公开(公告)号：US20100081808A1

公开(公告)日：2010-04-01

申请号：US12450034

申请日：2008-03-10

Applicant: Shoichi Kondo ,  Yuya Shimada

Inventor： Shoichi Kondo ,  Yuya Shimada

IPC: C07D491/22 ,  C07D301/12

CPC classification number: C07D301/12 ,  B01J31/1805 ,  B01J31/2213 ,  B01J2231/72 ,  B01J2531/0252 ,  B01J2531/46 ,  C07B53/00 ,  C07D303/04 ,  C07D493/04

Abstract: [Problems] To provide an efficient process for producing an optically active epoxy compound.[Means For Solving Problems] The process for producing an optically active epoxy compound comprises asymmetrically epoxidizing an unsaturated compound with an oxidizing agent in the presence of an optically active titanium-salen complex, an optically active titanium-salalen complex or an optically active titanium-salan complex, with addition of a buffering agent or a buffer solution. The process can inhibit catalyst degradation, reduce the amount of the catalyst used in the reaction, and inhibit a by-product, compared with the prior art, and can provide an optically active epoxy compound in high chemical yield and optical yield and with high quality, and therefore is an industrially useful process.

Abstract translation: [问题]提供一种制备光学活性环氧化合物的有效方法。 解决问题的方法光学活性环氧化合物的制造方法包括在光学活性的钛 - salen络合物，光学活性的钛 - salalen络合物或光学活性的钛 - 盐络合物的存在下，用氧化剂不对称地环氧化不饱和化合物， 沙仑复合物，加入缓冲剂或缓冲溶液。 与现有技术相比，该方法可以抑制催化剂降解，减少反应中使用的催化剂的量和抑制副产物，并且可以提供高化学产率和光学收率和高质量的光学活性环氧化合物 ，因此是一个工业上有用的过程。

公开(公告)号：US20100069683A1

公开(公告)日：2010-03-18

申请号：US12583943

申请日：2009-08-28

Applicant: Takashi Miki ,  Junichi Hori ,  Toshihide Takemoto ,  Noriyuki Utsumi ,  Takeaki Katayama ,  Masahito Watanabe ,  Kunihiko Murata

Inventor： Takashi Miki ,  Junichi Hori ,  Toshihide Takemoto ,  Noriyuki Utsumi ,  Takeaki Katayama ,  Masahito Watanabe ,  Kunihiko Murata

IPC: C07C37/00

CPC classification number: C07B53/00 ,  B01J31/1805 ,  B01J31/2295 ,  B01J2231/643 ,  B01J2531/0238 ,  B01J2531/822 ,  B01J2531/827 ,  C07F17/02

Abstract: The present invention provides an asymmetric reduction catalyst effective in preparing optically-active alcohol compounds having various functional groups, and a process for preparing optically-active alcohol compounds using said asymmetric reduction catalyst.The organic metal compound of the present invention is represented by the following general formula (1): wherein R1 and R2 may be mutually identical or different, and are an alkyl group, a phenyl group, a naphthyl group, a cycloalkyl group, or an alicyclic ring formed by binding R1 and R2, which may have a substituent; R3 is a hydrogen atom or an alkyl group; Cp is a cyclopentadienyl group, which may have a substituent, bound to M1 via a π bond; X1 is a halogen atom or a hydrido group; M1 is rhodium or iridium; and * denotes asymmetric carbon.

Abstract translation: 本发明提供了一种有效地制备具有各种官能团的光学活性醇化合物的不对称还原催化剂，以及使用该不对称还原催化剂制备光学活性醇化合物的方法。 本发明的有机金属化合物由以下通式（1）表示：其中R1和R2可以相同或不同，为烷基，苯基，萘基，环烷基或 通过结合可以具有取代基的R 1和R 2形成的脂环; R3是氢原子或烷基; Cp是可以具有取代基的环戊二烯基，其通过a和p结合到M1; 键; X1是卤原子或氢环; M1是铑或铱; 和*表示不对称碳。

公开(公告)号：US20090326274A1

公开(公告)日：2009-12-31

申请号：US12493043

申请日：2009-06-26

Applicant: Beatriz Dominguez ,  Antonio Zanotti-Gerosa ,  Gabriela Alexandra Grasa ,  Jonathan Alan Medlock

Inventor： Beatriz Dominguez ,  Antonio Zanotti-Gerosa ,  Gabriela Alexandra Grasa ,  Jonathan Alan Medlock

IPC: C07C45/61 ,  C07C211/01 ,  B01J31/02

CPC classification number: B01J31/1805 ,  B01J2231/643 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/828 ,  B01J2531/842 ,  B01J2531/845 ,  B01J2531/847 ,  C07B2200/07 ,  C07C29/143 ,  C07C311/18 ,  C07C2602/10 ,  C07C33/46 ,  C07C33/22 ,  C07C35/32

Abstract: A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.

Abstract translation: 描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或 烷氧基取代基。 手性二胺可用于制备适用于转移氢化反应的催化剂。

公开(公告)号：US20090259085A1

公开(公告)日：2009-10-15

申请号：US12103355

申请日：2008-04-15

Applicant: John R. Hagadorn

Inventor： John R. Hagadorn

IPC: C07D311/82 ,  C07C2/08 ,  B01J31/16

CPC classification number: C07F7/10 ,  B01J31/1805 ,  B01J2231/20 ,  B01J2531/0241 ,  B01J2531/46 ,  B01J2531/48 ,  B01J2531/49 ,  C08F10/00 ,  C08F110/02 ,  C08F210/16 ,  C08F4/64072 ,  C08F2500/03 ,  C08F210/14

Abstract: The invention relates to a process for producing a complex for use in olefin polymerization and oligomerization of the general formula (III): wherein Mt is a group 3 to 12 element in a +2 to +6 oxidation state with between 1 to 4 additional ligands (anionic and/or neutral) coordinated, wherein R1 and R2 are hydrogen, halogen, alkoxy, or a hydrocarbon group containing between 1 to 12 carbon atoms; E is a group 16 element, preferably O; Z is a direct bond between carbon atoms of the adjacent aromatic rings or a —CR3R4— or —SiR3R4— bridge between those carbon atoms, where R3 and R4 are hydrogen or a hydrocarbon groups with 1 to 10 carbons, R5, R6, R7 and R8 are hydrogen, halogen, alkoxy, or a hydrocarbon group containing between 1 to 10 carbon atoms and J1 and J2 are —NR9R10 or —PR9R10, where R9 is H or SiMe3 group and R10 is selected from a group consisting of alkyl, aryl, substituted aryl, heteroalkyl, and heteroaryl containing between 1 to 30 non-hydrogen atoms through a route involving novel precursors such as compounds represented by the general formula (I) where the various substitution options are adapted to produce the substituents shown for formula (III) above.

Abstract translation: 本发明涉及一种用于制备用于通式（III）的烯烃聚合和低聚的络合物的方法：其中Mt是+2至+6氧化态的3至12族元素，具有1至4个另外的配体 （阴离子和/或中性）配位，其中R 1和R 2是氢，卤素，烷氧基或含有1至12个碳原子的烃基; E是16族元素，优选O; Z是相邻芳环的碳原子之间的直接键或这些碳原子之间的-CR 3 R 4 - 或-SiR 3 R 4 - 桥，其中R 3和R 4是氢或具有1至10个碳的烃基，R 5，R 6，R 7和 R8是氢，卤素，烷氧基或含有1至10个碳原子的烃基，J1和J2是-NR9R10或-PR9R10，其中R9是H或SiMe3基团，R10选自烷基，芳基， 取代的芳基，杂烷基和含有1至30个非氢原子的杂芳基通过涉及新型前体的途径，例如由通式（I）表示的化合物，其中各种取代选项适于产生式（III）所示的取代基 以上。

公开(公告)号：US07554001B2

公开(公告)日：2009-06-30

申请号：US11873333

申请日：2007-10-16

Applicant: John Thomas Dixon ,  Peter Wasserscheid ,  David Shane McGuinness ,  Fiona Millicent Hess ,  Hulisani Maumela ,  David Hedley Morgan ,  Annette Bollman

Inventor： John Thomas Dixon ,  Peter Wasserscheid ,  David Shane McGuinness ,  Fiona Millicent Hess ,  Hulisani Maumela ,  David Hedley Morgan ,  Annette Bollman

IPC: C07C2/24

CPC classification number: C07C2/36 ,  B01J31/1805 ,  B01J31/189 ,  B01J31/226 ,  B01J31/24 ,  B01J2231/20 ,  B01J2531/0238 ,  B01J2531/62 ,  C07C2/32 ,  C07C323/25 ,  C07C2531/14 ,  C07C2531/22 ,  C07C2531/24 ,  C07F9/5004 ,  C07F9/5022 ,  C07F9/5027 ,  C07F9/5045 ,  C07F11/005

Abstract: The invention provides a mixed heteroatomic ligand for an oligomerization of olefins catalyst, which ligand includes at least three heteroatoms, of which at least one heteroatom is sulfur and at least two heteroatoms are not the same. The invention also provides a multidentate mixed heteroatomic ligand for an oligomerization of olefins catalyst, which ligand includes at least three heteroatoms of which at least one is a sulfur atom. The ligand may also contain, in addition to sulfur, at least one nitrogen or phosphorous heteroatom.

Abstract translation: 本发明提供用于烯烃催化剂低聚的混合的杂原子配体，该配体包括至少三个杂原子，其中至少一个杂原子是硫并且至少两个杂原子不相同。 本发明还提供用于烯烃催化剂低聚的多齿混合的杂原子配体，该配体包括至少三个其中至少一个是硫原子的杂原子。 除硫之外，配体还可含有至少一个氮或磷杂原子。

公开(公告)号：US20090156824A1

公开(公告)日：2009-06-18

申请号：US12251062

申请日：2008-10-14

Applicant: Akihiro Takemiya ,  Zhijian Liu ,  John F. Hartwig

Inventor： Akihiro Takemiya ,  Zhijian Liu ,  John F. Hartwig

IPC: C07C209/60 ,  B01J31/02 ,  C07D295/02 ,  C07D209/54 ,  C07D211/06

CPC classification number: C07D207/06 ,  B01J31/1805 ,  B01J31/2404 ,  B01J31/2409 ,  B01J31/2452 ,  B01J2231/324 ,  B01J2531/822 ,  C07C209/60 ,  C07D207/09 ,  C07D207/12 ,  C07D209/96 ,  C07D211/12 ,  C07D211/14

Abstract: A method includes reacting an amino group, a composition including rhodium and an organic ligand, and a substrate having structural formula (I) in a reaction mixture. R1 is an organic group including a sp3 carbon atom bonded to CA. R2 is selected from the group consisting of hydrogen, methyl, and an organic group including a sp3 carbon atom bonded to CA. R3 and R4 independently are selected from the group consisting of hydrogen, methyl, and an organic group including a sp3 carbon atom bonded to CB. The method further includes forming a hydroaminated product in the reaction mixture.

Abstract translation: 一种方法包括在反应混合物中使氨基，包含铑和有机配体的组合物和具有结构式（I）的底物反应。 R1是包含与CA键合的sp3碳原子的有机基团。 R2选自氢，甲基和包括与CA结合的sp 3碳原子的有机基团。 R 3和R 4独立地选自氢，甲基和包含与CB结合的sp 3碳原子的有机基团。 所述方法还包括在所述反应混合物中形成聚氨酯产物。

公开(公告)号：US20090099381A1

公开(公告)日：2009-04-16

申请号：US11918257

申请日：2006-03-20

Applicant: Tsutomu Katsuki ,  Bunnai Saito

Inventor： Tsutomu Katsuki ,  Bunnai Saito

IPC: C07F9/38 ,  C07F5/06 ,  C07C251/24 ,  C07C249/02

CPC classification number: C07C251/24 ,  B01J31/1805 ,  B01J31/2213 ,  B01J2231/30 ,  B01J2531/0252 ,  B01J2531/31 ,  C07B53/00 ,  C07F9/3808 ,  C07F9/4006

Abstract: The present invention relates to a production method capable of producing an optically active α-hydroxyphosphonic acid and its derivatives with sufficiently high enantioselectivity not only for aromatic aldehydes but also for aliphatic aldehydes, and more specifically to a method of producing an optically active α-hydroxyphosphonic acid and its derivatives, characterized in that an optically active aluminum(salalen) complex represented by any one of the following formulae (I), (I′), (II) and (II′): [wherein R1s are each alkyl group or aryl group independently; R2s are each alkyl group or aryl group independently; R3s are each alkyl group or aryl group independently, and two R3s may bond with each other to form a ring; R4s are each hydrogen atom, halogen atom, alkyl group, alkoxy group, nitro group, or cyano group independently; R5 is alkyl group; and X1 is halogen atom, alkyl group, alkoxy group, acetoxy group or toluenesulfonyloxy group] is used as a catalyst to asymmetrically hydrophosphonylate an aldehyde with phosphonic acid or its derivatives.

Abstract translation: 本发明涉及一种能够不仅对于芳族醛而且对于脂族醛产生具有足够高的对映体选择性的光学活性的α-羟基膦酸及其衍生物的制造方法，更具体地说，涉及一种制备光学活性的α-羟基膦酸 酸及其衍生物，其特征在于由下式（I），（I'），（II）和（II'）中的任何一种表示的光学活性铝（salalen）络合物：[其中R 1各自为烷基或 芳基独立; R2各自独立地为烷基或芳基; R3各自独立地为烷基或芳基，两个R 3可以彼此键合形成环; R4各自独立地为氢原子，卤素原子，烷基，烷氧基，硝基或氰基; R5是烷基; X 1为卤素原子，烷基，烷氧基，乙酰氧基或甲苯磺酰氧基]作为催化剂，用膦酸或其衍生物不对称地使膦酸化为醛。

公开(公告)号：US07473793B2

公开(公告)日：2009-01-06

申请号：US11353533

申请日：2006-02-13

Applicant: Koichi Mikami ,  Noburo Sayo

Inventor： Koichi Mikami ,  Noburo Sayo

IPC: C07F15/00 ,  C07C29/14

CPC classification number: C07F9/65527 ,  B01J31/1805 ,  B01J31/2409 ,  B01J2231/643 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  C07B2200/07 ,  C07C29/145 ,  C07C211/65 ,  C07F9/5022 ,  C07F9/5027 ,  C07F9/65517 ,  C07F9/65522 ,  C07F15/0046 ,  C07F15/0053 ,  C07C33/22 ,  C07C33/18 ,  C07C33/46

Abstract: A novel transition metal complex, preferably a ruthenium-phosphine complex or rhodium-phosphine complex, which is effectively usable in various asymmetric syntheses and, in particular, is more effectively usable in the asymmetric hydrogenation of various ketones; and a novel process for producing an optically active alcohol with the complex. The novel transition metal complex includes a ligand obtained by introducing a diarylphosphino group into each of the 2- and 2′-positions of diphenyl ether, benzophenone, benzhydrol, or the like. It preferably further includes an optically active 1,2-diphenylethylenediamine coordinated thereto. The complex preferably is a novel diphosphine-ruthenium-optically active diamine complex or diphosphine-rhodium-optically active diamine complex. The process comprises using the complex as an asymmetric hydrogenation catalyst to conduct the asymmetric hydrogenation of a ketone compound to thereby obtain an optically active alcohol in a high optical purity and a high yield.

Abstract translation: 一种新颖的过渡金属络合物，优选钌膦络合物或铑 - 膦配合物，其可有效地用于各种不对称合成，特别是更有效地用于各种酮的不对称氢化; 以及用该复合物生产光学活性醇的新方法。 新型过渡金属络合物包括通过将二芳基膦基引入二苯基醚，二苯甲酮，二苯甲醇等的2位和2位中的每一个得到的配位体。 其优选还包括与其配位的光学活性1,2-二苯基乙二胺。 络合物优选为新型二膦 - 钌 - 光学活性二胺络合物或二膦 - 铑光学活性二胺络合物。 该方法包括使用络合物作为不对称氢化催化剂进行酮化合物的不对称氢化，从而获得高光学纯度和高收率的光学活性醇。

公开(公告)号：US20080286490A1

公开(公告)日：2008-11-20

申请号：US11816688

申请日：2006-02-20

Applicant: Peter Bogdanoff ,  Sebastian Fiechter ,  Iris Herrmann

Inventor： Peter Bogdanoff ,  Sebastian Fiechter ,  Iris Herrmann

IPC: H05H1/24 ,  B01J19/08

CPC classification number: B01J37/349 ,  B01J21/18 ,  B01J31/1805 ,  B01J35/002 ,  B01J37/086 ,  B01J2531/845 ,  H01M4/9008 ,  H01M8/1011 ,  H01M2004/028 ,  Y02E60/523 ,  Y02P70/56

Abstract: A method for preparing a platinum-free chelate catalyst material as an intermediate product for selective electrocatalytic reduction of oxygen includes performing a low-temperature plasma treatment on a powdery form of the transition-metal chelate in a plasma reactor chamber having an inert plasma gas disposed therein. A plasma power, a plasma gas pressure, a plasma initialization and a treatment time of the low-temperature plasma treatment are selected so that molecules of the transition metal chelate are fragmented in the plasma and cross-link in a subsequent chemical reaction so as to form a carbon matrix and retain a basic chelate structure in a surrounding of the transition metal.

Abstract translation: 制备用于选择性电催化还原氧化的中间产物的无铂螯合催化剂材料的方法包括在具有惰性等离子体气体的等离子体反应器室中对过渡金属螯合物的粉末形式进行低温等离子体处理 其中。 选择等离子体功率，等离子体气体压力，等离子体初始化和低温等离子体处理的处理时间，使得过渡金属螯合物的分子在等离子体中碎裂并在随后的化学反应中交联，从而 形成碳基质并在过渡金属的周围保留碱性螯合物结构。

公开(公告)号：US07439314B2

公开(公告)日：2008-10-21

申请号：US10943199

申请日：2004-09-16

Applicant: Linda Kaye Johnson ,  Stephan J. McClain

Inventor： Linda Kaye Johnson ,  Stephan J. McClain

IPC: C08F4/70 ,  C08F4/80 ,  C08F220/02

CPC classification number: C08F10/00 ,  B01J31/1805 ,  B01J31/2282 ,  B01J2231/122 ,  B01J2531/847 ,  C07F9/46 ,  C07F9/5004 ,  C07F9/5009 ,  C07F15/0066 ,  C07F15/04 ,  C07F15/045 ,  C08F4/619 ,  C08F110/02 ,  C08F210/02 ,  C08F2500/04 ,  C08F2500/10 ,  C08F2500/20 ,  C08F220/10 ,  C08F2500/03 ,  C08F220/12 ,  C08F4/6028 ,  C08F4/64065 ,  C08F4/7031 ,  C08F4/7029 ,  C08F4/7019 ,  C08F4/7022 ,  C08F4/7014 ,  C08F4/7008 ,  C08F4/7006 ,  C08F4/40

Abstract: Transition metal complexes of selected monoanionic phosphine ligands, which also contain a selected Group 15 or 16 (IUPAC) element and which are coordinated to a Group 3 to 11 (IUPAC) transition metal or a lanthanide metal, are polymerization catalysts for the (co)polymerization of olefins such as ethylene and α-olefins, and the copolymerization of such olefins with polar group-containing olefins. These and other nickel complexes of neutral and monoanionic bidentate ligands copolymerize ethylene and polar comonomers, especially acrylates, at relatively high ethylene pressures and surprisingly high temperatures, and give good incorporation of the polar comonomers and good polymer productivity. These copolymers are often unique structures, which are described.

Abstract translation: 还包含选定的第15或16族（IUPAC）元素并且与第3至11族（IUPAC）过渡金属或镧系元素金属配位的选择性单阴离子膦配体的过渡金属络合物是用于（共） 烯烃如乙烯和α-烯烃的聚合，以及这些烯烃与极性基团烯烃的共聚。 中性和单阴离子双齿配体的这些和其它镍配合物在相对高的乙烯压力和惊人的高温下共聚乙烯和极性共聚单体，特别是丙烯酸酯，并且使极性共聚单体具有良好的掺入性和良好的聚合物生产率。 这些共聚物通常是独特的结构，其被描述。