中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

18 records (took 0.009 seconds)

    Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group
    1.
    发明授权
    Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group 失效
    具有降低的基质效应并含有醛反应性官能团的颗粒试剂

    公开(公告)号：US06231982B1

    公开(公告)日：2001-05-15

    申请号：US08988628

    申请日：1997-12-10

    Applicant: Chengrong Wang

    Inventor： Chengrong Wang

    IPC: B32B516

    CPC classification number: G01N33/548 ,  G01N33/5434 ,  G01N33/54393 ,  G01N2446/20 ,  G01N2446/86 ,  Y10T428/2998

    Abstract: The invention is directed to the preparation of magnetic and non-magnetic particles coated with a polyaldehyde dextran material and a process for making the same. The polyaldehyde dextran coated particles of the invention are suitable for use in immunological assays and exhibit a reduced matrix effect in such assays when compared to convention particles without a polyaldehyde dextran coating.

    Abstract translation: 本发明涉及涂覆有聚醛葡聚糖材料的磁性和非磁性颗粒的制备及其制备方法。 本发明的聚醛葡聚糖包被的颗粒适用于免疫测定，并且与常规的没有聚醛葡聚糖涂层的颗粒相比，在这种测定中表现出降低的基质效应。

    Carbamazepine derivatives used in particle reagents
    5.
    发明授权
    Carbamazepine derivatives used in particle reagents 失效
    用于粒子试剂的卡马西平衍生物

    公开(公告)号：US5830768A

    公开(公告)日：1998-11-03

    申请号：US832002

    申请日：1997-04-03

    Applicant: Chengrong Wang

    Inventor： Chengrong Wang

    IPC: G01N33/53 ,  A61K39/00 ,  C07D223/22 ,  C07D223/26 ,  C07D223/32 ,  G01N33/532 ,  G01N33/94 ,  G01N33/546

    CPC classification number: G01N33/532 ,  C07D223/22 ,  C07D223/32 ,  G01N33/9473 ,  G01N33/9486 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S435/975 ,  Y10S436/823 ,  Y10S530/806 ,  Y10T436/171538

    Abstract: The present invention provides a novel carbamazepine hydrazide compound suitable for covalent attachment to a polymer particle reagent, having the general formula ##STR1## The present invention also provides a novel carbamazepine acid compound suitable for attachment to proteins for the production of carbamazepine immunogens. The carbamazepine antigen of the present invention has the following general structure: ##STR2## where X is C.dbd.O, CH.sub.2 or SO.sub.2 ; Y is C.dbd.O, CH.sub.2, SO.sub.2 ; R is an alkyl and P is a protein or a hapten.

    Abstract translation: 本发明提供了一种新颖的卡马西平酰肼化合物，其适用于共价连接到具有通式的聚合物颗粒试剂。本发明还提供了一种新颖的卡马西平酸化合物，其适于与用于生产卡马西平免疫原的蛋白质连接。 本发明的卡马西平抗原具有以下通用结构：其中X为C = O，CH 2或SO 2; Y为C = O，CH 2，SO 2; R是烷基，P是蛋白质或半抗原。

    Compositions for use as a signal generation component and methods of using same
    6.
    发明授权
    Compositions for use as a signal generation component and methods of using same 有权
    用作信号发生组件的组合物及其使用方法

    公开(公告)号：US07691647B2

    公开(公告)日：2010-04-06

    申请号：US11499519

    申请日：2006-08-04

    Applicant: Alan R. Craig ,  Zhu Teng ,  Richard C. Wright ,  Chengrong Wang

    Inventor： Alan R. Craig ,  Zhu Teng ,  Richard C. Wright ,  Chengrong Wang

    IPC: G01N33/553 ,  G01N33/548 ,  G01N33/543 ,  G01N33/546 ,  G01N33/24 ,  C07C49/15 ,  C07C49/215

    CPC classification number: G01N33/586 ,  G01N33/582 ,  G01N2458/40 ,  Y10S435/968

    Abstract: Compositions suitable for use as signal generation components of an immunoassay, and methods for their use. According to one aspect of the invention, the composition includes a carrier having a coating of an aminodextran and a metal chelate incorporated therein. The metal chelate is present in the amount of at least 0.065 μMole per gram of carrier, and the aminodextran coating density averaging at least about 45 μg per milligram of carrier. In another aspect of the invention, carrier is dyed with a complex having the formula: M(L1)x(L2)y, wherein M is a metal selected from the group consisting of europium, terbium, dysprosium, samarium, osmium and ruthenium; L1 is a ligand selected from the group consisting of DPP, TOPO, TPPO; L2 comprises a ligand having the formula wherein R is one or more substituents, each substituent comprising an electron donating group; n=2-10; x=1-2; and y=2-4.

    Abstract translation: 适用于免疫测定的信号产生组分的组合物及其使用方法。 根据本发明的一个方面，组合物包括具有氨基葡聚糖和金属螯合物的涂层的载体。 金属螯合物以每克载体至少0.065mMole的量存在，并且氨基葡聚糖涂层密度平均至少约45μg/毫克载体。 在本发明的另一方面，载体用具有下式的复合物染色：M（L1）x（L2）y，其中M是选自铕，铽，镝，钐，锇和钌的金属; L1是选自DPP，TOPO，TPPO; L2包含具有下式的配体：其中R是一个或多个取代基，每个取代基包括给电子基团; n = 2-10; x = 1-2; y = 2-4。

    Method and composition useful for determining FK 506
    7.
    发明授权
    Method and composition useful for determining FK 506 有权
    用于确定FK 506的方法和组成

    公开(公告)号：US07186518B2

    公开(公告)日：2007-03-06

    申请号：US10719868

    申请日：2003-11-21

    Applicant: Chengrong Wang ,  Tie Q. Wei ,  Zhu Teng

    Inventor： Chengrong Wang ,  Tie Q. Wei ,  Zhu Teng

    IPC: G01N33/535 ,  G01N33/533 ,  G01N33/534 ,  G01N33/553

    CPC classification number: C07D498/18 ,  G01N33/9493 ,  Y10S436/815 ,  Y10S436/825

    Abstract: New derivatives of FK 506 are disclosed. These new derivatives and other derivatives that are useful for determining the levels of FK 506 in a sample are also provided as are assay procedures and kits for use in determining the levels of FK 506 or other macrophilin binding substances in blood, particularly un-extracted blood in the presence of specific binding proteins for FK 506.

    Abstract translation: 披露了FK 506的新衍生物。 这些新衍生物和其他可用于测定样品中FK 506水平的衍生物也可用于测定血液中FK 506或其他巨噬细胞结合物质，特别是未提取血液中的水平的测定程序和试剂盒 在FK 506的特异结合蛋白存在下。

    Compositions for use as a signal generation component and methods of using same
    8.
    发明申请
    Compositions for use as a signal generation component and methods of using same 有权
    用作信号发生组件的组合物及其使用方法

    公开(公告)号：US20060270063A1

    公开(公告)日：2006-11-30

    申请号：US11499519

    申请日：2006-08-04

    Applicant: Alan Craig ,  Zhu Teng ,  Richard Wright ,  Chengrong Wang

    Inventor： Alan Craig ,  Zhu Teng ,  Richard Wright ,  Chengrong Wang

    IPC: G01N33/543 ,  C07F5/00 ,  C07F15/00

    CPC classification number: G01N33/586 ,  G01N33/582 ,  G01N2458/40 ,  Y10S435/968

    Abstract: Compositions suitable for use as signal generation components of an immunoassay, and methods for their use. According to one aspect of the invention, the composition includes a carrier having a coating of an aminodextran and a metal chelate incorporated therein. The metal chelate is present in the amount of at least 0.065 μM per milligram of carrier, and the aminodextran coating density averaging at least about 45 μg per milligram of carrier. In another aspect of the invention, carrier is dyed with a complex having the formula: M(L1)x(L2)y, wherein M is a metal selected from the group consisting of europium, terbium, dysprosium, samarium, osmium and ruthenium; L1 is a ligand selected from the group consisting of DPP, TOPO, TPPO; L2 comprises a ligand having the formula wherein R is one or more substituents, each substituent comprising an electron donating group; n=2-10; x=1-2; and y=2-4.

    Abstract translation: 适用于免疫测定的信号产生组分的组合物及其使用方法。 根据本发明的一个方面，组合物包括具有氨基葡聚糖和金属螯合物的涂层的载体。 金属螯合物的存在量为每毫克至少0.065微摩尔的载体，并且氨基葡聚糖涂层的密度平均至少约为45毫克/毫克载体。 在本发明的另一方面，载体用具有下式的复合物染色：<？in-line-formula description =“In-line Formulas”end =“lead”？> M（L1）x （L2），<？in-line-formula description =“In-line formula”end =“tail”？>其中M是选自铕，铽， 镝，钐，锇和钌; L1是选自DPP，TOPO，TPPO; L2包含具有下式的配体：其中R是一个或多个取代基，每个取代基包括给电子基团; n = 2-10; x = 1-2; y = 2-4。

    Compositions for use as a Signal Generation Component and Methods of Using Same
    9.
    发明申请
    Compositions for use as a Signal Generation Component and Methods of Using Same 审中-公开
    用作信号发生组件的组合物及其使用方法

    公开(公告)号：US20090325316A1

    公开(公告)日：2009-12-31

    申请号：US12555734

    申请日：2009-09-08

    Applicant: Alan R. Craig ,  Zhu Teng ,  Richard C. Wright ,  Chengrong Wang

    Inventor： Alan R. Craig ,  Zhu Teng ,  Richard C. Wright ,  Chengrong Wang

    IPC: G01N33/553

    CPC classification number: G01N33/586 ,  G01N33/582 ,  G01N2458/40 ,  Y10S435/968

    Abstract: Compositions suitable for use as signal generation components of an immunoassay, and methods for their use. According to one aspect of the invention, the composition includes a carrier having a coating of an aminodextran and a metal chelate incorporated therein. The metal chelate is present in the amount of at least 0.065 μM per milligram of carrier, and the aminodextran coating density averaging at least about 45 μg per milligram of carrier. In another aspect of the invention, carrier is dyed with a complex having the formula: M(L1)x(L2)y, wherein M is a metal selected from the group consisting of europium, terbium, dysprosium, samarium, osmium and ruthenium; L1 is a ligand selected from the group consisting of DPP, TOPO, TPPO; L2 comprises a ligand having the formula wherein R is one or more substituents, each substituent comprising an electron donating group; n=2-10; x=1-2; and y=2-4.

    Abstract translation: 适用于免疫测定的信号产生组分的组合物及其使用方法。 根据本发明的一个方面，组合物包括具有氨基葡聚糖和金属螯合物的涂层的载体。 金属螯合物的存在量为每毫克至少0.065微摩尔的载体，并且氨基葡聚糖涂层的密度平均至少约为45毫克/毫克载体。 在本发明的另一方面，载体用具有下式的复合物染色：M（L1）x（L2）y，其中M是选自铕，铽，镝，钐，锇和钌的金属; L1是选自DPP，TOPO，TPPO; L2包含具有下式的配体：其中R是一个或多个取代基，每个取代基包括给电子基团; n = 2-10; x = 1-2; y = 2-4。

    Carbonate ionophore with improved selectivity
    10.
    发明授权
    Carbonate ionophore with improved selectivity 失效
    具有提高选择性的碳酸根离子载体

    公开(公告)号：US06391175B1

    公开(公告)日：2002-05-21

    申请号：US09716889

    申请日：2000-11-21

    Applicant: Chengrong Wang ,  Daniel Brown

    Inventor： Chengrong Wang ,  Daniel Brown

    IPC: G01N2740

    CPC classification number: G01N27/3335 ,  C07C235/84

    Abstract: The invention pertains to a novel ionophore having the general structure: wherein R1, R2, R3 and R4 are independently straight or branched chain alkyl having 4 to 12 carbon atoms or the alkyl groups may optionally contain a cycloalkyl group having 3 to 8 carbon atoms or R1 and R2 or R3 and R4 together with N to which they are attached, can form a ring having 5 to 8 carbon atoms. This ionophore has increased selectivity for carbonate ions over other ions, especially salicylate. The invention includes membranes containing effective amounts of the novel ionophores and -sensors containing these membranes.

    Abstract translation: 本发明涉及具有以下一般结构的新型离子载体：其中R1，R2，R3和R4独立地为具有4至12个碳原子的直链或支链烷基，或者烷基可任选地含有具有3-8个碳原子的环烷基或 R1和R2或R3和R4与它们所连接的N一起可以形成具有5至8个碳原子的环。 这种离子载体对碳酸根离子比其他离子，特别是水杨酸盐具有更高的选择性。 本发明包括含有有效量的新型离子载体和含有这些膜的传感器的膜。

Patent Agency Ranking