300/00
Abstract: A combination of active agents selected from a FoxM1 enhancer, an Id1 enhancer, and a JNK3 inhibitor and the uses thereof in promoting cardiomyocyte proliferation and treating heart diseases in a subject in need of the treatment.
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Patent Agency Ranking
公开(公告)号：US20180072993A1
公开(公告)日：2018-03-15
申请号：US15699011
申请日：2017-09-08
Applicant: Academia Sinica
Inventor： Patrick C.H. Hsieh , Desy S. Lee
CPC classification number: C12N5/0657 , A61K35/34 , C12N2501/50 , C12N2501/65 , C12N2502/1323 , C12N2502/28 , C12N2506/02 , C12Q1/6881 , C12Q2600/158 , G01N33/5061
Abstract: Methods for promoting maturation of cardiomyocytes, involving introducing a microRNA combination containing miR-125b, miR-199a, miR-221, and/or miR222, or suppression of ErbB4 in immature cardiomyocytes, which may be co-cultured with endothelial cells.
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87.发明授权公开(公告)号：US09891227B2
公开(公告)日：2018-02-13
申请号：US14701267
申请日：2015-04-30
Applicant: Academia Sinica
Inventor： Konan Peck , Pan-Chyr Yang , Yi-Chung Chang
IPC: G01N33/53 , G01N33/58 , G01N33/543 , G01N33/569
CPC classification number: G01N33/585 , G01N33/5308 , G01N33/54326 , G01N33/54333 , G01N33/56938
Abstract: Methods of assaying a biological target are disclosed. The method comprises: (a) providing a sample containing the biological target; (b) providing biotin-labeled first aptamers conjugated to a gold nanoparticle (GNP), and second aptamers conjugated to a magnetic bead, wherein the first and the second aptamers exhibit specific binding affinities to the target; (c) incubating the sample with the first and the second aptamers to obtain target-bound aptamers; (d) separating the target-bound aptamers from unbound aptamers; (e) eluting the first aptamers from the GNP; (f) incubating the eluted biotin-labeled first aptamers with streptavidin-magnetic beads and reporter gold nanoparticles (GNPs) to obtain a complex comprising: the bead, the first aptamers, attached to the bead; and the reporter GNPs captured by the bead through the first aptamers; (g) eluting the reporter GNPs captured; and (h) detecting the target by measuring and analyzing a light-scattering signal of the eluted reporter GNPs.
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88.发明授权公开(公告)号：US09890111B2
公开(公告)日：2018-02-13
申请号：US14960025
申请日：2015-12-04
Applicant: Academia Sinica
Inventor： Chi-Huey Wong , Che Alex Ma , Ting-Jen Rachel Cheng , Wei-Chieh Cheng
IPC: C07C235/64 , C12Q1/18 , C12Q1/48 , C07C235/84
CPC classification number: C07C235/64 , C07C235/84 , C07K2299/00 , C12Q1/18 , C12Q1/48 , G01N2333/91102 , G01N2500/00
Abstract: The crystal structure at 2.16 Å resolution of the full-length bacterial bifunctional transglycosylase penicillin-binding protein 1b (PBP1b) from Escherichia coli, in complex with its inhibitor moenomycin, is provided. The atomic coordinates of the complex as well as the moenomycin binding site are provided. Three dimensional structures of amino acid residues involved in moenomycin binding and transglycosylation activity are identified. Binding site for peptidoglycan synthesis inhibitors comprising inhibitor-binding site comprises amino acid residues from at least one of transglycosylase (TG), UvrB domain 2 homolog (UB2H) and transmembrane (TM) domains of PBP1b are identified at an atomic level of resolution. Methods for rational drug design based on the atomic coordinates are provided. Methods for screening for antibiotics based on anisotropic binding assay and transglycosylase inhibitor assays are provided. Novel antibiotics based on the screening assays of the invention are disclosed.
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公开(公告)号：US20170327542A9
公开(公告)日：2017-11-16
申请号：US15115179
申请日：2015-01-26
Applicant: Academia Sinica
Inventor： Tsung-Lin LI , Syue-Yi LYU , Yu-Chen LIU , Chin-Yuan CHANG
CPC classification number: C07K9/008 , A61K38/00 , C12P19/60 , Y02A50/473 , Y02A50/481
Abstract: Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting bacterial growth. Methods of using the compounds for treating and/or preventing bacterial infection as well as methods of preparing the compounds are also described.
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公开(公告)号：US20170290820A1
公开(公告)日：2017-10-12
申请号：US15496883
申请日：2017-04-25
Applicant: Academia Sinica
Inventor： Che-Kun James Shen , Yu-Chi Chou , Tsann-Long Su
IPC: A61K31/473 , G01N33/50 , A61K9/00 , A61K45/06
CPC classification number: A61K31/473 , A61K9/0053 , A61K45/06 , C07D221/14 , G01N33/5044 , G01N2333/805 , G01N2800/52 , A61K2300/00
Abstract: Compounds, pharmaceutical compositions, and methods for treating anemia β-thalassemia anemia or sickle cell anemia.
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