公开(公告)号：US11289317B2

公开(公告)日：2022-03-29

申请号：US17135963

申请日：2020-12-28

Applicant: Protein Metrics Inc.

Inventor： Yong Joo Kil ,  Eric Carlson

IPC: H01J49/00 ,  H01J49/02

Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.

公开(公告)号：US20200286722A1

公开(公告)日：2020-09-10

申请号：US16883983

申请日：2020-05-26

Applicant: Protein Metrics Inc.

Inventor： Marshall BERN

IPC: H01J49/00 ,  H01J49/16

Abstract: Methods and apparatuses for the identification and/or characterization of properties of a sample using mass spectrometry. The method involves using a measured spectrum of data from a sample taken with a mass spectrometer, deconvoluting the measured spectrum of data by applying parsimony weighting to minimize the number of charge states based on one or more of: the number of intense peaks in the mass spectrum; the number of harmonic relationships (e.g., masses in small integer ratios); and the number of off-by-one relationships (e.g., m/z bins with high probability for two adjacent charges). Thus, the underlying m/z spectrum may be inferred from the family of plausible deconvoluted spectra determined by applying parsimony and the inferred m/z spectrum may be used to identify and/or characterize the sample.

公开(公告)号：US20200234937A1

公开(公告)日：2020-07-23

申请号：US16713556

申请日：2019-12-13

Applicant: Protein Metrics Inc.

Inventor： Yong Joo KIL ,  Eric CARLSON

IPC: H01J49/00 ,  H01J49/02

Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.

公开(公告)号：US20190043703A1

公开(公告)日：2019-02-07

申请号：US16052506

申请日：2018-08-01

Applicant: PROTEIN METRICS INC.

Inventor： Marshall BERN ,  Yong Joo KIL

IPC: H01J49/00 ,  G01N33/58 ,  G01N33/68

CPC classification number: H01J49/0036 ,  G01N33/58 ,  G01N33/6848

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising interactive and dynamic selection of one or more masses and concurrent display of peaks (points) corresponding to that predicted mass value across other displays (MS1, deconvolved mass spectrum, etc.).

公开(公告)号：US09859917B2

公开(公告)日：2018-01-02

申请号：US15431381

申请日：2017-02-13

Applicant: Protein Metrics Inc.

Inventor： Doron Kletter

IPC: H03M7/34 ,  H03M7/40 ,  H03M7/46 ,  H03M7/42

CPC classification number: H03M7/40 ,  H03M7/24 ,  H03M7/30 ,  H03M7/3084 ,  H03M7/3088 ,  H03M7/42 ,  H03M7/46

Abstract: Disclosed are methods and systems for significantly compressing sparse multidimensional ordered series data comprised of indexed data sets, wherein each data set comprises an index, a first variable and a second variable. The methods and systems are particularly suited for compression of data recorded in double precision floating point format.

公开(公告)号：US09640376B1

公开(公告)日：2017-05-02

申请号：US14306020

申请日：2014-06-16

Applicant: Protein Metrics Inc.

Inventor： Christopher Becker ,  Marshall Bern ,  Yong Joo Kil ,  Michael Taejong Kim ,  Boyan Zhang

IPC: H01J49/00 ,  G06T11/20 ,  H01J49/02

CPC classification number: H01J49/0036 ,  G06T11/206 ,  H01J49/02

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

公开(公告)号：US20220067980A1

公开(公告)日：2022-03-03

申请号：US17462901

申请日：2021-08-31

Applicant: Protein Metrics Inc.

Inventor： Doron KLETTER

IPC: G06T9/00 ,  H04N19/119 ,  G06F17/15

Abstract: Described herein are computer-implemented methods for compressing sparse multidimensional ordered series data. In particular, these methods and apparatuses for performing them (including software) may be particularly well suited to efficiently compressing spectrographic data.

公开(公告)号：US20210335589A1

公开(公告)日：2021-10-28

申请号：US17240996

申请日：2021-04-26

Applicant: Protein Metrics Inc.

Inventor： Marshall BERN ,  Yong Joo KIL

IPC: H01J49/00 ,  G01N33/68 ,  G01N33/58

Abstract: This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising interactive and dynamic selection of one or more masses and concurrent display of peaks (points) corresponding to that predicted mass value across other displays (MS1, deconvolved mass spectrum, etc.).

公开(公告)号：US20210118659A1

公开(公告)日：2021-04-22

申请号：US17135963

申请日：2020-12-28

Applicant: Protein Metrics Inc.

Inventor： Yong Joo KIL ,  Eric CARLSON

IPC: H01J49/00 ,  H01J49/02

Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.

公开(公告)号：US20210048440A1

公开(公告)日：2021-02-18

申请号：US16859758

申请日：2020-04-27

Applicant: Protein Metrics Inc.

Inventor： Andrew NICHOLS ,  Marshall BERN ,  Yong Joo KIL ,  Eric CARLSON

IPC: G01N33/68 ,  H01J49/00

Abstract: Methods and apparatuses for the identification and/or characterization of properties of a macromolecule based on mass spectrometry data. Specifically, described herein are methods and apparatuses for converting peptide-level data into a pseudo-intact mass spectra. Also described herein are methods and apparatuses for converting peptide-level data into a pseudo-electropherogram. The methods may be well suited for analyzing proteins and protein complexes, including estimating properties of post-translational modifications of the proteins and protein complexes. Methods may include generating a theoretical graph or spectrum based on peptide-level mass spectrometry data. In some embodiments, the theoretical graph may be a theoretical intact mass spectrum or a theoretical charge distribution spectrum.