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    Non-invasive multi-modality radiographic surface markers
    2.
    发明授权
    Non-invasive multi-modality radiographic surface markers 失效
    非侵入性多模式射线照相表面标记

    公开(公告)号：US5368030A

    公开(公告)日：1994-11-29

    申请号：US942715

    申请日：1992-09-09

    Applicant: Simion J. Zinreich ,  Eva S. Zinreich ,  David C. Howson

    Inventor： Simion J. Zinreich ,  Eva S. Zinreich ,  David C. Howson

    IPC: A61B6/12 ,  A61B19/00 ,  A61B6/00 ,  A61B5/055

    CPC classification number: A61B6/12 ,  A61B90/39 ,  A61B2090/3995 ,  A61B6/4423

    Abstract: The device of the present application, an adhesive disk, relates to non-invasive multi-modality radiographic surface markers and provides means for marking patients and diagnostic images taken of those patients through different methods including X-Ray, Computerized Tomography, Positron Emission Tomograph, and Nuclear Magnetic Resonance Imaging among others. The device of the present application also provides means for enabling the accurate location of internal structures of a patient.

    Abstract translation: 本申请的装置，粘合盘涉及非侵入性多模式射线照相表面标记，并提供了通过不同方法对患者和患者进行标记的手段，包括X射线，计算机断层扫描，正电子发射断层扫描， 和核磁共振成像等。 本申请的装置还提供了使得能够准确定位患者的内部结构的装置。

    Sideport connector for catherization system
    3.
    发明授权
    Sideport connector for catherization system 失效
    用于导管系统的侧端连接器

    公开(公告)号：US5290248A

    公开(公告)日：1994-03-01

    申请号：US892593

    申请日：1992-05-28

    Applicant: Steven F. Bierman ,  David C. Howson

    Inventor： Steven F. Bierman ,  David C. Howson

    IPC: A61M39/10 ,  A61M39/14 ,  A61M5/32

    CPC classification number: A61M39/1011 ,  A61M2025/024 ,  A61M2039/1027 ,  A61M2039/1072 ,  A61M39/14

    Abstract: A sideport connector for an IV catheterization system is disclosed in which a secure connection can be maintained with standard Y-shaped sideport connectors, such as a septum-type connector. The connector of the present invention comprises a clip having a collar which slidably and, optionally, rotatably engages the septum in order to prevent accidental disengagement. The clip is prevented from disengaging motion by, preferably, a ratchet-pawl mechanism. In another embodiment, the clip can be mounted on the branch of the Y-shaped sideport. The connector also comprises a needle shield or, optionally, a cap to prevent self-injection and contamination.

    Abstract translation: 公开了用于IV导管插入系统的侧面连接器，其中可以用标准的Y形侧端连接器（例如隔膜型连接器）来保持安全连接。 本发明的连接器包括具有可滑动地和可选地可旋转地接合隔膜的套环的夹子，以防止意外脱开。 优选地，棘爪机构防止夹子脱离运动。 在另一个实施例中，夹子可以安装在Y形侧挡板的分支上。 连接器还包括针罩或任选的帽，以防止自身注射和污染。

    Safety enhanced device and method for effecting application of a therapeutic agent
    4.
    发明授权
    Safety enhanced device and method for effecting application of a therapeutic agent 失效
    用于实施治疗剂的安全性增强装置和方法

    公开(公告)号：US5088981A

    公开(公告)日：1992-02-18

    申请号：US80405

    申请日：1987-07-31

    Applicant: David C. Howson ,  Andrew D. Smith ,  Richard A. Simonelli

    Inventor： David C. Howson ,  Andrew D. Smith ,  Richard A. Simonelli

    IPC: A61M5/168 ,  A61M5/172

    CPC classification number: A61M5/172 ,  G06F19/3468 ,  A61M5/16827 ,  Y10S128/13

    Abstract: Safety enhanced device and method are disclosed for effecting application of a therapeutic agent. A removable and operationally non-volatile programmable element is used to control operation of a therapeutic agent delivery unit. A computer, operationally independent of the delivery unit, is utilized to establish coded information for programming of the programmable element while removed from the delivery unit. Operation of the delivery unit according to the program then established for the programmable element is simulated at the computer prior to actual programming of the programmable element to insure the integrity of subsequent delivery of the therapeutic agent to a patient by the delivery unit. The programmable element effects independent delivery of therapeutic agents in each of a plurality of channels under the control of the programmable element. The programmable element is programmed to establish a flow profile that is customized for a particular patient during each minute of each day, and patient demand for therapeutic agents can also be accommodated with safeguards being included to assure proper dispensing.

    Abstract translation: 公开了用于实施治疗剂的安全性增强的装置和方法。 可移动和可操作地非易失性可编程元件用于控制治疗剂递送单元的操作。 用于操作地独立于传送单元的计算机用于建立用于编程可编程元件的编码信息，同时从传送单元移除。 在可编程元件的实际编程之前，在计算机上模拟根据随后针对可编程元件建立的程序的传送单元的操作，以确保治疗剂随后由传送单元递送给患者的完整性。 可编程元件在可编程元件的控制下在多个通道中的每一个中实现治疗剂的独立递送。 可编程元件被编程为建立在每天的每一分钟期间为特定患者定制的流量分布，并且还可以容纳患者对治疗剂的需求，其中包括保证以确保适当的分配。

    Storage receptacle sealing and transfer apparatus
    5.
    发明授权
    Storage receptacle sealing and transfer apparatus 失效
    储存容器密封和传送装置

    公开(公告)号：US4834152A

    公开(公告)日：1989-05-30

    申请号：US78409

    申请日：1987-07-27

    Applicant: David C. Howson ,  Robert E. Havranek ,  John A. Popken ,  Frederick L. Stone

    Inventor： David C. Howson ,  Robert E. Havranek ,  John A. Popken ,  Frederick L. Stone

    IPC: A61J1/10 ,  A61J1/00 ,  A61J1/20 ,  A61J3/00 ,  A61M5/162

    CPC classification number: A61J1/2089 ,  A61J1/2096 ,  A61M5/162 ,  A61J1/201 ,  A61J1/2075 ,  A61J1/2082 ,  A61M2005/1623 ,  Y10S604/905

    Abstract: A storage receptacle sealing and transfer apparatus is disclosed for selectively enabling sealing and transfer of material to and from the receptacle. The apparatus is particularly useful for maintaining and later transferring drug and associated materials, under sterile conditions, to achieve mixing, as, is necessary, for example, in reconstituting a drug by mixing the drug with a diluent prior to delivery to a patient. The transfer apparatus is mounted at the aperture, or mouth, of a storage receptacle to seal the aperture until the contents are needed, and then to permit sterile transfer from one receptacle to another receptacle through a central passage. The apparatus also includes venting through one or more passages offset from the central passage for supplying or discharging air into the storage receptacle as needed, and a filter is included in each vent passage, with the filter being permeable to passage of gases, including air, in either direction through the vent passage, but precluding passage of liquid or solid materials or microorganisms in either direction through the vent passage. The central passage and all venting passages are sealed until use, and the central passage also includes a septum in one disclosed embodiment, with a penetrating unit being included for access through the septum to the interior of the storage receptacle for delivery or withdrawal of substance therefrom.

    Abstract translation: 公开了一种存储容器密封和传送装置，用于选择性地使材料能够与容器密封和转移。 该装置特别可用于在无菌条件下维持和稍后转移药物和相关材料以实现混合，因为例如在将药物与稀释剂混合之前通过在递送至患者之前混合来重建药物是必要的。 传送装置安装在存储容器的孔或口处，以密封孔直到需要内容物，然后允许通过中心通道从一个容器到另一容器的无菌转移。 该设备还包括通过偏离中心通道的一个或多个通道的排气，以根据需要将空气供应或排放到储存容器中，并且每个排气通道中包括过滤器，过滤器可透过包括空气在内的气体通过， 在通过排气通道的任一方向上，但是阻止液体或固体材料或微生物在任一方向通过排气通道。 中央通道和所有通气通道被密封直到使用，并且中心通道在一个公开的实施例中也包括隔膜，其中包括穿透单元以便通过隔膜进入储存容器的内部，用于从其中输送或抽出物质 。

    Device and method for effecting application of a therapeutic agent
    7.
    发明授权
    Device and method for effecting application of a therapeutic agent 失效
    用于治疗剂的施用的装置和方法

    公开(公告)号：US4810243A

    公开(公告)日：1989-03-07

    申请号：US068032

    申请日：1987-06-29

    Applicant: David C. Howson

    Inventor： David C. Howson

    IPC: A61M5/168 ,  A61M5/172 ,  A61M5/00

    CPC classification number: A61M5/172 ,  A61M5/16827 ,  Y10S128/12 ,  Y10S128/13

    Abstract: Device and method are disclosed for effecting application of a therapeutic agent. A removable programmable element is used to control operation of a delivery unit, which unit delivers the therapeutic agent to the patient. The programmable element is programmed, while removed from the delivery unit, by a computer that is operationally independent of the delivery unit to insure the integrity of subsequent delivery of the therapeutic agent to the patient by the delivery unit. The delivery unit requires no microprocessor and can include a plurality of channels for effecting independent delivery of therapeutic agents in each channel under the control of the programmable element. The programmable element is programmed with respect to available protocol informaton, including patient history, needs and tolerances, as well as therapeutic agent parameters, to thereby establish a flow profile that is customized for a particular patient during each moment of each day. Patient demand for therapeutic agents can also be accommodated with safeguards being included to assure proper dispensing of the demanded agents.

    Abstract translation: 公开了用于实施治疗剂的应用的装置和方法。 可移动可编程元件用于控制输送单元的操作，该单元将治疗剂递送给患者。 可编程元件被编程，同时从输送单元移除，该计算机在操作上独立于输送单元，以确保治疗剂随后由输送单元递送给患者的完整性。 递送单元不需要微处理器，并且可以包括多个通道，用于在可编程元件的控制下实现每个通道中的治疗剂的独立递送。 可编程元件相对于可用的协议信息进行编程，包括患者历史，需要和公差以及治疗剂参数，从而建立在每一天的每个时刻为特定患者定制的流量分布。 治疗剂的患者需求也可以被包括在内，以确保正确分配所要求的药剂。

    Body contact electrode structure for deriving electrical signals due to physiological activity
    8.
    发明授权
    Body contact electrode structure for deriving electrical signals due to physiological activity 失效
    生理活动导致电子信号的身体接触电极结构

    公开(公告)号：US4082087A

    公开(公告)日：1978-04-04

    申请号：US766836

    申请日：1977-02-07

    Applicant: David C. Howson

    Inventor： David C. Howson

    IPC: A61B5/0408 ,  A61B5/04

    CPC classification number: A61B5/04085

    Abstract: An electrode structure for use with medical electronics instruments such as electromyographs is described. A thin, flexible body of non-conductive material has one or more wells therein. A flexible conductive member which provides an electrode is disposed at the bottom of each well. The spacing between a plurality of electrodes, which can provide bipolar and ground inputs to the medical electronic instrument, is precisely determined by virtue of the disposition of the electrodes in the wells. The electrode structure provides contact with a body surface, usually the skin. To facilitate the contact a conductive jelly is used. This conductive jelly is received in the wells. It makes contact with the electrodes. Ribs are provided in the regions between the electrodes which form a seal at the skin so as to prevent the flow of conductive fluid between electrodes; thus preventing short circuits. The flexibility of the structure provides for comfort and reliable long term attachment and also for maintaining the contact of the electrodes and sealing ribs with the skin as the skin and muscle beneath, flex.

    Sensitive and rapid determination of antimicrobial susceptibility
    9.
    发明授权
    Sensitive and rapid determination of antimicrobial susceptibility 有权
    敏感和快速测定抗菌药物敏感性

    公开(公告)号：US08460887B2

    公开(公告)日：2013-06-11

    申请号：US12702210

    申请日：2010-02-08

    Applicant: David A. Goldberg ,  David C. Howson ,  Steven W. Metzger ,  Daniel A. Buttry ,  Steven Scott Saavedra

    Inventor： David A. Goldberg ,  David C. Howson ,  Steven W. Metzger ,  Daniel A. Buttry ,  Steven Scott Saavedra

    IPC: G01N33/53

    CPC classification number: G01N33/569 ,  B82Y5/00 ,  B82Y10/00 ,  B82Y20/00 ,  C12Q1/18 ,  G01N33/5438 ,  G01N33/561

    Abstract: The present invention relates to moving microorganisms to a surface, where they are grown in the presence and absence of antimicrobials, and by monitoring the growth of the microorganisms over time in the two conditions, their susceptibility to the antimicrobials can be determined. The microorganisms can be moved to the surface through electrophoresis, centrifugation or filtration. When the movement involves electrophoresis, the presence of oxidizing and reducing reagents lowers the voltage at which electrophoretic force can be generated and allows a broader range of means by which the target can be detected. Monitoring can comprise optical detection, and most conveniently includes the detection of individual microorganisms. The microorganisms can be stained in order to give information about their response to antimicrobials.

    Abstract translation: 本发明涉及将微生物移动到表面，其中它们在存在和不存在抗微生物剂的情况下生长，并且通过在两个条件下随时间监测微生物的生长，可以确定它们对抗微生物剂的敏感性。 微生物可通过电泳，离心或过滤移至表面。 当运动涉及电泳时，氧化和还原剂的存在降低了可以产生电泳力的电压，并允许可以检测目标的更宽范围的方法。 监测可以包括光学检测，并且最方便地包括检测单个微生物。 微生物可以被染色以便提供关于它们对抗微生物剂的反应的信息。

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