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公开(公告)号：US09623095B2
公开(公告)日：2017-04-18
申请号：US13824705
申请日：2012-02-29
Applicant: Karl-Josef Kallen , Thomas Kramps , Margit Schnee , Benjamin Petsch , Lothar Stitz
Inventor： Karl-Josef Kallen , Thomas Kramps , Margit Schnee , Benjamin Petsch , Lothar Stitz
CPC classification number: A61K39/155 , A61K39/00 , A61K39/12 , A61K39/145 , A61K45/06 , A61K47/59 , A61K47/6455 , A61K47/6921 , A61K2039/53 , A61K2039/54 , A61K2039/55 , A61K2039/55583 , A61K2039/572 , A61K2039/575 , A61K2039/6031 , A61K2039/622 , C12N2760/16134 , C12N2760/18534 , C12N2760/18571 , Y02A50/412
Abstract: The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of the newborn or infant and eliciting an immune response in said newborn or infant. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit.
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公开(公告)号：US08852587B2
公开(公告)日：2014-10-07
申请号：US12999045
申请日：2009-06-16
Applicant: Carsten Korth , Lothar Stitz , Benjamin Petsch , Andreas Müller-Schiffmann , Sirik Rutger Leliveld
Inventor： Carsten Korth , Lothar Stitz , Benjamin Petsch , Andreas Müller-Schiffmann , Sirik Rutger Leliveld
IPC: A61K39/395
CPC classification number: C07K16/2872 , A61K2039/505 , C07K7/08 , C07K14/47 , C07K2317/34 , C07K2317/565 , C07K2317/622
Abstract: The invention relates to an antibody, antibody fragment or derivative thereof which specifically recognizes a prion protein and which comprises a complementarity determining region (CDR), a retro-inverso D-peptide of said CDR and/or an anti-idiotypic antibody, antibody fragment or derivative thereof which recognizes said CDR. The invention further concerns a nucleic acid molecule encoding said antibody, antibody fragment or derivative thereof as well as a method for generating an antibody, antibody fragment or derivative thereof that specifically recognizes a prion protein, wherein an antibody that recognizes a specific domain of the prion protein is generated, an antigen-specific amino acid sequence is isolated from said antibody, and an anti-idiotypic antibody, antibody fragment or derivative thereof, which recognizes said antigen-specific amino acid sequence, is generated.
Abstract translation: 本发明涉及特异性识别朊病毒蛋白的抗体，抗体片段或其衍生物，其包含互补决定区（CDR），所述CDR的逆反式D-肽和/或抗独特型抗体，抗体片段 或其衍生物识别所述CDR。 本发明还涉及编码所述抗体，抗体片段或其衍生物的核酸分子以及产生特异性识别朊病毒蛋白的抗体，抗体片段或其衍生物的方法，其中识别朊病毒的特定结构域的抗体 产生蛋白质，从抗体中分离抗原特异性氨基酸序列，并产生识别所述抗原特异性氨基酸序列的抗独特型抗体，抗体片段或其衍生物。
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公开(公告)号：US6077510A
公开(公告)日：2000-06-20
申请号：US582776
申请日：1996-01-04
Applicant: W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Annette Schneemann
Inventor： W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Annette Schneemann
IPC: G01N33/53 , A61K38/00 , A61K39/00 , A61K39/12 , A61K48/00 , A61P25/00 , A61P31/12 , C07K14/08 , C07K16/10 , C12M1/00 , C12N7/00 , C12N15/09 , C12N15/40 , C12Q1/68 , G01N33/569 , C07K7/00 , C12Q1/70
CPC classification number: C07K14/005 , A01K2217/05 , A61K2039/51 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2760/00022 , C12N2760/00043 , Y10S435/975
Abstract: The present invention presents: genomic nucleotide sequence of Borna disease virus, nucleotide and amino acid sequences of Borna disease virus proteins, recombinant viral proteins, vectors and cells containing the sequences or encoding the proteins, ligand binding to these proteins such as antibodies, and the diagnostic and therapeutic uses of the foregoing.
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公开(公告)号：US6015660A
公开(公告)日：2000-01-18
申请号：US369822
申请日：1995-01-06
Applicant: W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Anette Schneemann
Inventor： W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Anette Schneemann
IPC: A61K38/00 , A61K39/00 , A61K48/00 , C07K14/08 , C12Q1/70 , G01N33/543 , G01N33/569
CPC classification number: C07K14/005 , A01K2217/05 , A61K2039/51 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2760/00022 , C12N2760/00043 , Y10S435/975
Abstract: The present invention presents: genomic nucleotide sequence of Borna disease virus, nucleotide and amino acid sequences of Borna disease virus proteins, recombinant viral proteins, vectors and cells containing the sequences or encoding the proteins, ligand binding to these proteins such as antibodies, and the diagnostic and therapeutic uses of the foregoing.
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Patent Agency Ranking
公开(公告)号：US20130336998A1
公开(公告)日：2013-12-19
申请号：US13824705
申请日：2012-02-29
Applicant: Karl-Josef Kallen , Thomas Kramps , Margit Schnee , Benjamin Petsch , Lothar Stitz
Inventor： Karl-Josef Kallen , Thomas Kramps , Margit Schnee , Benjamin Petsch , Lothar Stitz
CPC classification number: A61K39/155 , A61K39/00 , A61K39/12 , A61K39/145 , A61K45/06 , A61K47/59 , A61K47/6455 , A61K47/6921 , A61K2039/53 , A61K2039/54 , A61K2039/55 , A61K2039/55583 , A61K2039/572 , A61K2039/575 , A61K2039/6031 , A61K2039/622 , C12N2760/16134 , C12N2760/18534 , C12N2760/18571 , Y02A50/412
Abstract: The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age of not more than 2 years, preferably of not more than 1 year, more preferably of not more than 9 months or even 6 months, wherein the treatment comprises vaccination of the newborn or infant and eliciting an immune response in said newborn or infant. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit.
Abstract translation: 本发明涉及包含编码至少一种抗原的至少一种mRNA的疫苗，用于治疗新生儿和/或婴儿中的疾病，优选不超过2年，优选不超过1年的年龄， 更优选不超过9个月甚至6个月，其中所述治疗包括接种新生儿或婴儿并在所述新生儿或婴儿中引发免疫应答。 本发明还涉及包含这种疫苗和/或其组分的试剂盒和试剂盒，以及应用这种疫苗或试剂盒的方法。
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公开(公告)号：US20130295043A1
公开(公告)日：2013-11-07
申请号：US13824589
申请日：2012-02-29
Applicant: Karl-Josef Kallen , Thomas Kramps , Margit Schnee , Benjamin Petsch , Lothar Stitz
Inventor： Karl-Josef Kallen , Thomas Kramps , Margit Schnee , Benjamin Petsch , Lothar Stitz
IPC: A61K39/145 , A61K45/06 , A61K39/00
CPC classification number: A61K39/145 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K2039/53 , A61K2039/54 , A61K2039/55 , A61K2039/55505 , A61K2039/5555 , A61K2039/55555 , A61K2039/572 , A61K2039/585 , A61K2039/6031 , A61K2039/622 , A61K2039/70 , C12N7/00 , C12N2760/16134 , Y02A50/412
Abstract: The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in an elderly patient preferably exhibiting an age of at least 50 years, more preferably of at least 55 years, 60 years, 65 years, 70 years, or older, wherein the treatment comprises vaccination of the patient and eliciting an immune response in said patient. The present invention is furthermore directed to kits and kits of parts comprising such a vaccine and/or its components and to methods applying such a vaccine or kit.
Abstract translation: 本发明涉及包含编码至少一种抗原的至少一种mRNA的疫苗，其用于治疗老年患者的疾病，优选年龄至少为50岁，更优选为至少55岁，60岁，65岁 年龄，70岁或以上，其中所述治疗包括接种患者并在所述患者中引发免疫应答。 本发明还涉及包含这种疫苗和/或其组分的试剂盒和试剂盒，以及应用这种疫苗或试剂盒的方法。
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公开(公告)号：US08709410B2
公开(公告)日：2014-04-29
申请号：US12999045
申请日：2009-06-16
Applicant: Carsten Korth , Lothar Stitz , Benjamin Petsch , Andreas Müller-Schiffmann , Sirik Rutger Leliveld
Inventor： Carsten Korth , Lothar Stitz , Benjamin Petsch , Andreas Müller-Schiffmann , Sirik Rutger Leliveld
IPC: A61K39/395
Abstract: The invention relates to an antibody, antibody fragment or derivative thereof which specifically recognizes a prion protein and which comprises a complementarity determining region (CDR), a retro-inverso D-peptide of said CDR and/or an anti-idiotypic antibody, antibody fragment or derivative thereof which recognizes said CDR. The invention further concerns a nucleic acid molecule encoding said antibody, antibody fragment or derivative thereof as well as a method for generating an antibody, antibody fragment or derivative thereof that specifically recognizes a prion protein, wherein an antibody that recognizes a specific domain of the prion protein is generated, an antigen-specific amino acid sequence is isolated from said antibody, and an anti-idiotypic antibody, antibody fragment or derivative thereof, which recognizes said antigen-specific amino acid sequence, is generated.
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公开(公告)号：US20110098448A1
公开(公告)日：2011-04-28
申请号：US12999045
申请日：2009-06-16
Applicant: Carsten Korth , Lothar Stitz , Benjamin Petsch , Andreas Muller-Schiffmann , Sirik Rutger Leliveld
Inventor： Carsten Korth , Lothar Stitz , Benjamin Petsch , Andreas Muller-Schiffmann , Sirik Rutger Leliveld
CPC classification number: C07K16/2872 , A61K2039/505 , C07K7/08 , C07K14/47 , C07K2317/34 , C07K2317/565 , C07K2317/622
Abstract: The invention relates to an antibody, antibody fragment or derivative thereof which specifically recognizes a prion protein and which comprises a complementarity determining region (CDR), a retro-inverso D-peptide of said CDR and/or an anti-idiotypic antibody, antibody fragment or derivative thereof which recognizes said CDR. The invention further concerns a nucleic acid molecule encoding said antibody, antibody fragment or derivative thereof as well as a method for generating an antibody, antibody fragment or derivative thereof that specifically recognizes a prion protein, wherein an antibody that recognizes a specific domain of the prion protein is generated, an antigen-specific amino acid sequence is isolated from said antibody, and an anti-idiotypic antibody, antibody fragment or derivative thereof, which recognizes said antigen-specific amino acid sequence, is generated.
Abstract translation: 本发明涉及特异性识别朊病毒蛋白的抗体，抗体片段或其衍生物，其包含互补决定区（CDR），所述CDR的逆反式D-肽和/或抗独特型抗体，抗体片段 或其衍生物识别所述CDR。 本发明还涉及编码所述抗体，抗体片段或其衍生物的核酸分子以及产生特异性识别朊病毒蛋白的抗体，抗体片段或其衍生物的方法，其中识别朊病毒的特定结构域的抗体 产生蛋白质，从抗体中分离抗原特异性氨基酸序列，并产生识别所述抗原特异性氨基酸序列的抗独特型抗体，抗体片段或其衍生物。
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9.发明授权Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases 失效博尔纳病病毒序列，神经系统疾病的诊断和治疗
公开(公告)号：US06113905A
公开(公告)日：2000-09-05
申请号：US434831
申请日：1995-05-02
Applicant: W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Anette Schneemann
Inventor： W. Ian Lipkin , Thomas Briese , Stefanie Kliche , Patrick A. Schneider , Lothar Stitz , Anette Schneemann
IPC: A61K38/00 , A61K39/00 , A61K48/00 , A61P25/00 , A61P31/12 , C07K14/08 , A61K39/12 , C07K4/02 , C12Q1/70
CPC classification number: C07K14/005 , A01K2217/05 , A61K2039/51 , A61K38/00 , A61K39/00 , A61K48/00 , C12N2760/00022 , C12N2760/00043 , Y10S435/81
Abstract: The present invention presents: genomic nucleotide sequence of Borna disease virus, nucleotide and amino acid sequences of Borna disease virus proteins, recombinant viral proteins, vectors and cells containing the sequences or encoding the proteins, ligand binding to these proteins such as antibodies, and the diagnostic and therapeutic uses of the foregoing.
Abstract translation: 本发明提出：博尔那病病毒的基因组核苷酸序列，博尔纳病毒蛋白质的核苷酸和氨基酸序列，重组病毒蛋白质，含有序列或编码蛋白质的载体和细胞，与这些蛋白质如抗体结合的配体，以及 诊断和治疗用途。
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