MULTIMODAL NANOBIOSENSOR FOR DETECTING CANCER BIOMARKERS IN BLOOD SERUM

    公开(公告)号:US20230168239A1

    公开(公告)日:2023-06-01

    申请号:US17536017

    申请日:2021-11-27

    Abstract: An optical multimodal detection system for targeted detection of cancer biomarkers in blood serum. The system comprises of a nano-biosensor, a chamber for receiving the nano-biosensor, a localized surface plasmon resonance (LSPR) based detector, a plasmon enhanced fluorescence (PEF) based detector and a surface-enhanced Raman scattering (SERS) based detector. The nano-biosensor comprises of a glass substrate provided with an active site for receiving a sample of blood serum, and is dimensioned to define a flow channel for introducing the sample of blood serum into the nano-biosensor. The nano-biosensor is provided with a layer of amino-silane compound coating over the glass substrate and a plurality of gold nano-urchins (GNU) bound to the layer of silicone compound. The plurality of gold-nano-urchins are functionalized with a hydrazide linker molecule for allowing uniform-oriented conjugation of a Fc region of antibodies to a surface of gold nano-urchins thereby allowing Fab regions of antibodies for binding with cancer biomarkers.

    Control system for washroom devices

    公开(公告)号:US10241487B2

    公开(公告)日:2019-03-26

    申请号:US15104871

    申请日:2013-12-16

    Inventor: Saeid Mohmedi

    Abstract: A system for controlling a plurality of devices in a public washroom facility having a controller with an integrated circuit including at least one logic block providing one or more predetermined control instructions to one or more of the plurality of devices via at least one control block; the at least one control block defining a communication interface between the integrated circuit and the plurality of devices; at least one communication block receiving data from a communications interface for programming the integrated circuit to modify the one or more predetermined control instructions.

    EARLY CANCER BIOMARKER DETECTION USING COMBINED NANOPARTICLE-OPTICAL FIBRE, TUNABLE OPTICAL HETRODYNING, FLUORESCENCE AND SENSOR SYSTEM

    公开(公告)号:US20180348118A1

    公开(公告)日:2018-12-06

    申请号:US15996011

    申请日:2018-06-01

    Abstract: This invention relates a biomarker detection system, for detecting cancer biomarkers using optical heterodyning. The system includes a tunable laser configured to produce a plurality of laser beams of at least two frequencies, a pair of optical fibers coated with gold nanoparticles and functionalized with an antibody is configured to undergo a change of fiber surface of each optical fiber by adsorbing molecules of an analyte on a surface of the antibody, modify a reflection of the plurality of laser beams inside a fiber core of the each optical fiber when the each optical fiber is bent, and create an audible beat frequency; and perform spectral analysis. A frequency spectrum analyzer configured to provide a composition information of the adsorbed molecules based on a spectral analysis of the beat frequency.

    Multimodal nanobiosensor for detecting cancer biomarkers in blood serum

    公开(公告)号:US11828747B2

    公开(公告)日:2023-11-28

    申请号:US17536017

    申请日:2021-11-27

    Abstract: An optical multimodal detection system for targeted detection of cancer biomarkers in blood serum. The system comprises of a nano-biosensor, a chamber for receiving the nano-biosensor, a localized surface plasmon resonance (LSPR) based detector, a plasmon enhanced fluorescence (PEF) based detector and a surface-enhanced Raman scattering (SERS) based detector. The nano-biosensor comprises of a glass substrate provided with an active site for receiving a sample of blood serum, and is dimensioned to define a flow channel for introducing the sample of blood serum into the nano-biosensor. The nano-biosensor is provided with a layer of amino-silane compound coating over the glass substrate and a plurality of gold nano-urchins (GNU) bound to the layer of silicone compound. The plurality of gold-nano-urchins are functionalized with a hydrazide linker molecule for allowing uniform-oriented conjugation of a Fc region of antibodies to a surface of gold nano-urchins thereby allowing Fab regions of antibodies for binding with cancer biomarkers.

    METHOD FOR FABRICATION OF NANOSTRUCTURE

    公开(公告)号:US20220117905A1

    公开(公告)日:2022-04-21

    申请号:US17233469

    申请日:2021-04-17

    Abstract: A method for fabricating a nanostructure comprises adding a fungal mycelium (114) in a growth vessel (110). The growth vessel (110) comprising a growth medium (118). In the next step, the nanostructure is added in the growth vessel (110) which is then absorbed by the fungal mycelium (114) and finally distributed throughout the fungal mycelium (114). Further, a delivery vehicle for payload (206) is also disclosed which comprises the fabricated nanostructure.

    Fluid dispensing system
    8.
    发明授权

    公开(公告)号:US11346089B2

    公开(公告)日:2022-05-31

    申请号:US16618332

    申请日:2018-06-01

    Abstract: A fluid dispensing system comprises a first pipe, a second pipe and a thermoelectric generator. The first pipe is configured to carry fluid to the fluid dispensing system. The second pipe is configured to carry fluid to the fluid dispensing system. Temperature of the fluid carried by the first pipe is higher than temperature of the fluid carried by the second pipe. The thermoelectric generator comprises a first side and a second side. The first side of the thermoelectric generator is in thermal contact with the first pipe. The second side of the thermoelectric generator is in thermal contact with the second pipe. Temperature gradient is established between the first side and the second side due to difference in temperature in the first pipe and the second pipe. Electric current is generated by the thermoelectric generator as a result of the temperature gradient.

    FLUID DISPENSING SYSTEM
    9.
    发明申请

    公开(公告)号:US20210156126A1

    公开(公告)日:2021-05-27

    申请号:US16618332

    申请日:2018-06-01

    Abstract: A fluid dispensing system comprises a first pipe, a second pipe and a thermoelectric generator. The first pipe is configured to carry fluid to the fluid dispensing system. The second pipe is configured to carry fluid to the fluid dispensing system. Temperature of the fluid carried by the first pipe is higher than temperature of the fluid carried by the second pipe. The thermoelectric generator comprises a first side and a second side. The first side of the thermoelectric generator is in thermal contact with the first pipe. The second side of the thermoelectric generator is in thermal contact with the second pipe. Temperature gradient is established between the first side and the second side due to difference in temperature in the first pipe and the second pipe. Electric current is generated by the thermoelectric generator as a result of the temperature gradient.

    Control System For Wahsroom Devices
    10.
    发明申请
    Control System For Wahsroom Devices 审中-公开
    Wahsroom设备控制系统

    公开(公告)号:US20160313712A1

    公开(公告)日:2016-10-27

    申请号:US15104871

    申请日:2013-12-16

    Inventor: Saeid MOHMEDI

    Abstract: A system for controlling a plurality of devices in a public washroom facility having a controller with an integrated circuit including at least one logic block providing one or more predetermined control instructions to one or more of the plurality of devices via at least one control block; the at least one control block defining a communication interface between the integrated circuit and the plurality of devices; at least one communication block receiving data from a communications interface for programming the integrated circuit to modify the one or more predetermined control instructions.

    Abstract translation: 一种用于控制公共洗手间设施中的多个设备的系统,具有具有集成电路的控制器,该集成电路包括经由至少一个控制块向一个或多个设备提供一个或多个预定控制指令的至少一个逻辑块; 所述至少一个控制块限定所述集成电路和所述多个设备之间的通信接口; 至少一个通信块从通信接口接收数据,用于对集成电路进行编程以修改一个或多个预定的控制指令。

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