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公开(公告)号:US20230277604A1
公开(公告)日:2023-09-07
申请号:US18017934
申请日:2021-07-27
Inventor: Eijiro MIYAKO
CPC classification number: A61K35/74 , A61K49/0004 , A61N5/06 , A61P35/00 , A61K41/00 , A61N2005/0659
Abstract: It is an object of the present invention to provide a therapeutic agent or a diagnostic agent for cancer, which has high selectivity to cancer and also has low toxicity or little side effects. According to the present invention, provided is a therapeutic agent or a diagnostic agent for cancer, comprising photosynthetic bacteria.
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公开(公告)号:US11530286B2
公开(公告)日:2022-12-20
申请号:US16305576
申请日:2017-05-30
Applicant: OSAKA ORGANIC CHEMICAL INDUSTRY LTD. , JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Kazuaki Matsumura , Rajan Robin , Yoko Taniyama , Yoshiyuki Saruwatari
IPC: C08F291/14 , C12N9/36 , C12N9/96
Abstract: The present invention provides a protein aggregation inhibitor for use in preventing aggregation of a protein, containing a crosslinked polymer obtained by polymerizing polymerizable polymer components containing a sulfobetaine polymer obtained by polymerizing monomer components containing a sulfobetaine monomer, the sulfobetaine monomer, and a crosslinkable monomer.
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公开(公告)号:US20220005690A1
公开(公告)日:2022-01-06
申请号:US17282928
申请日:2019-10-11
Inventor: Yuki TANAKA , Hiroyuki HASHIMOTO , Mayuko NAKAMURA , Takashi MASUDA , Hideyuki TAKAGISHI
IPC: H01L21/02
Abstract: A method of forming a silicon film on a substrate having a fine pattern includes performing surface treatment with an adhesion promoter on the substrate having the fine pattern, forming a coating film by applying a silane polymer solution to the substrate on which the surface treatment has been performed, and heating the coating film.
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公开(公告)号:US11214590B2
公开(公告)日:2022-01-04
申请号:US16631653
申请日:2018-07-25
Inventor: Kenzo Fujimoto , Shigetaka Nakamura
Abstract: Provided are a compound represented by formula I that can be used in nucleic acid photoreaction techniques, and a photoreactive crosslinking agent comprising the compound.
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公开(公告)号:US11078211B2
公开(公告)日:2021-08-03
申请号:US16629148
申请日:2018-07-19
Inventor: Takahiro Inatsugi , Ayako Koto , Isao Ishimaru , Masahiko Takamura , Kenzo Fujimoto
IPC: C07D491/052 , C07F9/6561
Abstract: Provided are a compound represented by the following formula I; a novel photoreactive compound that can be used in nucleic acid photoreaction techniques by a photoreactive crosslinking agent comprising the compound; and a photoreactive crosslinking agent in which the photoreactive compound is used.
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公开(公告)号:US10995160B2
公开(公告)日:2021-05-04
申请号:US16313405
申请日:2017-06-29
Applicant: OSAKA ORGANIC CHEMICAL INDUSTRY LTD. , JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Kazuaki Matsumura , Rajan Robin , Yoko Taniyama , Yoshiyuki Saruwatari
IPC: C08F8/42 , C08F120/60
Abstract: The present invention provides a protein aggregation inhibitor for use in preventing aggregation of a protein, which contains a terminal sulfanyl group-containing sulfobetaine polymer having a repeat unit derived from a sulfobetaine monomer represented by the formula (II), and a noble metal particle, and in which the terminal sulfanyl group-containing sulfobetaine polymer is chemisorbed on the noble metal particle by the sulfanyl group (the groups in the following formula are as defined in the DESCRIPTION).
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公开(公告)号:US20210084891A1
公开(公告)日:2021-03-25
申请号:US16077801
申请日:2017-02-15
Inventor: Kazuaki Matsumura , Toshiaki Naka
IPC: A01N1/02
Abstract: Provided are a vitrification stabilizer for an animal cell cryopreservation fluid, and an animal cell cryopreservation fluid which exhibits superior vitrification capabilities due to the animal cell cryopreservation fluid containing the vitrification stabilizer for an animal cell cryopreservation fluid. The vitrification stabilizer for an animal cell cryopreservation fluid contains: an amphoteric polymer compound selected from the group consisting of (a) a carboxylated amphoteric polymer compound obtained by reacting ε-poly-L-lysine with butyl succinic anhydride, (b) a carboxylated amphoteric polymer compound obtained by reacting ε-poly-L-lysine with butyl succinic anhydride and succinic anhydride, or (c) a carboxylated amphoteric polymer compound obtained by reacting ε-poly-L-lysine with a compound represented by formula I; and (d) a sucrose polymer macromolecule to which epichlorohydrin has been crosslinked.
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公开(公告)号:US20200227609A1
公开(公告)日:2020-07-16
申请号:US16641220
申请日:2018-08-10
Inventor: Shigeyuki Tsurumi , Kazumasa YASUDA , Takeshi SOTOME , Mikio KOYANO , Takeshi TOYODA , Akinari MATOBA , Toshiharu MINAMIKAWA
Abstract: A thermoelectric material includes a parent phase in which an MgSiSn alloy is a main component, a void formed in the parent phase, and a silicon layer that is formed on at least a wall surface of the void and that includes silicon as a main component. The thermoelectric material further includes MgO in an amount of 1.0 wt. % or more and 20.0 wt. % or less. The silicon layer includes amorphous Si, or amorphous Si and nanosized Si crystals, and the parent phase includes a region in which the composition ratio of the Si of the chemical composition of the MgSiSn alloy is higher than in the other regions and a region in which the composition ratio of the Sn of the chemical composition of the MgSiSn alloy is higher than in the other regions. With these configurations, the thermoelectric material realizes both lower thermal conductivity and lower electrical resistivity.
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公开(公告)号:US10431731B2
公开(公告)日:2019-10-01
申请号:US15755282
申请日:2016-08-26
Inventor: Yuki Tagashira , Reijiro Shimura , Yuzuru Takamura , Jinwang Li , Tatsuya Shimoda , Toshiaki Watanabe , Nobuyuki Soyama
IPC: H01L41/43 , H01L41/318 , H01L27/11502 , H01L41/187 , H01L41/316 , H01L27/11521
Abstract: The present invention comprises: a step of applying a liquid composition for forming a PZT ferroelectric film; a step of drying the film applied with the liquid composition; a step of irradiating UV rays onto the dried film at a temperature of 150 to 200° C. in an oxygen-containing atmosphere; and after the application step, the drying step, and the UV irradiation step once, or more times, a step of firing for crystallizing a precursor film of the UV-irradiated ferroelectric film by raising a temperature with a rate of 0.5° C./second or higher in an oxygen-containing atmosphere or by raising a temperature with a rate of 0.2° C./second or higher in a non-oxygen containing atmosphere, followed by keeping the temperature at 400 to 500° C. An amount of liquid composition is set such that thickness of the ferroelectric film be 150 nm or more for each application and ozone is supplied during UV irradiation.
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公开(公告)号:US20180118859A1
公开(公告)日:2018-05-03
申请号:US15572966
申请日:2016-05-10
Applicant: OSAKA ORGANIC CHEMICAL INDUSTRY LTD. , JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor: Kazuaki MATSUMURA , Rajan ROBIN , Tsuyoshi FURUKAWA , Kentaro MAEHARA , Yoshiyuki SARUWATARI
CPC classification number: C08F20/60 , A23J3/00 , A23L15/30 , A23V2002/00 , C07K1/113 , C08F20/38 , C12N9/2462 , C12N9/96
Abstract: Provided is a protein aggregation inhibitor capable of inhibiting aggregation of a protein even when the protein is heated, and further, capable of inhibiting a decrease in the protein activity even when the protein is heated, which characteristically contains a sulfobetaine polymer obtained by polymerizing monomer components containing sulfobetaine monomer represented by the formula (I): wherein R1 is a hydrogen atom or a methyl group, R2 is an alkylene group having a carbon number of 1-4, R3 is an alkyl group having a carbon number of 1-4, R4 is an alkylene group having a carbon number of 1-4, and X is an —NH— group or an —O— group.
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