-
公开(公告)号:US20250163418A1
公开(公告)日:2025-05-22
申请号:US18940823
申请日:2024-11-07
Applicant: Northeastern University
Inventor: Ke Zhang
IPC: C12N15/113 , A61P21/00
Abstract: Provided herein are, in various embodiments, methods and compositions for treating muscular dystrophy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a composition comprising a bottlebrush polymer-oligonucleotide conjugate. Also provided herein are methods of making bottlebrush polymer-oligonucleotide conjugates.
-
公开(公告)号:US20250158113A1
公开(公告)日:2025-05-15
申请号:US18839319
申请日:2023-02-14
Applicant: Northeastern University
Inventor: Hongli Zhu , Daxian Cao
IPC: H01M10/0562 , H01M4/02 , H01M4/04 , H01M4/134 , H01M4/1391 , H01M4/36 , H01M4/38 , H01M4/525 , H01M4/62 , H01M4/66 , H01M10/0585
Abstract: Described herein is an all-solid-state battery comprising two or more mono cells connected in series, wherein: each mono cell comprises a lithium-based cathode, a sulfide solid electrolyte, and an anode; and adjacent mono cells are connected through a single, shared current collector in contact with a cathode and an anode of adjacent mono cells. The all-solid-state battery can be fabricated by stacking freestanding layers of the lithium-based cathode, the sulfide solid electrolyte, the anode, and the current collector in a bipolar design, and pressing the layers together to form the all-solid-state battery. The lithium-ion battery -can be incorporated into portable electronics and electric vehicles.
-
公开(公告)号:US20250141471A1
公开(公告)日:2025-05-01
申请号:US18927527
申请日:2024-10-25
Applicant: Northeastern University
Inventor: Hessam Mahdavifar
IPC: H03M13/11
Abstract: Error-corrected communication is provided. A base matrix is constructed. The base matrix comprises a plurality of columns. A plurality of permutations is applied to the base matrix to obtain a plurality of permuted matrices. A parity-check matrix is generated by concatenating the plurality of permuted matrices. A plurality of codewords is generated based on the parity-check matrix. A message is encoded according to the plurality of codewords. The encoded message is transmitted via a noisy channel.
-
公开(公告)号:US20250134791A1
公开(公告)日:2025-05-01
申请号:US18990742
申请日:2024-12-20
Applicant: Northeastern University
Inventor: Jeffrey N. Agar
IPC: A61K8/49 , A61K8/58 , A61K8/65 , A61K47/22 , A61Q3/02 , A61Q5/00 , C08F283/06 , C08F289/00 , C08G75/06 , C09D1/00 , C09D171/02 , C09D181/02 , C09D189/00 , C12N11/08 , C25D11/00
Abstract: Disclosed are polymers, methods of making polymers, and compositions, focused on cross-linking heterocycles comprising a moiety of Formula I with thiols and thiolates.
-
公开(公告)号:US20250120873A1
公开(公告)日:2025-04-17
申请号:US18911616
申请日:2024-10-10
Applicant: Northeastern University
Inventor: Max Shepherd , Divyansh Gupta
Abstract: The present disclosure provides a unidirectional actuator with customizable series elasticity. The actuator includes a winch, a cable coupled to the winch, a spring-loaded idler engaged with the cable, and a cam coupled to the spring-loaded idler. The spring-loaded idler comprises an idler arm and a spring member. The cam is shaped to provide a nonlinear stiffness versus force characteristic for the spring-loaded idler. The actuator can be applied in various applications, such as an ankle exoskeleton.
-
公开(公告)号:US20250086333A1
公开(公告)日:2025-03-13
申请号:US18031457
申请日:2023-02-08
Applicant: Northeastern University
Inventor: Xiwei ZHANG , Xiating FENG , Chunyuan XUE , Lei SHI
Abstract: Provided is a three-dimensional loading structure of an ultra-large physical simulation facility for deep engineering disasters. The three-dimensional loading structure comprises a horizontal ultra-large reaction frame, a vertical ultra-large reaction frame, ultra-long stroke lifting and locking hydraulic cylinders, five array distributed hydraulic actuator groups and a linear distributed hydraulic actuator group, wherein the horizontal ultra-large reaction frame adopts a frame structure being formed by splicing eight segments of arch beams, circular in an outer part and square in an inner part, and wrapped with prestressed carbon fibers, and the vertical ultra-large reaction frame adopts a double-beam four-column preload frame structure; the five array distributed hydraulic actuator groups are distributed around the horizontal ultra-large reaction frame and at a top of the vertical ultra-large reaction frame, and the linear distributed hydraulic actuator group is located at a center of a bottom of the vertical ultra-large reaction frame.
-
公开(公告)号:US12247245B2
公开(公告)日:2025-03-11
申请号:US17262031
申请日:2019-05-24
Applicant: NORTHEASTERN UNIVERSITY
Inventor: Kim Lewis , Anthony D'Onofrio , Thomas Curtis , Charlotte Berkes
IPC: C12Q1/18
Abstract: Assays for compounds having a desired biological activity against one but not both of a pair of microorganism species utilize separately detectable labels. The first and second microorganisms are different from each other, the first microorganisms exhibit a first detectable label, the second microorganisms exhibit a second detectable label different from the first detectable label, and neither of the labels interferes with detection of the other label. In various embodiments, the first and second microorganisms are incubated with a candidate compound or a producer thereof. The different labels permit isolation of microorganisms exhibiting one of the labels but not the other, indicating the desired activity, and the compound responsible for this differential response is isolated.
-
8.
公开(公告)号:US12228476B2
公开(公告)日:2025-02-18
申请号:US17781475
申请日:2021-07-29
Applicant: Northeastern University
Inventor: Feng Luan , Xu Li , Ziming Zhang , Yan Wu , Yuejiao Han , Dianhua Zhang
IPC: G01M99/00 , G01H17/00 , G06F18/2131 , G06F18/24 , G06N3/04 , G06N3/044 , G06N3/045 , G06N3/0464 , G06N3/08 , H04R1/40
Abstract: Provided is a fault signal locating and identifying method of industrial equipment based on a microphone array. The method includes the steps of: acquiring sound signals and dividing the acquired signals into a training set, a verifying set and a test set; performing feature extraction on the sound signals in the training set, and extracting a phase spectrogram and an amplitude spectrogram of a spectrogram; sending an output of a feature extraction module, as an input, to a CNN, and in each layer of the CNN, learning a translation invariance in the spectrogram by using a 2D CNN; in between the layers of the CNN, normalizing the output by using a batch normalization, and reducing a dimension by using a maximum pooling layer along a frequency axis; sending an output from the layers of the CNN to layers of RNN; using a linear activation function; and inputting an output of a full connection layer to two parallel full connection layer branches for fault identification and fault location, respectively.
-
公开(公告)号:US12181440B2
公开(公告)日:2024-12-31
申请号:US17881943
申请日:2022-08-05
Applicant: Northeastern University
Inventor: Roger W. Giese , Pushkar Kulkarni
Abstract: Disclosed is a method of desorbing an adsorbed material by subjecting to energy a diazirine adsorbed on a solid surface or a layer on the solid surface, which causes the diazirine to form a carbene and nitrogen gas; and using the energy of the resultant nitrogen gas to desorb the adsorbed material from the solid surface or a layer on the same. Also disclosed is a method of reacting the resultant carbene with (a) a material in the gas phase proximal to the first solid surface; (b) a material adsorbed on a second solid surface proximal to the first solid surface; or (c) a second solid surface proximal to the first solid surface.
-
公开(公告)号:US12169145B2
公开(公告)日:2024-12-17
申请号:US17422861
申请日:2020-01-21
Applicant: Northeastern University
Inventor: Matteo Rinaldi , Zhenyun Qian , Vageeswar Rajaram , Sungho Kang
IPC: G01J5/00 , G01J5/02 , G01J5/03 , G01J5/08 , G01J5/0806
Abstract: Zero-power system for remote monitoring of heat sources is provided. The systems detect failure indicators of remote equipment including power substations, oil rigs, large inaccessible machinery in a factory, and communications equipment. The systems also can be used to detect the presence of people in buildings or in other locations, so as to improve HVAC utilization in large buildings. When the zero-power monitoring systems detect heat sources, such as the presence of people, failure indicators, or a targeted environmental signal, a circuit is closed using the energy of the detected radiation, and activating an RFID tag, a radio transmitter, or an alarm. The monitoring systems can remain deployed and active for many years without the need for battery replacement.
-
-
-
-
-
-
-
-
-