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    Dispensing Apparatus
    3.
    发明申请
    Dispensing Apparatus 有权

    公开(公告)号：US20250127346A1

    公开(公告)日：2025-04-24

    申请号：US18693194

    申请日：2022-09-16

    Applicant: Colgate-Palmolive Company

    Inventor： Juhi SOLANKI ,  Francis TATU ,  Mark BARTLETT

    IPC: A47K10/44 ,  A47K10/32

    Abstract: A dispensing apparatus for holding and dispensing sheets containing a benefit composition. The dispensing apparatus includes a housing having a longitudinal axis, a base component having a dispensing slot, and a lid component coupled to the base component to define a storage cavity. A stack of sheets is positioned in the storage cavity and oriented at an oblique angle relative to the longitudinal axis of the housing. A dispensing member is configured to dispense a lowermost sheet from the stack. The lid component is alterable between a non-dispensing position and a dispensing position by applying a downward axial force onto the lid component relative to the base component during which the lid component engages the dispensing member and the dispensing member engages the lowermost sheet from the stack of sheets to dispense the lowermost sheet through the dispensing slot.

    Biomarker of gingivitis diagnosis and treatment
    7.
    发明授权
    Biomarker of gingivitis diagnosis and treatment 有权

    公开(公告)号：US12265086B2

    公开(公告)日：2025-04-01

    申请号：US17668456

    申请日：2022-02-10

    Applicant: Colgate-Palmolive Company

    Inventor： Dandan Chen ,  Harsh Mahendra Trivedi ,  James Masters ,  Richard P. Darveau ,  Jeffrey S. Mclean

    IPC: G01N33/68

    Abstract: Methods of identifying an individual as being a slow gingivitis responder or a high gingivitis responder are disclosed. Some methods are based on IL-1β levels in the individual's GCF at the site of inflammation. Some methods are based on MIF and/or CCL-1 levels in the individual's GCF in healthy tissue distant from the site of inflammation. Some disclosed methods are based on temporal differences in IL-8, IL-6 and/or TNFα levels in the individual's GCF in healthy tissue distant from the site of inflammation during the development of plaque induced inflammation. Methods of treating an individual who has gingivitis and methods of preventing gingivitis are also provided. The treatment and prevention methods comprise determining if individual is a slow gingivitis responder or a high gingivitis responder and applying oral care compositions to the individual's oral cavity.

    Oral cavity treatment device
    10.
    发明授权
    Oral cavity treatment device 有权

    公开(公告)号：US12239213B2

    公开(公告)日：2025-03-04

    申请号：US18311836

    申请日：2023-05-03

    Applicant: Colgate-Palmolive Company

    Inventor： Jianhong Qiu ,  Erin Speicher ,  Leighton Davies-Smith

    IPC: A61C19/06 ,  A46B11/00

    Abstract: A tooth sensitivity treatment device and an applicator tip thereof. The tooth sensitivity treatment device may be configured to dispense a sensitivity formulation onto a user's teeth. The tooth sensitivity treatment device may further be configured to massage the sensitivity formulation onto the user's teeth after dispensing. The applicator may have a bottom end, a top end, and a longitudinal axis extending therebetween. The applicator may include an application portion that is not intersected by the longitudinal axis. The application portion may have an outer surface that is oriented at an oblique angle relative to the longitudinal axis. The applicator may include a resilient material component and a rigid material component that are integrally coupled together. The resilient material component may form the entirety of the application portion to increase flexibility while massaging the sensitivity formulation onto the user's teeth.

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