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公开(公告)号：US08252795B2
公开(公告)日：2012-08-28
申请号：US12575589
申请日：2009-10-08
Applicant: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
Inventor： Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC: A01N43/58 , A61K31/50 , C07D487/00
CPC classification number: C07D487/04 , C07D498/04
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
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2.发明授权1,6-naphthyridine derivatives and their use to treat diabetes and related disorders 失效1,6-萘啶衍生物及其用于治疗糖尿病和相关疾病的用途公开(公告)号：US06964971B2
公开(公告)日：2005-11-15
申请号：US10684299
申请日：2003-10-10
Applicant: Yamin Wang , William H. Bullock , Libing Chen
Inventor： Yamin Wang , William H. Bullock , Libing Chen
IPC: A61K31/133 , A61K31/155 , A61K31/195 , A61K31/198 , A61K31/435 , A61K31/4375 , A61K31/44 , A61K31/4439 , A61K31/444 , A61K31/445 , A61K31/4453 , A61K31/4545 , A61K31/455 , A61K31/4709 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/64 , A61K31/7034 , A61K38/22 , A61K38/28 , A61K45/00 , A61K45/06 , A61P3/04 , A61P3/10 , A61P5/12 , A61P5/42 , A61P9/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07D471/02 , C07D471/04
CPC classification number: A61K45/06 , A61K31/44 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , A61K2300/00
Abstract: The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
Abstract translation: 本发明一般涉及下式的萘啶衍生物，其中U，X，Y和Z中的一个为氮，其余为C-R，其中R为氢或取代基。 更具体地，本发明涉及1,6-萘啶衍生物和含有这些衍生物的药物组合物。 本发明的方法包括施用本发明的萘啶衍生物用于治疗糖尿病和相关疾病。
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公开(公告)号：US20120283241A1
公开(公告)日：2012-11-08
申请号：US13552795
申请日：2012-07-19
Applicant: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
Inventor： Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC: A61K31/5025 , A61P35/00 , A61P17/06 , A61K31/538 , A61P35/02 , A61K31/5377 , C07D498/04 , C07D487/04 , A61P29/00
CPC classification number: C07D487/04 , C07D498/04
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
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公开(公告)号：US20100113458A1
公开(公告)日：2010-05-06
申请号：US12575589
申请日：2009-10-08
Applicant: Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
Inventor： Brian E. Fink , Libing Chen , Ashvinikumar V. Gavai , Liqi He , Soong-Hoon Kim , Andrew James Nation , Yufen Zhao , Litai H. Zhang
IPC: A61K31/5025 , C07D487/00
CPC classification number: C07D487/04 , C07D498/04
Abstract: The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式（I）化合物及其药学上可接受的盐。 式（I）咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
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公开(公告)号：US20060084680A1
公开(公告)日：2006-04-20
申请号：US10537630
申请日：2003-12-19
Applicant: Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens
Inventor： Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Xin Ma , Joachim Rudolph , Sidney Liang , Christiana Akuche , Rico Lavoie , Libing Chen , Dyuti Majumdar , Philip Wickens
IPC: A61K31/445 , A61K31/195 , A61K31/192
CPC classification number: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04
Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
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Patent Agency Ranking
6.发明授权1,6-naphthyridine derivatives and their use to treat diabetes and related disorders 失效1,6-萘啶衍生物及其用于治疗糖尿病和相关疾病的用途公开(公告)号：US06677352B1
公开(公告)日：2004-01-13
申请号：US10253215
申请日：2002-09-23
Applicant: Yamin Wang , William H. Bullock , Libing Chen
Inventor： Yamin Wang , William H. Bullock , Libing Chen
IPC: A61K31435
CPC classification number: A61K45/06 , A61K31/44 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D471/04 , A61K2300/00
Abstract: The invention relates generally to naphthyridine derivatives of the formula wherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,6-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
Abstract translation: 本发明一般涉及U，X，Y和Z之一的萘啶衍生物是氮，其它是C-R，其中R是氢或取代基。 更具体地，本发明涉及1,6-萘啶衍生物和含有这些衍生物的药物组合物。 本发明的方法包括施用本发明的萘啶衍生物用于治疗糖尿病和相关疾病。
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公开(公告)号：US08389527B2
公开(公告)日：2013-03-05
申请号：US12866365
申请日：2009-02-06
Applicant: Brian E. Fink , Soong-Hoon Kim , Yufen Zhao , Ping Chen , Wayne Vaccaro , Litai Zhang , Ashvinikumar V Gavai , Dharmpal S Dodd , Libing Chen
Inventor： Brian E. Fink , Soong-Hoon Kim , Yufen Zhao , Ping Chen , Wayne Vaccaro , Litai Zhang , Ashvinikumar V Gavai , Dharmpal S Dodd , Libing Chen
IPC: A01N43/58 , A01N43/60 , C61K31/50 , C07D487/00
CPC classification number: C07D487/04
Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
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公开(公告)号：US20100323994A1
公开(公告)日：2010-12-23
申请号：US12866365
申请日：2009-02-06
Applicant: Brian E. Fink , Soong-Hoon Kim , Yufen Zhao , Ping Chen , Wayne Vaccaro , Litai Zhang , Ashvinikumar V. Gaval , Dharmpal S. Dodd , Libing Chen
Inventor： Brian E. Fink , Soong-Hoon Kim , Yufen Zhao , Ping Chen , Wayne Vaccaro , Litai Zhang , Ashvinikumar V. Gaval , Dharmpal S. Dodd , Libing Chen
IPC: A61K31/5025 , C07D487/04 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K31/397 , A61P35/00 , A61P17/06 , A61P19/02
CPC classification number: C07D487/04
Abstract: The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I imidazopyridazines inhibit protein kinase activity thereby making them useful as anticancer agents.
Abstract translation: 本发明提供式I化合物及其药学上可接受的盐。 式I咪唑并哒嗪抑制蛋白激酶活性，从而使其成为抗癌剂。
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9.发明申请Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 失效茚基乙酸衍生物及其作为药剂，中间体和制备方法的用途公开(公告)号：US20100204472A1
公开(公告)日：2010-08-12
申请号：US12759328
申请日：2010-04-13
Applicant: Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens
Inventor： Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens
IPC: C07D239/34 , C07D401/04 , C07D405/10 , C07D213/85 , C07D213/72 , C07D213/55 , C07D513/04 , C07D277/30 , C07D239/42
CPC classification number: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04
Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
Abstract translation: 本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。
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公开(公告)号：US20080064734A1
公开(公告)日：2008-03-13
申请号：US11897620
申请日：2007-08-31
Applicant: Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
Inventor： Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
IPC: A61K31/415 , A61P3/04 , C07D231/10
CPC classification number: C07D231/38 , C07D401/04 , C07D403/12 , C07D413/12 , C07D471/04
Abstract: The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
Abstract translation: 本发明涉及苯胺基吡唑化合物，药物组合物和治疗糖尿病及相关疾病的方法。
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