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    Compositions containing polysaccharides
    1.
    发明授权
    Compositions containing polysaccharides 有权
    含多糖的组合物

    公开(公告)号：US09579303B2

    公开(公告)日：2017-02-28

    申请号：US11884433

    申请日：2006-02-14

    Applicant: Chyi-Cheng Chen ,  Bruno H. Leuenberger

    Inventor： Chyi-Cheng Chen ,  Bruno H. Leuenberger

    IPC: A61K36/00 ,  A61K31/352 ,  A61K36/48 ,  A61K9/16

    CPC classification number: A61K31/352 ,  A61K9/1652 ,  A61K36/48

    Abstract: The disclosure relates to compositions, preferably in the form of a powder and/or granules, which contain as principal components a first component selected from the group consisting of isoflavones, soy products containing at least one isoflavone, and mixtures thereof, together with a polysaccharide as second component. A preferred first component is genistein or a pharmaceutically acceptable salt or derivative thereof (e.g. genistin). A preferred second component is pectin. The disclosure further relates to a process for the manufacture of such compositions, and their use in dietary supplements, pharmaceutical and personal care compositions. The disclosure is also directed to the use of a polysaccharide for improving the flowability of a component selected from the group consisting of isoflavones, soy products, preferably those containing at least one isoflavone, and mixtures thereof.

    Abstract translation: 本公开内容涉及组合物，优选为粉末和/或颗粒形式，其以主要组分的形式含有选自异黄酮，含有至少一种异黄酮的大豆制品及其混合物的第一组分，以及多糖 作为第二个组成部分。 优选的第一组分是染料木黄酮或其药学上可接受的盐或衍生物（例如染料木黄酮）。 优选的第二组分是果胶。 本公开还涉及制备这种组合物的方法及其在膳食补充剂，药物和个人护理组合物中的用途。 本公开还涉及多糖用于改善选自异黄酮，大豆产品，优选含有至少一种异黄酮的那些的组分的流动性及其混合物的流动性的用途。

    Compositions Containing Polysaccharides
    3.
    发明申请
    Compositions Containing Polysaccharides 有权
    含多糖的组合物

    公开(公告)号：US20080193575A1

    公开(公告)日：2008-08-14

    申请号：US11884433

    申请日：2006-02-14

    Applicant: Chyi-Cheng Chen ,  Bruno H. Leuenberger

    Inventor： Chyi-Cheng Chen ,  Bruno H. Leuenberger

    IPC: A61K31/352 ,  A61K36/48

    CPC classification number: A61K31/352 ,  A61K9/1652 ,  A61K36/48

    Abstract: The present invention relates to compositions, preferably in the form of a powder and/or granules, which contain as principal components a first component selected from the group consisting of isoflavones, soy products containing at least one isoflavone, and mixtures thereof, together with a polysaccharide as second component. A preferred first component is genistein or a pharmaceutically acceptable salt or derivative thereof (e.g. genistin). A preferred second component is pectin. The present invention further relates to a process for the manufacture of such compositions, and their use in dietary supplements, pharmaceutical and personal care compositions. The present invention is also directed to the use of a polysaccharide for improving the flowability of a component selected from the group consisting of isoflavones, soy products, preferably those containing at least one isoflavone, and mixtures thereof.

    Abstract translation: 本发明涉及组合物，优选以粉末和/或颗粒的形式，其以主要组分的形式含有选自异黄酮，含有至少一种异黄酮的大豆制品及其混合物的第一组分，以及一种 多糖作为第二成分。 优选的第一组分是染料木黄酮或其药学上可接受的盐或衍生物（例如染料木黄酮）。 优选的第二组分是果胶。 本发明还涉及制备这种组合物的方法及其在膳食补充剂，药物和个人护理组合物中的用途。 本发明还涉及多糖用于改善选自异黄酮，大豆制品，优选含有至少一种异黄酮的组分的组分的流动性及其混合物的流动性的用途。

    Synthesis of L-fructose and derivatives thereof
    4.
    发明授权
    Synthesis of L-fructose and derivatives thereof 失效
    L-果糖及其衍生物的合成

    公开(公告)号：US4623721A

    公开(公告)日：1986-11-18

    申请号：US613184

    申请日：1984-05-23

    Applicant: Chyi-Cheng Chen ,  Roy L. Whistler

    Inventor： Chyi-Cheng Chen ,  Roy L. Whistler

    IPC: C07H1/00 ,  C07H3/02 ,  C07H9/04 ,  C07H15/04 ,  C07H3/10

    CPC classification number: C07H9/04 ,  C07H3/02

    Abstract: It is disclosed that L-fructose can be produced in high yield from L-sorbose. The process involves the inversion of the hydroxyl groups on carbon atoms C3 and C4 of L-sorbose to produce L-fructose. This inversion can be accomplished in simple, commercial equipment with the aid of common reagents. L-sorbose or an appropriately blocked derivative thereof is reacted so as to introduce or create a good leaving group, preferably mesyl or tosyl, at chiral carbon C3 thereby displacing the hydroxyl previously at that position. The leaving group is then displaced, preferably under alkaline conditions, in such a way that the hydroxyl oxygen atom at chiral carbon C4 attaches to chiral carbon C3, thereby displacing the leaving group while forming a 3,4-oxirane (epoxide) ring. The 3,4-oxirane ring forms in a downward position relative to the Haworth presentation thereby inverting chiral carbon C3 during formation of the 3,4-oxirane ring.The 3,4-oxirane ring is then opened under acidic or alkaline conditions to yield a sugar ring with a hydroxyl group in a position above the sugar ring at chiral carbon C4, and a hydroxyl group in a downward position at C3.Removal of any remaining blocking groups yields L-fructose. This may be accomplished by acid hydrolysis.There are also disclosed novel classes of compounds which act as intermediaries in the synthesis of L-fructose.

    Abstract translation: 公开了L-果糖可以高收率从L-山梨糖生产。 该过程涉及L-山梨糖的碳原子C3和C4上的羟基的反转以产生L-果糖。 借助于常用试剂，可以在简单的商业设备中完成这种反演。 使L-山梨糖或其适当封闭的衍生物反应，以在手性碳C3处引入或产生良好的离去基团，优选甲磺酰基或甲苯磺酰基，从而在该位置预先置换羟基。 然后优选在碱性条件下将离去基团置换，使得手性碳C4上的羟基氧原子连接到手性碳C3上，从而置换离去基团同时形成3,4-环氧乙烷（环氧化物）环。 3,4-环氧乙烷环相对于Haworth呈现在向下的位置，因此在形成3,4-环氧乙烷环期间反转手性碳C3。 然后在酸性或碱性条件下打开3,4-环氧乙烷环，得到手性碳C 4上糖基上方羟基上的糖环，在C3下方的羟基。 除去任何剩余的封闭基团产生L-果糖。 这可以通过酸水解完成。 还公开了在L-果糖的合成中作为中间体的新类化合物。

    Compositions comprising pectin and ascorbic acid
    8.
    发明申请
    Compositions comprising pectin and ascorbic acid 审中-公开
    包含果胶和抗坏血酸的组合物

    公开(公告)号：US20050008692A1

    公开(公告)日：2005-01-13

    申请号：US10488451

    申请日：2002-08-24

    Applicant: Chyi-cheng Chen ,  Bruno Leuenberger

    Inventor： Chyi-cheng Chen ,  Bruno Leuenberger

    IPC: A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K31/375 ,  A61K47/36 ,  A61P3/02

    CPC classification number: A61K9/205 ,  A61K31/375

    Abstract: Ascorbic acid compositions in the form of a powder and/or granules contain as principle components L-ascorbic acid and/or a pharmaceutically acceptable salt thereof, and a high molecular (300 kDalton or higher) pectin. The compositions are compressible into tablets with improved mechanical strength and hardness.

    Abstract translation: 粉末形式和/或颗粒形式的抗坏血酸组合物含有作为主要成分的L-抗坏血酸和/或其药学上可接受的盐和高分子量（300kDa以上）的果胶。 组合物可压缩成具有改善的机械强度和硬度的片剂。

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