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公开(公告)号：US20090285831A1
公开(公告)日：2009-11-19
申请号：US12403897
申请日：2009-03-13
Applicant: Andrew NASH , Giuseppe MACCARONE , Pierre David SCOTNEY
Inventor： Andrew NASH , Giuseppe MACCARONE , Pierre David SCOTNEY
IPC: A61K39/395 , C12N5/00 , C07K16/22
Abstract: The present invention relates generally to immunointeractive molecules and more particularly antibodies which bind to vascular endothielial growth factor-B (VEGF-B) or its functional or structural equivalent and inhibit the biological activity of VEGF-B. In particular the present invention relates to deimmunized such as humanized or human antibodies that bind to VEGF-B and inhibit the biological activity of VEGF-B. These antibodies have uses in the treatment or prevention of diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling. The present invention further contemplates a method of modulating diseases associated with perturbations in normal vasculogenesis or angiogenesis or vascular remodelling by the administration of the subject antibodies. The present invention further provides an assay system useful for identifying antibodies which bind to VEGF-B and block the biological activity of VEGF-B. Accordingly, a method of screening for inhibitors of the biological activity of VEGF-B is also provided.
Abstract translation: 本发明一般涉及免疫相互作用分子，更具体地涉及结合血管内皮生长因子-B（VEGF-B）或其功能或结构等同物并抑制VEGF-B生物学活性的抗体。 特别地，本发明涉及结合VEGF-B并抑制VEGF-B的生物学活性的去免疫化的人源化或人抗体。 这些抗体在治疗或预防与正常血管发生或血管生成或血管重构中的扰动相关的疾病中具有用途。 本发明进一步考虑了通过施用本发明的抗体调节与正常血管发生或血管发生或血管重构中的扰动有关的疾病的方法。 本发明还提供了可用于鉴定结合VEGF-B并阻断VEGF-B的生物学活性的抗体的测定系统。 因此，还提供了筛选VEGF-B生物活性抑制剂的方法。
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公开(公告)号：US07213127B2
公开(公告)日：2007-05-01
申请号：US10455808
申请日：2003-06-06
Applicant: Flavio Rampogna , Pierre-David Pfister , Jean-Marc Masgonty , Christian Piguet
Inventor： Flavio Rampogna , Pierre-David Pfister , Jean-Marc Masgonty , Christian Piguet
IPC: G06F12/06
CPC classification number: G06F9/342 , G06F9/30181
Abstract: A system for generating addresses for a digital signal processor in which the program instructions include a code for accessing a memory associated with said processor. An address calculation circuit calculates each access address to the memory on the basis of operation codes designated by the address generation code of one of the instructions and of the content of one address register selected from said address registers. Each address generation code defines an operation code to be sent to the calculation circuit. Each of the address registers is further associated with a configuration register designated at the same time as the address register by the address generation code, and each of the configuration registers contains a set of predefined operation codes, each adapted to command a predetermined calculation operation in the calculation circuit.
Abstract translation: 一种用于产生数字信号处理器的地址的系统，其中所述程序指令包括用于访问与所述处理器相关联的存储器的代码。 地址计算电路根据由指令之一的地址生成代码和从所述地址寄存器中选择的一个地址寄存器的内容指定的操作码，计算每个存取地址到存储器。 每个地址生成代码定义要发送到计算电路的操作码。 每个地址寄存器还与由地址生成代码与地址寄存器同时指定的配置寄存器进一步相关联，并且每个配置寄存器包含一组预定义的操作代码，每个预定义操作代码适于命令预定的计算操作 计算电路。
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3.发明授权公开(公告)号：US06653064B1
公开(公告)日：2003-11-25
申请号：US09668300
申请日：2000-09-25
Applicant: Wolfram Jochum , Jean-Pierre David , Koichi Matsuo , Erwin F. Wagner
Inventor： Wolfram Jochum , Jean-Pierre David , Koichi Matsuo , Erwin F. Wagner
IPC: C12Q100
CPC classification number: C07K14/4702 , A01K2217/05 , G01N33/6872 , G01N33/6893
Abstract: The present invention relates to a screening method for identifying a substance for the treatment of bone disorders that are associated with reduced bone mass in which the substance is tested for its ability to upregulate the expression of Fra-1 or to modulate the expression of a Fra-1 target gene in osteoblasts where the upregulation or modulation results in an increased bone formation in vivo. The identified osteoinductive compounds and DNA molecules encoding biologically active Fra-1 molecules can be used for the therapy of bone disorders characterized by a circumscribed or systemic reduction of bone mass.
Abstract translation: 本发明涉及一种筛选方法，用于鉴定用于治疗骨质疏松症的物质，所述物质与骨量减少有关，其中该物质被测试其上调Fra-1表达的能力或调节Fra的表达 -1靶基因在成骨细胞中，其中上调或调节导致体内骨形成增加。 所鉴定的骨诱导化合物和编码生物活性的Fra-1分子的DNA分子可用于治疗特征在于骨量限制或全身减少的骨疾病。
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公开(公告)号：US5953049A
公开(公告)日：1999-09-14
申请号：US691737
申请日：1996-08-02
Applicant: David N. Horn , Amir M. Mane , Pierre David Wellner
Inventor： David N. Horn , Amir M. Mane , Pierre David Wellner
IPC: H04N7/15 , H04N21/2368 , H04N21/434 , H04N7/14
CPC classification number: H04N21/2368 , H04N21/242 , H04N21/4307 , H04N21/4341 , H04N7/15
Abstract: In an illustrative embodiment, an audio/video conferencing system comprises two or more audio/video terminals, in which the transmitted and/or received audio is automatically adjusted to provide synchronization between audio and video during periods of monologue (i.e., single talker active for significant duration). During interactive periods in which more than one talker is active, the audio delay is automatically adjusted to be less than the video delay, thus improving audio conference quality.
Abstract translation: 在说明性实施例中，音频/视频会议系统包括两个或更多个音频/视频终端，其中发送和/或接收的音频被自动调整以在独白期间提供音频和视频之间的同步（即，对于 显着持续时间）。 在多个讲话者活动的交互期间，音频延迟自动调整为小于视频延迟，从而提高音频会议质量。
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5.发明授权Hybrid component with high strength/mass ratio and method of manufacturing said component 失效具有高强度/质量比的混合组分和制造所述组分的方法
公开(公告)号：US5887332A
公开(公告)日：1999-03-30
申请号：US804074
申请日：1997-02-21
Applicant: Christophe Jean Roger Champenois , Laurent Jean Pierre David , Gerard Michel Roland Gueldry , Robert Lucien Martinou
Inventor： Christophe Jean Roger Champenois , Laurent Jean Pierre David , Gerard Michel Roland Gueldry , Robert Lucien Martinou
CPC classification number: F01D5/286 , B29C37/0082 , B29C70/08 , B29C70/48 , F01D5/282 , F04D29/324 , B29L2031/08 , B29L2031/082 , F05D2230/311 , F05D2230/312 , F05D2240/303 , Y02T50/67 , Y02T50/672 , Y02T50/673 , Y10T29/49337 , Y10T29/49982 , Y10T29/49984 , Y10T428/24995 , Y10T428/249951 , Y10T428/249952
Abstract: The invention provides a high-strength hybrid component comprising a relatively soft first part -made of a composite material consisting of an organic matrix reinforced with fibres, a relatively hard second part made of metal, metal alloy or ceramic, and a transition layer made of a composite material consisting of a matrix of a material which is weldable to the hard part and fibres which are extensions of the fibres of the soft part. The transition layer matrix and the hard part may be formed by deposition of molten material on to the fibre preform of the soft part, using flame, electric arc or plasma, and the resin matrix of the soft part is impregnated into the preform and polymerized afterwards.Alternatively, the hard part may be machined to shape and welded to the transition layer before completing the soft part.
Abstract translation: 本发明提供了一种高强度混合组分，其包括由纤维增强的有机基质组成的复合材料的相对柔软的第一部分，由金属，金属合金或陶瓷制成的相对较硬的第二部分，以及由 由可与硬质部分焊接的材料的基质和作为软质部分的纤维的延伸部的纤维构成的复合材料。 可以通过使用火焰，电弧或等离子体将熔融材料沉积到软质部件的纤维预成型体上而形成过渡层基体和硬质部分，并且将软质部分的树脂基体浸渍到预成型体中并随后聚合 。 或者，可以在完成软部件之前将硬质部件加工成形状并焊接到过渡层。
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Patent Agency Ranking
公开(公告)号：US06689138B2
公开(公告)日：2004-02-10
申请号：US10059232
申请日：2002-01-31
Applicant: André Léchot , Patrick M. White , Pierre-David Bourgeois , Ezzedine Mahmoud
Inventor： André Léchot , Patrick M. White , Pierre-David Bourgeois , Ezzedine Mahmoud
IPC: A61B1716
CPC classification number: B23B31/117 , B23B2228/16 , Y10T279/17
Abstract: According to the invention, a torque-transmitting assembly is described. A female coupling member defines a shape with a tapered bore. A radially flexible sleeve member has a wall with a tapered exterior surface, received within the bore, and an inner surface defining a through-bore. An elongated shaft member made of super-elastic alloy has an outer surface that is received within the through-bore. Relative motion among at least two of the members causes the inner surface to contact the outer surface, inducing a super-elastic activation in the shaft, simultaneously securing the members together in a fixed relative position. The radially flexible sleeve member has a plurality of collet fingers, which preferably contact the shaft at discrete locations. It is further preferred that the super-elastic activation in the shaft occurs as a result of the discrete contact thereby changing the cross-sectional shape of the shaft, which is generally non-circular, e.g., polygonal, in a further preferred form. A surgical device, e.g., a flexible reamer, is descibed as incorporating the present assembly.
Abstract translation: 根据本发明，描述了扭矩传递组件。 阴联接构件限定具有锥形孔的形状。 径向柔性的套筒构件具有壁，该壁具有锥形的外表面，容纳在孔内，以及限定通孔的内表面。 由超弹性合金制成的细长轴构件具有容纳在通孔内的外表面。 至少两个构件之间的相对运动导致内表面接触外表面，在轴中引起超弹性活动，同时将构件固定在固定的相对位置。 径向柔性套筒构件具有多个夹头，其优选地在离散位置处接触轴。 进一步优选的是，轴中的超弹性活动是由于离散的接触而发生的，从而以更优选的形式改变了通常为非圆形，例如多边形的轴的横截面形状。 手术装置，例如柔性铰刀，被描述为并入本组件。
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7.发明授权Hybrid component with high strength/mass ratio and method of manufacturing said component 失效具有高强度/质量比的混合组分和制造所述组分的方法
公开(公告)号：US06132857A
公开(公告)日：2000-10-17
申请号：US215292
申请日：1998-12-18
Applicant: Christophe Jean Roger Champenois , Laurent Jean Pierre David , Gerard Michel Roland Gueldry , Robert Lucien Martinou
Inventor： Christophe Jean Roger Champenois , Laurent Jean Pierre David , Gerard Michel Roland Gueldry , Robert Lucien Martinou
CPC classification number: F01D5/286 , B29C37/0082 , B29C70/08 , B29C70/48 , F01D5/282 , F04D29/324 , B29L2031/08 , B29L2031/082 , F05D2230/311 , F05D2230/312 , F05D2240/303 , Y02T50/67 , Y02T50/672 , Y02T50/673 , Y10T29/49337 , Y10T29/49982 , Y10T29/49984 , Y10T428/24995 , Y10T428/249951 , Y10T428/249952
Abstract: A high-strength hybrid component including a relatively soft first part made of a composite material including an organic matrix reinforced with fibers, a relatively hard second part made of metal, metal alloy, or ceramic, and a transition layer made of a composite material including a matrix of a material that is weldable to the hard part and fibers that are extensions of the fibers of the soft part. The transition layer matrix and the hard part may be formed by deposition of molten material on to the fiber preform of the soft part using flame, electric arc, or plasma. The resin matrix of the soft part is impregnated into the preform and polymerized afterwards. Alternatively, the hard part may be machined to shape and welded to the transition layer before completing the soft part.
Abstract translation: 一种高强度混合部件，其特征在于，包括由纤维增强的有机基体，由金属，金属合金或陶瓷构成的相对硬的第二部分的复合材料构成的比较软的第一部分，以及由复合材料构成的过渡层， 与硬质部件可焊接的材料的基体和作为软质部件的纤维的延伸部的纤维。 可以通过使用火焰，电弧或等离子体将熔融材料沉积到柔软部件的纤维预制件上来形成过渡层基体和硬部分。 将软部分的树脂基体浸入预成型体中并进行聚合。 或者，可以在完成软部件之前将硬质部件加工成形状并焊接到过渡层。
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公开(公告)号：US08822644B2
公开(公告)日：2014-09-02
申请号：US11659179
申请日：2005-08-02
Applicant: Andrew Nash , Felicity Meredith Dunlop , Manuel Baca , Louis Jerry Fabri , Pierre David Scotney
Inventor： Andrew Nash , Felicity Meredith Dunlop , Manuel Baca , Louis Jerry Fabri , Pierre David Scotney
CPC classification number: C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/73 , C07K2317/76
Abstract: The present invention relates generally to the field of cancer therapy and prophylaxis. More particularly, the present invention provides growth factor antagonists which inhibit the growth of cancers including tumors and pre-cancerous tissue. Even more particularly, the present invention is directed to antagonists of vascular endothelial growth factor-B and their use to inhibit the growth of cancer including tumor tissue and pre-cancerous tissue.
Abstract translation: 本发明一般涉及癌症治疗和预防领域。 更具体地，本发明提供了抑制癌症包括肿瘤和癌前组织的生长的生长因子拮抗剂。 更具体地，本发明涉及血管内皮生长因子B的拮抗剂及其抑制癌症生长的用途，包括肿瘤组织和癌前组织。
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公开(公告)号：US6031491A
公开(公告)日：2000-02-29
申请号：US125110
申请日：1998-09-15
Applicant: Jean-Pierre Daniel , Mohamed Himdi , Daniel Gaudin , Jean-Pierre David
Inventor： Jean-Pierre Daniel , Mohamed Himdi , Daniel Gaudin , Jean-Pierre David
CPC classification number: H01Q21/065 , H01Q21/22
Abstract: A broadband array antenna which delivers an axisymmetric main lobe. The antenna includes patches arranged with an interruption of periodicity in one of the planes and is corner-fed by tree like feed lines from a central point of energization. Opposite each path is a parasitic element for broadening the band. This device can be used in particular with measurement radar.
Abstract translation: PCT No.PCT / FR97 / 02314 Sec。 371日期：1998年9月15日 102（e）1998年9月15日PCT PCT 1997年12月16日PCT公布。 公开号WO98 / 27616 日期1998年6月25日一种传输轴对称主瓣的宽带阵列天线。 天线包括在其中一个平面中周期性中断布置的补片，并且由来自中心点通电的树状馈送线转角馈送。 每个路径相对的是用于扩展频带的寄生元件。 该装置特别适用于测量雷达。
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10.发明授权Process for moulding high strength elongated parts made of a fibre-resin composite 失效用于模制由纤维树脂复合材料制成的高强度细长部件的方法
公开(公告)号：US5885504A
公开(公告)日：1999-03-23
申请号：US736719
申请日：1996-10-25
CPC classification number: B29C37/005 , B29C35/0288 , B29C70/48 , B29C2035/1616 , B29C2045/7343 , B29C2045/7393 , B29C35/04 , B29L2031/08
Abstract: A process for moulding high strength elongated parts made of a fibre-resin composite material, especially turbomachine blades such as fan blades, is disclosed wherein a plurality of heating and cooling elements are arranged within the body of the mould at intervals along the length of the mould cavity, and the liquid resin which is injected at one end into the mould cavity containing the fibre preform is polymerized progressively from the opposite end of the mould cavity, while maintaining the supply of liquid resin under pressure to the cavity, by successively de-activating the cooling elements, which maintain the resin in the liquid state, at predetermined time intervals starting from said opposite end of the mould cavity and progressing in turn towards said one end, and in synchronism therewith successively activating the heating elements to raise the temperature of the resin to the polymerizing temperature progressing in turn from said opposite end to said one end of the mould cavity. The process enables shrink cavities in the finished part to be avoided.
Abstract translation: 公开了一种用于模制由纤维树脂复合材料制成的高强度细长部件的方法，特别是诸如风扇叶片的涡轮机叶片，其中多个加热和冷却元件沿模具的长度间隔设置在模具主体内 模腔和在一端注入到含有纤维预制件的模腔中的液态树脂从模腔的相对端逐渐聚合，同时通过依次去除空腔中的液体树脂的压力， 启动从模腔的相对端开始的预定时间间隔将树脂保持在液态的冷却元件，并且依次朝向所述一端前进，同时随后激活加热元件以提高温度 聚合温度的树脂从模具的相反端向所述一端依次进行 ty。 该过程使得可以避免成品部件中的收缩腔。
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