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公开(公告)号:US11944098B2
公开(公告)日:2024-04-02
申请号:US17889670
申请日:2022-08-17
Inventor: Fred H. Yelverton , Lambert McCarty
IPC: A01N43/653 , A01N33/04 , A01N33/18 , A01N43/90
CPC classification number: A01N43/653 , A01N33/04 , A01N33/18 , A01N43/90
Abstract: Disclosed are methods for selectively controlling or modifying the growth of Poa annus in a turfgrass using a composition comprising an herbicidally-effective amount tebuconazole, or a salt thereof.
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公开(公告)号:US20240024325A1
公开(公告)日:2024-01-25
申请号:US18023797
申请日:2021-08-30
Applicant: Emory University , Clemson University Research Foundation
Inventor: Spencer B. Huggett , Rohan H. C. Palmer , Robert Anholt , Trudy MacKay
IPC: A61K31/519 , A61K31/5513 , A61K45/06 , A61P25/30
CPC classification number: A61K31/519 , A61K31/5513 , A61K45/06 , A61P25/30
Abstract: This disclosure relates to using compounds disclosed herein to treat or prevent cocaine use disorder, cocaine toxicity, or other drug related disorders. In certain embodiments, this disclosure relates to methods of treating drug addiction or to help prevent relapse. In certain embodiments, this disclosure relates to methods of treating or preventing cocaine use disorder, cocaine toxicity, or other use disorders comprising administering an effective amount of a compound disclosed herein, such as ibrutinib, [(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one], derivative, or salt thereof to a subject in need thereof. In certain embodiments, the compound is a Bruton's tyrosine kinase (BTK) inhibitor.
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公开(公告)号:US20230340200A1
公开(公告)日:2023-10-26
申请号:US18007992
申请日:2021-06-03
Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION
Inventor: SRIKANTH PILLA , JAMES SCOTT STERNBERG
IPC: C08G71/04
CPC classification number: C08G71/04 , C08G2101/00
Abstract: Bio-based polymer precursors and non-isocyanate polyurethanes (NIPU) and non-isocyanate polyurethane foams (NIPUF) that can be formed from the precursors, as well as methods for the synthesis of the precursors and the polyurethane products are described. The bio-based polymer precursors are formed through functionalization of a bio-based polyol, e.g., lignin, with cyclic carbonates. The bio-based polyol starting materials need not be pre-processed and can include Kraft lignin. NIPU/NIPUF can be synthesized through a ring opening curing reaction of cyclic carbonates of the bio-based polyol precursor with diamines. The carbonates and diamines can include non-toxic bio-based carbonates.
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公开(公告)号:US11799091B2
公开(公告)日:2023-10-24
申请号:US17224429
申请日:2021-04-07
Applicant: Clemson University
Inventor: Mark E. Roberts , Robert K. Emmett , Stephen E. Creager
CPC classification number: H01M4/9008 , H01M8/08 , H01M8/188 , H01M2004/8684 , H01M2004/8689 , H01M2300/0011
Abstract: Provided herein is a redox flow battery comprising an anode comprising anodic redox mediators; a negative electrolyte tank comprising an anolyte; and an anode pump capable of circulating the anolyte through the anode. The redox flow battery further comprises a cathode comprising cathodic redox mediators; a positive electrolyte tank comprising a catholyte and a cathode pump capable of circulating the catholyte through the cathode. A separator is between the anode and cathode.
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公开(公告)号:US20230191283A1
公开(公告)日:2023-06-22
申请号:US18108828
申请日:2023-02-13
Applicant: CLEMSON UNIVERSITY RESEARCH FOUNDATION
Inventor: R. KENNETH MARCUS , TERRI F. BRUCE , LEI WANG , SISI HUANG , TYLER Y. SLONECKI , RHONDA REIGERS POWELL
CPC classification number: B01D15/327 , C07K14/47 , C12N9/00 , C12N15/10 , C12N15/1017 , G01N1/405 , G01N33/5005 , A61K35/68
Abstract: A relatively fast, inexpensive, and non-destructive method for separation and isolation of biologically active nanoparticles is described. Methods include the use of solid phase separation medis such as channeled fibers in a hydrophobic interaction chromatography (HIC) protocol to isolate biologically active nanoparticles from other components of a mixture. Biologically active nanoparticles can include natural nanoparticles (e.g., exosomes, lysosomes, virus particles) as well as synthetic nanoparticles (liposomes, genetically modified virus particles, etc.)
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公开(公告)号:US11633355B2
公开(公告)日:2023-04-25
申请号:US16286898
申请日:2019-02-27
Applicant: Clemson University Research Foundation
Inventor: Jeoung Soo Lee
IPC: A61K9/107 , A61K9/51 , A61K47/69 , A61K45/06 , A61P7/02 , A61P9/00 , A61K47/59 , A61K31/436 , C12N15/113 , A61K31/704 , A61K31/4015 , A61K31/713 , B82Y5/00
Abstract: Provided herein are multi-functional particles. The particles may include poly(lactide-co-glycolide)-g-polyethylenimine (PLGA-g-PEI (PgP)), at least one targeting moiety, at least one therapeutic agent, and/or at least one nucleic acid. Also provided herein are methods of using the multi-functional particles.
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公开(公告)号:US20220390810A1
公开(公告)日:2022-12-08
申请号:US17838632
申请日:2022-06-13
Applicant: Clemson University
Inventor: Eric G. Johnson , Jerome Keith Miller , Richard Watkins , Kaitlyn Morgan , Wenzhe Li , Yuan Li
Abstract: This system and method of for providing a tunable orbital angular momentum system for providing higher order Bessel beams comprising: an acousto-optical deflector configured to receive an input beam, deflect a first portion of the input beam a first deflection angle relative to an axis of propagation and along an optical axis and deflect a second portion of the input beam a second deflection angle relative to the optical axis; a line generator disposed along the optical angle for receiving the first portion and the second portion of the input beam and provide an elliptical Gaussian mean; a log-polar optics assembly disposed along the optical angle for receiving the elliptical Gaussian beam and wrapping the elliptical Gaussian beam with an asymmetric ring; and, a Fourier lens configured to receive the wrapped elliptical Gaussian beam.
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公开(公告)号:US11510906B1
公开(公告)日:2022-11-29
申请号:US16811135
申请日:2020-03-06
Applicant: Clemson University
Inventor: Daniel C. Whitehead , James C. Morris , Chandima J. Narangoda
IPC: A61K31/4196 , A61P33/02 , A61K31/502
Abstract: A drug product and method for treating a parasitic disease in a host is described. The drug product comprises:
a carrier matrix; and
a drug substance having the formula: wherein:
R1 is selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;
each R3 is independently selected from the group consisting of H, aliphatic of 1 to 100 carbons and arene comprising up to 100 carbons;
Y represents those elements necessary to form a 5 or 6 membered ring;
X is selected from the group consisting of B, O, N, S, Se and P; and
n is 1-4 as necessary to complete the valence of X.-
公开(公告)号:US11452294B2
公开(公告)日:2022-09-27
申请号:US16770442
申请日:2018-12-06
Inventor: Fred H. Yelverton , Lambert McCarty
IPC: A01N43/90 , A01N43/653 , A01N33/04 , A01N33/18
Abstract: Disclosed are methods for selectively controlling or modifying the growth of Poa annua in a turfgrass using a composition comprising an herbicidally-effective amount tebuconazole, or a salt thereof.
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公开(公告)号:US20220125071A1
公开(公告)日:2022-04-28
申请号:US17512136
申请日:2021-10-27
Applicant: Clemson University Research Foundation
Inventor: Dilrukshi Thavarajah , Pushparajah Thavarajah
Abstract: Disclosed herein are various organic plant protein compositions including a balanced amino acid profile with no chemical residues. Further disclosed herein are methods for creating organic plant protein compositions from organic plant material(s). In some embodiments, the organic plant protein composition includes pea protein, sorghum protein, organic baking powder, and organic vinegar.
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