公开(公告)号：US08985116B2

公开(公告)日：2015-03-24

申请号：US11759916

申请日：2007-06-07

Applicant: Rajiv Doshi ,  Bryan Loomas ,  Ryan Kendall Pierce ,  Arthur Ferdinand ,  Arthur G. Sandoval ,  Jeffrey W. Servaites ,  Matthew Durack ,  Daniel Francis Kennedy

Inventor： Rajiv Doshi ,  Bryan Loomas ,  Ryan Kendall Pierce ,  Arthur Ferdinand ,  Arthur G. Sandoval ,  Jeffrey W. Servaites ,  Matthew Durack ,  Daniel Francis Kennedy

IPC: A61M11/00 ,  A61M16/06 ,  A62B23/06 ,  A61M16/08 ,  A61M16/20 ,  A61M16/10 ,  A61F5/08 ,  A61M15/08 ,  A61F5/56

CPC classification number: A62B23/06 ,  A61F5/08 ,  A61F5/56 ,  A61M15/08 ,  A61M15/085 ,  A61M16/0616 ,  A61M16/0688 ,  A61M16/0866 ,  A61M16/106 ,  A61M16/208

Abstract: Described herein are nasal devices. In particular, layered nasal respiratory devices are described. Layered nasal device may include a layered airflow resistor that is configured to resist airflow in a first direction more than airflow in a second direction and that includes a flap valve adjacent to a flap valve limiting layer and an adhesive holdfast layer that is configured to secure the layered airflow resistor in communication with the subject's nasal cavity. Methods of using and methods of assembling layered nasal device are also described.

Abstract translation: 这里描述的是鼻装置。 特别地，描述了分层的鼻呼吸装置。 层状鼻装置可以包括分层气流阻力器，其被配置成抵抗第一方向上的气流，而不是沿着第二方向的气流，并且包括与瓣阀限制层相邻的瓣阀和被配置成固定 分层气流电阻器与受试者的鼻腔连通。 还描述了使用方法和组装分层鼻装置的方法。

公开(公告)号：US08944071B2

公开(公告)日：2015-02-03

申请号：US13590129

申请日：2012-08-20

Applicant: Bryan Loomas ,  Michael D. Laufer ,  David P. Thompson

Inventor： Bryan Loomas ,  Michael D. Laufer ,  David P. Thompson

IPC: A61B19/00 ,  A61F7/12 ,  A61B18/18 ,  A61M29/00 ,  A61B18/08 ,  A61B18/02 ,  A61B18/14 ,  A61M29/02 ,  A61N1/40 ,  A61N5/00 ,  A61N1/06 ,  A61B18/00 ,  A61M25/00 ,  A61B17/00

CPC classification number: A61B18/02 ,  A61B18/04 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/003 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00803 ,  A61B2018/0212 ,  A61B2090/3614 ,  A61F7/123 ,  A61F2007/0018 ,  A61F2007/0059 ,  A61F2007/126 ,  A61M25/0043 ,  A61M29/00 ,  A61M29/02 ,  A61M2025/0096 ,  A61M2210/1039 ,  A61N1/06 ,  A61N1/403 ,  A61N5/00

Abstract: Methods of increasing gas exchange performed by the lung by damaging lung cells, damaging tissue, causing trauma, and/or destroying airway smooth muscle tone with an apparatus inserted into an airway of the lung are disclosed. The damaging of lung cells, damaging tissue, causing trauma, and/or destroying smooth muscle tone with the apparatus may be accomplished via any one of or combinations of the following: heating the airway; cooling the airway; delivering a liquid to the airway; delivering a gas to the airway; puncturing the airway; tearing the airway; cutting the airway; applying ultrasound to the airway; and applying ionizing radiation to the airway.

Abstract translation: 公开了通过用插入肺内气道的装置来增加由肺损伤肺细胞，损伤组织，引起创伤和/或破坏气道平滑肌张力的气体交换的方法。 可以通过以下任何一种或组合来实现肺细胞损伤，损伤组织，引起创伤和/或破坏平滑肌张力：加热气道; 冷气道 向气道输送液体; 向气道输送气体; 刺穿气道; 撕裂气道; 切断气道; 将超声波应用于气道; 并向气道施加电离辐射。

公开(公告)号：US08020700B2

公开(公告)日：2011-09-20

申请号：US12329271

申请日：2008-12-05

Applicant: Rajiv Doshi ,  Bryan Loomas ,  Enrique F. Mendez ,  Arthur G. Sandoval ,  Jeffrey W. Servaites ,  Matthew Durack

Inventor： Rajiv Doshi ,  Bryan Loomas ,  Enrique F. Mendez ,  Arthur G. Sandoval ,  Jeffrey W. Servaites ,  Matthew Durack

IPC: B65D83/10 ,  A61M15/08

CPC classification number: B26D3/10 ,  B26D3/08 ,  B26F1/02 ,  B26F1/3846

Abstract: Described herein are packaging systems for nasal devices, and methods of packaging and/or dispensing nasal devices. A packaging system may include one or a plurality of nasal devices removably secured to a support backing, and a dispenser. In some variations an applicator may also be included. Methods of using and methods of assembling packaging systems and dispensers are also described.

Abstract translation: 这里描述了用于鼻装置的包装系统，以及包装和/或分配鼻装置的方法。 包装系统可以包括可拆卸地固定到支撑背衬的一个或多个鼻部装置和分配器。 在一些变型中，还可以包括施用器。 还描述了使用方法和组装包装系统和分配器的方法。

公开(公告)号：US20100204689A1

公开(公告)日：2010-08-12

申请号：US12765704

申请日：2010-04-22

Applicant: Christopher J. Danek ,  Bryan Loomas ,  Thomas Keast ,  Michael D. Laufer

Inventor： Christopher J. Danek ,  Bryan Loomas ,  Thomas Keast ,  Michael D. Laufer

IPC: A61B17/00 ,  A61B18/04

CPC classification number: A61N5/00 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/003 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00541 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00803 ,  A61B2090/3614 ,  A61M25/0043 ,  A61M29/02 ,  A61M2025/0096 ,  A61M2210/1039 ,  A61N1/06 ,  A61N1/403

Abstract: A method for treating the lung during an acute episode of reversible chronic obstructive pulmonary disease such as an asthma attack. The method comprises transferring energy to an airway wall of an airway such that a diameter of the airway is increased. The energy may be transferred to the airway wall prior to, during or after an asthma attack. The energy may be transferred in an amount sufficient to temporarily or permanently increase the diameter of the airway. The method may be performed while the airway is open, closed or partially closed.

Abstract translation: 在可逆性慢性阻塞性肺疾病如哮喘发作的急性发作期间治疗肺的方法。 该方法包括将能量传递到气道的气道壁，使得气道的直径增加。 在哮喘发作之前，期间或之后，能量可能转移到气道壁。 能量可以以足以临时或永久地增加气道直径的量来转移。 该方法可以在气道打开，关闭或部分关闭时进行。

公开(公告)号：US07422584B2

公开(公告)日：2008-09-09

申请号：US10615491

申请日：2003-07-07

Applicant: Bryan Loomas ,  Gary Kaplan

Inventor： Bryan Loomas ,  Gary Kaplan

IPC: A61B18/18

CPC classification number: A61F2/04 ,  A61F2002/046

Abstract: This is directed to improving the gaseous exchange in a lung of an individual and particularly, this is directed to improving the gaseous exchange in individuals having chronic obstructive pulmonary disease. It generally includes fluidly connecting the lung to an extrapleural airway such as the trachea. In one variation, a conduit is deployed to place the lung and the trachea in fluid communication which allows trapped oxygen-reduced air to pass directly out of the lung and into the trachea. Removing nonfunctional air from the lung tends to improve the gaseous exchange of oxygen into the blood and decompress hyper-inflated lungs. Sealant and biocompatible adhesives may be provided on the exterior of the conduit to prevent side flow, leaks and to otherwise prevent air from entering spaces not intended to receive air such as the pleura space.

Abstract translation: 这旨在改善个体肺中的气体交换，特别是涉及改善具有慢性阻塞性肺疾病的个体中的气体交换。 它通常包括将肺流体连接到胸膜前气道如气管。 在一个变型中，部署导管以将肺和气管置于流体连通中，其允许被捕获的减氧空气直接通过肺部并进入气管。 从肺部去除非功能性空气有助于改善氧气进入血液的气体交换并减压超膨胀的肺。 可以在导管的外部设置密封剂和生物相容性粘合剂，以防止侧流，泄漏并防止空气进入不想接收诸如胸膜空间的空气的空间。

公开(公告)号：US20080041373A1

公开(公告)日：2008-02-21

申请号：US11811339

申请日：2007-06-07

Applicant: Rajiv Doshi ,  Bryan Loomas ,  Ryan Pierce ,  Elliot Sather ,  Arthur Sandoval ,  Jeffrey Servaites ,  Sandrine Lebas ,  Matthew Durack

Inventor： Rajiv Doshi ,  Bryan Loomas ,  Ryan Pierce ,  Elliot Sather ,  Arthur Sandoval ,  Jeffrey Servaites ,  Sandrine Lebas ,  Matthew Durack

IPC: A61M15/08

CPC classification number: A62B23/06 ,  A61F5/08 ,  A61F5/56 ,  A61M15/08 ,  A61M15/085 ,  A61M16/0616 ,  A61M16/0688 ,  A61M16/0866 ,  A61M16/106 ,  A61M16/208

Abstract: Described herein are adhesive nasal devices. In particular, the adhesive nasal respiratory devices described herein are configured to be worn in communication with a subject's nasal cavity and may include a rim body having a passageway therethrough, an airflow resistor in communication with the passageway of the rim body, and a flexible, adhesive holdfast layer extending outward from the periphery of the rim body. The rim body region may be formed from multiple parts (e.g., a first and a second rim body region), and the airflow resistor may be secured between the parts forming the rim body. Methods of manufacturing and assembling these adhesive nasal devices are also described.

Abstract translation: 这里描述的是粘性鼻装置。 特别地，本文所述的粘合性鼻呼吸器具被配置为与被检者的鼻腔连通，并且可以包括具有通过其的通道的边缘体，与边缘体的通道连通的气流电阻器， 粘合保持层从边缘体的周边向外延伸。 轮辋体区域可以由多个部分（例如，第一和第二边缘体区域）形成，并且气流阻力器可以固定在形成轮辋主体的部件之间。 还描述了制造和组装这些粘合剂鼻装置的方法。

公开(公告)号：US07264002B2

公开(公告)日：2007-09-04

申请号：US10809991

申请日：2004-03-26

Applicant: Christopher James Danek ,  Michael Biggs ,  Bryan Loomas ,  Michael D. Laufer ,  Gary Kaplan ,  Kelly Shriner

Inventor： Christopher James Danek ,  Michael Biggs ,  Bryan Loomas ,  Michael D. Laufer ,  Gary Kaplan ,  Kelly Shriner

IPC: A61B19/00

CPC classification number: A61B18/12 ,  A61B17/22004 ,  A61B18/00 ,  A61B18/08 ,  A61B18/14 ,  A61B18/1485 ,  A61B18/1492 ,  A61B2017/00115 ,  A61B2017/00292 ,  A61B2017/003 ,  A61B2017/22062 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00541 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00803 ,  A61B2018/044 ,  A61B2018/046 ,  A61B2018/1807 ,  A61B2090/3614 ,  A61M25/0043 ,  A61M29/00 ,  A61M2025/0096 ,  A61M2210/1039 ,  A61N5/0601

Abstract: This relates to treating an asthmatic lung and more particularly, relates to advancing a treatment device into the lung and treating the lung with the device. This also includes additional steps of treating the airway wall, applying energy or heat to the airway wall in an asthmatic lung.

Abstract translation: 这涉及治疗哮喘肺，更具体地涉及将治疗装置推进到肺中并用装置治疗肺。 这还包括治疗气道壁，向哮喘肺中的气道壁施加能量或热量的附加步骤。

公开(公告)号：US20050187579A1

公开(公告)日：2005-08-25

申请号：US11117905

申请日：2005-04-29

Applicant: Christopher Danek ,  Bryan Loomas ,  Thomas Keast ,  Michael Laufer

Inventor： Christopher Danek ,  Bryan Loomas ,  Thomas Keast ,  Michael Laufer

IPC: A61B18/08 ,  A61B18/14 ,  A61M25/00 ,  A61M29/00 ,  A61N1/06 ,  A61N1/40 ,  A61N1/00

CPC classification number: A61B18/02 ,  A61B18/04 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/003 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00803 ,  A61B2018/0212 ,  A61B2090/3614 ,  A61F7/123 ,  A61F2007/0018 ,  A61F2007/0059 ,  A61F2007/126 ,  A61M25/0043 ,  A61M29/00 ,  A61M29/02 ,  A61M2025/0096 ,  A61M2210/1039 ,  A61N1/06 ,  A61N1/403 ,  A61N5/00

Abstract: A method for treating the lung during an acute episode of reversible chronic obstructive pulmonary disease such as an asthma attack. The method comprises transferring energy to an airway wall of an airway such that a diameter of the airway is increased. The energy may be transferred to the airway wall prior to, during or after an asthma attack. The energy may be transferred in an amount sufficient to temporarily or permanently increase the diameter of the airway. The method may be performed while the airway is open, closed or partially closed.

公开(公告)号：US20050159736A9

公开(公告)日：2005-07-21

申请号：US09999851

申请日：2001-10-25

Applicant: Christopher Danek ,  Bryan Loomas ,  Thomas Keast ,  Michael Laufer

Inventor： Christopher Danek ,  Bryan Loomas ,  Thomas Keast ,  Michael Laufer

IPC: A61B18/08 ,  A61B18/14 ,  A61M25/00 ,  A61M29/00 ,  A61N1/06 ,  A61N1/40 ,  A61B18/18 ,  A61B18/04 ,  A61F7/00 ,  A61F7/12 ,  A61B19/00

CPC classification number: A61B18/02 ,  A61B18/04 ,  A61B18/08 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/003 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00803 ,  A61B2018/0212 ,  A61B2090/3614 ,  A61F7/123 ,  A61F2007/0018 ,  A61F2007/0059 ,  A61F2007/126 ,  A61M25/0043 ,  A61M29/00 ,  A61M29/02 ,  A61M2025/0096 ,  A61M2210/1039 ,  A61N1/06 ,  A61N1/403 ,  A61N5/00

Abstract: A method for treating the lung during an acute episode of reversible chronic obstructive pulmonary disease such as an asthma attack. The method comprises transferring energy to an airway wall of an airway such that a diameter of the airway is increased. The energy may be transferred to the airway wall prior to, during or after an asthma attack. The energy may be transferred in an amount sufficient to temporarily or permanently increase the diameter of the airway. The method may be performed while the airway is open, closed or partially closed.

Abstract translation: 在可逆性慢性阻塞性肺疾病如哮喘发作的急性发作期间治疗肺的方法。 该方法包括将能量传递到气道的气道壁，使得气道的直径增加。 在哮喘发作之前，期间或之后，能量可能转移到气道壁。 能量可以以足以临时或永久地增加气道直径的量来转移。 该方法可以在气道打开，关闭或部分关闭时进行。

公开(公告)号：US06602266B1

公开(公告)日：2003-08-05

申请号：US09492729

申请日：2000-01-27

Applicant: Bryan Loomas ,  James Davenport ,  Mark Mathis

Inventor： Bryan Loomas ,  James Davenport ,  Mark Mathis

IPC: A61F900

CPC classification number: A61F2/147 ,  A61B2017/306 ,  A61B2017/320052 ,  A61F9/013

Abstract: This invention is a surgical device for producing a generally circular, interlamellar pathway within the corneal stroma of the eye. The device is made up of three major components: a vacuum centering guide having an inner bore which fits at one end against the front of the eye, a barrel which fits within the inner bore of the centering guide and to which is attached the third major component, a generally circular dissecting ring. The dissecting ring is shaped in such way that when an eye surgeon twists the barrel to which the ring is attached, the ring moves through the interlamellar space in the stroma producing the desired channel or pathway. The centering guide may optionally include a ring having one or more pins which firmly engage the cornea's epiphilium. The constituent parts of the surgical device, particularly the dissecting ring, also form a part of this invention. A split ring, or intracorneal ring (“ICR”), is inserted into the intrastromal passageway produced by the inventive device. The ICR changes the shape of the cornea and, in doing so, provides a chosen measure of visual correction.

Abstract translation: 本发明是用于在眼睛的角膜基质内产生大致圆形的层间途径的手术装置。 该装置由三个主要部件组成：具有内孔的真空定心导向件，该内孔适合于一端靠近眼睛的前端，一个装在中心导向件内孔内的筒体， 组件，一般为环形解剖环。 解剖环的形状使得当眼外科医生扭转环所附着的圆筒时，环移动通过基质中的层间空间，产生所需的通道或通路。 定心引导件可以可选地包括具有一个或多个销的环，其牢固地接合角膜的骨架。 手术装置的组成部分，特别是解剖环，也构成本发明的一部分。 将裂口环或颈内环（“ICR”）插入由本发明装置产生的基质内通道。 ICR改变了角膜的形状，在这样做时，提供了一种选择的视力矫正措施。