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公开(公告)号：US12286423B2
公开(公告)日：2025-04-29
申请号：US17235120
申请日：2021-04-20
Applicant: Novartis AG , Katholieke Universiteit Leuven , Korea Research Institute of Chemical Technology
Inventor： Johan Neyts , Daniel Poon , Keith Bruce Pfister , Young-Sik Jung , Soo Bong Han , Yashwardhan R. Malpani , Prashant Chakrasali , Bishyajit Kumar Biswas , Chong-Kyo Lee , Chonsaeng Kim , Jin Soo Shin , Hae Soo Kim
IPC: C07D405/12 , A61K45/06 , A61P31/14 , C07D307/93 , C07D405/14
Abstract: The invention provides compounds of Formula (I): as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.
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公开(公告)号：US20250090491A1
公开(公告)日：2025-03-20
申请号：US18797480
申请日：2024-08-07
Applicant: Novartis AG , Katholieke Universiteit Leuven , Korea Research Institute of Chemical Technology
Inventor： Johan NEYTS , Daniel POON , Keith Bruce PFISTER , Young-Sik JUNG , Soo Bong HAN , Yashwardhan R. MALPANI , Prashant CHAKRASALI , Sang-Ho LEE , Chong-Kyo LEE , Chonsaeng KIM , Jin Soo SHIN , Hae Soo KIM
IPC: A61K31/343 , A61P31/14 , C07D307/93
Abstract: This disclosure provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections.
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公开(公告)号：US20250082762A1
公开(公告)日：2025-03-13
申请号：US18949466
申请日：2024-11-15
Inventor： Pil Ho KIM , Sung Yun CHO , Jae Du HA , Chi Hoon PARK , Jong Yeon HWANG , Hyun Jin KIM , Song Hee LEE , Ye Seul LIM , Han Wool KIM , Sun Mi YOO , Beom Seon SUH , Ji Youn PARK , Je Ho RYU , Jung Min AHN , Hee Jung MOON , Ho Hyun LEE
Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.
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公开(公告)号：US20250073341A1
公开(公告)日：2025-03-06
申请号：US18949437
申请日：2024-11-15
Inventor： Pil Ho KIM , Sung Yun CHO , Jae Du HA , Chi Hoon PARK , Jong Yeon HWANG , Hyun Jin KIM , Song Hee LEE , Ye Seul LIM , Han Wool KIM , Sun Mi YOO , Beom Seon SUH , Ji Youn PARK , Je Ho RYU , Jung Min AHN , Hee Jung MOON , Ho Hyun LEE
Abstract: The present invention relates to a novel heterocyclic compound and a composition, for preventing or treating a cancer, an autoimmune disease, and an inflammatory disease, comprising same. The novel heterocyclic compound of the present invention is a bifunctional compound having a Bruton's tyrosine kinase (BTK) degradation function via a ubiquitin proteasome pathway, and may be utilized as a composition for preventing or treating a cancer, an autoimmune disease, and Parkinson's disease.
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公开(公告)号：US12209916B2
公开(公告)日：2025-01-28
申请号：US17023003
申请日：2020-09-16
Inventor： Jieon Lee , Woo-keun Kim , Seokjoo Yoon
IPC: C12Q1/6816 , C01B32/198 , G01K11/12 , G01N27/414
Abstract: The present invention relates to a composition for temperature sensors including graphene oxide, DNAzyme and PNA, a temperature sensing method and a kit using the same. In the present invention, when the DNAzyme/PNA duplex is dissociated at a certain temperature, graphene oxide adsorbs PNA with excellent selectivity and irreversibility, enabling recall of temperature, to permit delayed color development in the time of need. Also, the target temperature can be easily and quickly detected with the naked eye through the color change of the colorimetric reagent, and the thermosensor is technically convenient and easy to apply, so it can be used in various biological applications. Moreover, it can be used as a barcode (on/off) system using a combination of PNA probes with various lengths, and thus can be broadly applied to sensing a diverse range of temperatures.
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Patent Agency Ranking
公开(公告)号：US20240400760A1
公开(公告)日：2024-12-05
申请号：US18575707
申请日：2022-05-27
Inventor： Jong Chan WON , Yun Ho KIM , No Kyun PARK , Yu Jin SO , Jin Soo KIM , Jong Min PARK , Sung Mi YOO , Yi Young KANG , Hyun Jin PARK , Yu Mi HA , Ji Yun CHUNG , Hyun Tae LIM , Eun Byeol SEO , Ji Won LEE , Hyun Jeong AHN
Abstract: The present invention provides a polyamic acid aqueous solution composition capable of polymerizing polyamic acid in water rather than in an organic solvent, as well as achieving a high imidization rate during low-temperature curing.
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公开(公告)号：US12152201B2
公开(公告)日：2024-11-26
申请号：US17817289
申请日：2022-08-03
Applicant: POSTECH Research and Business Development Foundation , Korea Research Institute of Chemical Technology
Inventor： Suk Bong Hong , Hwajun Lee , Jiho Shin , Na Young Kang , Yong-Ki Park
IPC: C10G11/05
Abstract: Provided is a method of converting a hydrocarbon using a catalyst/catalyst support including a PST-32 or PST-2 zeolite, which has an effect of increasing the selectivity/yield of a light olefin product and reducing a side reaction to sustain catalytic activity, in various hydrocarbon conversion reactions, in particular, catalytic cracking of diesel.
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公开(公告)号：US12128384B2
公开(公告)日：2024-10-29
申请号：US17278542
申请日：2019-09-24
Inventor： Yong Tae Kim , Sung Woo Lee , Seung Ju Han , Seok Ki Kim , Hyun Woo Kim
IPC: B01J23/745 , B01J21/08 , B01J35/02 , B01J35/10 , B01J35/40 , B01J35/61 , B01J37/00 , B01J37/04 , C07C2/24
CPC classification number: B01J23/745 , B01J21/08 , B01J35/40 , B01J35/612 , B01J37/0036 , B01J37/0081 , B01J37/04 , C07C2/24 , C07C2523/745
Abstract: The present disclosure relates to a catalyst for direct nonoxidative conversion of methane and a method of preparing the same, and more particularly to a method of preparing a catalyst for direct nonoxidative conversion of methane, in which a catalyst optimized for the direct conversion reaction of methane can be easily prepared without precise control of the reaction conditions for direct conversion of methane, thereby simultaneously maximizing the catalytic reaction rate and minimizing coke formation, and exhibiting stable catalytic performance even after long-term operation, and to a catalyst for direct nonoxidative conversion of methane prepared using the above method.
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9.发明公开公开(公告)号：US20240318025A1
公开(公告)日：2024-09-26
申请号：US18259508
申请日：2021-12-28
Inventor： Eun-Ho SOHN , Hyeon Jun HEO , Won Wook SO , In Joon PARK , Bong Jun CHANG , Sang Goo LEE , Myoung Sook LEE , Shin Hong YOOK , Ju Hyeon KIM , Ji Hoon BAIK , Myung Seok OH , Jong Min KIM
IPC: C09D127/16 , C08J5/18 , C09D7/63
CPC classification number: C09D127/16 , C08J5/18 , C09D7/63 , C08J2327/16
Abstract: The present invention relates to a fluorine-based polymer coating film, an optical substrate comprising same, and a method for manufacturing the optical substrate, and provides a fluorine-based polymer coating film which is formed from fluorine-based polymer nanoparticles coming in contact and being bound to each other, and which is coated on a substrate to improve infrared transmittance. The fluorine-based polymer coating film according to the present invention has improved infrared transmittance, and since the size of the fluorine-based polymer nanoparticles is controlled to control the ultraviolet-infrared transmittance, transmission wavelength selectivity can be improved.
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10.发明公开公开(公告)号：US20240255523A1
公开(公告)日：2024-08-01
申请号：US18290436
申请日：2022-05-03
Inventor： Sun-Woong KANG , Hye Eun SHIM , Byoung-Seok LEE , Ji Sek HAN , Sumi JANG
CPC classification number: G01N33/6887 , G01N33/5005 , G01N2333/78
Abstract: The present invention relates to a method for producing a cartilage model, comprising the step of simultaneously culturing a porous natural polymer support and a cartilage cell; a cartilage model produced by the method; and a method for testing the activity or toxicity of a test substance, comprising the step of treating the cartilage model with the test substance. A mature cartilage or aged cartilage model that can substitute an animal model may be produced using the method for producing the cartilage model according to the present invention, and the effectiveness and safety of the test substance may be accurately verified using the cartilage model thus produced, and thus, the cartilage model may be diversely utilized in the fields of new medicine development, disease research, and artificial organ development.
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