公开(公告)号：US20240212800A1

公开(公告)日：2024-06-27

申请号：US18544488

申请日：2023-12-19

Applicant: LumanLab Inc. ,  Korea University Research and Business Foundation ,  Korea University Research and Business Foundation, Sejong Campus

Inventor： Jae Hyun LIM ,  Chul Hyun CHO ,  Seung Pil PACK

IPC: G16H10/20 ,  A61B5/16 ,  G16H50/20 ,  G16H50/30

CPC classification number: G16H10/20 ,  A61B5/16 ,  G16H50/20 ,  G16H50/30 ,  A61B2503/06

Abstract: An electronic device and a method to assess a mental health state of an adolescent by using a survey formed based on an artificial intelligence (AI). The method comprises: collecting physical information of a user through a pre-installed application, verifying survey questions regarding a mental health depending on the physical information, and verifying answers to the verified survey questions through the application; forming additional survey questions after having verified the answers and calculating a prediction rate of an appearance of symptoms of a mental illness regarding the additional survey questions by using AI models; verifying a set of survey questions including a plurality of sub-questions depending on the calculated prediction rate; outputting the verified set of survey questions through the application; outputting result data by adjusting the prediction rate; and transmitting the outputted result data.

公开(公告)号：US20220289657A1

公开(公告)日：2022-09-15

申请号：US17637565

申请日：2020-08-21

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Youngjoo BYUN ,  Hee Deung PARK ,  Sangjin NAM ,  Sang-Hyun SON ,  So Young HAM ,  Han Shin KIM

IPC: C07C49/255 ,  C07C49/248 ,  C07C49/235 ,  A61K31/12 ,  A61P31/04

Abstract: The present invention relates to a 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof, the compound being capable of inhibiting biofilm formation and production of virulence factors. The 4-gingerol derivative compound according to the present invention has binding affinity to RhlR and corresponding RhlR antagonism activity that are significantly improved, and therefore can effectively inhibit biofilm formation and production of virulence factors. Furthermore, various bacterial infectious diseases caused by biofilms can be fundamentally prevented or treated by using a pharmaceutical composition comprising the 4-gingerol derivative compound, or a racemate, isomer, or pharmaceutically acceptable salt thereof as an active ingredient.

公开(公告)号：US20200283364A1

公开(公告)日：2020-09-10

申请号：US16632592

申请日：2018-07-19

Applicant: Korea University Research and Business Foundation, Sejong Campus ,  Korea University Research and Business Foundation

Inventor： Youngjoo BYUN ,  Hee-Deung PARK ,  Sang-Hyun SON ,  Eunji CHA ,  So-Young HAM ,  Hyunsuk CHOI

IPC: C07C49/255 ,  C07C49/245 ,  A61P31/04

Abstract: The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.

公开(公告)号：US20240238445A1

公开(公告)日：2024-07-18

申请号：US18552290

申请日：2022-07-08

Applicant: NEURACLE SCIENCE CO., LTD. ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS

Inventor： Jae Young SEONG ,  Youngjoo BYUN ,  Hoyun KWAK ,  Sitaek OH ,  Min-Hyeok LEE ,  Yongwoo JEONG ,  Nui HA ,  Eun-Ho CHO ,  Suhyun LEE ,  Sang-Myeong LEE ,  Yerim LEE ,  Eun Bee CHO ,  Jae Keun LEE ,  Han-Byul KIM ,  Soon-gu KWON

IPC: A61K48/00 ,  A61K31/055 ,  A61K31/085 ,  A61K31/136 ,  A61K31/137 ,  A61K38/08 ,  A61K38/10 ,  A61K38/17 ,  A61K45/06 ,  A61K47/64 ,  A61P25/02 ,  A61P25/28 ,  C12N5/0793

CPC classification number: A61K48/005 ,  A61K31/055 ,  A61K31/085 ,  A61K31/136 ,  A61K31/137 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/64 ,  A61P25/02 ,  A61P25/28 ,  C12N5/0619

Abstract: The present disclosure provides mimic molecules that are capable of specifically targeting a FAM19A5 protein, and thereby, inhibiting, reducing, and/or dissociating the interaction between members of the LRRC4 protein family and the FAM19A5 protein. The present disclosure also provides methods for promoting neurite outgrowth, by administering a mimic molecule described herein.

公开(公告)号：US11964935B2

公开(公告)日：2024-04-23

申请号：US16632592

申请日：2018-07-19

Applicant: Korea University Research and Business Foundation, Sejong Campus ,  Korea University Research and Business Foundation

Inventor： Youngjoo Byun ,  Hee-Deung Park ,  Sang-Hyun Son ,  Eunji Cha ,  So-Young Ham ,  Hyunsuk Choi

IPC: C07C49/255 ,  A61P31/04 ,  C07C49/245

CPC classification number: C07C49/255 ,  A61P31/04 ,  C07C49/245

Abstract: The present invention relates to a gingerol derivative having inhibitory activity against biofilm formation and a pharmaceutical composition for preventing or treating infections caused by biofilms including the gingerol derivative as an active ingredient. The gingerol derivative of the present invention exhibits significantly improved binding affinity for LasR and inhibitory activity against biofilm formation. Therefore, the gingerol derivative of the present invention can act on various membrane surfaces where biofilms tend to form and can effectively inhibit the formation of the corresponding biofilms. In addition, the use of the pharmaceutical composition according to the present invention can fundamentally prevent or treat a variety of infections caused by biofilms due to the presence of the gingerol derivative in the pharmaceutical composition.

公开(公告)号：US11298534B2

公开(公告)日：2022-04-12

申请号：US16235498

申请日：2018-12-28

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  Korea University Research and Business Foundation, Sejong Campus

Inventor： Hoon Jai Chun ,  Jung Hwa Hong ,  Dong Geun Sul ,  Bora Keum ,  Eun Sun Kim ,  Hyuk Soon Choi ,  Seung Han Kim

IPC: A61N1/00 ,  A61N1/36 ,  A61N1/372 ,  A61N1/05 ,  A61B17/00

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

公开(公告)号：US20190321631A1

公开(公告)日：2019-10-24

申请号：US16235498

申请日：2018-12-28

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Hoon Jai Chun ,  Jung Hwa Hong ,  Dong Geun Sul ,  Bora Keum ,  Eun Sun Kim ,  Hyuk Soon Choi ,  Seung Han Kim

IPC: A61N1/36 ,  A61N1/372 ,  A61N1/05

Abstract: A stimulator for a digestive organ includes a case, a substrate member disposed in the case, and an electrode member connected to the substrate member and extending to protrude outwardly from the case. The electrode member may have a shape of a wire and may be configured to provide an electrical stimulation in a state of being inserted and fixed at a predetermined location within a digestive organ.

公开(公告)号：US20250169099A1

公开(公告)日：2025-05-22

申请号：US18682728

申请日：2022-08-09

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Chul-Ho LEE ,  Donghun LEE

IPC: H10D30/47 ,  H10D30/01 ,  H10D62/80

Abstract: Disclosed are a high-mobility atomic layer semiconductor device based on modulation doping and a method for fabricating the same, which prevent a charge scattering phenomenon caused by ionized impurities by modulation doping dopants such that the dopants are spatially separated from a channel layer of an atomic layer semiconductor device having an atomic layer semiconductor heterojunction structure band-aligned. According to an embodiment of the present disclosure, a high-mobility atomic layer semiconductor device based on modulation doping includes a substrate, an atomic layer semiconductor heterojunction structure band-aligned in type I or type II and including a channel layer allowing movement of an electron and a doping layer, wherein the channel layer and the doping layer are stacked on the substrate, and a dopant formed on the doping layer and including a material for supplying an electron or a hole to the channel layer. The dopant is doped while being spatially separated from the channel layer through the doping layer, instead of being directly doped into the channel layer.

公开(公告)号：US20250160002A1

公开(公告)日：2025-05-15

申请号：US18947282

申请日：2024-11-14

Applicant: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Hyun-Yong YU ,  Kyu Hyun HAN

IPC: H01L29/66 ,  H01L21/441 ,  H01L29/786

Abstract: Disclosed are low-plasma treatment-based metal transfer technology, high-quality source-drain formation technology, and a method of manufacturing a semiconductor device using the same. The method of manufacturing the semiconductor device includes preparing an oxide substrate, sequentially depositing a contact metal, Ti, and Au on the oxide substrate, performing plasma treatment on the oxide substrate on which the contact metal, the Ti, and the Au are deposited, attaching an organic film on the oxide substrate on which the contact metal, the Ti, and the Au are deposited, and removing oxide of the oxide substrate.

公开(公告)号：US12301717B2

公开(公告)日：2025-05-13

申请号：US18172747

申请日：2023-02-22

Applicant: Samsung Electronics Co., Ltd. ,  KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION

Inventor： Dongwook Shim ,  Donghoon Lee

IPC: H04L9/32 ,  G06F3/06

Abstract: An electronic device is provided. The electronic device includes a memory and a processor, the processor allocates first and second address spaces (AS) to the memory in rich execution environment (REE) when detecting a request to write data, writes the data to the first AS and detect access to the second address space in the REE, configures access permission of a first user virtual memory AS (VMAS), mapped to the first address space, in the REE so that write access is deactivated by a trusted environment manager when detecting access to the second AS, configures access permission of a second user VMAS, mapped to the second AS, in the REE so that read access is activated and write access is deactivated, and configures access permission of a first kernel VMAS, mapped to the first AS, in the REE so that write access is deactivated by the trusted environment manager.