公开(公告)号：US08695723B2

公开(公告)日：2014-04-15

申请号：US12994676

申请日：2008-11-19

Applicant: Immanuel Werner ,  Harald Schindler ,  Gerhard Meixner ,  Juergen Schlipf ,  Stefan Holst ,  Andreas Strasser

Inventor： Immanuel Werner ,  Harald Schindler ,  Gerhard Meixner ,  Juergen Schlipf ,  Stefan Holst ,  Andreas Strasser

IPC: B25D17/24

CPC classification number: B25D17/24 ,  B25D17/06 ,  B25D2250/121 ,  B25D2250/245 ,  B25D2250/345 ,  B25D2250/371

Abstract: The invention is based on a hammer drill and/or chisel hammer, having an impact mechanism unit, an impact mechanism housing and at least one damping unit. The invention proposes that the damping unit is arranged on the impact mechanism housing along a main extension direction of the impact mechanism unit.

Abstract translation: 本发明基于锤钻和/或凿锤，具有冲击机构单元，冲击机构壳体和至少一个阻尼单元。 本发明提出，阻尼单元沿冲击机构单元的主延伸方向布置在冲击机构壳体上。

公开(公告)号：US20130172177A1

公开(公告)日：2013-07-04

申请号：US13824113

申请日：2011-09-13

Applicant: Imme Domke ,  Wolfgang Rohde ,  Piotr Antoni Bazula ,  Norbert Mronga ,  Yong Liu ,  Martin Dieterle ,  Stanley Roth ,  Curtis Zimmermann ,  Xinyi Wei ,  Philipp Raff ,  Stephan Andreas Schunk ,  Olga Gerlach ,  Andreas Strasser ,  Michael Paul

Inventor： Imme Domke ,  Wolfgang Rohde ,  Piotr Antoni Bazula ,  Norbert Mronga ,  Yong Liu ,  Martin Dieterle ,  Stanley Roth ,  Curtis Zimmermann ,  Xinyi Wei ,  Philipp Raff ,  Stephan Andreas Schunk ,  Olga Gerlach ,  Andreas Strasser ,  Michael Paul

IPC: B01J23/42

CPC classification number: B01J23/42 ,  B01D53/945 ,  B01D2255/1021 ,  B01D2255/1023 ,  B01D2255/1025 ,  B01D2255/1026 ,  B01D2255/104 ,  B01D2255/2065 ,  B01D2255/20707 ,  B01D2255/20715 ,  B01D2255/20723 ,  B01D2255/2073 ,  B01D2255/20738 ,  B01D2255/20746 ,  B01D2255/20753 ,  B01D2255/20761 ,  B01D2255/20769 ,  B01D2255/20784 ,  B01D2255/20792 ,  B01D2255/9202 ,  B01D2255/9205 ,  B01D2255/9207 ,  B01D2258/012 ,  B01J21/04 ,  B01J21/08 ,  B01J35/0013 ,  B01J35/0086 ,  B01J35/08 ,  B01J35/1014 ,  B01J35/1019 ,  B01J37/0072 ,  B01J37/0203 ,  B01J37/0205 ,  B01J37/0211 ,  B01J37/036 ,  B01J37/088 ,  B01J37/16 ,  Y02T10/22

Abstract: A catalyst comprising (i) a support, (ii) metal particles and (iii) a shell which is arranged between the metal particles, wherein the shell (iii) comprises silicon oxide.

Abstract translation: 一种催化剂，其包含（i）载体，（ii）金属颗粒和（iii）布置在金属颗粒之间的壳，其中壳（iii）包含氧化硅。

公开(公告)号：US20110052603A1

公开(公告)日：2011-03-03

申请号：US12444579

申请日：2007-10-05

Applicant: Philippe Bouillet ,  Andreas Strasser ,  Steve Gerondakis ,  Fook Lin Tai ,  Thomas Kaufmann ,  Raffi Gugasyan

Inventor： Philippe Bouillet ,  Andreas Strasser ,  Steve Gerondakis ,  Fook Lin Tai ,  Thomas Kaufmann ,  Raffi Gugasyan

IPC: A61K39/395 ,  C12N5/00 ,  A61K31/7088 ,  A61K38/02 ,  A61K38/45 ,  A61K38/46 ,  A61K38/48 ,  A61P37/06 ,  A61P31/12 ,  A61P1/16 ,  A61P35/00

CPC classification number: A61K38/45 ,  A61K38/482 ,  A61K38/4873

Abstract: The present invention relates generally to a method of modulating tumor necrosis factor-mediated apoptosis and to agents useful for same. More particularly, the present invention contemplates a method of modulating tumor necrosis factor-mediated hepatocyte apoptosis by modulating an intracellular Bim and/or Bid-dependent signalling mechanism. The method of the present invention is useful, inter alia, in the treatment and/or prophylaxis of conditions characterized by aberrant, unwanted or otherwise inappropriate tumor necrosis factor-mediated apoptosis. The present invention is further directed to methods for identifying and/or designing agents capable of modulating the subject Bim and/or Bid-dependent signalling mechanism.

Abstract translation: 本发明一般涉及调节肿瘤坏死因子介导的细胞凋亡的方法以及可用于其的药剂。 更具体地，本发明考虑通过调节细胞内Bim和/或Bid依赖性信号传导机制来调节肿瘤坏死因子介导的肝细胞凋亡的方法。 本发明的方法尤其可用于治疗和/或预防以异常，不想要或其他不适当的肿瘤坏死因子介导的细胞凋亡为特征的病症。 本发明还涉及用于鉴定和/或设计能够调节受试者Bim和/或Bid依赖性信号传导机制的试剂的方法。

公开(公告)号：US07829450B2

公开(公告)日：2010-11-09

申请号：US11936541

申请日：2007-11-07

Applicant: Markus Hammer ,  Guenther Ruhl ,  Andreas Strasser ,  Michael Melzl ,  Reinhard Goellner ,  Doerthe Groteloh

Inventor： Markus Hammer ,  Guenther Ruhl ,  Andreas Strasser ,  Michael Melzl ,  Reinhard Goellner ,  Doerthe Groteloh

IPC: H01L21/44

CPC classification number: H01L23/3192 ,  H01L24/03 ,  H01L24/05 ,  H01L2224/05006 ,  H01L2224/05082 ,  H01L2224/05184 ,  H01L2224/05571 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2924/0002 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01007 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01027 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01032 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/01068 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/05042 ,  H01L2924/14 ,  Y10S438/954 ,  Y10S438/958 ,  H01L2924/00014 ,  H01L2224/05552

Abstract: In a method of processing a contact pad, a passivation layer stack including at least one passivation layer is formed on at least an upper surface of a contact pad region. A first portion of the passivation layer stack is removed from above the contact pad region, wherein a second portion of the passivation layer remains on the contact pad region and covers the contact pad region. An adhesion layer is formed on the passivation layer stack. The adhesion layer is patterned, wherein the adhesion layer is removed from above the contact pad region. Furthermore, the second portion of the passivation layer stack is removed.

Abstract translation: 在处理接触焊盘的方法中，在接触焊盘区域的至少上表面上形成包括至少一个钝化层的钝化层堆叠。 钝化层堆叠的第一部分从接触焊盘区域上方去除，其中钝化层的第二部分保留在接触焊盘区域上并覆盖接触焊盘区域。 在钝化层堆叠上形成粘附层。 图案化附着层，其中从接触焊盘区域上方去除粘附层。 此外，去除钝化层堆叠的第二部分。

公开(公告)号：US20100199368A1

公开(公告)日：2010-08-05

申请号：US12498691

申请日：2009-07-07

Applicant: Andreas STRASSER ,  Hamsa PUTHALAKATH ,  Andreas VILLUNGER ,  Leigh COULTAS ,  Jennifer BEAUMONT ,  Lorraine Ann O'REILLY ,  David Ching Siang HUANG

Inventor： Andreas STRASSER ,  Hamsa PUTHALAKATH ,  Andreas VILLUNGER ,  Leigh COULTAS ,  Jennifer BEAUMONT ,  Lorraine Ann O'REILLY ,  David Ching Siang HUANG

IPC: A01K67/00 ,  C07H21/04 ,  C07K14/435 ,  A61K38/16 ,  C07K16/00

CPC classification number: C07K14/4747 ,  A01K2217/05 ,  A61K38/00

Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bmf”, and to genetic sequences encoding same and to regulatory sequences such as a promoter sequence directing expression of Bmf. Bmf comprises a BH3 domain which facilitates interaction to pro-survival Bcl-2 family members thereby triggering apoptosis. Bmf is regarded, therefore, as a BH3-only molecule. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry. The present invention further contemplates genetically modified animals in which one or both alleles of Bmf are mutated or partially or wholly deleted alone or in combination with a mutation in one or both alleles of another Bcl-2-type molecule such as but not limited to Bim. The genetically modified animals are useful inter alia in screening for agents which ameliorate the symptoms of diseases caused by defects in apoptosis or which specifically promote apoptosis of target cells.

Abstract translation: 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bmf”，以及编码它们的遗传序列以及调节序列，例如引导Bmf表达的启动子序列。 Bmf包含BH3结构域，其促进与生存Bcl-2家族成员的相互作用，从而引发细胞凋亡。 因此，Bmf被认为是仅BH3分子。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。 本发明进一步考虑了遗传修饰的动物，其中Bmf的一个或两个等位基因单独突变或部分或全部缺失，或与另一个Bcl-2型分子的一个或两个等位基因中的突变组合，例如但不限于Bim 。 遗传修饰的动物尤其可用于筛选改善由凋亡缺陷引起的疾病症状或特异性促进靶细胞凋亡的药剂。

公开(公告)号：US07636516B2

公开(公告)日：2009-12-22

申请号：US11814394

申请日：2006-09-11

Applicant: Karl Frauhammer ,  Gerhard Meixner ,  Martin Rittner ,  Heinz Schnerring ,  Andreas Strasser

Inventor： Karl Frauhammer ,  Gerhard Meixner ,  Martin Rittner ,  Heinz Schnerring ,  Andreas Strasser

IPC: H02P5/00

CPC classification number: B25F5/00 ,  B25D16/006 ,  Y10S388/937

Abstract: The invention relates to a machine tool comprising an electric motor (2) which serves to drive a tool and which has an adjustable, electric brush arrangement (3), and comprising a mode selector switch (6) having various switch positions. Provision is made for an adjusting device (8) to displace the brush arrangement (3) as a function of the switch position of the mode selector switch (6). Furthermore, the invention relates to a corresponding method.

Abstract translation: 本发明涉及一种包括电动机（2）的机床，其用于驱动工具并具有可调整的电刷装置（3），并且包括具有各种开关位置的模式选择器开关（6）。 根据模式选择器开关（6）的开关位置，调整装置（8）用于移动刷子装置（3）。 此外，本发明涉及一种相应的方法。

公开(公告)号：US20090115074A1

公开(公告)日：2009-05-07

申请号：US11936541

申请日：2007-11-07

Applicant: Markus Hammer ,  Guenther Ruhl ,  Andreas Strasser ,  Michael Melzl ,  Reinhard Goellner ,  Doerthe Groteloh

Inventor： Markus Hammer ,  Guenther Ruhl ,  Andreas Strasser ,  Michael Melzl ,  Reinhard Goellner ,  Doerthe Groteloh

IPC: H01L21/441 ,  H01L23/52

CPC classification number: H01L23/3192 ,  H01L24/03 ,  H01L24/05 ,  H01L2224/05006 ,  H01L2224/05082 ,  H01L2224/05184 ,  H01L2224/05571 ,  H01L2224/05624 ,  H01L2224/05647 ,  H01L2924/0002 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01007 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01018 ,  H01L2924/01027 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01032 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/01068 ,  H01L2924/01074 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/05042 ,  H01L2924/14 ,  Y10S438/954 ,  Y10S438/958 ,  H01L2924/00014 ,  H01L2224/05552

Abstract: In a method of processing a contact pad, a passivation layer stack including at least one passivation layer is formed on at least an upper surface of a contact pad region. A first portion of the passivation layer stack is removed from above the contact pad region, wherein a second portion of the passivation layer remains on the contact pad region and covers the contact pad region. An adhesion layer is formed on the passivation layer stack. The adhesion layer is patterned, wherein the adhesion layer is removed from above the contact pad region. Furthermore, the second portion of the passivation layer stack is removed.

Abstract translation: 在处理接触焊盘的方法中，在接触焊盘区域的至少上表面上形成包括至少一个钝化层的钝化层堆叠。 钝化层堆叠的第一部分从接触焊盘区域上方去除，其中钝化层的第二部分保留在接触焊盘区域上并覆盖接触焊盘区域。 在钝化层堆叠上形成粘附层。 图案化附着层，其中从接触焊盘区域上方去除粘附层。 此外，去除钝化层堆叠的第二部分。

公开(公告)号：US07064193B1

公开(公告)日：2006-06-20

申请号：US09508832

申请日：1998-09-17

Applicant: Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

Inventor： Suzanne Cory ,  Jerry Adams ,  David C. S. Huang ,  Liam O'Connor ,  Andreas Strasser ,  Hamsa Puthalakath ,  Lorraine O'Reilly

IPC: C12N15/11 ,  C07K14/00

CPC classification number: C07K14/4747 ,  A61K38/00

Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bim”, and to genetic sequences encoding same. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry.

公开(公告)号：US20050064593A1

公开(公告)日：2005-03-24

申请号：US10479307

申请日：2002-05-30

Applicant: Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine O'reilly ,  David Huang

Inventor： Andreas Strasser ,  Hamsa Puthalakath ,  Andreas Villunger ,  Leigh Coultas ,  Jennifer Beaumont ,  Lorraine O'reilly ,  David Huang

IPC: A01K67/027 ,  A61K38/00 ,  A61K45/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00 ,  C07K14/47 ,  C07K16/18 ,  C12N5/10 ,  C12N15/09 ,  C12N15/11 ,  C12N15/12 ,  C12P21/08 ,  G01N33/53 ,  A61K48/00 ,  C07H21/04

CPC classification number: C07K14/4747 ,  A01K2217/05 ,  A61K38/00

Abstract: The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bmf”, and to genetic sequences encoding same and to regulatory sequences such as a promoter sequence directing expression of Bmf. Bmf comprises a BH3 domain which facilitates interaction to pro-survival Bcl-2 family members thereby triggering apoptosis. Bmf is regarded, therefore, as a BH3-only molecule. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry. The present invention further contemplates genetically modified animals in which one or both alleles of Bmf are mutated or partially or wholly deleted alone or in combination with a mutation in one or both alleles of another Bcl-2-type molecule such as but not limited to Bim. The genetically modified animals are useful inter alia in screening for agents which ameliorate the symptoms of diseases caused by defects in apoptosis or which specifically promote apoptosis of target cells.

Abstract translation: 本发明一般涉及能够特别调节哺乳动物细胞凋亡和编码其的遗传序列的新型分子。 更具体地，本发明涉及Bcl-2家族蛋白质的新成员，本文称为“Bmf”，以及编码它们的遗传序列以及调节序列，例如引导Bmf表达的启动子序列。 Bmf包含BH3结构域，其促进与生存Bcl-2家族成员的相互作用，从而引发细胞凋亡。 因此，Bmf被认为是仅BH3分子。 本发明的分子可用于例如治疗，诊断，抗体产生以及作为能够调节生理细胞死亡或生存和/或调节细胞周期进入的治疗剂的筛选工具。 本发明进一步考虑了遗传修饰的动物，其中Bmf的一个或两个等位基因单独突变或部分或全部缺失，或与另一个Bcl-2型分子的一个或两个等位基因中的突变组合，例如但不限于Bim 。 遗传修饰的动物尤其可用于筛选改善由凋亡缺陷引起的疾病症状或特异性促进靶细胞凋亡的药剂。

公开(公告)号：US08614616B2

公开(公告)日：2013-12-24

申请号：US13008591

申请日：2011-01-18

Applicant: Stefan Willkofer ,  Uwe Wahl ,  Bernhard Knott ,  Markus Hammer ,  Andreas Strasser

Inventor： Stefan Willkofer ,  Uwe Wahl ,  Bernhard Knott ,  Markus Hammer ,  Andreas Strasser

IPC: H01F5/00 ,  H01F27/28

CPC classification number: H01L23/4952 ,  H01F2017/0086 ,  H01L23/48 ,  H01L23/49575 ,  H01L23/5227 ,  H01L23/645 ,  H01L24/45 ,  H01L24/48 ,  H01L24/49 ,  H01L25/0657 ,  H01L28/10 ,  H01L2224/32145 ,  H01L2224/32245 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48247 ,  H01L2224/4903 ,  H01L2224/49107 ,  H01L2224/73215 ,  H01L2224/73265 ,  H01L2924/00014 ,  H01L2924/01322 ,  H01L2924/14 ,  H01L2924/19042 ,  H01L2924/19102 ,  H01L2924/19104 ,  H01L2924/19107 ,  Y10T29/4902 ,  H01L2924/00 ,  H01L2224/45015 ,  H01L2924/207

Abstract: A semiconductor device, a method of manufacturing a semiconductor device and a method for transmitting a signal are disclosed. In accordance with an embodiment of the present invention, the semiconductor device comprises a first semiconductor chip comprising a first coil, a second semiconductor chip comprising a second coil inductively coupled to the first coil, and an isolating intermediate layer between the first semiconductor chip and the second semiconductor chip.

Abstract translation: 公开了半导体器件，半导体器件的制造方法和发送信号的方法。 根据本发明的实施例，半导体器件包括第一半导体芯片，其包括第一线圈，第二半导体芯片，包括感应耦合到第一线圈的第二线圈，以及在第一半导体芯片和第二线圈之间的隔离中间层 第二半导体芯片。