公开(公告)号：US10390856B2

公开(公告)日：2019-08-27

申请号：US13351836

申请日：2012-01-17

Applicant: Michelle Journey ,  Sean Caffey ,  Mark Humayun ,  John Huculak

Inventor： Michelle Journey ,  Sean Caffey ,  Mark Humayun ,  John Huculak

IPC: A61B17/28 ,  A61B17/30 ,  A61B17/00 ,  A61B17/29 ,  A61F9/00 ,  A61F13/51

Abstract: Surgical introducers aid surgeons in the implantation of medical devices. The introducer provides support and an even distribution of force for ease of insertion and prevention of damage to the medical device while protecting the tissue into which the device is implanted. A representative embodiment includes or consists of a locking device, a pair of forceps, a specially configured and/or angled head with a seat for the device to be implanted, and a gripping area.

公开(公告)号：US09468524B2

公开(公告)日：2016-10-18

申请号：US14834484

申请日：2015-08-25

Applicant: Sean Caffey ,  Charles DeBoer ,  Mark Humayun ,  Yu-Chong Tai

Inventor： Sean Caffey ,  Charles DeBoer ,  Mark Humayun ,  Yu-Chong Tai

IPC: A61F2/16 ,  A61F9/00

CPC classification number: A61F2/1662 ,  A61F2/1635 ,  A61F9/0008 ,  A61F2250/0002 ,  A61F2250/0003

Abstract: Advances in filling apparatus, handheld tools, surgical techniques and intraoperative biometry for implanting and adjusting an accommodative liquid lens are disclosed. The lens may be attached to or retained within a handheld surgical tool, which can be fluidly connectable to a filling console to fill the lens with a liquid. In various embodiments, a filling console facilitates aspirating liquid out of the lens in order to ensure the absence of residual bubbles and filling of the lens with fluid during surgery, as well as during post-operative adjustments to the lens. Actuated by the surgeon, the filling console can aspirate fluid from the lens and inject fluid into the lens following insertion thereof.

Abstract translation: 公开了用于植入和调节调节液体透镜的灌装设备，手持工具，手术技术和术中生物测定的进展。 透镜可以附接到或保持在手持式手术工具中，该手术工具可以流体地连接到填充控制台以用液体填充透镜。 在各种实施例中，填充控制台便于将液体从透镜吸出，以确保在外科手术期间以及在镜片的手术后调整期间不存在残留气泡和填充透镜。 由外科医生执行，灌装控制台可以从透镜吸出液体，并在插入后将液体注入镜片。

公开(公告)号：US20150272727A1

公开(公告)日：2015-10-01

申请号：US14670686

申请日：2015-03-27

Applicant: Mark Humayun ,  Charles DeBoer ,  Yu-Chong Tai ,  Sean Caffey ,  Craig Alan Cable, II

Inventor： Mark Humayun ,  Charles DeBoer ,  Yu-Chong Tai ,  Sean Caffey ,  Craig Alan Cable, II

IPC: A61F2/16

CPC classification number: A61F2/1635 ,  A61F2/1613 ,  A61F2002/1682 ,  A61F2002/16901 ,  A61F2220/0008 ,  A61F2250/0009 ,  A61F2250/001 ,  A61F2250/0013 ,  A61F2250/0051 ,  A61F2250/0071 ,  A61F2250/0091

Abstract: Mechanical and/or adhesive coupling features are added to an intraocular lens during fabrication or thereafter, and provide beneficial mechanical coupling to the lens capsule. The coupling features may pass through or otherwise engage complementary coupling apertures in the crystalline lens capsule.

Abstract translation: 机械和/或粘合剂结合特征在制造期间或此后被添加到人工晶状体中，并且提供对透镜胶囊的有益的机械耦合。 耦合特征可以穿过或以其它方式接合晶状体囊中的互补耦合孔。

公开(公告)号：US20140271901A1

公开(公告)日：2014-09-18

申请号：US14218850

申请日：2014-03-18

Applicant: Mark Humayun

Inventor： Mark Humayun

IPC: A61K38/48 ,  A61K9/00 ,  A61K9/14

CPC classification number: A61K41/0047 ,  A61F9/00745 ,  A61K9/0009 ,  A61K9/0048 ,  A61K9/5015 ,  A61K38/43 ,  A61K38/48 ,  A61K38/484 ,  A61N7/00 ,  A61N2007/0039 ,  C12Y304/21007

Abstract: Methods and compositions are provided here to manage tractional membranes, as well as other diseases and disorders of the eye. Compositions comprising microbubbles associated with enzymes or vitreolytic agents, are provided. The method of the present invention involves administration of the microbubble and an enzyme or vitreolytic agent to a subject in need thereof, followed by application of ultrasound.

Abstract translation: 这里提供了方法和组合物来管理牵引膜，以及眼睛的其它疾病和病症。 提供了包含与酶或玻璃质分解剂相关的微泡的组合物。 本发明的方法包括向有需要的受试者施用微泡和酶或玻璃体解质剂，然后施加超声波。

公开(公告)号：US08771347B2

公开(公告)日：2014-07-08

申请号：US13350612

申请日：2012-01-13

Applicant: Charles DeBoer ,  Yu-Chong Tai ,  Mark Humayun

Inventor： Charles DeBoer ,  Yu-Chong Tai ,  Mark Humayun

IPC: A61F2/16

CPC classification number: A61F2/1635 ,  A61F2/1613 ,  A61F9/007 ,  A61F2250/0003 ,  A61L27/48 ,  A61L2430/16 ,  C08G2261/3424 ,  C08L65/04

Abstract: Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. One or more silicone elastomeric patches located outside the optical path on the anterior side but away from the equator can be accessed by surgical needles in order to fill or adjust optically clear fluid within the lens. The fluid can be adjusted in order to set a base dioptric power of the lens and otherwise adjust a lens after its initial insertion. The elastomeric patches are sized so that they self-seal after a needle is withdrawn. A straight or stepped slit in the patch can allow a blunt needle to more easily access the interior of the lens.

Abstract translation: 系统，装置和方法用于假体可注射的眼内透镜。 可以通过外科手术针来访问位于前侧但远离赤道的光路外侧的一个或多个有机硅弹性体贴片，以便填充或调整透镜内的光学透明流体。 可以调节流体以便设置透镜的基础屈光度，并在其初始插入之后调整透镜。 弹性体贴片的尺寸使得它们在针被取出后自我密封。 贴片中的直的或阶梯的狭缝可以使钝针更容易地进入透镜的内部。

公开(公告)号：US08711364B2

公开(公告)日：2014-04-29

申请号：US13106388

申请日：2011-05-12

Applicant: Jeffrey Brennan ,  Mark Humayun ,  Sean Caffey

Inventor： Jeffrey Brennan ,  Mark Humayun ,  Sean Caffey

IPC: G01B9/02

CPC classification number: G01B9/02028 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  A61B5/04001 ,  A61B2562/0209 ,  A61B2562/0233 ,  A61B2562/043 ,  A61B2562/063 ,  A61F2009/00851 ,  A61N1/0529 ,  A61N1/0551 ,  A61N1/3605 ,  G01B9/02007 ,  G01B9/02016 ,  G01B9/02027 ,  G01B9/02091 ,  G01N21/4795 ,  H04J14/02

Abstract: A multiplexed OCT imaging system includes a plurality of sample arms, an imaging engine, and an optical controller. The sample arms are optically coupled to the imaging engine via the optical controller; the optical controller multiplexes optical signals from the sample arms to permit some of the sample arms to operate sequentially or simultaneously.

Abstract translation: 复用的OCT成像系统包括多个样本臂，成像引擎和光学控制器。 样品臂通过光学控制器光学耦合到成像引擎; 光学控制器复用来自样品臂的光学信号，以允许一些样品臂顺序地或同时地操作。

公开(公告)号：US08623000B2

公开(公告)日：2014-01-07

申请号：US13084471

申请日：2011-04-11

Applicant: Mark Humayun ,  Charles DeBoer ,  Ralph Kerns ,  Matthew McCormick ,  Prashant Bhadri ,  Lawrence Chong

Inventor： Mark Humayun ,  Charles DeBoer ,  Ralph Kerns ,  Matthew McCormick ,  Prashant Bhadri ,  Lawrence Chong

IPC: A61B17/00 ,  A61F9/00 ,  A61B17/32 ,  B65D6/04

CPC classification number: A61F9/00736 ,  A61B18/1206 ,  A61B50/33 ,  A61B90/30 ,  A61B90/98 ,  A61B2017/00199 ,  A61B2017/00221 ,  A61B2017/00225 ,  A61B2017/0023 ,  A61B2017/00544 ,  A61B2017/00734 ,  A61B2018/00601 ,  A61B2050/3008 ,  A61F9/00745

Abstract: A biological tissue cutting and fluid aspiration system provides a plurality of surgical instruments operable independent of an external control console. In some embodiments, each surgical instrument may include all sensors and controls directly applicable to the surgical instrument, and may be used independently. In some embodiments, instruments communicate status information to each other, and adjust operating parameters based on the communications.

Abstract translation: 生物组织切割和流体抽吸系统提供可独立于外部控制台操作的多个外科器械。 在一些实施例中，每个外科器械可以包括直接适用于外科器械的所有传感器和控制器，并且可以独立地使用。 在一些实施例中，仪器彼此通信状态信息，并且基于通信来调整操作参数。

公开(公告)号：US08512722B2

公开(公告)日：2013-08-20

申请号：US12842593

申请日：2010-07-23

Applicant: Choon Woo Lee ,  Robert H. Grubbs ,  Mark Humayun

Inventor： Choon Woo Lee ,  Robert H. Grubbs ,  Mark Humayun

IPC: A01N25/10

CPC classification number: C09D5/14 ,  A01N33/12 ,  C08G73/0206 ,  C08G73/0226 ,  C09D5/1637 ,  C09D179/02 ,  D06M16/00 ,  Y10T428/31721 ,  Y10T428/31725 ,  A01N25/34 ,  A01N2300/00

Abstract: The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to the substrate. In one embodiment, for example, there is provided a quaternary amine-containing polymeric coating comprising propylene and ethylene repeat units.

Abstract translation: 本公开提供了适合于在基底上制备涂层的方法和材料。 涂层包含季胺基，因此赋予基底抗菌性能。 在一个实施方案中，例如，提供了包含丙烯和乙烯重复单元的含季铵的聚合物涂层。

公开(公告)号：US20130143326A1

公开(公告)日：2013-06-06

申请号：US13355426

申请日：2012-01-20

Applicant: Yu-Chong Tai ,  Bo Lu ,  Mark Humayun

Inventor： Yu-Chong Tai ,  Bo Lu ,  Mark Humayun

IPC: C12N5/071 ,  C12N5/077 ,  C23C16/44

CPC classification number: A61L27/16 ,  A61L27/50 ,  A61L27/56 ,  A61L2430/16 ,  B01D71/44 ,  B01D2325/06 ,  C12N5/0068 ,  C12N2533/30 ,  C12N2535/10 ,  C12N2539/00

Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.

Abstract translation: 公开了具有较厚区域散布的具有光滑前侧和超薄区域（例如，0.01μm至5μm厚）的薄聚对二甲苯C膜。 与光滑的前侧相比，膜的背面可能是粗糙的。 膜可以在体外用于在实验室或体内生长细胞的单层，作为外科手术植入的生长层，例如替代眼睛中的Bruch膜。 聚对二甲苯的薄区域是半渗透性的，以允许血清中的蛋白质通过，并且厚区域给予外科医生处理的机械支持。 光滑的前侧允许单层细胞生长，粗糙的背面有助于防止细胞附着在那里。

公开(公告)号：US20120325704A1

公开(公告)日：2012-12-27

申请号：US13312948

申请日：2011-12-06

Applicant: Ralph Kerns ,  Mark Humayun ,  Matthew T. McCormick ,  Trent Spencer Wells ,  Lawrence Chong ,  Jaw Chyng Lue

Inventor： Ralph Kerns ,  Mark Humayun ,  Matthew T. McCormick ,  Trent Spencer Wells ,  Lawrence Chong ,  Jaw Chyng Lue

IPC: A61B19/02 ,  B65B3/04

CPC classification number: A61B50/33 ,  A61B50/20 ,  A61B90/30 ,  A61B90/50 ,  A61B2017/00221 ,  A61B2017/00225 ,  A61B2017/00398 ,  A61B2017/00477 ,  A61B2017/00734 ,  A61B2217/005 ,  A61B2217/007 ,  A61F9/007 ,  A61F9/00736 ,  A61M1/0001 ,  A61M3/0254 ,  A61M2205/7536

Abstract: A surgical apparatus for use by a surgeon can include a tray and a plurality of surgical instruments. The tray can have a plurality of structures located on an upper side of the tray for receiving the plurality of surgical instruments. The tray can receive a separate control unit. The tray can also have a fluid reservoir receiver for receiving a bottle or container of fluid, such as balanced salt solution. The fluid reservoir receiver can include one or more features, including, a spike, an air vent, and a light. A separate container can be used to place the bottle or container of fluid into the fluid reservoir receiver on the tray. This separate container can include a collapsible section.

Abstract translation: 由外科医生使用的手术装置可以包括托盘和多个外科器械。 托盘可以具有位于托盘的上侧的多个结构，用于容纳多个外科器械。 托盘可以接收单独的控制单元。 托盘还可以具有用于接收流体的瓶或容器的流体储存器接收器，例如平衡盐溶液。 流体储存器接收器可以包括一个或多个特征，包括尖峰，通气孔和光。 可以使用单独的容器将流体的瓶子或容器放置在托盘上的流体储存器接收器中。 这个单独的容器可以包括可折叠部分。