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公开(公告)号:US12268491B2
公开(公告)日:2025-04-08
申请号:US17416959
申请日:2019-12-20
Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITED
Inventor: James Avery , Mark Runciman , George Mylonas
IPC: G01B7/16 , A61B5/06 , A61B34/30 , A61B5/0536
Abstract: A sensor system comprising: a deformable structure; a plurality of electrodes operably connectable to the deformable structure; an electrical conductor operably connected to the deformable structure and electrically couplable to each of the electrodes; a current source connectable to predetermined electrodes; a current injector for injecting current from the current source through predetermined electrodes; a voltage recorder for recording the voltage between predetermined pairs of electrodes; and an analyser for analysing voltage recordings to thereby determine the shape of the deformable structure.
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公开(公告)号:US20250100888A1
公开(公告)日:2025-03-27
申请号:US18907401
申请日:2024-10-04
Applicant: Imperial College Innovations Limited
Inventor: Jason Stafford , Omar Matar , Camille Petit
Abstract: The invention provides an apparatus for fluidic exfoliation of a layered material comprising: a housing of circular cross-section defined by a housing wall; a hollow rotor of circular cross-section having a first end and a second end and a wall positioned therebetween arranged concentrically within the housing, wherein the wall of the hollow rotor defines an inner chamber and the space in between the wall of the hollow rotor and the housing wall defines an outer chamber, and wherein a fluid flow path is provided between the inner chamber and the outer chamber; a fluid inlet in fluid communication with the inner chamber or the outer chamber; and a fluid outlet in fluid communication with the other of the inner chamber or the outer chamber; wherein the outer chamber has a width such that on passage of a fluid comprising the layered material from the inlet to the outlet through the outer chamber, a shear rate sufficient to exfoliate the layered material may be applied to the fluid comprising the layered material in the outer chamber by rotation of the hollow rotor.
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公开(公告)号:US12260582B2
公开(公告)日:2025-03-25
申请号:US17943865
申请日:2022-09-13
Applicant: Imperial College Innovations Limited
Inventor: Kentaro Wada , Edgar Antonio Sucar Escamilla , Stephen Lloyd James , Daniel James Lenton , Andrew Davison
Abstract: A computer-implemented method of estimating a pose of a target object in a three-dimensional scene includes: obtaining image data and associated depth information representing a view of the three-dimensional scene; processing the image data and the associated depth information to generate a volumetric reconstruction for each of a plurality of objects in the three-dimensional scene, including the target object; determining a volumetric grid containing the target object; generating, using the generated volumetric reconstructions, occupancy data indicating portions of the volumetric grid occupied by free space and portions of the volumetric grid occupied by objects other than the target object; and estimating the pose of the target object using the generated occupancy data and pointwise feature data for a plurality of points on a surface of the target object.
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公开(公告)号:US20250067674A1
公开(公告)日:2025-02-27
申请号:US18549950
申请日:2022-03-11
Applicant: Imperial College Innovations Ltd
Inventor: Mary Ryan , Fang Xie , Sarah Madeline Fothergill
IPC: G01N21/64
Abstract: The present invention relates to the metal enhanced fluorescence and chips designed to improve the usefulness of current chips. Specifically, the chips of the present invention are able to enhance fluorescence from a range of spectral regions.
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公开(公告)号:US12226426B2
公开(公告)日:2025-02-18
申请号:US17279205
申请日:2019-09-25
Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITED
Inventor: Peter Sarkies
IPC: A61K31/7036 , A61K31/255
Abstract: The present invention provides a therapeutic combination for use in treating an infection with a pathogen. The therapeutic combination comprises an aminoglycoside antibiotic; and a nucleic acid monoalkylating agent that substitutes a single nucleotide of a nucleic acid with an alkyl group, wherein the therapeutic combination provides an enhanced suppression of a pathogen when compared with an otherwise identical composition lacking said aminoglycoside antibiotic; or wherein the therapeutic combination provides an enhanced suppression of a pathogen when compared with an otherwise identical composition lacking said nucleic acid monoalkylating agent; and kits for performing said method.
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公开(公告)号:US20240315981A1
公开(公告)日:2024-09-26
申请号:US18570611
申请日:2022-06-14
Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITED
Inventor: Rongjun Chen , Xuhan Liu , Robin Shattock , Anna Blakney , Yifan Liu
IPC: A61K9/51 , A61K39/00 , A61K39/145 , A61K39/215 , A61P37/04
CPC classification number: A61K9/5123 , A61K9/5146 , A61K9/5192 , A61K39/145 , A61K39/215 , A61P37/04 , A61K2039/53
Abstract: The invention relates to a sub-micron particle comprising a payload molecule and a lipid structure being surrounded by an outer layer comprising an amphiphilic copolymer. The invention extends to method of producing the sub-micron particle. The invention also encompasses pharmaceutical compositions and vaccines comprising the sub-micron particle and medical uses thereof.
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公开(公告)号:US20240292819A1
公开(公告)日:2024-09-05
申请号:US18573114
申请日:2022-06-23
Applicant: Imperial College Innovations Limited , Polo D’Innovazione di Genomica Genetica e Biologia SRL
Inventor: Chrysanthi Taxiarchi , Roberto Galizi , Andrea Crisanti , Alekos Simoni , Rocco D'Amato
IPC: A01K67/033 , C12N15/85
CPC classification number: A01K67/0339 , C12N15/8509 , A01K2217/052 , A01K2227/706 , A01K2267/01 , C12N2800/105
Abstract: The present invention relates to an anti-CRISPR construct useful to counteract the spread of a gene-drive in an arthropod population. The invention is also concerned with a system comprising the anti-CRISPR construct and a crispr-based gene-drive construct, a method of producing a genetically modified arthropod, a genetically modified arthropod, and a method for counteracting a CRISPR-based gene-drive in an arthropod population.
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公开(公告)号:US12054719B2
公开(公告)日:2024-08-06
申请号:US16099153
申请日:2017-04-28
Applicant: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIV. TRINITY OF QUEEN ELIZABETH NEARD DUBLIN , IMPERIAL COLLEGE INNOVATIONS LIMITED , DUKE UNIVERSITY
Inventor: Peter Humphries , Marian Humphries , Matthew Campbell , Anna-Sophia Kiang , Daniel Stamer , Darryl Ray Overby , Chi Shing Lawrence Tam
IPC: C07H21/02 , A61P27/06 , C07H21/04 , C12N15/113
CPC classification number: C12N15/1138 , A61P27/06 , C12N15/113 , C12N2310/122 , C12N2310/14 , C12N2310/531 , C12N2320/30 , C12N2320/32
Abstract: The present invention is directed to an RNAi-inducing agent capable of reducing and/or inhibiting the expression of proteins associated with the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Specifically, the RNAi-inducing agent is capable of reducing and/or inhibiting the expression of proteins expressed in the tight junction complex or supporting the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Methods using this RNAi-inducing agent are also contemplated.
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公开(公告)号:US12053886B2
公开(公告)日:2024-08-06
申请号:US17207281
申请日:2021-03-19
Applicant: Imperial College Innovations Limited
Inventor: Stephen Lloyd James , Michael Bloesch , Andrew Davison
IPC: B25J9/16 , G05B19/4155
CPC classification number: B25J9/163 , B25J9/1661 , G05B19/4155
Abstract: A control system for a robotic device comprising a task embedding network to receive one or more demonstrations of a task and to generate a task embedding. The task embedding comprises a representation of the task, and each demonstration comprises one or more observations of a performance of the task. The control system includes a control network to receive the task embedding from the task embedding network and to apply a policy to map a plurality of successive observations of the robotic device to respective control instructions for the robotic device. The policy applied by the control network is modulated across the plurality of successive observations of the robotic device using the task embedding from the task embedding network.
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公开(公告)号:US20240207312A1
公开(公告)日:2024-06-27
申请号:US18287542
申请日:2022-04-21
Applicant: Imperial College Innovations Limited
Inventor: Xiaoning Xu , Weiwei Ma , Yuxin Qian
CPC classification number: A61K35/17 , A61K39/4611 , A61K39/4631 , A61K39/464411 , A61K39/46444 , A61P35/02 , C07K16/246 , C07K16/2833 , C12N5/0636 , C12N15/86 , A61K2239/13 , A61K2239/48
Abstract: The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating, and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention is also concerned with methods for expansion of MAIT cells in vitro.
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