公开(公告)号：US07050157B2

公开(公告)日：2006-05-23

申请号：US10200384

申请日：2002-07-19

Applicant: James R. Braig ,  Peter Rule ,  Robert D. Gaffney ,  Philip C. Hartstein ,  Julian M. Cortella ,  Kenneth I. Li ,  Bernhard B. Sterling ,  Peng Zheng ,  W. Dale Hall ,  Kenneth G. Witte ,  Mark D. Agostino ,  Daniel S. Goldberger

Inventor： James R. Braig ,  Peter Rule ,  Robert D. Gaffney ,  Philip C. Hartstein ,  Julian M. Cortella ,  Kenneth I. Li ,  Bernhard B. Sterling ,  Peng Zheng ,  W. Dale Hall ,  Kenneth G. Witte ,  Mark D. Agostino ,  Daniel S. Goldberger

IPC: G01N33/48

CPC classification number: A61B5/1455 ,  A61B5/01 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150061 ,  A61B5/150213 ,  A61B5/150274 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150755 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/157 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/35

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

公开(公告)号：US09289169B2

公开(公告)日：2016-03-22

申请号：US14088076

申请日：2013-11-22

Applicant: OptiScan Biomedical Corporation

Inventor： Peter Rule ,  Gil Rivas

IPC: A61B5/00 ,  A61B5/15 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61M5/172 ,  G01N21/27 ,  G06F19/00 ,  A61B5/157 ,  A61B5/1459 ,  A61M5/14 ,  A61M5/168 ,  A61M5/142 ,  G01N21/35 ,  G01N21/359

CPC classification number: G06F19/3412 ,  A61B5/0002 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150305 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/4839 ,  A61B5/7435 ,  A61B5/7475 ,  A61B2560/0271 ,  A61B2560/029 ,  A61B2560/0437 ,  A61M5/1415 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/6072 ,  A61M2230/201 ,  G01N21/274 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/359 ,  G01N33/49 ,  G06F19/00 ,  G06F19/3418 ,  G06F19/3468 ,  G06F19/3487 ,  G16H15/00 ,  G16H40/40

Abstract: Some embodiments provide a system for synchronizing and configuring monitoring devices. In some embodiments, a patient monitoring device settings module is configured to automatically provide configuration settings to a plurality of patient monitoring devices. A monitoring device data module is configured to receive measurement data from at least one of the patient monitoring devices. An electronic medical records system interface is configured to provide patient data at least partially derived from the received measurement data to an electronic medical records system. A patient records interface is configured to provide patient data to at least one of the patient monitoring devices.

Abstract translation: 一些实施例提供用于同步和配置监视设备的系统。 在一些实施例中，患者监视设备设置模块被配置为自动地向多个患者监视设备提供配置设置。 监视设备数据模块被配置为从至少一个患者监视设备接收测量数据。 电子医疗记录系统接口被配置为将至少部分地从接收到的测量数据导出的患者数据提供给电子病历系统。 患者记录界面被配置为向至少一个患者监视设备提供患者数据。

公开(公告)号：US09091676B2

公开(公告)日：2015-07-28

申请号：US13156295

申请日：2011-06-08

Applicant: Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan, II ,  David Callicoat

IPC: G01N33/49 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/153 ,  A61B5/00 ,  G01N21/31 ,  G01N21/35

CPC classification number: G01N33/491 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150801 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61B5/7275 ,  A61B2560/0223 ,  A61B2560/0233 ,  A61B2560/0437 ,  A61B2560/0443 ,  A61B2562/0238 ,  A61B2562/08 ,  G01N21/35 ,  G01N2021/3174 ,  G01N2201/1215 ,  G01N2201/1293 ,  G06F19/00

Abstract: Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.

Abstract translation: 提供了用于分析流体样品的多个组分的系统和方法。 在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。 在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。 在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。 在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分 的样品分离后。

公开(公告)号：US07364562B2

公开(公告)日：2008-04-29

申请号：US11314731

申请日：2005-12-21

Applicant: James R. Braig ,  Richard Keenan

Inventor： James R. Braig ,  Richard Keenan

IPC: A61M35/00

CPC classification number: A61B5/157 ,  A61B5/14532 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61M5/14212 ,  A61M2230/20 ,  G01N21/35

Abstract: A method for maintaining clear passageways in an extracorporeal blood flow system. The method comprises intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system. Also disclosed is an extracorporeal blood flow system. The system comprises a passageway, and a device operatively connected to provide one or more anti-clotting agents to a least a portion of said passageway.

Abstract translation: 一种用于在体外血液流动系统中保持清晰通道的方法。 该方法包括间歇地向体外血液流通系统的通道提供一种或多种抗凝血剂。 还公开了一种体外血液流动系统。 该系统包括通道和可操作地连接以向所述通道的至少一部分提供一种或多种抗凝血剂的装置。

公开(公告)号：US07009180B2

公开(公告)日：2006-03-07

申请号：US10319409

申请日：2002-12-12

Applicant: Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Philip C. Hartstein ,  Robert D. Gaffney

Inventor： Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Philip C. Hartstein ,  Robert D. Gaffney

IPC: G01N21/35

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  A61B2562/0295 ,  G01N21/274 ,  G01N21/314 ,  G01N21/35 ,  G01N27/3271

Abstract: A method uses spectroscopy to determine an analyte concentration in a sample. The method includes producing an absorbance spectrum of the sample. The method further includes shifting the absorbance spectrum to zero in a wavelength region. The method further includes subtracting a water or other substance contribution from the absorbance spectrum.

公开(公告)号：US06959211B2

公开(公告)日：2005-10-25

申请号：US10213730

申请日：2002-08-06

Applicant: Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian M. Cortella ,  Heidi M. Smith ,  Roger O. Herrera ,  Kenneth G. Witte ,  Philip C. Hartstein ,  Mark D. Agostino

Inventor： Peter Rule ,  James R. Braig ,  Daniel S. Goldberger ,  Julian M. Cortella ,  Heidi M. Smith ,  Roger O. Herrera ,  Kenneth G. Witte ,  Philip C. Hartstein ,  Mark D. Agostino

IPC: A61B5/00 ,  G01N21/01 ,  G01N21/03 ,  G01N21/35

CPC classification number: A61B5/01 ,  A61B5/061 ,  A61B5/14532 ,  A61B5/6824 ,  G01J3/0286 ,  G01J3/0291 ,  G01N21/01 ,  G01N21/35 ,  G01N2021/0389 ,  G01N2201/021 ,  G01N2201/0245

Abstract: A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.

Abstract translation: 提供了一种用于无创光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。 在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。 穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。 当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。 当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

公开(公告)号：US07722537B2

公开(公告)日：2010-05-25

申请号：US11314173

申请日：2005-12-21

Applicant: Bernhard B. Sterling ,  James R. Braig ,  Peter Rule ,  W. Dale Hall ,  Mark Wechsler ,  Jennifer H. Gable

Inventor： Bernhard B. Sterling ,  James R. Braig ,  Peter Rule ,  W. Dale Hall ,  Mark Wechsler ,  Jennifer H. Gable

IPC: A61B5/00

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M2205/12 ,  A61M2230/20 ,  A61M2230/201 ,  G01N1/14 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N2021/0346

Abstract: An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.

Abstract translation: 一种用于分析体液组成的装置。 该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端以及间歇地可操作以从患者抽取体液样本的至少一个泵。 该装置还包括流体分析器，定位成分析样品的至少一部分并测量两种或多种分析物的存在。 还公开了一种用于分析患者体液组成的方法。 该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。 该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。

公开(公告)号：US07061593B2

公开(公告)日：2006-06-13

申请号：US10219627

申请日：2002-08-14

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein

IPC: G01N33/48

CPC classification number: A61B5/01 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/157 ,  A61B5/6826 ,  A61B5/6838 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/35

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

公开(公告)号：US06931328B2

公开(公告)日：2005-08-16

申请号：US10291908

申请日：2002-11-08

Applicant: James R. Braig ,  Gary E. Hewett ,  Michael A. Munrow ,  Julian M. Cortella ,  Kamrava Azizi ,  Daniel S. Goldberger

Inventor： James R. Braig ,  Gary E. Hewett ,  Michael A. Munrow ,  Julian M. Cortella ,  Kamrava Azizi ,  Daniel S. Goldberger

IPC: A61B5/00 ,  G06F19/00

CPC classification number: A61B5/1495 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2560/0271 ,  A61B2562/0295 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/40 ,  G16H40/63 ,  Y10S707/99945

Abstract: An analyte concentration monitoring system having network-based communication features which provide a link between an analyte detection system and a centralized computer. The analyte detection system has a processor that calculates analyte concentration in accordance with software executable by the processor. Under certain conditions, the software needs to be updated. Accordingly, when the analyte detection system is connected to the centralized computer, the centralized computer determines whether a software update is needed. If a software update is needed, then the centralized computer conveniently provides the software update to the analyte detection system without intervention from a user.

Abstract translation: 分析物浓度监测系统，其具有基于网络的通信特征，其提供分析物检测系统和集中式计算机之间的连接。 分析物检测系统具有根据可由处理器执行的软件计算分析物浓度的处理器。 在某些条件下，软件需要更新。 因此，当分析物检测系统连接到集中式计算机时，集中式计算机确定是否需要软件更新。 如果需要软件更新，则集中式计算机可方便地向分析物检测系统提供软件更新，而无需用户干预。