公开(公告)号：US20250164486A1

公开(公告)日：2025-05-22

申请号：US18809113

申请日：2024-08-19

Applicant: Biogen MA Inc.

Inventor： Gary Lewis Bloomgren ,  Carmen Bozic ,  Sophia Lee ,  Meena Subramanyam ,  Tatiana Plavina

IPC: G01N33/569

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).

公开(公告)号：US20250108109A1

公开(公告)日：2025-04-03

申请号：US18715243

申请日：2022-11-30

Applicant: UCB BIOPHARMA SRL ,  BIOGEN MA INC.

Inventor： ANDREW JEFFREY YATES ,  KATIA BENACCETTA ,  JAN MASSANT

IPC: A61K39/395 ,  A61K9/16 ,  A61K9/19 ,  A61K47/10 ,  A61K47/26 ,  A61K47/60

Abstract: The present invention relates to the field of pharmaceutical compositions. More particularly it is directed to pharmaceutical compositions comprising an antibody molecule, more particularly a Fab-PEG or a Fab′-PEG molecule, e.g., at high concentrations, and to methods of producing such formulations. Pharmaceutical compositions according to the invention can be lyophilised and are stable upon storage at a temperature from about 2 to 25° C. for an appropriate period of time.

公开(公告)号：US20250073434A1

公开(公告)日：2025-03-06

申请号：US18765894

申请日：2024-07-08

Applicant: Biogen MA Inc.

Inventor： Daniel J. Abrams ,  Lisa Lynn Shafer

IPC: A61M27/00 ,  A61B10/00 ,  A61M5/14 ,  A61M5/142 ,  A61M5/158 ,  A61M5/165 ,  A61M25/00 ,  A61M39/02

Abstract: An implantable medical device for delivering therapeutic fluid to, and withdrawing cerebrospinal fluid (CSF) from, a CSF-containing space, includes a first inlet configured to be accessed by a needle of an aspiration device; a first outlet; a first fluid pathway extending from the first inlet to the first outlet; a second inlet; a second outlet; and a second fluid pathway extending from the second inlet to the second outlet. The first fluid pathway is free of a filter configured to prevent passage of a microbe.

公开(公告)号：US12233248B2

公开(公告)日：2025-02-25

申请号：US17508758

申请日：2021-10-22

Applicant: Biogen MA Inc.

Inventor： Haiming Wu

IPC: A61M5/315 ,  A61M5/31

Abstract: A device that regulates, monitors, and provides data on the progress of a large-volume injector during its injection sequence. The device comprises an injector and a monitor assembly. The injector has a syringe having a plunger, and a biasing device that biases the plunger through the syringe. The monitor assembly comprises a resistance unit configured to resist movement of the plunger, a gear connected to the plunger by the resistance unit, and a control unit configured to monitor the position, and regulate the rotation, of the gear. Wherein linear movement of the plunger causes the gear to rotate so that the control unit generates information on the position of the plunger.

公开(公告)号：US20250003983A1

公开(公告)日：2025-01-02

申请号：US18731059

申请日：2024-05-31

Applicant: BIOGEN MA INC.

Inventor： Gary Lewis BLOOMGREN ,  Carmen BOZIC ,  Sophia LEE ,  Amy PACE ,  Tatiana PLAVINA ,  Meena SUBRAMANYAM

IPC: G01N33/68 ,  C07K16/28 ,  C12N7/00 ,  C12Q1/70 ,  G01N33/569

Abstract: The invention relates to methods of assessing a patient' s risk of developing Progressive multifocal leukoencephalopathy (PML).

公开(公告)号：US20240400506A1

公开(公告)日：2024-12-05

申请号：US18692541

申请日：2022-09-16

Applicant: BIOGEN MA INC.

Inventor： Liang Chen ,  Erwin Irdam ,  Daw-long Albert Kwok ,  Nocole Madden ,  John Mascho

IPC: C07D207/404 ,  A61K9/20 ,  A61K31/4015

Abstract: Many active pharmaceutical ingredients (API) are available in tablet form. Particles of the API should have a favorable compaction profile in order to be compressed into tablets, especially when the API is present in a large weight percentage in the tablet. Disclosed herein are particles of diroximel fumarate having improved characteristic for tablet formation, and methods of producing the same.

公开(公告)号：US20240301422A1

公开(公告)日：2024-09-12

申请号：US18661354

申请日：2024-05-10

Applicant: Biogen MA Inc.

Inventor： Holly Kordasiewicz

IPC: C12N15/113 ,  A61K9/00 ,  A61K31/7125 ,  A61K47/02 ,  A61K47/46 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28

CPC classification number: C12N15/113 ,  A61K9/0019 ,  A61K31/7125 ,  A61P25/08 ,  A61P25/14 ,  A61P25/28 ,  A61K47/02 ,  A61K47/46 ,  C12N2310/11 ,  C12N2310/31 ,  C12N2310/315 ,  C12N2310/322 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/3525

Abstract: Provided are compounds, methods, and pharmaceutical compositions for reducing the amount or activity of Tau mRNA in a cell or animal, and in certain instances reducing the amount of Tau protein in a cell or animal. Such compounds, methods, and pharmaceutical compositions are useful to ameliorate at least one symptom of a neurodegenerative disease. Such symptoms include loss of memory, loss of motor function, and increase in the number and/or volume of neurofibrillary inclusions. Such neurodegenerative diseases include tauopathies, Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy (PSP), Chronic Traumatic Encephalopathy (CTE), Corticobasal Ganglionic Degeneration (CBD), Epilepsy, and Dravet's Syndrome.

公开(公告)号：US12066442B2

公开(公告)日：2024-08-20

申请号：US17393335

申请日：2021-08-03

Applicant: Biogen MA Inc.

Inventor： Gary Lewis Bloomgren ,  Carmen Bozic ,  Sophia Lee ,  Meena Subramanyam ,  Tatiana Plavina

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  C12N2710/22011 ,  G01N2333/025 ,  G01N2469/20 ,  G01N2800/28 ,  G01N2800/2814 ,  G01N2800/50 ,  G01N2800/52

Abstract: The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).

公开(公告)号：US12018046B2

公开(公告)日：2024-06-25

申请号：US17718116

申请日：2022-04-11

Applicant: Biogen MA Inc.

Inventor： Austen Ng ,  Robert S. Gronke

IPC: C07K1/18 ,  C07K14/715 ,  C07K14/755

CPC classification number: C07K1/18 ,  C07K14/7151 ,  C07K14/755 ,  C07K2319/30

Abstract: The present invention relates to improved methods in the separation recombinant polypeptides with post-translational modifications from complex mixtures through the use of a cation exchange medium.

公开(公告)号：US20240199743A1

公开(公告)日：2024-06-20

申请号：US18286721

申请日：2022-04-13

Applicant: BIOGEN MA INC.

Inventor： Shibeshih Mitiku BELACHEW

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/00 ,  A61P25/28

CPC classification number: C07K16/2842 ,  A61K9/0019 ,  A61P25/28 ,  A61K2039/505 ,  A61K2039/545

Abstract: Provided herein are methods for administering disease-modifying antibody therapies to asymptomatic and/or early-stage multiple sclerosis patients, including Radiologically Isolated Syndrome patients, based on the identification and/or co-localization of slowly expanding lesions and paramagnetic rim lesions in magnetic resonance images from said patients.