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    Laser-Scatter Measurement Instrument For Organism Detection And Related Network
    3.
    发明申请
    Laser-Scatter Measurement Instrument For Organism Detection And Related Network 审中-公开

    公开(公告)号：US20200372976A1

    公开(公告)日：2020-11-26

    申请号：US16947655

    申请日：2020-08-11

    Applicant: BacterioScan LTD

    Inventor： Dana A. Marshall ,  Theodore S. McMinn ,  Dan Vadim Regelman

    IPC: G16B50/00 ,  C12Q1/04 ,  B01L3/00 ,  G01N21/51

    Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples such that, once a certain bacterial concentration is achieved, the higher concentration sample can be used with a mass spectrometer to identify the type of bacteria. The instrument and mass spectrometer can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.

    Cuvette Assembly Having Chambers For Containing Samples To Be Evaluated Through Optical Measurement
    4.
    发明申请
    Cuvette Assembly Having Chambers For Containing Samples To Be Evaluated Through Optical Measurement 审中-公开

    公开(公告)号：US20200290036A1

    公开(公告)日：2020-09-17

    申请号：US16887792

    申请日：2020-05-29

    Applicant: BacterioScan LTD

    Inventor： Dana A. Marshall ,  Theodore S. McMinn ,  Dan Vadim Regelman

    IPC: B01L3/00 ,  G01N21/51

    Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.

    Multi-sample laser-scatter measurement instrument with incubation feature and systems for using the same
    5.
    发明授权
    Multi-sample laser-scatter measurement instrument with incubation feature and systems for using the same 有权

    公开(公告)号：US10233481B2

    公开(公告)日：2019-03-19

    申请号：US14959054

    申请日：2015-12-04

    Applicant: BacterioScan LTD

    Inventor： Dana A. Marshall ,  Theodore S. McMinn ,  Dan Vadim Regelman

    IPC: C12Q1/06 ,  G01N33/487 ,  G01N21/51 ,  B01L3/00 ,  G01N21/25 ,  G01N21/47

    Abstract: An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The light source and sensor are on a bench that is on a translational or rotational mechanical platform such that optical beam can be moved to multiple sample containers. The instrument can be used for taking measurements of organism concentration in multiple samples as a production tool for microbiology. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples during the test. In another aspect, the instrument can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.

    Laser-scatter measurement instrument having carousel-based fluid sample arrangement
    6.
    发明授权
    Laser-scatter measurement instrument having carousel-based fluid sample arrangement 有权

    公开(公告)号：US10006857B2

    公开(公告)日：2018-06-26

    申请号：US15005321

    申请日：2016-01-25

    Applicant: BacterioScan LTD

    Inventor： Dana A. Marshall ,  Dan Vadim Regelman

    IPC: G01N21/51 ,  G01N21/03

    CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N2021/513 ,  G01N2201/0231 ,  G01N2201/0415

    Abstract: An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.

    Cuvette assembly having chambers for containing samples to be evaluated through optical measurement
    7.
    发明授权
    Cuvette assembly having chambers for containing samples to be evaluated through optical measurement 审中-公开

    公开(公告)号：US10668466B2

    公开(公告)日：2020-06-02

    申请号：US16050105

    申请日：2018-07-31

    Applicant: BacterioScan LTD

    Inventor： Dana A. Marshall ,  Theodore S. McMinn ,  Dan Vadim Regelman

    IPC: B01L3/00 ,  G01N21/51

    Abstract: The present invention is a cuvette assembly for use in optically measuring at least one characteristic of particles within a plurality of liquid samples. The cuvette assembly comprises a main body having internal walls and external walls, and a plurality of cuvettes within the main body at least partially being defined by the internal walls. Each of the plurality of cuvettes has a liquid-input chamber for receiving a respective one of the plurality of liquid samples, a filter, and an optical chamber for receiving a respective filtered liquid sample caused by passing the respective one of the plurality of liquid samples through the filter. Each of the optical chambers includes an entry window for allowing transmission of an input light beam through the filtered liquid sample and an exit window for transmitting a forward scatter signal caused by the particles within the filtered liquid sample.

    Laser-Scatter Measurement Instrument Having Carousel-Based Fluid Sample Arrangement
    8.
    发明申请
    Laser-Scatter Measurement Instrument Having Carousel-Based Fluid Sample Arrangement 审中-公开

    公开(公告)号：US20180313753A1

    公开(公告)日：2018-11-01

    申请号：US16013643

    申请日：2018-06-20

    Applicant: BacterioScan LTD

    Inventor： Dana A. Marshall ,  Dan Vadim Regelman

    IPC: G01N21/51 ,  G01N21/03

    CPC classification number: G01N21/51 ,  G01N21/0303 ,  G01N2021/513 ,  G01N2201/0231 ,  G01N2201/0415

    Abstract: An instrument determines a concentration of bacteria in a plurality of fluid samples, and comprises a housing, a rotatable platform, a plurality of fluid containers, a light source, a sensor, and a motor. The rotatable platform is within the housing. The fluid containers are located on the rotatable platform. Each fluid container holds a corresponding one of the plurality of fluid samples, and has an input window and an output window. The light source provides an input beam for transmission into the input windows of the fluid containers and through the corresponding fluid samples. The input beam creates a forward-scatter signal associated with the concentration of bacteria. The motor rotates the rotatable platform so that the input beam sequentially passes through each fluid sample. A sensor within the housing detects the forward-scatter signal exiting from the output window associated with the fluid sample receiving the input beam.

    PIPETTE HAVING INTEGRATED FILTRATION ASSEMBLY
    9.
    发明申请
    PIPETTE HAVING INTEGRATED FILTRATION ASSEMBLY 审中-公开
    配套集成过滤装置

    公开(公告)号：US20160184743A1

    公开(公告)日：2016-06-30

    申请号：US14978826

    申请日：2015-12-22

    Applicant: BacterioScan LTD

    Inventor： Dana A. Marshall ,  Robert W. Beckmann

    IPC: B01D27/10

    CPC classification number: B01L3/0275 ,  B01L2300/0681 ,  B01L2400/0605

    Abstract: The present invention is a pipette-filtration assembly having a main body defining a first channel, a second channel, a first valve, and a second valve. The first valve is associated with the first channel and permits flow in a first direction while substantially hindering flow in a second direction. The second valve is associated with the second channel and permits flow in the second direction while substantially hindering flow in the first direction. At least one filter is used to filter a fluid sample as the fluid sample flows in the first direction and/or the second direction. The pipette-filtration assembly is preferably disposable and includes one or two stages of integral filtration, primarily for use with an air-displacement pipetting or transfer system.

    Abstract translation: 本发明是一种移液管过滤组件，其具有限定第一通道，第二通道，第一阀和第二阀的主体。 第一阀门与第一通道相关联并且允许沿第一方向流动，同时基本上妨碍沿第二方向的流动。 第二阀与第二通道相关联并且允许沿第二方向的流动，同时基本上妨碍沿第一方向的流动。 当流体样品沿第一方向和/或第二方向流动时，使用至少一个过滤器来过滤流体样品。 移液器 - 过滤组件优选是一次性的并且包括一个或两个阶段的整体过滤，主要用于空气置换移液或转移系统。

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