公开(公告)号：US20140179936A1

公开(公告)日：2014-06-26

申请号：US14054063

申请日：2013-10-15

Applicant: AEL MINING SERVICES LIMITED

Inventor： Andre Pienaar ,  Laurence Justin Pienaar Wilson ,  Michael Stockenhuber

IPC: C06B49/00 ,  C07D301/12 ,  C07C201/10 ,  C07C273/18

CPC classification number: C06B49/00 ,  C07C29/36 ,  C07C201/02 ,  C07C201/10 ,  C07C273/18 ,  C07C273/1809 ,  C07C273/1863 ,  C07D301/12 ,  C07C31/24 ,  C07C275/50 ,  C07C275/06 ,  C07C203/04

Abstract: A method producing a surfactant from glycerol by converting glycerol, in a first step, to glycidol, polymerizing glycidol to an aliphatic alcohol and finally substituting a hydroxyl group with a substitute anion.

Abstract translation: 通过将甘油转化成缩水甘油，将缩水甘油聚合成脂肪族醇，最后用取代阴离子取代羟基，从甘油中转化甘油的方法。

公开(公告)号：US20140066662A1

公开(公告)日：2014-03-06

申请号：US14012411

申请日：2013-08-28

Applicant: BROMINE COMPOUNDS LTD.

Inventor： Jacob OREN

IPC: C07C201/10

CPC classification number: C07C201/10 ,  C07C201/12 ,  C07C205/15

Abstract: The invention provides a process for preparing bronopol, which process comprises charging a reaction vessel with water, bromopicrin, nitromethane and paraformaldehyde, gradually feeding a base into said reaction vessel under stirring, bringing the reaction to completion and separating bronopol from the aqueous reaction mixture.

Abstract translation: 本发明提供了一种制备青霉酚的方法，该方法包括向反应容器中加入水，溴氰菊酯，硝基甲烷和多聚甲醛，在搅拌下逐渐向碱性物质中加入碱，使反应完成，并从反应混合物中分离出丙三醇。

公开(公告)号：US08124810B2

公开(公告)日：2012-02-28

申请号：US12651946

申请日：2010-01-04

Applicant: Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Miβlitz ,  Ernst Baumann

Inventor： Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Miβlitz ,  Ernst Baumann

IPC: C07C319/14

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6烷基，R 2是C 1 -C 6烷基，R 3，R 4，R 5是氢，C 1 -C 6 - 烷基 ，或R4和R5一起形成键，R6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法。

公开(公告)号：US20110251392A1

公开(公告)日：2011-10-13

申请号：US13168029

申请日：2011-06-24

Applicant: George Wu ,  Anantha R. Sudhakar ,  Mingsheng Huang ,  Tao Wang ,  Vijay Sabesan ,  Ji Xie ,  Frank Xing Chen ,  Marc Poirier ,  Daw-long Kwok ,  Jian Cui ,  Xiaojing Yang ,  Tiruvettipuram K. Thiruvengadam ,  Jing Liao ,  Ilia A. Zavialov ,  Hoa N. Nguyen ,  Ngiap Kie. Lim

Inventor： George Wu ,  Anantha R. Sudhakar ,  Mingsheng Huang ,  Tao Wang ,  Vijay Sabesan ,  Ji Xie ,  Frank Xing Chen ,  Marc Poirier ,  Daw-long Kwok ,  Jian Cui ,  Xiaojing Yang ,  Tiruvettipuram K. Thiruvengadam ,  Jing Liao ,  Ilia A. Zavialov ,  Hoa N. Nguyen ,  Ngiap Kie. Lim

IPC: C07F9/141 ,  C07C205/56 ,  C07C309/16 ,  C07D213/02 ,  C07C235/00 ,  C07C205/44 ,  C07D307/77 ,  C07D277/64

CPC classification number: C07D263/56 ,  C07C69/606 ,  C07C69/732 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C205/55 ,  C07C231/10 ,  C07C231/12 ,  C07C235/28 ,  C07C303/32 ,  C07C309/08 ,  C07C2601/16 ,  C07D277/64 ,  C07D307/92 ,  C07D333/56 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07F7/1804 ,  C07F9/58 ,  Y02P20/55 ,  C07C233/28

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

Abstract translation: 本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。 该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。 本文教导的化学结构可以举例说明如下：

公开(公告)号：US20100311968A1

公开(公告)日：2010-12-09

申请号：US12797343

申请日：2010-06-09

Applicant: Jason Chi-Chung Choy ,  Saul Jaime-Figueroa

Inventor： Jason Chi-Chung Choy ,  Saul Jaime-Figueroa

IPC: C07F7/18 ,  C07C45/65 ,  C07C37/055 ,  C07F5/02 ,  C07C27/00 ,  C07C51/09 ,  C07D213/55 ,  C07D235/26

CPC classification number: C07F5/027 ,  C07B41/02 ,  C07C29/00 ,  C07C37/0555 ,  C07C201/10 ,  C07C253/30 ,  C07D213/803 ,  C07D235/26 ,  C07F7/1892 ,  Y02P20/55 ,  C07C33/46 ,  C07C39/07 ,  C07C255/35 ,  C07C205/56

Abstract: Organic compounds having t-butyl ester or BOC carbonate protecting groups are effectively deprotected by heating in a fluorinated alcohol solution.

Abstract translation: 通过在氟化醇溶液中加热，有效地将具有叔丁酯或BOC碳酸酯保护基的有机化合物去保护。

公开(公告)号：US20100105920A1

公开(公告)日：2010-04-29

申请号：US12651946

申请日：2010-01-04

Applicant: Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

Inventor： Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

IPC: C07D261/04 ,  C07C381/00

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I.Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6烷基，R 2是C 1 -C 6烷基，R 3，R 4，R 5是氢，C 1 -C 6 - 烷基 ，或R4和R5一起形成键，R6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法。

公开(公告)号：US20090281321A1

公开(公告)日：2009-11-12

申请号：US12505079

申请日：2009-07-17

Applicant: George Wu ,  Anantha R. Sudhakar ,  Tao Wang ,  Ji Xie ,  Frank Xing Chen ,  Marc Poirier ,  Mingsheng Huang ,  Vijay Sabesan ,  Daw-long Kwok ,  Jian Cui ,  Xiaojing Yang ,  Tiruvettipuram K. Thiruvengadam ,  Jing Liao ,  Ilia A. Zavialov ,  Hoa N. Nguyen ,  Ngiap Kie Lim

Inventor： George Wu ,  Anantha R. Sudhakar ,  Tao Wang ,  Ji Xie ,  Frank Xing Chen ,  Marc Poirier ,  Mingsheng Huang ,  Vijay Sabesan ,  Daw-long Kwok ,  Jian Cui ,  Xiaojing Yang ,  Tiruvettipuram K. Thiruvengadam ,  Jing Liao ,  Ilia A. Zavialov ,  Hoa N. Nguyen ,  Ngiap Kie Lim

IPC: C07C69/608 ,  C07D405/08 ,  C07F9/40 ,  C07D307/92 ,  C07D417/08 ,  C07D277/64

CPC classification number: C07D263/56 ,  C07C69/606 ,  C07C69/732 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C205/55 ,  C07C231/10 ,  C07C231/12 ,  C07C235/28 ,  C07C303/32 ,  C07C309/08 ,  C07C2601/16 ,  C07D277/64 ,  C07D307/92 ,  C07D333/56 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07F7/1804 ,  C07F9/58 ,  Y02P20/55 ,  C07C233/28

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

Abstract translation: 本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。 该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。 本文教导的化学结构可以举例说明如下：

公开(公告)号：US07309802B2

公开(公告)日：2007-12-18

申请号：US10417083

申请日：2003-04-17

Applicant: Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

Inventor： Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

IPC: C07C239/08

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6 - - 烷基，R 2是C 1 -C 6 - 烷基，R 3，R 4， R 5是氢，C 1 -C 6 - 烷基或R 4和/或 R 5一起形成键，R 6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法。

公开(公告)号：US20070161800A1

公开(公告)日：2007-07-12

申请号：US11684630

申请日：2007-03-11

Applicant: Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Gotz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Boumann

Inventor： Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Gotz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Boumann

IPC: C07D261/02 ,  C07C317/32

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6 - - 烷基，R 2是C 1 -C 6 - 烷基，R 3，R 4， R 5是氢，C 1 -C 6 - 烷基或R 4和/或 R 5一起形成键，R 6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法。

公开(公告)号：US06437168B1

公开(公告)日：2002-08-20

申请号：US09941826

申请日：2001-08-29

Applicant: Kouichi Hirota

Inventor： Kouichi Hirota

IPC: C07C25500

CPC classification number: C07C201/10 ,  C07B39/00 ,  C07C17/208 ,  C07C253/30 ,  C07C255/50 ,  C07C205/12

Abstract: A method for efficiently extracting a reaction product containing a target aromatic fluorine compound formed by the halogen exchange reaction of an aromatic chlorine compound with a fluorinating agent quickly from the reaction vessel without suffering part of the reaction product to remain as a residue inside the reaction vessel is disclosed. Specifically, the reaction product is extracted from the reactor subsequently to the halogen exchange reaction at a temperature in the range of 20-250° C. By this method, the reaction product formed in consequence of the halogen exchange reaction can be efficiently extracted quickly from the reaction vessel, and that without suffering occurrence of a residue of the reaction product.

Abstract translation: 通过芳族氯化合物与氟化剂的卤素交换反应形成的目标芳香族氟化合物的反应产物从反应容器中快速提取而不会产生部分反应产物残留在反应容器内部的方法 被披露。 具体地说，在20-250℃的温度下，从反应器中抽出反应产物进行卤素交换反应。通过这种方法，由于卤素交换反应而形成的反应产物可以从 反应容器，并且不会发生反应产物的残留物。