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公开(公告)号：US09757497B2
公开(公告)日：2017-09-12
申请号：US13469844
申请日：2012-05-11
Applicant: Joram Slager
Inventor： Joram Slager
CPC classification number: A61L29/14 , A61K9/145 , A61K9/70 , A61L29/085 , A61L29/126 , A61L29/16 , A61L2300/416 , A61L2300/602 , A61L2300/63 , A61L2300/802 , F04C2270/0421
Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.
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2.发明授权Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices for implantation or injection 有权硅烷官能化疏水性α（1→4）吡喃葡萄糖聚合物和聚合物基质用于植入或注射公开(公告)号：US08802121B2
公开(公告)日：2014-08-12
申请号：US12792365
申请日：2010-06-02
Applicant: Aleksey V. Kurdyumov , Nathan A. Lockwood , Joram Slager , Dale G. Swan , Robert Hergenrother
Inventor： Aleksey V. Kurdyumov , Nathan A. Lockwood , Joram Slager , Dale G. Swan , Robert Hergenrother
CPC classification number: A61K39/39591 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/624 , C07K2317/55 , Y10T428/31663 , C08L71/02 , C08L67/04
Abstract: Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic α(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
Abstract translation: 描述了硅烷官能化的疏水性α（1→4）吡喃葡萄糖聚合物和聚合物基质。 生物可降解基质可以由具有反应性侧挂甲硅烷基醚基团的疏水性α（1→4）吡喃葡萄糖聚合物形成。 甲硅烷基醚基团的反应通过结合到器件的器件表面，聚合物 - 聚合物交联或两者来提供改进的基质形成。 可生物降解基质可用于制备可植入和可注射的医疗器械，包括那些释放生物活性剂的医疗器械。
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3.发明申请公开(公告)号：US20130110222A1
公开(公告)日：2013-05-02
申请号：US13588118
申请日：2012-08-17
Applicant: Joram Slager
Inventor： Joram Slager
IPC: A61F2/95
CPC classification number: A61F2/95 , A61L29/08 , A61L29/14 , A61L31/08 , A61L31/14 , A61L2400/10 , A61L2400/12 , A61L2400/18
Abstract: The present invention relates to medical devices including a superhydrophobic surface or coating, a superoleophobic surface or coating, a coating or surface that is both superhydrophobic and superoleophobic, or a combination of such coatings and surfaces. Such a coating or surface can impart advantageous lubricity, hemocompatibility, or both to the medical device or its surface.
Abstract translation: 本发明涉及包括超疏水表面或涂层，超疏油表面或涂层，超疏水性和超疏油性的涂层或表面的医疗装置，或这些涂层和表面的组合。 这样的涂层或表面可以赋予医疗装置或其表面有利的润滑性，血液相容性或两者。
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公开(公告)号：US20120296274A1
公开(公告)日：2012-11-22
申请号：US13469844
申请日：2012-05-11
Applicant: Joram Slager
Inventor： Joram Slager
IPC: A61K9/70 , A61M25/10 , B05D1/36 , A61M35/00 , A61K31/337 , A61K31/436
CPC classification number: A61L29/14 , A61K9/145 , A61K9/70 , A61L29/085 , A61L29/126 , A61L29/16 , A61L2300/416 , A61L2300/602 , A61L2300/63 , A61L2300/802 , F04C2270/0421
Abstract: Embodiments of the invention include devices and coatings for devices including coated hydrophobic active agent particles. In an embodiment, the invention includes a drug delivery device including a substrate; and coated therapeutic agent particles disposed on the substrate, the coated therapeutic agent particles comprising a particulate hydrophobic therapeutic agent; and a cationic agent in contact with the particulate hydrophobic therapeutic agent. Other embodiments are also included herein.
Abstract translation: 本发明的实施方案包括用于包括涂覆的疏水活性剂颗粒的装置的装置和涂层。 在一个实施方案中，本发明包括药物递送装置，其包括基底; 以及设置在基材上的被覆治疗剂颗粒，所述涂敷的治疗剂颗粒包含颗粒状疏水性治疗剂; 和与颗粒疏水治疗剂接触的阳离子剂。 本文还包括其它实施例。
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公开(公告)号：US08241921B2
公开(公告)日：2012-08-14
申请号：US12647780
申请日：2009-12-28
Applicant: Joram Slager , Aron B. Anderson
Inventor： Joram Slager , Aron B. Anderson
IPC: G01N33/558
CPC classification number: A61L27/48 , A61L27/54 , A61L31/129 , A61L31/16 , A61L2300/252 , A61L2300/256 , A61L2300/622 , C08L71/02 , C08L31/04 , C08L33/10
Abstract: The present invention is directed to polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the elution control matrix includes a polymeric matrix having a first polymer and a plurality of microparticles that include the hydrophilic bioactive agent. In one embodiment, the matrix includes a polymer comprising hydrophilic and hydrophobic portions. In another embodiment, the microparticles include a crosslinked hydrophilic polymer.
Abstract translation: 本发明涉及用于控制释放亲水生物活性剂的聚合物基质。 通常，洗脱控制基质包括具有第一聚合物和包含亲水生物活性剂的多个微粒的聚合物基质。 在一个实施方案中，基质包括包含亲水和疏水部分的聚合物。 在另一个实施方案中，微粒包括交联的亲水性聚合物。
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Patent Agency Ranking
公开(公告)号：US20100303878A1
公开(公告)日：2010-12-02
申请号：US12792309
申请日：2010-06-02
Applicant: Joram Slager , Robert Hergenrother
Inventor： Joram Slager , Robert Hergenrother
IPC: A61K39/395 , A61K38/00 , A61F2/02 , A61P35/00
CPC classification number: A61K39/39591 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/624 , C07K2317/55 , Y10T428/31663 , C08L71/02 , C08L67/04
Abstract: The present invention is directed to biodegradable polymeric matrices for the controlled release of a hydrophilic bioactive agent. Generally, the biodegradable matrices include an aliphatic polyester copolymer and microparticulates that include the hydrophilic bioactive agent. In some embodiments, the matrix includes a second biodegradable polymer comprising hydrophilic and hydrophobic portions. Exemplary matrix forms are device coatings and medical implants. Matrices of the invention demonstrated high bioactive agent loading, were able to modulate release of the bioactive agent in a therapeutic manner, and also maintained high levels of activity for therapeutically useful large molecule bioactive agents, such as proteins.
Abstract translation: 本发明涉及用于控制释放亲水生物活性剂的可生物降解的聚合物基质。 通常，生物可降解基质包括脂族聚酯共聚物和包含亲水生物活性剂的微粒。 在一些实施方案中，基质包括包含亲水和疏水部分的第二可生物降解聚合物。 示例性的矩阵形式是装置涂层和医疗植入物。 本发明的基质表现出高生物活性剂负载，能够以治疗方式调节生物活性剂的释放，并且还对治疗有用的大分子生物活性剂如蛋白质保持高水平的活性。
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7.发明申请METHOD AND APPARATUS FOR DELIVERY OF A THERAPEUTIC AGENT WITH AN EXPANDABLE MEDICAL DEVICE 有权用可扩展医疗器械输送治疗药物的方法和装置公开(公告)号：US20100292668A1
公开(公告)日：2010-11-18
申请号：US12774954
申请日：2010-05-06
Applicant: Joram Slager
Inventor： Joram Slager
CPC classification number: A61M25/10 , A61B17/12022 , A61B17/12172 , A61B17/12177 , A61B17/1219 , A61B2017/00893 , A61F2/82 , A61F2250/0067 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/622 , A61M29/02 , A61M2025/105
Abstract: Described herein is a medical device that has a collapsed configuration and an expanded configuration wherein one or more polymeric network layers are applied to the substrate and microparticles embedded in the polymeric network. The polymeric network layer or layers is/are configured to retain the microparticles when the device is in a collapsed configuration and to release the microparticles when the device is in an expanded configuration. Methods for delivering a therapeutic agent using the device and making the device are also disclosed.
Abstract translation: 本文描述的是具有折叠构型和扩展构型的医疗装置，其中将一个或多个聚合物网络层施加到基底和嵌入聚合物网络中的微粒。 聚合物网络层被配置为当装置处于折叠构型时保持微粒，并且当装置处于扩张构型时释放微粒。 还公开了使用该装置递送治疗剂并制备该装置的方法。
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公开(公告)号：US20100008966A1
公开(公告)日：2010-01-14
申请号：US12502473
申请日：2009-07-14
Applicant: Joram Slager , Joseph Schmidt McGonigle , Aron Brent Anderson , Robert W. Hergenrother
IPC: A61K9/14 , A61K31/7088 , A61K9/00 , A61K31/7105 , A61P35/00
CPC classification number: A61L27/54 , A61K48/0041 , A61L27/34 , A61L2300/258 , A61L2300/606
Abstract: Embodiments of the invention include devices for the release of nucleic acids and related methods. In an embodiment, the invention includes an active agent eluting coating including a polymeric matrix, a cationic carrier agent disposed with the matrix, and an active agent disposed within the matrix, the active agent including nucleic acids substantially uncomplexed with the cationic carrier agent. In an embodiment, the invention includes a method of making an implantable medical device including selecting a concentration of a cationic carrier agent corresponding to a desired elution profile, combining a matrix forming polymer, an active agent, a solvent, and the cationic carrier agent to form a coating composition having the selected concentration of the cationic carrier agent, the active agent comprising nucleic acids, and depositing the coating composition onto the surface of a substrate. Other embodiments are included herein.
Abstract translation: 本发明的实施方案包括用于释放核酸的装置和相关方法。 在一个实施方案中，本发明包括活性剂洗脱涂层，其包括聚合物基质，与基质一起布置的阳离子载体剂和置于基质内的活性剂，所述活性剂包括与阳离子载体试剂基本上未络合的核酸。 在一个实施方案中，本发明包括制备可植入医疗装置的方法，包括选择对应于所需洗脱曲线的阳离子载体试剂的浓度，将形成基质的聚合物，活性剂，溶剂和阳离子载体试剂组合到 形成具有选定浓度的阳离子载体试剂，活性剂包含核酸并将该涂料组合物沉积在基材表面上的涂料组合物。 本文还包括其它实施例。
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9.发明授权Combination degradable and non-degradable matrices for active agent delivery 有权用于活性剂递送的组合可降解和不可降解的基质公开(公告)号：US08968782B2
公开(公告)日：2015-03-03
申请号：US11770316
申请日：2007-06-28
Applicant: Ralph A. Chappa , Robert W. Hergenrother , Paula Bushendorf , Joram Slager
Inventor： Ralph A. Chappa , Robert W. Hergenrother , Paula Bushendorf , Joram Slager
IPC: A61K47/30 , A61K38/02 , A61K9/00 , A61K39/395 , A61K45/00 , A61L27/58 , A61L27/48 , A61L27/54 , C08L23/08 , C08L33/08 , C08L71/02
CPC classification number: A61L27/58 , A61L27/48 , A61L27/54 , A61L2300/252 , A61L2300/256 , A61L2300/604 , C08L23/0853 , C08L23/0869 , C08L33/08 , C08L71/02 , C08L2201/06 , C08L2666/22
Abstract: The present invention relates to relates to combination degradable and non-degradable matrices and related methods. In an embodiment, the invention includes an active agent delivery matrix including a degradable polymer network, a non-degradable polymer network, the non-degradable polymer network interspersed within the degradable polymer network, and an active agent. In an embodiment, the invention includes an active agent elution control matrix including a degradable polymer; and a non-degradable polymer interspersed with the degradable polymer. In an embodiment, the invention includes a method of making an active agent delivery matrix including mixing a degradable polymer with a first solvent to form a degradable polymer solution; mixing a non-degradable polymer with a second solvent to form a non-degradable polymer solution; and simultaneously depositing the degradable polymer solution and the non-degradable polymer solution onto a substrate.
Abstract translation: 本发明涉及可降解和不可降解的基质和相关方法。 在一个实施方案中，本发明包括活性剂递送基质，其包括可降解聚合物网络，不可降解聚合物网络，散布在可降解聚合物网络内的不可降解聚合物网络和活性剂。 在一个实施方案中，本发明包括包含可降解聚合物的活性剂洗脱控制基质; 和散布有可降解聚合物的不可降解聚合物。 在一个实施方案中，本发明包括制备活性剂递送基质的方法，包括将可降解聚合物与第一溶剂混合以形成可降解聚合物溶液; 将不可降解的聚合物与第二溶剂混合以形成不可降解的聚合物溶液; 同时将可降解聚合物溶液和不可降解聚合物溶液沉积在基材上。
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公开(公告)号：US08709827B2
公开(公告)日：2014-04-29
申请号：US12215504
申请日：2008-06-27
Applicant: Joram Slager , John V. Wall
Inventor： Joram Slager , John V. Wall
IPC: G01N33/558 , C07K16/00 , A61K31/28
CPC classification number: A61K9/1658 , A61K9/5052
Abstract: The invention provides polypeptide microparticles and methods for the preparation thereof using a nucleating agent.
Abstract translation: 本发明提供了多肽微粒及其使用成核剂制备的方法。
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