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    System and method for purging oxygen from medical vials
    1.
    发明授权
    System and method for purging oxygen from medical vials 有权

    公开(公告)号：US11053037B2

    公开(公告)日：2021-07-06

    申请号：US16116020

    申请日：2018-08-29

    Applicant: Insys Development Company, Inc.

    Inventor： Simon Freed ,  David C. Woodruff

    IPC: B65B31/04 ,  B65B7/28 ,  B65B3/00 ,  B65B55/10 ,  B65B55/02 ,  B65B31/02 ,  B67C7/00

    Abstract: A medical vial filling system is adapted to fill a medical vial with a solution and cap the filled medical vial. A purging system includes a manifold disposed between a filling station and a capping station. The manifold includes a filling inlet port and a plurality of output ports. The output ports are positioned in a space proximate the filling station and in a space over the transport mechanism. A stoppering block includes a capping chamber for receiving a bushing positioned at the capping station. The stoppering block comprises a stoppering inlet port, a first nozzle opening into the capping chamber and a second nozzle extending into the capping chamber and directed into the medical vial when the medical vial is position in the capping station. A supply of non-reactive gas at the filling inlet port directs flow of the non-reactive gas out the manifold outlet ports to evacuate air and substitute the non-reactive gas in the filled medical vial and at the stoppering inlet port directs flow of the non-reactive gas in a flood zone surround a space above the medical vials when the medical vial is positioned in the capping station and in a stream directed into the medical vial when the medical vial is positioned in the capping station.

    LIQUID BUPRENORPHINE FORMULATIONS
    8.
    发明申请
    LIQUID BUPRENORPHINE FORMULATIONS 有权
    液体保护素配方

    公开(公告)号：US20170042884A1

    公开(公告)日：2017-02-16

    申请号：US15336547

    申请日：2016-10-27

    Applicant: Insys Development Company, Inc.

    Inventor： Kiran P. Amancha ,  Chandeshwari S. Chilampalli ,  Venkat R. Goskonda

    IPC: A61K31/485 ,  A61K47/18 ,  A61K47/22 ,  A61K9/00 ,  A61K47/10

    CPC classification number: A61K31/485 ,  A61K9/006 ,  A61K9/08 ,  A61K31/4748 ,  A61K47/02 ,  A61K47/10 ,  A61K47/12 ,  A61K47/183 ,  A61K47/22 ,  A61K47/40 ,  A61K2300/00

    Abstract: The invention provides liquid formulations containing buprenorphine, a pharmaceutically acceptable salt thereof, or a derivative thereof. The invention further provides liquid formulations containing buprenorphine and naloxone, pharmaceutically acceptable salts thereof or derivatives thereof. The invention further provides a method of treating pain or opioid dependence by administering liquid formulations containing buprenorphine or a combination of buprenorphine and naloxone, a pharmaceutically acceptable salt thereof, or a derivative thereof to a patient in need thereof.

    Abstract translation: 本发明提供含有丁丙诺啡，其药学上可接受的盐或其衍生物的液体制剂。 本发明还提供含有丁丙诺啡和纳洛酮的药物制剂，其药学上可接受的盐或其衍生物。 本发明还提供了一种通过给予含有丁丙诺啡或丁丙诺啡和纳洛酮组合的药物制剂，其药学上可接受的盐或其衍生物给有需要的患者来治疗疼痛或阿片样物质依赖性的方法。

    LIQUID NALOXONE SPRAY
    10.
    发明申请
    LIQUID NALOXONE SPRAY 审中-公开
    液体纳洛酮喷雾

    公开(公告)号：US20160354363A1

    公开(公告)日：2016-12-08

    申请号：US15238909

    申请日：2016-08-17

    Applicant: Insys Development Company, Inc.

    Inventor： Kiran Amancha ,  Shivani Chilampalli ,  Thrimoorthy Potta ,  Ningxin Yan ,  Venkat R. Goskonda

    IPC: A61K31/485 ,  A61K9/00 ,  A61K9/08 ,  A61K47/10 ,  A61K47/18

    Abstract: The invention provides stable liquid formulations containing naloxone, a pharmaceutically acceptable salt or a derivative thereof. The invention further provides methods for treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering the liquid formulations of the present invention both intranasally and sublingually to a patient in need thereof. Further, the invention provides a method of treating opioid dependence, opioid overdose, and congenital insensitivity to pain with anhidrosis by administering intranasally and sublingually the naloxone formulations of the present invention.

    Abstract translation: 本发明提供含有纳洛酮，其药学上可接受的盐或衍生物的稳定的液体制剂。 本发明进一步提供了通过将本发明的液体制剂鼻内和舌下给予有需要的患者来治疗阿片样物质依赖性，阿片样物质过量和先天性对无痛性疼痛的不敏感性的方法。 此外，本发明提供了一种通过鼻内和舌下施用本发明的纳洛酮制剂来治疗阿片样物质依赖性，阿片样物质过量和对具有无汗症的疼痛的先天性不敏感性的方法。

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